Reactome | SUGT1 [cytosol]

SUGT1 [cytosol]

Stable Identifier

R-HSA-874107

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Suppressor of G2 allele of SKP1 homolog, SUGT1_HUMAN, SGT1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9Y2Z0 SUGT1

Gene Names

SUGT1

Chain

initiator methionine:, chain:2-365

Reference Genes

BioGPS Gene:10910 SUGT1

COSMIC (genes):SUGT1 SUGT1

CTD Gene:10910 SUGT1

dbSNP Gene:10910 SUGT1

ENSEMBL:ENSG00000165416 SUGT1

ENSEMBL_homo_sapiens_GENE:ENSG00000165416.15 SUGT1

HGNC:16987 SUGT1

KEGG Gene (Homo sapiens):10910 SUGT1

Monarch:10910 SUGT1

NCBI Gene:10910 SUGT1

OMIM:604098 SUGT1

UCSC:Q9Y2Z0 SUGT1

Reference Transcript

Other Identifiers

10910

11724281_a_at

11754522_a_at

16775066

223329_PM_x_at

223329_x_at

223330_PM_s_at

223330_s_at

224309_PM_s_at

224309_s_at

228045_PM_at

228045_at

244368_PM_x_at

244368_x_at

3490745

3490746

3490747

3490748

3490751

3490753

3490755

3490756

3490760

3490761

3490762

3490763

3490764

3490768

3490769

3490773

3490774

3490775

3490777

3490779

3490780

3490781

3490782

3490783

3490784

3490785

3490786

3490787

3490788

3490790

45409_at

51862_at

53020_at

60796_at

7969271

A_14_P128265

A_23_P162787

A_23_P162795

A_32_P161455

GE58414

GO:0000151

GO:0000776

GO:0003723

GO:0005515

GO:0005634

GO:0005694

GO:0005737

GO:0005829

GO:0007010

GO:0007051

GO:0014841

GO:0031647

GO:0032991

GO:0043226

GO:0051087

GO:0051382

GO:0065003

GO:0106222

HMNXSV003022612

Hs.21411.0.A1_3p_at

Hs.24104.0.A1_3p_at

ILMN_1898880

ILMN_2054725

PH_hs_0027763

PH_hs_0040090

TC13000226.hg

g12654186_3p_a_at

g7643785_3p_a_at

Participates

as an input of

SGT1 binds HSP90 (Homo sapiens)

as a component of

SUGT1:HSP90 [cytosol] (Homo sapiens)

Inferred To

SGT1 [cytosol] (Saccharomyces cerevisiae)

SUGT1 [cytosol] (Bos taurus)

SUGT1 [cytosol] (Canis familiaris)

SUGT1 [cytosol] (Gallus gallus)

SUGT1 [cytosol] (Sus scrofa)

Sugt1 [cytosol] (Mus musculus)

Sugt1 [cytosol] (Rattus norvegicus)

git7 [cytosol] (Schizosaccharomyces pombe)

Sgt1 [cytosol] (Drosophila melanogaster)

sugt1 [cytosol] (Danio rerio)

sugt1 [cytosol] (Dictyostelium discoideum)

sugt1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001307760.1, NP_006695.1, NP_001124384.1

OpenTargets

ENSG00000165416

HPA

ENSG00000165416-SUGT1

GeneCards

Q9Y2Z0

Ensembl

ENST00000310528, ENSP00000367208, ENSG00000165416, ENSP00000308067, ENST00000343788

PRO

Q9Y2Z0

Pharos - Targets

Q9Y2Z0

PDB

1RL1

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:A0A0H3NF38 A0A0H3NF38			0.737	7
UniProt:Q8IW35 CEP97	1	CEP97 [cytosol] (R-HSA-5626440)	0.615	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	9
UniProt:O60346 PHLPP1	1	PHLPP1 [cytosol] (R-HSA-199421)	0.604	3
UniProt:Q9Y239 NOD1	1	NOD1 [cytosol] (R-HSA-168407)	0.564	5
UniProt:Q96II8 LRCH3			0.527	4
UniProt:Q9UF56 FBXL17	1	FBXL17 [nucleoplasm] (R-HSA-9708570)	0.527	5
UniProt:Q9H4P4 RNF41	1	RNF41 [cytosol] (R-HSA-975977)	0.527	2
UniProt:Q14318 FKBP8	2	PolyUb-FKBP8 [mitochondrial outer membrane] (R-HSA-6783001) FKBP8 [mitochondrial outer membrane] (R-HSA-5696928)	0.527	2
UniProt:Q13451 FKBP5	2	FKBP5 [cytosol] (R-HSA-5618096) FKBP5 [nucleoplasm] (R-HSA-8939165)	0.527	3
UniProt:Q15404 RSU1	1	RSU1 [cytosol] (R-HSA-446297)	0.527	2
UniProt:Q13309 SKP2	3	SKP2 [cytosol] (R-HSA-975495) PolyUb-SKP2 [nucleoplasm] (R-HSA-9687073) SKP2 [nucleoplasm] (R-HSA-975554)	0.527	3
UniProt:O75427 LRCH4			0.499	2
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.483	4

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