Reactome | SH3BP4 [cytosol]

SH3BP4 [cytosol]

Stable Identifier

R-HSA-8866227

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

SH3 domain-binding protein 4, SH3B4_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9P0V3 SH3BP4

Gene Names

SH3BP4, BOG25, EHB10, TTP

Chain

chain:1-963

Reference Genes

BioGPS Gene:23677 SH3BP4

COSMIC (genes):SH3BP4 SH3BP4

CTD Gene:23677 SH3BP4

dbSNP Gene:23677 SH3BP4

ENSEMBL:ENSG00000130147 SH3BP4

HGNC:10826 SH3BP4

Monarch:23677 SH3BP4

NCBI Gene:23677 SH3BP4

OMIM:605611 SH3BP4

UCSC:Q9P0V3 SH3BP4

Reference Transcript

Other Identifiers

11720658_a_at

11751004_x_at

11754466_a_at

16892750

222258_PM_s_at

222258_s_at

231468_PM_at

231468_at

23677

2533492

2533494

2533497

2533498

2533499

2533500

2533511

2533512

2533513

2533515

2533516

2533517

2533524

2533525

2533527

2533528

2533529

2533538

2533539

2533540

2533543

2533544

2533545

2533546

2533547

2533548

2533555

2533556

2533557

2533558

2533559

2533561

63396_at

8049435

A_14_P120051

A_14_P140004

A_23_P79259

A_33_P3271121

A_33_P3273369

GE58598

GO:0005092

GO:0005515

GO:0005634

GO:0005737

GO:0005905

GO:0006897

GO:0008285

GO:0010508

GO:0016192

GO:0030136

GO:0030308

GO:0031267

GO:0031410

GO:0032007

GO:0034260

GO:0042802

GO:0043226

GO:0050790

GO:0061462

GO:0070062

GO:0071230

GO:0098772

HMNXSV003011512

Hs.17667.1.S1_3p_a_at

Hs.89969.0.A1_3p_at

ILMN_1785330

PH_hs_0027587

PH_hs_0030751

TC02001426.hg

TC02001427.hg

TC02003904.hg

p26130

This entity regulates

Negatively

RRAGA,B exchanges GDP for GTP (Homo sapiens)

Inferred To

sh3bp4a [cytosol] (Danio rerio)

SH3BP4 [cytosol] (Bos taurus)

SH3BP4 [cytosol] (Canis familiaris)

SH3BP4 [cytosol] (Gallus gallus)

SH3BP4 [cytosol] (Sus scrofa)

sh3bp4 [cytosol] (Xenopus tropicalis)

Sh3bp4 [cytosol] (Mus musculus)

Sh3bp4 [cytosol] (Rattus norvegicus)

Cross References

OpenTargets

ENSG00000130147

ENSEMBL

ENSP00000340237, ENST00000409212, ENSP00000375867, ENST00000344528, ENST00000392011, ENSP00000386862

HPA

ENSG00000130147-SH3BP4

PRO

Q9P0V3

Pharos - Targets

Q9P0V3

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.905	10
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.763	6
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.745	6
UniProt:O14908 GIPC1	1	GIPC1 [cytoplasm] (R-HSA-9839329)	0.736	5
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.731	5
UniProt:P02786 TFRC	5	TFRC(1-760) [plasma membrane] (R-HSA-917983) TFRC(1-760) [endosome membrane] (R-HSA-8961829) TFRC(1-760) [cytoplasmic vesicle membrane] (R-HSA-434196) TFRC(1-760) [Golgi membrane] (R-HSA-434330) TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (R-HSA-8869124)	0.668	6
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.65	3
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.64	4
UniProt:P39052 Dnm2	5	DNM2 [Golgi membrane] (R-RNO-2980842) DNM2 [endocytic vesicle membrane] (R-RNO-2029000) Dnm2 [cytosol] (R-RNO-9619847) DNM2 [lysosomal membrane] (R-RNO-2980840) Dynamin-2 [plasma membrane] (R-RNO-941852)	0.611	5
UniProt:P42566 EPS15	2	p-Y849 EPS15 [cytosol] (R-HSA-8867028) EPS15 [cytosol] (R-HSA-182920)	0.609	2
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.536	2
UniProt:Q14627 IL13RA2	1	IL13RA2 [extracellular region] (R-HSA-449666)	0.527	2
UniProt:Q12798 CETN1	7	PolyUb-Misfolded CETN1 [late endosome lumen] (R-HSA-9659982) CETN1 [cilium] (R-HSA-9639700) Misfolded CETN1 [cilium] (R-HSA-9639714) Misfolded CETN1 [cytosol] (R-HSA-9640113) Ub-Misfolded CETN1 [cytosol] (R-HSA-9641110) PolyUb-Misfolded CETN1 [cytosol] (R-HSA-9641126) PolyUb-Misfolded CETN1 [lysosomal lumen] (R-HSA-9659990)	0.527	2
UniProt:Q9Y279 VSIG4			0.527	2
UniProt:Q8TF65 GIPC2			0.527	2
UniProt:P49746 THBS3	1	THBS3 [extracellular region] (R-HSA-66522)	0.527	2
UniProt:Q8NFQ8 TOIP2			0.527	2
UniProt:P50570 DNM2	5	DNM2 [Golgi membrane] (R-HSA-2980842) DNM2 [endocytic vesicle membrane] (R-HSA-2029000) DNM2 [cytosol] (R-HSA-2213180) DNM2 [lysosomal membrane] (R-HSA-2980840) DNM2 [plasma membrane] (R-HSA-2984201)	0.524	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.519	4
UniProt:Q9HB21 PLEKHA1	1	PLEKHA1 [plasma membrane] (R-HSA-8870328)	0.508	2
UniProt:Q9ULV3 CIZ1			0.508	2

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