Me-diphthine EEF2 [cytosol]

Stable Identifier
R-HSA-5367025
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
methylated diphthine EEF2
Icon
Me-diphthine EEF2 [cytosol] icon
Me-diphthine EEF2 [cytosol] icon
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
24739148 Dph7 catalyzes a previously unknown demethylation step in diphthamide biosynthesis

Chen, W, Ci, B, Zhang, S, Su, X, Lin, Z, Lin, H

J. Am. Chem. Soc. 2014
External Reference Information
External Reference
UniProt:P13639 EEF2
Gene Names
EEF2, EF2
Chain
initiator methionine:1, chain:2-858
Reference Genes
BioGPS Gene:1938 EEF2
COSMIC (genes):EEF2 EEF2
CTD Gene:1938 EEF2
dbSNP Gene:1938 EEF2
ENSEMBL:ENSG00000167658 EEF2
ENSEMBL:ENSG00000167658.16 EEF2
HGNC:3214 EEF2
KEGG Gene (Homo sapiens):1938 EEF2
Monarch:1938 EEF2
NCBI Gene:1938 EEF2
OMIM:130610 EEF2
UCSC:P13639 EEF2
Reference Transcript
Other Identifiers
11715781_a_at
11715782_a_at
11715783_x_at
11748763_a_at
11748764_x_at
11751022_x_at
11757678_s_at
16867212
18671261
18671262
18671263
18671264
18671265
18671266
18671267
18671268
18671269
18671270
18671271
18671273
18671274
18671275
18671276
1938
200094_PM_s_at
200094_s_at
204102_PM_s_at
204102_s_at
36587_at
3846539
3846540
3846541
3846542
3846543
3846544
3846545
3846548
3846549
3846551
3846553
3846555
3846556
3846557
3846559
3846561
3846562
3846563
3846564
3846565
3846567
3846568
3846569
3846570
8032730
A_24_P87763
GE60349
GO:0000166
GO:0002244
GO:0002376
GO:0003723
GO:0003746
GO:0003824
GO:0003924
GO:0005515
GO:0005525
GO:0005576
GO:0005615
GO:0005634
GO:0005737
GO:0005829
GO:0005844
GO:0005886
GO:0006412
GO:0006414
GO:0016020
GO:0016235
GO:0016787
GO:0019901
GO:0030154
GO:0031410
GO:0034774
GO:0043022
GO:0043226
GO:0045182
GO:0045202
GO:0045296
GO:0045727
GO:0048856
GO:0070062
GO:0110165
GO:1904813
GO:1990904
HMNXSV003054355
ILMN_1738383
PH_hs_0004308
TC19001054.hg
X51466_at
g4503482_3p_a_at
Participates
as an input of
as an output of
Other forms of this molecule
EEF2 [ficolin-1-rich granule lumen]
EEF2 [extracellular region]
EEF2 [secretory granule lumen]
EEF2 [cytosol]
aminocarboxypropyl EEF2 [cytosol]
nascent EEF2 [cytosol]
diphthine EEF2 [cytosol]
ADP-ribo-EEF2 [cytosol]
Me3K525-EEF2 [cytosol]
Inferred To
si:dkey-110c1.4 [cytosol] (Danio rerio)
si:dkey-110c1.3 [cytosol] (Danio rerio)
EEF2 [cytosol] (Gallus gallus)
EEF2 [cytosol] (Sus scrofa)
Homologues of Me-diphthine EEF2 [cytosol] (Danio rerio)
Homologues of Me-diphthine EEF2 [cytosol] (Dictyostelium discoideum)
Me-diphthine EEF2 [cytosol] (Bos taurus)
Me-diphthine EEF2 [cytosol] (Caenorhabditis elegans)
Me-diphthine EEF2 [cytosol] (Canis familiaris)
Me-diphthine EEF2 [cytosol] (Danio rerio)
Me-diphthine EEF2 [cytosol] (Dictyostelium discoideum)
Me-diphthine EEF2 [cytosol] (Drosophila melanogaster)
Me-diphthine EEF2 [cytosol] (Mus musculus)
Me-diphthine EEF2 [cytosol] (Plasmodium falciparum)
Me-diphthine EEF2 [cytosol] (Rattus norvegicus)
Me-diphthine EEF2 [cytosol] (Saccharomyces cerevisiae)
Me-diphthine EEF2 [cytosol] (Schizosaccharomyces pombe)
eef2.1 [cytosol] (Xenopus tropicalis)
cinC [cytosol] (Dictyostelium discoideum)
Modified Residues
Name
modified L-histidine residue (diphthine methyl ester residue) at 715
Coordinate
715
Modification
diphthine methyl ester residue
PsiMod Name
modified L-histidine residue
PsiMod Definition
A protein modification that modifies an L-histidine residue.
Cross References
RefSeq
Guide to Pharmacology - Targets
OpenTargets
HPA
GeneCards
Ensembl
PRO
Pharos - Targets
Orphanet
PDB
HMDB Protein
Interactors (7)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P42858 HTT  1 0.556 3
 UniProt:Q9NRI5 DISC1      0.553 2
 UniProt:P62993 GRB2  1 0.527 2
 UniProt:Q5S007 LRRK2  1 0.527 3
 UniProt:Q16539 MAPK14  7 0.527 2
 UniProt:Q99714 HSD17B10  1 0.499 3
 UniProt:P13569 CFTR  17 0.483 13
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