Reactome | PDIA6 [endoplasmic reticulum membrane]

PDIA6 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-535530

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Protein disulfide-isomerase A6, PDIA6_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q15084 PDIA6

Gene Names

PDIA6, ERP5, P5, TXNDC7

Chain

signal peptide:1-19, chain:20-440

Reference Genes

BioGPS Gene:10130 PDIA6

COSMIC (genes):PDIA6 PDIA6

CTD Gene:10130 PDIA6

dbSNP Gene:10130 PDIA6

ENSEMBL:ENSG00000143870 PDIA6

HGNC:30168 PDIA6

KEGG:hsa:10130 PDIA6

Monarch:10130 PDIA6

NCBI Gene:10130 PDIA6

OMIM:611099 PDIA6

UCSC:Q15084 PDIA6

Reference Transcript

Other Identifiers

10130

11715434_a_at

11745720_s_at

11749778_a_at

16894452

207668_PM_x_at

207668_x_at

208638_PM_at

208638_at

208639_PM_x_at

208639_x_at

216640_PM_s_at

216640_s_at

2540321

2540322

2540323

2540326

2540329

2540331

2540332

2540333

2540334

2540335

2540337

2540341

2540342

2540344

2540345

2540348

2540350

2540354

2540355

2540356

41750_at

74808_s_at

8050278

A_24_P319715

D49489_at

GE61375

GO:0003756

GO:0003824

GO:0005515

GO:0005615

GO:0005737

GO:0005783

GO:0005788

GO:0005789

GO:0005793

GO:0005829

GO:0005886

GO:0006457

GO:0015035

GO:0016491

GO:0016853

GO:0031410

GO:0034663

GO:0034976

GO:0042470

GO:0043226

GO:0043231

GO:0070062

GO:0140096

HMNXSV003029351

HMNXSV003040605

Hs.182429.1.S2_3p_at

Hs.182429.2.S1_3p_a_at

ILMN_1680626

PH_hs_0023080

TC02001573.hg

Participates

as an output of

Expression of PDIA6 (Protein disulfide-isomerase A6) (Homo sapiens)

Other forms of this molecule

PDIA6 [endoplasmic reticulum lumen]

p-PDIA6 [endoplasmic reticulum lumen]

Cross References

RefSeq

NP_001269635.1, NP_001269633.1, NP_005733.1, NP_001269634.1, NP_001269636.1

OpenTargets

ENSG00000143870

ENSEMBL

ENSP00000384459, ENSP00000438778, ENSP00000272227, ENST00000404371, ENST00000272227, ENST00000540494, ENSP00000385385, ENST00000381611, ENST00000404824, ENST00000617249, ENSP00000371024, ENSP00000481892

IntEnz

5.3.4.1

HPA

ENSG00000143870-PDIA6

PRO

Q15084

Pharos - Targets

Q15084

GlyGen

Q15084

PDB

3VWW, 1X5D, 3W8J, 4EF0, 8CPQ, 4GWR

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	16
UniProt:P11021 HSPA5	6	HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [extracellular region] (R-HSA-351322)	0.564	2
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:O43681 GET3	1	ASNA1 [cytosol] (R-HSA-9609520)	0.556	3
UniProt:Q96EQ0 SGTB			0.556	3
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.527	3
UniProt:P49286 MTNR1B	1	MTNR1B [plasma membrane] (R-HSA-419349)	0.527	2
UniProt:Q13618 CUL3	3	G76-NEDD8-K712-CUL3 [cytosol] (R-HSA-8952516) CUL3 [nucleoplasm] (R-HSA-5635033) CUL3 [cytosol] (R-HSA-975979)	0.527	2
UniProt:P48039 MTNR1A	1	MTNR1A [plasma membrane] (R-HSA-419316)	0.527	2
UniProt:Q13162 PRDX4	3	PRDX4 [ficolin-1-rich granule lumen] (R-HSA-6803286) PRDX4 [extracellular region] (R-HSA-6806512) PRDX4 [secretory granule lumen] (R-HSA-6803305)	0.525	2
UniProt:P03366 POL			0.462	2

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