Reactome | HSPE1 [cytosol]

HSPE1 [cytosol]

Stable Identifier

R-HSA-9714750

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase cycle (Homo sapiens)
      - RHOG GTPase cycle (Homo sapiens)
        
        RHOG binds effectors at the plasma membrane (Homo sapiens)
        
        RHOG plasma membrane effectors [cytosol] (Homo sapiens)
        
        HSPE1 [cytosol] (Homo sapiens)
        
        RHOG:GTP:RHOG plasma membrane effectors [plasma membrane] (Homo sapiens)
        
        RHOG plasma membrane effectors [cytosol] (Homo sapiens)
        
        HSPE1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P61604 HSPE1

Gene Names

HSPE1

Chain

initiator methionine:, chain:2-102

Reference Genes

BioGPS Gene:3336 HSPE1

COSMIC (genes):HSPE1 HSPE1

CTD Gene:3336 HSPE1

dbSNP Gene:3336 HSPE1

ENSEMBL:ENSG00000115541 HSPE1

ENSEMBL_homo_sapiens_GENE:ENSG00000115541.11 HSPE1

HGNC:5269 HSPE1

KEGG Gene (Homo sapiens):3336 HSPE1

Monarch:3336 HSPE1

NCBI Gene:3336 HSPE1

OMIM:600141 HSPE1

UCSC:P61604 HSPE1

Reference Transcript

RefSeq:NM_002157.2 HSPE1

Other Identifiers

11716350_a_at

11716351_s_at

11753996_x_at

205133_PM_s_at

205133_s_at

2521481

2521482

2521488

2521491

2521493

2521494

2521495

2521496

3336

3608284

39353_at

72987_f_at

8047223

GE79023

GO:0001649

GO:0003723

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005739

GO:0005759

GO:0006457

GO:0006919

GO:0006986

GO:0016020

GO:0030154

GO:0043226

GO:0044183

GO:0046872

GO:0051082

GO:0051085

GO:0051087

GO:0070062

HMNXSV003050387

ILMN_2092536

U07550_at

g4504522_3p_a_at

Participates

as a candidate of

RHOG plasma membrane effectors [cytosol] (Homo sapiens)

Inferred To

cpn10 [cytosol] (Danio rerio)

Dmel\CG11267 [cytosol] (Drosophila melanogaster)

Homologues of HSPE1 [cytosol] (Mus musculus)

Hspe1 [cytosol] (Mus musculus)

Hspe1 [cytosol] (Rattus norvegicus)

hspe1 [cytosol] (Xenopus tropicalis)

Hspe1-rs1 [cytosol] (Mus musculus)

HSPE1 [cytosol] (Bos taurus)

HSPE1 [cytosol] (Caenorhabditis elegans)

HSPE1 [cytosol] (Canis familiaris)

HSPE1 [cytosol] (Dictyostelium discoideum)

HSPE1 [cytosol] (Gallus gallus)

HSPE1 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_002148.1

OpenTargets

ENSG00000115541

HPA

ENSG00000115541-HSPE1

GeneCards

P61604

Ensembl

ENSP00000233893, ENSG00000115541, ENST00000233893

PRO

P61604

Pharos - Targets

P61604

PDB

6HT7, 8G7O, 8G7N, 6MRD, 6MRC, 4PJ1

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	17
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4

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