Reactome | DLG1 [cytosol]

DLG1 [cytosol]

Stable Identifier

R-HSA-416332

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Disks large homolog 1, DLG1_HUMAN

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Locations in the PathwayBrowser

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Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Glutamate binding, activation of AMPA receptors and synaptic plasticity (Homo sapiens)
      - Trafficking of AMPA receptors (Homo sapiens)
        
        Trafficking of GluR1-containing AMPA receptors (Homo sapiens)
        
        DLG1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q12959 DLG1

Gene Names

DLG1

Chain

chain:1-904

Reference Genes

BioGPS Gene:1739 DLG1

COSMIC (genes):DLG1 DLG1

CTD Gene:1739 DLG1

dbSNP Gene:1739 DLG1

ENSEMBL:ENSG00000075711 DLG1

ENSEMBL_homo_sapiens_GENE:ENSG00000075711 DLG1

HGNC:2900 DLG1

KEGG Gene (Homo sapiens):1739 DLG1

Monarch:1739 DLG1

NCBI Gene:1739 DLG1

OMIM:601014 DLG1

UCSC:Q12959 DLG1

Reference Transcript

Other Identifiers

0000460731

00230+2.7.4.8

11739308_s_at

11739309_x_at

11739310_a_at

11741748_a_at

11749113_a_at

11749114_x_at

11752182_a_at

11752615_a_at

11752616_x_at

16307

16963455

1739

1PDR

202514_at

202515_at

202516_s_at

217208_s_at

2713195

2713196

2713197

2713198

2713199

2713200

2713201

2713205

2713208

2713211

2713213

2713214

2713216

2713217

2713221

2713224

2713228

2713229

2713233

2713242

2713247

2713251

2713256

2713261

2713262

2713263

2713267

2713269

2713272

2713278

2713279

2713281

2713299

2713301

2713304

2713305

2713306

2713312

2713314

2M3M

2OQS

2X7Z

3LRA

3RL7

3RL8

3W9Y

40065_s_at

40246_at

4AMH

4G69

69593

8093191

A0A0C4DFT3

A8MUT6

A_23_P212034

A_23_P416142

A_24_P131752

A_33_P3224380

AAA50598

AAA50599

AAI40842

AAI44652

ABQ66269

AC068302

AC092937

AK294772

AK294855

B4E2H8

BAG57902

BAG57959

BC140841

BC144651

C9IYP1

C9J110

C9JCP6

C9JN61

C9JUA9

CAB016307

CCDS3327

CCDS43194

CCDS56300

CCDS56301

CCDS87192

CH471191

DLG1

DLG1-201

DLG1-205

DLG1-208

DLG1-210

DLG1-213

DLG1-215

DLG1-216

DLG1-217

E7EQD7

EAW53610

EAW53611

EAW53612

EAW53614

EF553524

ENSG00000075711

ENSP00000345731

ENSP00000376187

ENSP00000391732

ENSP00000396658

ENSP00000398939

ENSP00000407531

ENSP00000411278

ENSP00000413238

ENST00000346964

ENST00000346964.6

ENST00000392382

ENST00000392382.6

ENST00000419354

ENST00000419354.5

ENST00000422288

ENST00000422288.5

ENST00000443183

ENST00000443183.5

ENST00000448528

ENST00000448528.6

ENST00000450955

ENST00000450955.5

ENST00000452595

ENST00000452595.5

EntrezGene:1739

F2Z2L0

g4758161_3p_a_at

GE81346

GE88049

GO:0000122

GO:0000165

GO:0001657

GO:0001658

GO:0001771

GO:0001772

GO:0001935

GO:0002088

GO:0002369

GO:0002376

GO:0003674

GO:0004385

GO:0004721

GO:0005198

GO:0005515

GO:0005575

GO:0005604

GO:0005634

GO:0005737

GO:0005783

GO:0005789

GO:0005794

GO:0005829

GO:0005874

GO:0005886

GO:0005911

GO:0005923

GO:0006464

GO:0006470

GO:0007010

GO:0007015

GO:0007093

GO:0007155

GO:0007163

GO:0007165

GO:0007267

GO:0007268

GO:0008022

GO:0008092

GO:0008104

GO:0008150

GO:0008283

GO:0008284

GO:0008328

GO:0008360

GO:0009790

GO:0009898

GO:0014069

GO:0014704

GO:0015459

GO:0016020

GO:0016032

GO:0016301

GO:0016323

GO:0016324

GO:0016328

GO:0016791

GO:0019899

GO:0019900

GO:0019901

GO:0019902

GO:0022607

GO:0030054

GO:0030432

GO:0030838

GO:0030866

GO:0030953

GO:0031012

GO:0031253

GO:0031434

GO:0031579

GO:0031594

GO:0031641

GO:0032147

GO:0032947

GO:0032991

GO:0033268

GO:0034330

GO:0034629

GO:0034641

GO:0035255

GO:0035748

GO:0042110

GO:0042130

GO:0042383

GO:0042391

GO:0042982

GO:0043005

GO:0043113

GO:0043219

GO:0043226

GO:0043268

GO:0043622

GO:0044281

GO:0044325

GO:0044403

GO:0045121

GO:0045197

GO:0045202

GO:0045211

GO:0045296

GO:0045930

GO:0046037

GO:0046710

GO:0048471

GO:0048608

GO:0048704

GO:0048729

GO:0048745

GO:0048856

GO:0050680

GO:0051660

GO:0051898

GO:0060022

GO:0061024

GO:0070062

GO:0070373

GO:0070830

GO:0072659

GO:0097016

GO:0097025

GO:0097120

GO:0098609

GO:0098839

GO:0098911

GO:0098919

GO:0098978

GO:0099562

GO:0099645

GO:1902305

GO:1903078

GO:1903286

GO:1903753

GO:1903760

GO:1903764

GO:2000310

H7C166

HGNC:2900

HPA069593

Hs.154294.0.S2_3p_at

Hs.154294.0.S3_3p_at

Hs.154294.3.S1_3p_a_at

ILMN_1701958

IPR001452

IPR001478

IPR004172

IPR008144

IPR008145

IPR015143

IPR016313

IPR019583

IPR019590

IPR020590

IPR027417

IPR036028

IPR036034

IPR036892

MIM:601014

NM_001098424

NM_001204387

NM_001204388

NM_001290983

NM_001366214

NM_004087

NP_001091894

NP_001191316

NP_001191317

NP_001277912

NP_001353133

NP_001353137

NP_001353138

NP_001353141

NP_001353143

NP_001353144

NP_001353145

NP_001353147

NP_001353148

NP_004078

PF00018

PF00595

PF00625

PF09058

PF10600

PF10608

PH_hs_0024513

PH_hs_0031823

PH_hs_0035891

SM00072

SM00228

SM00326

SM00569

SM01277

TC03002174.hg

U13896

U13896_at

U13897

UPI000013CD24

UPI000013CD25

UPI00004DF217

UPI0000D61BDD

UPI00018E1808

UPI000198CBE8

UPI000198CBE9

XM_005269289

XM_011512502

XM_011512505

XM_011512506

XM_017005800

XM_017005801

XM_017005802

XM_017005803

XM_017005804

XM_017005805

XM_017005806

XM_017005807

XM_017005808

XM_017005809

XM_017005811

XM_017005812

XM_017005813

XM_017005814

XM_017005816

XM_017005817

XM_017005818

XM_017005819

XM_017005820

XM_017005821

XM_017005822

XM_017005823

XM_017005824

XP_005269346

XP_011510804

XP_011510807

XP_011510808

XP_016861289

XP_016861290

XP_016861291

XP_016861292

XP_016861294

XP_016861295

XP_016861296

XP_016861297

XP_016861298

XP_016861300

XP_016861301

XP_016861302

XP_016861305

XP_016861306

XP_016861307

XP_016861308

XP_016861309

XP_016861310

XP_016861312

XP_016861313

XR_001740036

XR_001740037

XR_001740038

XR_001740039

XR_001740040

XR_001740041

XR_001740043

XR_001740044

Participant Of

input

Trafficking of GluR1-containing AMPA receptors

Other forms of this molecule

DLG1 [endoplasmic reticulum membrane]

DLG1 [transport vesicle membrane]

DLG1 [plasma membrane]

Inferred To

DLG1 [cytosol] (Canis familiaris)

DLG1 [cytosol] (Gallus gallus)

DLG1 [cytosol] (Mus musculus)

DLG1 [cytosol] (Rattus norvegicus)

DLG1 [cytosol] (Sus scrofa)

Cross References

RefSeq

XP_016861307.1, XP_016861295.1, XP_011510808.1, XP_016861299.1, XP_011510804.1, NP_001091894.1, XP_016861290.1, XP_016861291.1, XP_016861296.1, NP_001191315.1, NP_004078.2, XP_016861306.1, XP_011510805.1, XP_005269346.1, XP_016861292.1, XP_016861289.1, XP_016861309.1, XP_016861305.1, NP_001191316.1, XP_016861297.1, NP_001277912.1, XP_016861308.1, XP_016861294.1, NP_001191317.1, XP_016861298.1, XP_011510807.1

OpenTargets

ENSG00000075711

GeneCards

Q12959

PRO

Q12959

Orphanet

24473

PDB

3RL7, 1PDR, 2OQS, 2X7Z, 4AMH, 2M3M, 4G69, 3W9Y, 3LRA, 3RL8

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06463 VE6			0.845	5
UniProt:P03126 VE6			0.722	3
UniProt:Q9NS75 CYSLTR2	1	CYSLTR2 [plasma membrane] (R-HSA-416399)	0.704	6
UniProt:Q96KB5 TOPK			0.664	7
UniProt:P89079 E4OR1			0.656	4
UniProt:P06239 LCK	4	p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [plasma membrane] (R-HSA-8857940) p-Y394-LCK [cytosol] (R-HSA-202308) LCK [cytosol] (R-HSA-167609)	0.656	3
UniProt:P78536 ADAM17	1	ADAM17 [plasma membrane] (R-HSA-179878)	0.65	7
UniProt:P85299 PRR5	1	PRR5 [cytosol] (R-HSA-6795323)	0.609	2
UniProt:Q9UQB3 CTND2			0.609	2
UniProt:Q99569 PKP4	2	PKP4 [plasma membrane] (R-HSA-6814401) PKP4 [cornified envelope] (R-HSA-8847721)	0.609	3
UniProt:P0C2L3 F163B			0.609	3
UniProt:Q7Z628 NET1	1	NET1 [cytosol] (R-HSA-3006799)	0.609	5
UniProt:Q14CM0 FRPD4			0.609	4
UniProt:P53778 MAPK12	3	p-T183,Y185-MAPK12 [cytosol] (R-HSA-171021) MAPK12 [nucleoplasm] (R-HSA-448833) MAPK12 [cytosol] (R-HSA-171025)	0.609	2
UniProt:P17386 VE6			0.609	2
UniProt:Q15311 RALBP1	1	RALBP1 [cytosol] (R-HSA-195194)	0.609	3
UniProt:Q13224 GRIN2B	6	GRIN2B [plasma membrane] (R-HSA-419558) p-Y1252,Y1336,Y1474-GRIN2B [plasma membrane] (R-HSA-3928477) p-Y-GRIN2B [plasma membrane] (R-HSA-9612185) GRIN2B [endoplasmic reticulum membrane] (R-HSA-9609765) GRIN2B [transport vesicle membrane] (R-HSA-9610568) p-Y1474-GRIN2B [plasma membrane] (R-HSA-9032602)	0.609	3
UniProt:A1A5B4 ANO9	1	ANO9 [plasma membrane] (R-HSA-2684954)	0.573	2
UniProt:Q96PE1 AGRA2			0.573	2
UniProt:Q9C0D5 TANC1			0.558	3
UniProt:P36507 MAP2K2	5	MAP2K2(11-400) [cytosol] (R-HSA-5211337) MAP2K2(1-10) [cytosol] (R-HSA-5211334) p-S,T-MAP2K2 [cytosol] (R-HSA-109848) MAP2K2 [cytosol] (R-HSA-59504) p-S222,S226-MAP2K2 [cytosol] (R-HSA-169292)	0.543	10
UniProt:P36799 VE6			0.524	2
UniProt:O60333-3 KIF1B			0.508	4