Reactome | PPP2CB [cytosol]

PPP2CB [cytosol]

Stable Identifier

R-HSA-165987

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PP2A-catalytic subunit C beta isoform

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - Mitotic Spindle Checkpoint (Homo sapiens)
    - Amplification of signal from the kinetochores (Homo sapiens)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
        
        MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Homo sapiens)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        Mad1 binds kinetochore (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        Release of activated MAD2 from kinetochores (Homo sapiens)
        
        Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Separation of Sister Chromatids (Homo sapiens)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        Separation of sister chromatids (Homo sapiens)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
    - Mitotic Prometaphase (Homo sapiens)
      - EML4 and NUDC in mitotic spindle formation (Homo sapiens)
        
        EML4 recruits NUDC to mitotic spindle (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
      - Kinetochore capture of astral microtubules (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
      - Resolution of Sister Chromatid Cohesion (Homo sapiens)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        Kinetochore assembly (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)

Hemostasis (Homo sapiens)

- Platelet homeostasis (Homo sapiens)
  - Platelet sensitization by LDL (Homo sapiens)
    - PECAM-1 binds PP2A (Homo sapiens)
      - PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
      - p-PECAM:PP2A [plasma membrane] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - PIP3 activates AKT signaling (Homo sapiens)
    - Negative regulation of the PI3K/AKT network (Homo sapiens)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
        
        AKT1 dephosphorylation by PP2A-B56-beta,gamma (Homo sapiens)
        
        PP2A-B56-beta,gamma [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        IER3 recruits MAPKs to PP2A-B56-beta,gamma (Homo sapiens)
        
        PP2A-B56-beta,gamma [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers [cytosol] (Homo sapiens)
        
        PP2A-B56-beta,gamma [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        MAPKs phosphorylate PP2A (Homo sapiens)
        
        PP2A-A:PP2A-C [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers [cytosol] (Homo sapiens)
        
        PP2A-B56-beta,gamma [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - Negative regulation of MAPK pathway (Homo sapiens)
        
        PP2A dephosphorylates RAF1 (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
      - RAF activation (Homo sapiens)
        
        PP2A dephosphorylates KSR1 (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PP2A dephosphorylates inactive RAFs (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        DARPP-32 events (Homo sapiens)
        
        DARPP-32 is dephosphorylated on Thr75 by PP2A (Homo sapiens)
        
        PP2A-ABdeltaC complex [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by FGFR (Homo sapiens)
    - Signaling by FGFR1 (Homo sapiens)
      - Negative regulation of FGFR1 signaling (Homo sapiens)
        
        Spry regulation of FGF signaling (Homo sapiens)
        
        PPA2A dephosphorylates SPRY2 (Homo sapiens)
        
        PPA2A (A:C):S112/S115 p-SPRY2 [cytosol] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PPA2A(A:C):SPRY2 [cytosol] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PPTN11 dephosphorylates SPRY2 (Homo sapiens)
        
        PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Homo sapiens)
        
        PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        SPRY2 binds CBL (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        SPRY2 binds GRB2 (Homo sapiens)
        
        PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Homo sapiens)
        
        PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        SPRY2 is phosphorylated by phosphorylated MNK1 (Homo sapiens)
        
        PP2A(A:C):S112/S121-pSPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PP2A(A:C):SPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        SPRY2 translocates to the plasma membrane (Homo sapiens)
        
        PP2A(A:C):SPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PPA2A(A:C):SPRY2 [cytosol] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        SRC phosphorylates SPRY2 on Y55 and Y227 (Homo sapiens)
        
        PP2A(A:C):S112/S121-pSPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PP2A(A:C):SPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
    - Signaling by FGFR2 (Homo sapiens)
      - Negative regulation of FGFR2 signaling (Homo sapiens)
        
        Spry regulation of FGF signaling (Homo sapiens)
        
        PPA2A dephosphorylates SPRY2 (Homo sapiens)
        
        PPA2A (A:C):S112/S115 p-SPRY2 [cytosol] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PPA2A(A:C):SPRY2 [cytosol] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PPTN11 dephosphorylates SPRY2 (Homo sapiens)
        
        PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Homo sapiens)
        
        PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        SPRY2 binds CBL (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        SPRY2 binds GRB2 (Homo sapiens)
        
        PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Homo sapiens)
        
        PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        SPRY2 is phosphorylated by phosphorylated MNK1 (Homo sapiens)
        
        PP2A(A:C):S112/S121-pSPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PP2A(A:C):SPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        SPRY2 translocates to the plasma membrane (Homo sapiens)
        
        PP2A(A:C):SPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PPA2A(A:C):SPRY2 [cytosol] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        SRC phosphorylates SPRY2 on Y55 and Y227 (Homo sapiens)
        
        PP2A(A:C):S112/S121-pSPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PP2A(A:C):SPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
    - Signaling by FGFR3 (Homo sapiens)
      - Negative regulation of FGFR3 signaling (Homo sapiens)
        
        Spry regulation of FGF signaling (Homo sapiens)
        
        PPA2A dephosphorylates SPRY2 (Homo sapiens)
        
        PPA2A (A:C):S112/S115 p-SPRY2 [cytosol] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PPA2A(A:C):SPRY2 [cytosol] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PPTN11 dephosphorylates SPRY2 (Homo sapiens)
        
        PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Homo sapiens)
        
        PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        SPRY2 binds CBL (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        SPRY2 binds GRB2 (Homo sapiens)
        
        PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Homo sapiens)
        
        PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        SPRY2 is phosphorylated by phosphorylated MNK1 (Homo sapiens)
        
        PP2A(A:C):S112/S121-pSPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PP2A(A:C):SPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        SPRY2 translocates to the plasma membrane (Homo sapiens)
        
        PP2A(A:C):SPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PPA2A(A:C):SPRY2 [cytosol] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        SRC phosphorylates SPRY2 on Y55 and Y227 (Homo sapiens)
        
        PP2A(A:C):S112/S121-pSPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PP2A(A:C):SPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
    - Signaling by FGFR4 (Homo sapiens)
      - Negative regulation of FGFR4 signaling (Homo sapiens)
        
        Spry regulation of FGF signaling (Homo sapiens)
        
        PPA2A dephosphorylates SPRY2 (Homo sapiens)
        
        PPA2A (A:C):S112/S115 p-SPRY2 [cytosol] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PPA2A(A:C):SPRY2 [cytosol] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PPTN11 dephosphorylates SPRY2 (Homo sapiens)
        
        PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Homo sapiens)
        
        PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        SPRY2 binds CBL (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        SPRY2 binds GRB2 (Homo sapiens)
        
        PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Homo sapiens)
        
        PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        SPRY2 is phosphorylated by phosphorylated MNK1 (Homo sapiens)
        
        PP2A(A:C):S112/S121-pSPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PP2A(A:C):SPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        SPRY2 translocates to the plasma membrane (Homo sapiens)
        
        PP2A(A:C):SPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PPA2A(A:C):SPRY2 [cytosol] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        SRC phosphorylates SPRY2 on Y55 and Y227 (Homo sapiens)
        
        PP2A(A:C):S112/S121-pSPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PP2A(A:C):SPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Homo sapiens)
        
        PP2A (A:C) [cytosol] (Homo sapiens)
        
        PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases Activate Formins (Homo sapiens)
        
        AURKB phosphorylates DIAPH2-2 at kinetochores (Homo sapiens)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        CDC42:GTP recruits DIAPH2-2 to kinetochores (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
- Signaling by WNT (Homo sapiens)
  - Degradation of beta-catenin by the destruction complex (Homo sapiens)
    - AXIN is phosphorylated in the destruction complex (Homo sapiens)
      - AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
      - p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
    - Assembly of the destruction complex (Homo sapiens)
      - AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
      - PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
    - Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Homo sapiens)
      - RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Homo sapiens)
        
        p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
      - p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
    - Association of beta-catenin with the destruction complex (Homo sapiens)
      - CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
      - p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
    - Beta-catenin phosphorylation cascade (Homo sapiens)
      - Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Homo sapiens)
        
        CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
      - Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 (Homo sapiens)
        
        p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
      - Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Homo sapiens)
        
        p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
      - Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Homo sapiens)
        
        p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
    - Degradation of ubiquitinated beta catenin by the proteasome (Homo sapiens)
      - p-AXIN:CK1alpha:GSK3B:phospho-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
      - ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Homo sapiens)
        
        RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Homo sapiens)
        
        p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
    - Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Homo sapiens)
      - p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
    - Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Homo sapiens)
      - RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Homo sapiens)
        
        p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
      - ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Homo sapiens)
        
        RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Homo sapiens)
        
        p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
    - Phosphorylation of APC component of the destruction complex (Homo sapiens)
      - p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
      - p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
  - TCF dependent signaling in response to WNT (Homo sapiens)
    - Disassembly of the destruction complex and recruitment of AXIN to the membrane (Homo sapiens)
      - Beta-catenin is released from the destruction complex (Homo sapiens)
        
        CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
      - PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex (Homo sapiens)
        
        CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)
        
        p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A-catalytic subunit C [cytosol] (Homo sapiens)
        
        PPP2CB [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62714 PPP2CB

Gene Names

PPP2CB

Chain

chain:1-309

Reference Genes

BioGPS Gene:5516 PPP2CB

COSMIC (genes):PPP2CB PPP2CB

CTD Gene:5516 PPP2CB

dbSNP Gene:5516 PPP2CB

ENSEMBL:ENSG00000104695 PPP2CB

HGNC:9300 PPP2CB

KEGG:hsa:5516 PPP2CB

Monarch:5516 PPP2CB

NCBI Gene:5516 PPP2CB

OMIM:176916 PPP2CB

UCSC:P62714 PPP2CB

Reference Transcript

RefSeq:NM_001009552.1 PPP2CB

Other Identifiers

11716041_a_at

11716042_x_at

11726558_a_at

17076083

201374_3p_x_at

201374_PM_x_at

201374_x_at

201375_PM_s_at

201375_s_at

3130214

3130216

3130217

3130218

3130219

3130220

3130222

3130223

3130224

3130225

3130226

3130227

3130228

3130229

3130233

3130234

3130235

3130239

3130240

3130241

3130242

3130243

5516

8150126

924_s_at

A_23_P134693

GE58000

GE79502

GO:0000159

GO:0000278

GO:0000775

GO:0000922

GO:0003824

GO:0004721

GO:0004722

GO:0005515

GO:0005634

GO:0005694

GO:0005737

GO:0005829

GO:0005856

GO:0006355

GO:0006470

GO:0007005

GO:0008092

GO:0008637

GO:0010288

GO:0010468

GO:0010629

GO:0010804

GO:0016787

GO:0017018

GO:0030163

GO:0032088

GO:0034976

GO:0035970

GO:0042542

GO:0043161

GO:0043226

GO:0044325

GO:0046580

GO:0046677

GO:0046872

GO:0048156

GO:0070262

GO:0090443

GO:0140096

GO:1904528

HMNXSV003036743

Hs.80350.0.S1_3p_at

Hs.80350.0.S1_3p_x_at

ILMN_1675693

ILMN_1712659

ILMN_1768582

J03805_s_at

PH_hs_0027708

TC08001111.hg

g4758951_3p_a_at

Participates

as a member of

PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)

as a candidate of

PP2A-catalytic subunit C [cytosol] (Homo sapiens)

Other forms of this molecule

MeL-PPP2CB [nucleoplasm]

p-Y307-PPP2CB [cytosol]

PPP2CB [nucleoplasm]

Inferred To

ppp2cb [cytosol] (Danio rerio)

ppp2cb [cytosol] (Xenopus tropicalis)

PPP2CA [cytosol] (Caenorhabditis elegans)

PPP2CA [cytosol] (Dictyostelium discoideum)

PPP2CA [cytosol] (Drosophila melanogaster)

PPP2CA [cytosol] (Saccharomyces cerevisiae)

PPP2CA [cytosol] (Schizosaccharomyces pombe)

PPP2CB [cytosol] (Bos taurus)

PPP2CB [cytosol] (Canis familiaris)

PPP2CB [cytosol] (Gallus gallus)

PPP2CB [cytosol] (Mus musculus)

PPP2CB [cytosol] (Rattus norvegicus)

PPP2CB [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001009552.1

ENSEMBL

ENST00000221138, ENSP00000221138, ENSG00000104695

OpenTargets

ENSG00000104695

GeneCards

PPP2CB

HPA

ENSG00000104695-PPP2CB

PRO

P62714

Pharos - Targets

P62714

GlyGen

P62714

HMDB Protein

HMDBP08685

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63151 PPP2R2A	2	PPP2R2A [nucleoplasm] (R-HSA-1564978) PPP2R2A [cytosol] (R-HSA-377253)	0.886	8
UniProt:Q9Y570 PPME1	1	PPME1 [nucleoplasm] (R-HSA-8857790)	0.788	6
UniProt:O43815 STRN	5	STRN [cytosol] (R-HSA-9037081) STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9700467)	0.788	6
UniProt:Q86XL3 ANKLE2	2	Ac-K302-ANKLE2 [endoplasmic reticulum membrane] (R-HSA-9667946) ANKLE2 [endoplasmic reticulum membrane] (R-HSA-2529000)	0.725	5
UniProt:Q9Y6E0 STK24	4	STK24 [cytosol] (R-HSA-351829) STK24(1-313) [cytosol] (R-HSA-351892) STK24(314-443) [cytosol] (R-HSA-351898) STK24(1-313) [nucleoplasm] (R-HSA-351944)	0.669	3
UniProt:Q9Y2T1 AXIN2	4	AXIN2 [cytosol] (R-HSA-3640821) RibC-AXIN2 [cytosol] (R-HSA-3640842) Ub-RibC-AXIN2 [cytosol] (R-HSA-3640859) ub-AXIN2 [cytosol] (R-HSA-4641131)	0.645	4
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.643	3
UniProt:Q9P289 STK26	3	MST4 [cytosol] (R-HSA-351918) MST4(1-305) [cytosol] (R-HSA-351855) MST4(306-416) [cytosol] (R-HSA-351903)	0.527	2
UniProt:P67775 PPP2CA	4	PPP2CA [cytosol] (R-HSA-165971) PPP2CA [nucleoplasm] (R-HSA-165978) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) MeL-PPP2CA [nucleoplasm] (R-HSA-8857791)	0.527	2
UniProt:Q9BRV8 SIKE1	1	SIKE1 [cytosol] (R-HSA-916828)	0.527	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	11

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