Reactome | VCP [azurophil granule lumen]

VCP [azurophil granule lumen]

Stable Identifier

R-HSA-6800438

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

azurophil granule lumen

Synonyms

p97 ATPase, Transitional endoplasmic reticulum ATPase, TERA_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P55072 VCP

Gene Names

VCP

Chain

initiator methionine:1, chain:2-806

Reference Genes

BioGPS Gene:7415 VCP

COSMIC (genes):VCP VCP

CTD Gene:7415 VCP

dbSNP Gene:7415 VCP

ENSEMBL:ENSG00000165280 VCP

ENSEMBL_homo_sapiens_GENE:ENSG00000165280 VCP

HGNC:12666 VCP

KEGG Gene (Homo sapiens):7415 VCP

Monarch:7415 VCP

NCBI Gene:7415 VCP

OMIM:601023 VCP

Reference Transcript

RefSeq:NM_007126.3 VCP

Other Identifiers

0007100136

11733010_a_at

11745875_x_at

11746412_x_at

11758451_s_at

12728

12814

17093570

208648_at

208649_s_at

3204407

3204408

3204409

3204410

3204412

3204414

3204415

3204417

3204419

3204420

3204421

3204422

3204423

3204425

3204426

3204429

3204430

3204432

3204433

3204435

3204437

3204440

3204441

33818_at

3EBB

3HU1

3HU2

3HU3

3QC8

3QQ7

3QQ8

3QWZ

3TIW

44058_at

4KDI

4KDL

4KLN

4KO8

4KOD

4P0A

5593

56348_at

5B6C

5C18

5C19

5C1A

5C1B

5DYG

5DYI

5EPP

5FTJ

5FTK

5FTL

5FTM

5FTN

5GLF

5IFS

5IFW

5KIW

5KIY

5X4L

7415

8160914

A_23_P83045

A_24_P127828

A_24_P295412

AAC07984

AAD43016

AAI10914

AAI21795

AC004472

ACI46036

ACI46044

AF100752

AK312310

AL353795

BAG35235

BC110913

BC121794

C9IZA5

C9JUP7

CAA94809

CAB005593

CCDS6573

CH471071

EAW58404

ENSG00000165280

ENSP00000351777

ENST00000358901

EntrezGene:7415

FJ224344

FJ224352

g5410289_3p_a_at

GE54792

GE79640

GO:0000166

GO:0000278

GO:0000502

GO:0002376

GO:0003674

GO:0003723

GO:0005102

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005764

GO:0005773

GO:0005783

GO:0005789

GO:0005811

GO:0005829

GO:0006091

GO:0006259

GO:0006281

GO:0006302

GO:0006457

GO:0006464

GO:0006511

GO:0006734

GO:0006810

GO:0006888

GO:0006914

GO:0006919

GO:0006950

GO:0006974

GO:0007010

GO:0007034

GO:0007049

GO:0007165

GO:0007267

GO:0008150

GO:0008219

GO:0008289

GO:0009056

GO:0009058

GO:0010494

GO:0010498

GO:0010918

GO:0016192

GO:0016236

GO:0016567

GO:0016579

GO:0016787

GO:0016887

GO:0018279

GO:0019079

GO:0019899

GO:0019903

GO:0019904

GO:0019985

GO:0022607

GO:0030234

GO:0030433

GO:0030968

GO:0030970

GO:0031334

GO:0031410

GO:0031593

GO:0031625

GO:0032182

GO:0032436

GO:0032510

GO:0032991

GO:0034098

GO:0034214

GO:0034605

GO:0034641

GO:0034655

GO:0034774

GO:0035578

GO:0035617

GO:0035800

GO:0035861

GO:0036435

GO:0036503

GO:0036513

GO:0042288

GO:0042802

GO:0042981

GO:0043161

GO:0043167

GO:0043209

GO:0043226

GO:0043231

GO:0043312

GO:0043531

GO:0044281

GO:0044389

GO:0044403

GO:0044877

GO:0045184

GO:0045732

GO:0046034

GO:0048471

GO:0051186

GO:0051228

GO:0051260

GO:0055085

GO:0061857

GO:0065003

GO:0070062

GO:0070842

GO:0070987

GO:0071712

GO:0072389

GO:0090263

GO:0097352

GO:1903006

GO:1903007

GO:1903715

GO:1903843

GO:1903862

GO:1904288

GO:1904813

GO:1904949

GO:1990381

GO:1990730

GO:2000158

GO:2001171

HGNC:12666

HPA012728

HPA012814

Hs.106357.0.S2_3p_at

ILMN_1665376

ILMN_1777220

IPR003338

IPR003593

IPR003959

IPR003960

IPR004201

IPR005938

IPR009010

IPR015415

IPR027417

IPR029067

LRG_657

MIM:167320

MIM:601023

MIM:613954

MIM:616687

NM_001354927

NM_001354928

NM_007126

NP_001341856

NP_001341857

NP_009057

PF00004

PF02359

PF02933

PF09336

PH_hs_0024763

SM00382

SM01072

SM01073

TC09001048.hg

TC09002468.hg

uc003zvy.3

UPI000005FB2E

V9HW80

VCP

VCP-201

Z70768

Participant Of

hasMember

Azurophil granule lumen proteins [azurophil granule lumen]

Other forms of this molecule

Me3K315-VCP [cytosol]

VCP [endoplasmic reticulum membrane]

VCP [nucleoplasm]

VCP [ficolin-1-rich granule lumen]

VCP [secretory granule lumen]

VCP [extracellular region]

VCP [cytosol]

Inferred To

VCP [azurophil granule lumen] (Caenorhabditis elegans)

VCP [azurophil granule lumen] (Canis familiaris)

VCP [azurophil granule lumen] (Dictyostelium discoideum)

VCP [azurophil granule lumen] (Drosophila melanogaster)

VCP [azurophil granule lumen] (Gallus gallus)

VCP [azurophil granule lumen] (Mus musculus)

VCP [azurophil granule lumen] (Plasmodium falciparum)

VCP [azurophil granule lumen] (Rattus norvegicus)

VCP [azurophil granule lumen] (Saccharomyces cerevisiae)

VCP [azurophil granule lumen] (Schizosaccharomyces pombe)

VCP [azurophil granule lumen] (Xenopus tropicalis)

Homologues of VCP [azurophil granule lumen] (Gallus gallus)

Cross References

RefSeq

NP_009057.1

OpenTargets

ENSG00000165280

GeneCards

P55072

ZINC - Substances

TERA_HUMAN

DOCK Blaster

4KDI, 5DYI, 3TIW, 5C18, 3QQ8, 4KDL, 5DYG, 3QQ7, 5GLF, 5B6C, 5EPP, 5C19, 3HU3, 3HU1, 3QC8, 3HU2, 3EBB, 5IFS, 4KOD, 3QWZ, 5X4L, 4P0A, 4KO8, 5IFW, 5C1B, 4KLN, 5C1A

ZINC target

P55072

PRO

P55072

BRENDA (Homo sapiens)

3.6.4.6

ZINC - Predictions - Purchasable

TERA_HUMAN

Orphanet

15706

HMDB Protein

HMDBP11971

PDB

5FTM, 5C1B, 5B6C, 5FTN, 3QQ7, 4KLN, 4KDL, 3TIW, 3QWZ, 5FTK, 4P0A, 5DYI, 5FTL, 4KDI, 5C1A, 5IFW, 3HU2, 4KOD, 5X4L, 5FTJ, 3HU3, 5C19, 5C18, 5KIY, 5EPP, 5IFS, 5DYG, 5GLF, 3QQ8, 3QC8, 3EBB, 4KO8, 3HU1, 5KIW

Interactors (47)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UNZ2 NSF1C			0.939	17
UniProt:Q9BZE9 ASPSCR1	1	ASPSCR1 [cytoplasmic vesicle membrane] (R-HSA-1449582)	0.869	23
UniProt:P55072 VCP	8	VCP [endoplasmic reticulum membrane] (R-HSA-8943105) Me3K315-VCP [cytosol] (R-HSA-8932209) VCP [nucleoplasm] (R-HSA-5643745) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [secretory granule lumen] (R-HSA-6801039) VCP [extracellular region] (R-HSA-6806191) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [cytosol] (R-HSA-1181251)	0.846	7
UniProt:Q9UKV5 AMFR	1	AMFR [endoplasmic reticulum membrane] (R-HSA-975999)	0.835	10
UniProt:P54252-1 ATXN3			0.833	18
UniProt:Q9BZV1 UBXN6			0.822	17
UniProt:Q8TAT6 NPLOC4	1	NPLOC4 [nucleoplasm] (R-HSA-5654987)	0.774	6
UniProt:P68543 UBX2A			0.756	12
UniProt:O94888 UBXN7	1	UBXN7 [cytosol] (R-HSA-8956071)	0.748	17
UniProt:Q92890 UFD1	1	UFD1L [nucleoplasm] (R-HSA-5654993)	0.743	5
UniProt:Q96CS3 FAF2	2	FAF2 [azurophil granule lumen] (R-HSA-6799138) FAF2 [extracellular region] (R-HSA-6806183)	0.734	12
UniProt:Q92575 UBXN4			0.688	11
UniProt:Q14CS0 UBX2B			0.683	9
UniProt:Q96LJ8 UBX10			0.641	7
UniProt:O00124 UBXN8			0.641	8
UniProt:Q9UNN5-1 FAF1			0.618	4
UniProt:Q9Y4K3 TRAF6	8	PolyUb-TRAF6 [cytosol] (R-HSA-6782845) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) TRAF6 [endosome membrane] (R-HSA-450272) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [plasma membrane] (R-HSA-936955)	0.589	2
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.573	2
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.57	3
UniProt:Q13617 CUL2	3	CUL2 [nucleoplasm] (R-HSA-1234126) CUL2 [cytosol] (R-HSA-416982) G76-NEDD8-K689-CUL2 [cytosol] (R-HSA-8952511)	0.527	2
UniProt:B1AQ61 B1AQ61			0.525	4
UniProt:P26045 PTPN3	1	PTPN3 [plasma membrane] (R-HSA-5490317)	0.524	2
UniProt:Q5T124-6 UBXN11			0.524	7
UniProt:O96017 CHEK2	3	p-T68-CHEK2 [nucleoplasm] (R-HSA-113825) p-S,3T-CHEK2 [nucleoplasm] (R-HSA-5683784) CHEK2 [nucleoplasm] (R-HSA-113824)	0.524	2
UniProt:O94868 FCSD2			0.508	2
UniProt:Q9UNN5 FAF1			0.499	2
UniProt:Q13619 CUL4A	2	G76-NEDD8-K705-CUL4A [nucleoplasm] (R-HSA-8952514) CUL4A [nucleoplasm] (R-HSA-976006)	0.499	2
UniProt:Q9WTX6 Cul1	3	Cul1 [nucleoplasm] (R-MMU-9008723) G76-NEDD8-K720-CUL1 [cytosol] (R-MMU-8952519) CUL1 [cytosol] (R-MMU-174230)	0.499	2
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.499	2
UniProt:Q969W3 F104A			0.488	2
UniProt:Q08426 EHHADH	2	EHHADH [cytosol] (R-HSA-9033147) EHHADH [peroxisomal matrix] (R-HSA-400155)	0.488	2
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.488	2
UniProt:Q9Y263 PLAP			0.488	2
UniProt:O60941-5 DTNB			0.488	2
UniProt:Q96LK0 CEP19			0.488	2
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.488	2
UniProt:O94941 UBOX5	1	UBOX5 [cytosol] (R-HSA-976034)	0.488	2
UniProt:Q5VVQ6 YOD1	1	YOD1 [cytosol] (R-HSA-6781909)	0.488	2
UniProt:P24278 ZBT25			0.488	2
UniProt:P32969 RPL9	1	RPL9 [cytosol] (R-HSA-72492)	0.488	2
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.488	2
UniProt:Q9H7H0-2 METTL17			0.488	2
UniProt:Q6GPH4 XAF1	1	XAF1 [cytosol] (R-HSA-1015680)	0.488	2
UniProt:Q96HA8 NTAQ1			0.488	2
UniProt:P0CG30 GSTT2B	1	GSTT2B [cytosol] (R-HSA-3302073)	0.488	2
UniProt:P04578-PRO_0000038428 ENV			0.462	2
UniProt:Q86TM6 SYVN1	1	SYVN1(1-617) [endoplasmic reticulum membrane] (R-HSA-535496)	0.462	2