Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
COPB1 [transport vesicle]
Stable Identifier
R-HSA-6808736
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
transport vesicle
Synonyms
Coatomer beta subunit
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
coatomer [transport vesicle] (Homo sapiens)
tetrameric coatomer complex [transport vesicle] (Homo sapiens)
COPB1 [transport vesicle] (Homo sapiens)
ERGIC-to-Golgi vesicles bind dynein:dynactin (Homo sapiens)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
coatomer [transport vesicle] (Homo sapiens)
tetrameric coatomer complex [transport vesicle] (Homo sapiens)
COPB1 [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
coatomer [transport vesicle] (Homo sapiens)
tetrameric coatomer complex [transport vesicle] (Homo sapiens)
COPB1 [transport vesicle] (Homo sapiens)
Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
coatomer [transport vesicle] (Homo sapiens)
tetrameric coatomer complex [transport vesicle] (Homo sapiens)
COPB1 [transport vesicle] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
coatomer [transport vesicle] (Homo sapiens)
tetrameric coatomer complex [transport vesicle] (Homo sapiens)
COPB1 [transport vesicle] (Homo sapiens)
ERGIC-to-Golgi vesicles bind dynein:dynactin (Homo sapiens)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
coatomer [transport vesicle] (Homo sapiens)
tetrameric coatomer complex [transport vesicle] (Homo sapiens)
COPB1 [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
coatomer [transport vesicle] (Homo sapiens)
tetrameric coatomer complex [transport vesicle] (Homo sapiens)
COPB1 [transport vesicle] (Homo sapiens)
Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
coatomer [transport vesicle] (Homo sapiens)
tetrameric coatomer complex [transport vesicle] (Homo sapiens)
COPB1 [transport vesicle] (Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Golgi-to-ER retrograde transport (Homo sapiens)
COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Homo sapiens)
RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo [transport vesicle] (Homo sapiens)
coatomer [transport vesicle] (Homo sapiens)
tetrameric coatomer complex [transport vesicle] (Homo sapiens)
COPB1 [transport vesicle] (Homo sapiens)
Retrograde COPI vesicles bind kinesin and microtubules (Homo sapiens)
RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo [transport vesicle] (Homo sapiens)
coatomer [transport vesicle] (Homo sapiens)
tetrameric coatomer complex [transport vesicle] (Homo sapiens)
COPB1 [transport vesicle] (Homo sapiens)
RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo [transport vesicle] (Homo sapiens)
coatomer [transport vesicle] (Homo sapiens)
tetrameric coatomer complex [transport vesicle] (Homo sapiens)
COPB1 [transport vesicle] (Homo sapiens)
Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Homo sapiens)
RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo [transport vesicle] (Homo sapiens)
coatomer [transport vesicle] (Homo sapiens)
tetrameric coatomer complex [transport vesicle] (Homo sapiens)
COPB1 [transport vesicle] (Homo sapiens)
External Reference Information
External Reference
UniProt:P53618 COPB1
Gene Names
COPB1, COPB, MSTP026
Chain
initiator methionine:, chain:2-953
Reference Genes
BioGPS Gene:1315 COPB1
COSMIC (genes):COPB1 COPB1
CTD Gene:1315 COPB1
dbSNP Gene:1315 COPB1
ENSEMBL:ENSG00000129083 COPB1
ENSEMBL_homo_sapiens_GENE:ENSG00000129083.13 COPB1
HGNC:2231 COPB1
KEGG Gene (Homo sapiens):1315 COPB1
Monarch:1315 COPB1
NCBI Gene:1315 COPB1
OMIM:600959 COPB1
UCSC:P53618 COPB1
Reference Transcript
RefSeq:NM_001144061.1 COPB1
RefSeq:NM_016451.4 COPB1
RefSeq:NM_001144062.1 COPB1
Other Identifiers
11743275_a_at
1315
16736014
201358_PM_s_at
201358_s_at
201359_PM_at
201359_at
3363932
3363933
3363934
3363935
3363937
3363940
3363943
3363944
3363945
3363947
3363949
3363951
3363952
3363954
3363957
3363958
3363959
3363961
3363962
3363963
3363964
3363965
3363966
3363967
3363968
3363971
3363972
3363974
3363975
3363976
34326_at
7946703
A_33_P3287263
GE56656
GO:0000139
GO:0005198
GO:0005515
GO:0005737
GO:0005783
GO:0005789
GO:0005793
GO:0005794
GO:0005798
GO:0005829
GO:0005886
GO:0006886
GO:0006888
GO:0006891
GO:0015031
GO:0016020
GO:0016192
GO:0030117
GO:0030126
GO:0030133
GO:0030137
GO:0030663
GO:0030667
GO:0031410
GO:0043226
GO:0043231
GO:0070821
GO:0101003
HMNXSV003058333
ILMN_1699112
PH_hs_0000384
TC11003473.hg
X82103_at
g7705368_3p_a_at
g7705368_3p_x_at
Participates
as a component of
tetrameric coatomer complex [transport vesicle] (Homo sapiens)
Other forms of this molecule
COPB1 [endoplasmic reticulum membrane]
COPB1 [Golgi membrane]
COPB1 [cytosol]
COPB1 [ficolin-1-rich granule membrane]
COPB1 [secretory granule membrane]
COPB1 [plasma membrane]
COPB1 [tertiary granule membrane]
Inferred To
copb1 [transport vesicle]
(Danio rerio)
copb1 [transport vesicle]
(Xenopus tropicalis)
betaCOP [transport vesicle]
(Drosophila melanogaster)
Copb1 [transport vesicle]
(Mus musculus)
Copb1 [transport vesicle]
(Rattus norvegicus)
COPB1 [transport vesicle]
(Bos taurus)
COPB1 [transport vesicle]
(Canis familiaris)
COPB1 [transport vesicle]
(Gallus gallus)
COPB1 [transport vesicle]
(Plasmodium falciparum)
COPB1 [transport vesicle]
(Sus scrofa)
copb [transport vesicle]
(Dictyostelium discoideum)
SEC26 [transport vesicle]
(Saccharomyces cerevisiae)
copb-1 [transport vesicle]
(Caenorhabditis elegans)
sec26 [transport vesicle]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_001137534.1
,
NP_057535.1
,
NP_001137533.1
OpenTargets
ENSG00000129083
GeneCards
P53618
HPA
ENSG00000129083-COPB1
Ensembl
ENST00000439561
,
ENSG00000129083
,
ENST00000249923
,
ENSP00000397873
,
ENSP00000249923
PRO
P53618
Pharos - Targets
P53618
HMDB Protein
HMDBP08331
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.706
13
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
6
UniProt:Q9UH99 SUN2
1
SUN2 [nuclear envelope]
(R-HSA-912382)
0.564
3
UniProt:P56945 BCAR1
4
p-Y-BCAR1 [cytosol]
(R-HSA-372645)
p-Y12-BCAR1 [cytosol]
(R-HSA-5218739)
p-Y165,Y664-BCAR1 [cytosol]
(R-HSA-8848723)
BCAR1 [cytosol]
(R-HSA-201625)
0.556
3
UniProt:P60468 SEC61B
3
SEC61B [cytosol]
(R-HSA-5250571)
SEC61B [endoplasmic reticulum membrane]
(R-HSA-264899)
SEC61B [phagocytic vesicle membrane]
(R-HSA-1236882)
0.527
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
