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PPIA [ficolin-1-rich granule lumen]
Stable Identifier
R-HSA-6801391
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
ficolin-1-rich granule lumen
Synonyms
Cyp A protein
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of ficolin-rich granule lumen proteins (Homo sapiens)
Ficolin-rich granule lumen proteins [ficolin-1-rich granule lumen] (Homo sapiens)
PPIA [ficolin-1-rich granule lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P62937 PPIA
Gene Names
PPIA, CYPA
Chain
chain:1-165, initiator methionine:, chain:2-165
Reference Genes
BioGPS Gene:5478 P629372
COSMIC (genes):PPIA PPIA
CTD Gene:5478 P629372
dbSNP Gene:5478 P629372
ENSEMBL:ENSG00000196262 PPIA
HGNC:9253 P629372
KEGG:hsa:5478 P629372
Monarch:5478 P629372
NCBI Gene:5478 P629372
OMIM:123840 P629372
UCSC:P62937 P629372
Reference Transcript
RefSeq:NM_001300981.1 P629372
RefSeq:NM_021130.4 P629372
Participates
as a member of
Ficolin-rich granule lumen proteins [ficolin-1-rich granule lumen] (Homo sapiens)
Other forms of this molecule
PPIA [cytosol]
PPIA [extracellular region]
PPIA [secretory granule lumen]
PPIA [extracellular exosome]
Inferred To
Cyp1 [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
Ppia [ficolin-1-rich granule lumen]
(Mus musculus)
Ppia [ficolin-1-rich granule lumen]
(Rattus norvegicus)
ppiab [ficolin-1-rich granule lumen]
(Danio rerio)
PPIA [ficolin-1-rich granule lumen]
(Bos taurus)
PPIA [ficolin-1-rich granule lumen]
(Caenorhabditis elegans)
PPIA [ficolin-1-rich granule lumen]
(Canis familiaris)
PPIA [ficolin-1-rich granule lumen]
(Gallus gallus)
PPIA [ficolin-1-rich granule lumen]
(Sus scrofa)
ppia [ficolin-1-rich granule lumen]
(Xenopus tropicalis)
Cross References
Guide to Pharmacology - Targets
2751
ENSEMBL
ENSP00000503804
,
ENST00000678789
,
ENST00000489459
,
ENSP00000502945
,
ENST00000677107
,
ENSP00000419425
,
ENST00000355968
,
ENST00000678805
,
ENST00000468812
,
ENSP00000430817
,
ENSP00000427976
,
ENSG00000196262
,
ENSP00000504216
,
ENST00000677022
,
ENSP00000504735
OpenTargets
ENSG00000196262
ZINC - Substances
PPIA_HUMAN
ZINC target
P62937
PRO
P62937
GlyGen
P62937
PDB
7PCJ
,
4N1Q
,
6GJL
,
5FJB
,
1M9F
,
6X4M
,
5NOS
,
1VBT
,
6GJY
,
5KV0
,
8TBL
,
6ZDJ
,
8G9Q
,
4YUH
,
7N9X
,
8TBI
,
2MZU
,
5KV1
,
6Y9X
,
7UXM
,
1AWS
,
5NOV
,
2ALF
,
1CWI
,
1AWU
,
3K0M
,
3K0Q
,
1CWL
,
9BG1
,
1CWO
,
1M9D
,
1OCA
,
6U5D
,
2X2D
,
7TA8
,
6X4Q
,
5T9W
,
6X4O
,
4N1N
,
2X2C
,
1W8M
,
6U5C
,
5NOT
,
9BFY
,
6GS6
,
1W8L
,
4YUG
,
4YUI
,
5NOQ
,
5KV5
,
5NOR
,
6GJI
,
2X25
,
8TBJ
,
5KUW
,
4N1O
,
6X3Y
,
8TBG
,
2RMA
,
7UPN
,
5T9Z
,
6GJJ
,
1RMH
,
1M9C
,
3K0O
,
1CWB
,
1AK4
,
5NOZ
,
6Y9V
,
1AWR
,
1CWH
,
1CWK
,
3K0N
,
3K0R
,
3RDD
,
1M63
,
1CWM
,
5TA4
,
1ZKF
,
5KUV
,
3ODI
,
4YUO
,
7QBW
,
8TBF
,
1MIK
,
5KUU
,
2MS4
,
5KUS
,
4YUM
,
6BTA
,
5KUQ
,
1M9E
,
4N1R
,
1VBS
,
4YUK
,
1M9X
,
6U5G
,
1W8V
,
2RMB
,
8G9P
,
5KUZ
,
5KUR
,
7UXN
,
1NMK
,
2XGY
,
7UXJ
,
5WC7
,
6Y9Y
,
3CYH
,
6Y9Z
,
9AX6
,
5NOW
,
5LUD
,
1CWF
,
1AWT
,
1CWJ
,
5NOY
,
1AWV
,
7ABT
,
1MF8
,
6X4P
,
8TBH
,
5T9U
,
5KV7
,
5KUN
,
5KV6
,
1BCK
,
3ODL
,
6GJN
,
5KV4
,
5NOU
,
8HZ8
,
5F66
,
6X4N
,
4CYH
,
4YUJ
,
5KV2
,
4N1S
,
4N1M
,
1M9Y
,
6X3R
,
6GJR
,
5KUO
,
8TBM
,
5KV3
,
4N1P
,
2CYH
,
8TBK
,
6I42
,
1CWA
,
5NOX
,
1CWC
,
3CYS
,
2CPL
,
3K0P
,
6Y9W
,
1AWQ
,
2N0T
,
6U5E
,
1FGL
,
6GJP
,
1YND
,
4YUP
,
5CYH
,
8TBN
,
5TA2
,
4YUL
,
5KUL
,
4IPZ
,
6GJM
,
4YUN
,
2X2A
HPA
ENSG00000196262-PPIA
GeneCards
PPIA
Pharos - Targets
P62937
ZINC - Predictions - Purchasable
PPIA_HUMAN
HMDB Protein
HMDBP10691
Interactors (22)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-8S-N [cytosol]
(R-COV-9729335)
p-S188,206-N [cytosol]
(R-COV-9729324)
N [cytosol]
(R-COV-9694300)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
0.713
3
UniProt:P59595 N
9
N [cytosol]
(R-COV-9683625)
p-S177-N [cytosol]
(R-COV-9683754)
ADPr-p-S177-N [cytosol]
(R-COV-9686058)
SUMO1-K62-ADPr-p-S177-N [cytosol]
(R-COV-9682916)
SUMO1-K62-ADPr-p-S177-N [viral capsid]
(R-COV-9685478)
SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9683641)
N [plasma membrane]
(R-COV-9683611)
SUMO1-K62-ADPr-p-S177-N [nucleolus]
(R-COV-9683730)
SUMO1-K62-ADPr-p-S177-N [plasma membrane]
(R-COV-9686063)
0.676
4
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.666
4
UniProt:Q72497 Q72497
0.623
7
UniProt:P46108-1 CRK
0.595
4
UniProt:Q99IB8-PRO_0000045602
0.59
2
UniProt:P35613 BSG
2
BSG [plasma membrane]
(R-HSA-197673)
BSG [Golgi membrane]
(R-HSA-204478)
0.589
2
UniProt:O14686 KMT2D
1
KMT2D [nucleoplasm]
(R-HSA-1183219)
0.558
2
UniProt:Q00535 CDK5
4
CDK5 [cytosol]
(R-HSA-180064)
p-Y15-CDK5 [cytosol]
(R-HSA-399809)
p-Y15,S159-CDK5 [nucleoplasm]
(R-HSA-6805249)
CDK5 [nucleoplasm]
(R-HSA-8863586)
0.556
3
UniProt:O75376 NCOR1
2
NCOR1 [nucleoplasm]
(R-HSA-442501)
NCOR1 [cytosol]
(R-HSA-1253310)
0.556
3
UniProt:O43614 HCRTR2
1
HCRTR2 [plasma membrane]
(R-HSA-389421)
0.556
3
UniProt:Q8TBB1 LNX1
1
LNX1 [cytosol]
(R-HSA-8851641)
0.556
3
UniProt:P62841 RPS15
2
RPS15 [cytosol]
(R-HSA-72335)
RPS15 [nucleoplasm]
(R-HSA-6798706)
0.556
3
UniProt:O00429 DNM1L
2
DNM1L [cytosol]
(R-HSA-351943)
DNM1L [mitochondrial outer membrane]
(R-HSA-351942)
0.527
5
UniProt:Q13618 CUL3
3
CUL3 [cytosol]
(R-HSA-975979)
CUL3 [nucleoplasm]
(R-HSA-5635033)
G76-NEDD8-K712-CUL3 [cytosol]
(R-HSA-8952516)
0.527
2
UniProt:Q96PV0 SYNGAP1
1
SYNGAP1 [cytosol]
(R-HSA-5658217)
0.527
3
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.527
2
UniProt:O00267 SUPT5H
1
p-SUPT5H [nucleoplasm]
(R-HSA-3009372)
0.508
2
UniProt:P0C6X7-PRO_0000037309 REP
0.508
4
UniProt:Q16849 PTPRN
0.508
3
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
12
UniProt:O95831 AIFM1
0.463
2
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