Reactome | DLG1 [cytosol]

DLG1 [cytosol]

Stable Identifier

R-HSA-416332

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Disks large homolog 1, DLG1_HUMAN

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Locations in the PathwayBrowser

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Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Glutamate binding, activation of AMPA receptors and synaptic plasticity (Homo sapiens)
      - Trafficking of AMPA receptors (Homo sapiens)
        
        Trafficking of GluR1-containing AMPA receptors (Homo sapiens)
        
        DLG1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q12959 DLG1

Gene Names

DLG1

Chain

chain:1-904

Reference Genes

BioGPS Gene:1739 DLG1

COSMIC (genes):DLG1 DLG1

CTD Gene:1739 DLG1

dbSNP Gene:1739 DLG1

ENSEMBL:ENSG00000075711 DLG1

HGNC:2900 DLG1

KEGG Gene (Homo sapiens):1739 DLG1

Monarch:1739 DLG1

NCBI Gene:1739 DLG1

OMIM:601014 DLG1

UCSC:Q12959 DLG1

Reference Transcript

Other Identifiers

0000460731

11739308_s_at

11739309_x_at

11739310_a_at

11741748_a_at

11749113_a_at

11749114_x_at

11752182_a_at

11752615_a_at

11752616_x_at

16963455

1739

202514_at

202515_at

202516_s_at

217208_s_at

2713195

2713196

2713197

2713198

2713199

2713200

2713201

2713205

2713208

2713211

2713213

2713214

2713216

2713217

2713221

2713224

2713228

2713229

2713233

2713242

2713247

2713251

2713256

2713261

2713262

2713263

2713267

2713269

2713272

2713278

2713279

2713281

2713299

2713301

2713304

2713305

2713306

2713307

2713308

2713309

2713310

2713311

2713312

2713313

2713314

2713326

40065_s_at

40246_at

8093191

A_23_P212034

A_23_P416142

A_24_P131752

A_33_P3224380

GE81346

GE88049

GO:0000003

GO:0000122

GO:0000165

GO:0000278

GO:0000902

GO:0001657

GO:0001658

GO:0001771

GO:0001772

GO:0001935

GO:0002088

GO:0002376

GO:0003013

GO:0003674

GO:0004385

GO:0004721

GO:0005198

GO:0005515

GO:0005575

GO:0005576

GO:0005604

GO:0005615

GO:0005622

GO:0005634

GO:0005737

GO:0005783

GO:0005789

GO:0005794

GO:0005829

GO:0005856

GO:0005874

GO:0005886

GO:0005911

GO:0005923

GO:0006464

GO:0006470

GO:0006810

GO:0006950

GO:0007010

GO:0007015

GO:0007049

GO:0007155

GO:0007163

GO:0007165

GO:0007267

GO:0007268

GO:0008022

GO:0008092

GO:0008104

GO:0008150

GO:0008283

GO:0008284

GO:0008328

GO:0008360

GO:0009058

GO:0009790

GO:0009898

GO:0014069

GO:0014704

GO:0015459

GO:0016020

GO:0016032

GO:0016301

GO:0016323

GO:0016324

GO:0016328

GO:0016791

GO:0019899

GO:0019900

GO:0019901

GO:0019902

GO:0022607

GO:0030054

GO:0030432

GO:0030838

GO:0030866

GO:0030953

GO:0031012

GO:0031253

GO:0031434

GO:0031579

GO:0031594

GO:0031641

GO:0032147

GO:0032991

GO:0033268

GO:0034330

GO:0034629

GO:0034641

GO:0035748

GO:0042110

GO:0042130

GO:0042383

GO:0042391

GO:0042982

GO:0043005

GO:0043113

GO:0043219

GO:0043226

GO:0043268

GO:0043622

GO:0044281

GO:0044325

GO:0044403

GO:0045121

GO:0045197

GO:0045202

GO:0045296

GO:0046037

GO:0046710

GO:0048471

GO:0048608

GO:0048704

GO:0048729

GO:0048745

GO:0048856

GO:0050680

GO:0051660

GO:0051898

GO:0055085

GO:0060022

GO:0060090

GO:0061024

GO:0065003

GO:0070062

GO:0070373

GO:0070830

GO:0072659

GO:0097016

GO:0097025

GO:0097060

GO:0097120

GO:0098609

GO:0098839

GO:0098911

GO:0098919

GO:0098978

GO:0099562

GO:0099645

GO:1902305

GO:1902473

GO:1903078

GO:1903286

GO:1903753

GO:1903760

GO:1903764

GO:2000134

GO:2000310

HMNXSV003002738

Hs.154294.0.S2_3p_at

Hs.154294.0.S3_3p_at

Hs.154294.3.S1_3p_a_at

ILMN_1701958

PH_hs_0024513

PH_hs_0031823

PH_hs_0035891

TC03002174.hg

U13896_at

g4758161_3p_a_at

Participates

as an input of

Trafficking of GluR1-containing AMPA receptors (Homo sapiens)

Other forms of this molecule

DLG1 [endoplasmic reticulum membrane]

DLG1 [transport vesicle membrane]

DLG1 [plasma membrane]

Inferred To

DLG1 [cytosol] (Canis familiaris)

DLG1 [cytosol] (Gallus gallus)

DLG1 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001191315.1, XP_011510808.1, XP_016861299.1, XP_016861295.1, XP_016861290.1, XP_016861305.1, XP_016861307.1, NP_001191316.1, NP_004078.2, XP_011510804.1, XP_016861296.1, XP_016861306.1, XP_016861291.1, XP_005269346.1, NP_001277912.1, XP_016861308.1, XP_011510805.1, NP_001191317.1, XP_016861289.1, XP_016861297.1, NP_001091894.1, XP_016861292.1, XP_016861309.1, XP_011510807.1, XP_016861298.1, XP_016861294.1

OpenTargets

ENSG00000075711

HPA

ENSG00000075711-DLG1

GeneCards

Q12959

Ensembl

ENST00000419354, ENST00000443183, ENSP00000376187, ENSP00000411278, ENST00000667157, ENSP00000413238, ENSP00000499602, ENST00000666007, ENSP00000499542, ENST00000661453, ENST00000422288, ENSP00000499384, ENST00000450955, ENSP00000398939, ENSP00000499580, ENST00000452595, ENST00000655488, ENSP00000350303, ENST00000670935, ENST00000670455, ENST00000392382, ENST00000669565, ENST00000671185, ENSP00000499657, ENSP00000396658, ENSP00000499414, ENSP00000499793, ENSP00000499437, ENST00000663148, ENST00000448528, ENSP00000499514, ENSP00000499413, ENSP00000345731, ENST00000659716, ENST00000346964, ENSP00000391732, ENSP00000407531, ENST00000357674, ENSG00000075711

PRO

Q12959

Pharos - Targets

Q12959

GlyGen

Q12959

Orphanet

24473

PDB

4G69, 3W9Y, 1PDR, 2OQS, 4AMH, 2M3M, 2X7Z, 3RL7, 3RL8, 3LRA

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06463 VE6			0.845	5
UniProt:Q9NS75 CYSLTR2	2	CYSLTR1,2 [plasma membrane] (R-HSA-163618) CYSLTR2 [plasma membrane] (R-HSA-416399)	0.772	7
UniProt:P03126 VE6			0.722	3
UniProt:Q15311 RALBP1	1	RALBP1 [cytosol] (R-HSA-195194)	0.702	5
UniProt:Q96KB5 TOPK			0.664	7
UniProt:P89079 E4OR1			0.656	4
UniProt:P78536 ADAM17	6	ADAM17(215-827) [Golgi membrane] (R-HSA-9662839) ADAM17 [endoplasmic reticulum lumen] (R-HSA-9662763) ADAM17(1-214) [Golgi membrane] (R-HSA-9662784) ADAM17 [Golgi membrane] (R-HSA-9662835) ADAM17(215-827) [plasma membrane] (R-HSA-9663048) ADAM17 [plasma membrane] (R-HSA-179878)	0.65	7
UniProt:P06239 LCK	4	p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [plasma membrane] (R-HSA-8857940) p-Y394-LCK [cytosol] (R-HSA-202308) LCK [cytosol] (R-HSA-167609)	0.628	3
UniProt:P25054 APC	86	APC C1410* [cytosol] (R-HSA-9666925) APC R213* [cytosol] (R-HSA-9666924) APC K1310* [cytosol] (R-HSA-9666926) APC R499* [cytosol] (R-HSA-9666927) APC R1450* [cytosol] (R-HSA-5251499) APC G1357* [cytosol] (R-HSA-9666940) APC L1488* [cytosol] (R-HSA-9666941) APC S1400* [cytosol] (R-HSA-9666942) APC S1346* [cytosol] (R-HSA-9666943) APC R405* [cytosol] (R-HSA-9666936) APC S1281* [cytosol] (R-HSA-9666937) APC E1573* [cytosol] (R-HSA-9666938) APC R805* [cytosol] (R-HSA-9666939) APC R1386* [cytosol] (R-HSA-9666932) APC S1327* [cytosol] (R-HSA-9666933) APC E1209* [cytosol] (R-HSA-9666934) APC Q1469* [cytosol] (R-HSA-9666935) APC R564* [cytosol] (R-HSA-9666928) APC E1536* [cytosol] (R-HSA-9666929) APC G1288* [cytosol] (R-HSA-9666930) APC G1312* [cytosol] (R-HSA-9666931) APC R283* [cytosol] (R-HSA-9666988) APC Q1367* [cytosol] (R-HSA-9666989) APC E1353* [cytosol] (R-HSA-9666990) APC R332* [cytosol] (R-HSA-9666991) APC K993* [cytosol] (R-HSA-9666984) APC R876* [cytosol] (R-HSA-9666985) APC R302* [cytosol] (R-HSA-9666986) APC E1309* [cytosol] (R-HSA-9666987) APC Y935* [cytosol] (R-HSA-9666980) APC E1286* [cytosol] (R-HSA-9666981) APC Q1378* [cytosol] (R-HSA-9666982) APC R554* [cytosol] (R-HSA-9666983) APC S1356* [cytosol] (R-HSA-9666976) APC R232* [cytosol] (R-HSA-9666977) APC E1379* [cytosol] (R-HSA-9666978) APC E984* [cytosol] (R-HSA-9666979) APC R1114* [cytosol] (R-HSA-9666996) APC S1282* [cytosol] (R-HSA-9666997) APC Q1328* [cytosol] (R-HSA-9666998) APC E1295* [cytosol] (R-HSA-9666992) APC E1151* [cytosol] (R-HSA-9666993) APC E1322* [cytosol] (R-HSA-9666994) APC E1345* [cytosol] (R-HSA-9666995) APC K1308* [cytosol] (R-HSA-9666956) APC S1344* [cytosol] (R-HSA-9666957) APC E1577* [cytosol] (R-HSA-9666958) APC Q1127* [cytosol] (R-HSA-9666959) APC E1464* [cytosol] (R-HSA-9666952) APC E1317* [cytosol] (R-HSA-9666953) APC G1309Dfs4 [cytosol] (R-HSA-4791251) APC W1049 [cytosol] (R-HSA-9666954) APC Q1429* [cytosol] (R-HSA-9666955) APC L1564* [cytosol] (R-HSA-9666948) APC Q1294* [cytosol] (R-HSA-9666949) APC K1363* [cytosol] (R-HSA-9666950) APC E1408* [cytosol] (R-HSA-9666951) APC E1284* [cytosol] (R-HSA-9666944) APC E1374* [cytosol] (R-HSA-9666945) APC Q767* [cytosol] (R-HSA-9666946) APC E941* [cytosol] (R-HSA-9666947) APC Q1303* [cytosol] (R-HSA-9666972) APC S943* [cytosol] (R-HSA-9666973) APC E1306* [cytosol] (R-HSA-9666975) APC S895* [cytosol] (R-HSA-9666969) APC S1315* [cytosol] (R-HSA-9666970) APC G1412* [cytosol] (R-HSA-9666971) APC Y1376* [cytosol] (R-HSA-9666964) APC Q886* [cytosol] (R-HSA-9666965) APC S1392* [cytosol] (R-HSA-9666966) APC S1539* [cytosol] (R-HSA-9666967) APC E1451* [cytosol] (R-HSA-9666960) APC E1397* [cytosol] (R-HSA-9666961) APC Q1406* [cytosol] (R-HSA-9666962) APC E1544* [cytosol] (R-HSA-9666963) APC F1197* [cytosol] (R-HSA-5246655) APC Q1338* [cytosol] (R-HSA-5246654) APC S811* [cytosol] (R-HSA-5246652) APC I1417 fs2 [cytosol] (R-HSA-5246651) APC E1554 [cytosol] (R-HSA-5246648) p-ub-APC [cytosol] (R-HSA-3009421) K63polyUb-APC [cytosol] (R-HSA-5246690) APC [nucleoplasm] (R-HSA-3361755) APC(1-777) [cytosol] (R-HSA-2976014) APC(778-2843) [cytosol] (R-HSA-2976013) APC [cytosol] (R-HSA-2976015)	0.623	2
UniProt:Q9UQB3 CTND2			0.609	2
UniProt:P0C2L3 F163B			0.609	3
UniProt:Q14CM0 FRPD4			0.609	4
UniProt:P17386 VE6			0.609	2
UniProt:P85299 PRR5	1	PRR5 [cytosol] (R-HSA-6795323)	0.609	2
UniProt:Q99569 PKP4	2	PKP4 [plasma membrane] (R-HSA-6814401) PKP4 [cornified envelope] (R-HSA-8847721)	0.609	3
UniProt:Q7Z628 NET1	1	NET1 [cytosol] (R-HSA-3006799)	0.609	5
UniProt:Q13224 GRIN2B	6	p-Y1474-GRIN2B [plasma membrane] (R-HSA-9032602) p-Y1252,Y1336,Y1474-GRIN2B [plasma membrane] (R-HSA-3928477) GRIN2B [transport vesicle membrane] (R-HSA-9610568) GRIN2B [endoplasmic reticulum membrane] (R-HSA-9609765) p-Y-GRIN2B [plasma membrane] (R-HSA-9612185) GRIN2B [plasma membrane] (R-HSA-419558)	0.609	3
UniProt:Q5VV41 ARHGEF16	1	ARHGEF16 [cytosol] (R-HSA-2976623)	0.59	3
UniProt:A1A5B4 ANO9	1	ANO9 [plasma membrane] (R-HSA-2684954)	0.573	2
UniProt:Q96PE1 AGRA2			0.573	2
UniProt:P06427 VE6			0.573	3
UniProt:P53778 MAPK12	3	p-T183,Y185-MAPK12 [cytosol] (R-HSA-171021) MAPK12 [nucleoplasm] (R-HSA-448833) MAPK12 [cytosol] (R-HSA-171025)	0.571	2
UniProt:Q9C0D5 TANC1			0.558	3
UniProt:P36507 MAP2K2	12	MAP2K2(11-400) [cytosol] (R-HSA-5211337) MAP2K2(1-10) [cytosol] (R-HSA-5211334) MAP2K2 C125S [cytosol] (R-HSA-9652070) MAP2K2 P128Q [cytosol] (R-HSA-9652082) MAP2K2 V35M [cytosol] (R-HSA-9652086) MAP2K2 Y134C [cytosol] (R-HSA-9652089) p-S222,S226-MAP2K2 [cytosol] (R-HSA-169292) MAP2K2 [cytosol] (R-HSA-59504) p-S,T-MAP2K2 [cytosol] (R-HSA-109848) MAP2K2 N126D [cytosol] (R-HSA-9652079) MAP2K2 L46F [cytosol] (R-HSA-9652076) MAP2K2 F57C [cytosol] (R-HSA-9652073)	0.543	10
UniProt:P36799 VE6			0.524	2
UniProt:O60333-3 KIF1B			0.508	4

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