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Me-diphthine EEF2 [cytosol]
Stable Identifier
R-HSA-5367025
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
methylated diphthine EEF2
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Homo sapiens)
Synthesis of diphthamide-EEF2 (Homo sapiens)
DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Homo sapiens)
Me-diphthine EEF2 [cytosol] (Homo sapiens)
DPH7 hydrolyzes a methyl group on Me-diphthine EEF2 (Homo sapiens)
Me-diphthine EEF2 [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
24739148
Dph7 catalyzes a previously unknown demethylation step in diphthamide biosynthesis
Chen, W
,
Ci, B
,
Zhang, S
,
Su, X
,
Lin, Z
,
Lin, H
J. Am. Chem. Soc.
2014
External Reference Information
External Reference
UniProt:P13639 EEF2
Gene Names
EEF2, EF2
Chain
initiator methionine:, chain:2-858
Reference Genes
BioGPS Gene:1938 EEF2
COSMIC (genes):EEF2 EEF2
CTD Gene:1938 EEF2
dbSNP Gene:1938 EEF2
ENSEMBL:ENSG00000167658 EEF2
HGNC:3214 EEF2
KEGG:hsa:1938 EEF2
Monarch:1938 EEF2
NCBI Gene:1938 EEF2
OMIM:130610 EEF2
UCSC:P13639 EEF2
Reference Transcript
RefSeq:NM_001961.3 EEF2
Other Identifiers
11715781_a_at
11715782_a_at
11715783_x_at
11748763_a_at
11748764_x_at
11751022_x_at
11757678_s_at
16651415
16651417
16651419
16651421
16651423
16651425
16651431
16651433
16651435
16651439
16651441
16651443
16651445
16651461
16651463
16651465
16651467
16651469
16651471
16651473
16651475
16651477
16651485
16651487
16867212
16867229
18671261
18671262
18671263
18671264
18671265
18671266
18671267
18671268
18671269
18671270
18671271
18671272
18671273
18671274
18671275
18671276
1938
200094_PM_s_at
200094_s_at
204102_PM_s_at
204102_s_at
36587_at
3846539
3846540
3846541
3846542
3846543
3846544
3846545
3846546
3846547
3846548
3846549
3846550
3846551
3846552
3846553
3846554
3846555
3846556
3846557
3846558
3846559
3846561
3846562
3846563
3846564
3846565
3846566
3846567
3846568
3846569
3846570
8032730
8032749
A_21_P0000277
A_24_P87763
GE60349
GO:0002244
GO:0003723
GO:0003746
GO:0003824
GO:0003924
GO:0005515
GO:0005525
GO:0005576
GO:0005634
GO:0005737
GO:0005829
GO:0005840
GO:0005886
GO:0006412
GO:0006414
GO:0016020
GO:0016235
GO:0016787
GO:0019901
GO:0030154
GO:0034774
GO:0043022
GO:0043226
GO:0045182
GO:0045202
GO:0045296
GO:0045727
GO:0070062
GO:1904813
GO:1990904
HMNXSV003006939
HMNXSV003054355
ILMN_1738383
PH_hs_0004308
RNA33775|snoRNA_scaRNA_371_66
TC19001054.hg
TC19001055.hg
X51466_at
g4503482_3p_a_at
Participates
as an input of
DPH7 hydrolyzes a methyl group on Me-diphthine EEF2 (Homo sapiens)
as an output of
DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Homo sapiens)
Other forms of this molecule
EEF2 [secretory granule lumen]
EEF2 [extracellular region]
EEF2 [ficolin-1-rich granule lumen]
EEF2 [cytosol]
aminocarboxypropyl EEF2 [cytosol]
nascent EEF2 [cytosol]
diphthine EEF2 [cytosol]
ADP-ribo-EEF2 [cytosol]
Me3K525-EEF2 [cytosol]
Inferred To
EEF2 [cytosol]
(Canis familiaris)
EEF2 [cytosol]
(Gallus gallus)
Me-diphthine EEF2 [cytosol]
(Bos taurus)
Me-diphthine EEF2 [cytosol]
(Caenorhabditis elegans)
Me-diphthine EEF2 [cytosol]
(Danio rerio)
Me-diphthine EEF2 [cytosol]
(Dictyostelium discoideum)
Me-diphthine EEF2 [cytosol]
(Drosophila melanogaster)
Me-diphthine EEF2 [cytosol]
(Mus musculus)
Me-diphthine EEF2 [cytosol]
(Plasmodium falciparum)
Me-diphthine EEF2 [cytosol]
(Rattus norvegicus)
Me-diphthine EEF2 [cytosol]
(Saccharomyces cerevisiae)
Me-diphthine EEF2 [cytosol]
(Schizosaccharomyces pombe)
Me-diphthine EEF2 [cytosol]
(Sus scrofa)
eef2.1 [cytosol]
(Xenopus tropicalis)
Modified Residues
Name
modified L-histidine residue (diphthine methyl ester residue) at 715
Coordinate
715
Modification
diphthine methyl ester residue
PsiMod Name
modified L-histidine residue
PsiMod Definition
A protein modification that modifies an L-histidine residue.
Cross References
Guide to Pharmacology - Targets
2756
OpenTargets
ENSG00000167658
ENSEMBL
ENSP00000307940
,
ENST00000309311
HPA
ENSG00000167658-EEF2
PRO
P13639
Pharos - Targets
P13639
Orphanet
EEF2
GlyGen
P13639
HMDB Protein
HMDBP02947
PDB
6Z6N
,
4V6X
,
6D9J
,
8Y0W
,
8Y0X
,
6Z6M
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.615
21
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.569
8
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:Q9NRI5 DISC1
0.553
2
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.527
3
UniProt:P59665 DEFA1
9
DEFA1(20-94) [Golgi lumen]
(R-HSA-1467282)
DEFA1(66-94) [Golgi lumen]
(R-HSA-975663)
DEFA1(20-65) [Golgi lumen]
(R-HSA-8864970)
DEFA1(1-94) [Golgi lumen]
(R-HSA-1467215)
DEFA1(66-94) [extracellular region]
(R-HSA-1461998)
DEFA1(66-94) [azurophil granule lumen]
(R-HSA-1470038)
DEFA1(65-94) [extracellular region]
(R-HSA-1462022)
omega-N-(ADP-ribosyl)-L-arginine-DEFA1(65-94) [extracellular region]
(R-HSA-1972397)
DEFA1(65-94) [azurophil granule lumen]
(R-HSA-1470053)
0.527
2
UniProt:Q16539 MAPK14
7
MAPK14 [ficolin-1-rich granule lumen]
(R-HSA-6803280)
MAPK14 [extracellular region]
(R-HSA-6806453)
MAPK14 [secretory granule lumen]
(R-HSA-6803300)
MAPK14 [nucleoplasm]
(R-HSA-446223)
MAPK14 [cytosol]
(R-HSA-428933)
p-T180,Y182-MAPK14 [cytosol]
(R-HSA-428935)
p-T180,Y182-MAPK14 [nucleoplasm]
(R-HSA-446227)
0.527
2
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.527
2
UniProt:Q99714 HSD17B10
1
HSD17B10 [mitochondrial matrix]
(R-HSA-70831)
0.499
3
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