Reactome | LPCAT1 [endoplasmic reticulum membrane]

LPCAT1 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-1498772

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Lysophosphatidylcholine acyltransferase 1, PFAAP3

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8NF37 LPCAT1

Gene Names

LPCAT1, AYTL2, PFAAP3

Chain

chain:1-534

Reference Genes

BioGPS Gene:79888 LPCAT1

COSMIC (genes):LPCAT1 LPCAT1

CTD Gene:79888 LPCAT1

dbSNP Gene:79888 LPCAT1

ENSEMBL:ENSG00000153395 LPCAT1

ENSEMBL_homo_sapiens_GENE:ENSG00000153395.10 LPCAT1

HGNC:25718 LPCAT1

KEGG Gene (Homo sapiens):79888 LPCAT1

Monarch:79888 LPCAT1

NCBI Gene:79888 LPCAT1

OMIM:610472 LPCAT1

UCSC:Q8NF37 LPCAT1

Reference Transcript

RefSeq:NM_024830.4 LPCAT1

Other Identifiers

11715638_s_at

16994002

201818_PM_at

201818_at

2845975

2845976

2845977

2845978

2845979

2845980

2845981

2845982

2845983

2845985

2845987

2845989

2845990

2845992

2845993

2845996

2845997

2846004

2846005

2846009

2846010

2846011

2846029

2846030

2846031

2846032

41176_at

41177_at

79888

8110841

A_23_P213471

A_24_P406006

GE54472

GO:0000139

GO:0003824

GO:0003841

GO:0005509

GO:0005764

GO:0005773

GO:0005783

GO:0005789

GO:0005794

GO:0005811

GO:0005886

GO:0006629

GO:0006644

GO:0006650

GO:0006654

GO:0006656

GO:0008374

GO:0008654

GO:0016020

GO:0016740

GO:0016746

GO:0030163

GO:0031410

GO:0035577

GO:0036148

GO:0036151

GO:0042171

GO:0043129

GO:0043226

GO:0045732

GO:0046872

GO:0047144

GO:0047159

GO:0047184

GO:0047191

GO:0047192

GO:0048856

GO:0050200

GO:0060041

GO:2001246

HMNXSV003047580

ILMN_1702171

PH_hs_0010652

PH_hs_0039651

TC05001110.hg

g13376233_3p_at

Participates

as a member of

as an output of

STARD10 transports PC from ER membrane to lamellar body membrane (Homo sapiens)

as a component of

STARD10:LPCAT1:PC [endoplasmic reticulum membrane] (Homo sapiens)

as an input of

STARD10 binds LPCAT1 and PC (Homo sapiens)

Other forms of this molecule

LPCAT1 [plasma membrane]

LPCAT1 [azurophil granule membrane]

Inferred To

LPCAT1 [endoplasmic reticulum membrane] (Bos taurus)

LPCAT1 [endoplasmic reticulum membrane] (Canis familiaris)

LPCAT1 [endoplasmic reticulum membrane] (Gallus gallus)

LPCAT1 [endoplasmic reticulum membrane] (Mus musculus)

LPCAT1 [endoplasmic reticulum membrane] (Plasmodium falciparum)

LPCAT1 [endoplasmic reticulum membrane] (Rattus norvegicus)

LPCAT1 [endoplasmic reticulum membrane] (Sus scrofa)

LPCAT [endoplasmic reticulum membrane] (Drosophila melanogaster)

lpcat1 [endoplasmic reticulum membrane] (Danio rerio)

lpcat1 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_079106.3

OpenTargets

ENSG00000153395

GeneCards

Q8NF37

HPA

ENSG00000153395-LPCAT1

Ensembl

ENSP00000423472, ENSG00000153395, ENSP00000283415, ENST00000475622, ENST00000283415

PRO

Q8NF37

Pharos - Targets

Q8NF37

HMDB Protein

HMDBP07289

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.527	2
UniProt:O14975 SLC27A2	5	SLC27A2 [cytosol] (R-HSA-9033090) SLC27A2 [plasma membrane] (R-HSA-6806316) SLC27A2 [specific granule membrane] (R-HSA-6799565) SLC27A2 [endoplasmic reticulum membrane] (R-HSA-193386) SLC27A2 [peroxisomal membrane] (R-HSA-389579)	0.527	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	9

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