Reactome | ATP2B1 [plasma membrane]

ATP2B1 [plasma membrane]

Stable Identifier

R-HSA-418301

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Plasma membrane calcium-transporting ATPase 1, AT2B1_HUMAN, PMCA1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P20020 ATP2B1

Gene Names

ATP2B1, PMCA1

Chain

initiator methionine:, chain:2-1220

Reference Genes

BioGPS Gene:490 ATP2B1

COSMIC (genes):ATP2B1 ATP2B1

CTD Gene:490 ATP2B1

dbSNP Gene:490 ATP2B1

ENSEMBL:ENSG00000070961 ATP2B1

HGNC:814 ATP2B1

KEGG:hsa:490 ATP2B1

Monarch:490 ATP2B1

NCBI Gene:490 ATP2B1

OMIM:108731 ATP2B1

UCSC:P20020 ATP2B1

Reference Transcript

Other Identifiers

11727930_a_at

11743863_a_at

11743864_a_at

11743865_s_at

16768341

209281_PM_s_at

209281_s_at

212930_PM_at

212930_at

215716_PM_s_at

215716_s_at

34188_at

3464982

3464984

3464985

3464986

3464987

3464988

3464989

3464990

3464994

3464995

3464997

3464998

3464999

3465000

3465001

3465002

3465007

3465008

3465009

3465011

3465012

3465014

3465015

3465016

3465018

3465019

3465020

3465022

3465025

3465026

3465031

3465032

3465033

3465038

3465039

37661_at

490

61289_at

7965359

A_23_P128319

A_33_P3267185

A_33_P3267186

GE54654

GE57641

GO:0000166

GO:0001772

GO:0001818

GO:0003013

GO:0003056

GO:0003824

GO:0005215

GO:0005388

GO:0005515

GO:0005516

GO:0005524

GO:0005654

GO:0005886

GO:0006816

GO:0006874

GO:0008217

GO:0015085

GO:0016020

GO:0016323

GO:0016328

GO:0016787

GO:0016887

GO:0030165

GO:0030501

GO:0030672

GO:0031410

GO:0034220

GO:0042734

GO:0042995

GO:0043226

GO:0043231

GO:0045202

GO:0046872

GO:0051480

GO:0051481

GO:0051928

GO:0055085

GO:0070062

GO:0070588

GO:0098684

GO:0098978

GO:0140657

GO:1900076

GO:1903779

GO:1990034

HMNXSV003045520

Hs.20952.0.S1_3p_at

Hs.78546.2.A1_3p_a_at

ILMN_1750599

ILMN_1813399

ILMN_1824297

ILMN_2401933

J04027_at

PH_hs_0008624

PH_hs_0022028

PH_hs_0031052

TC12001798.hg

g184269_3p_a_at

Participates

as a member of

ATP2B1-4 [plasma membrane] (Homo sapiens)

Inferred To

ATP2B1 [plasma membrane] (Bos taurus)

ATP2B1 [plasma membrane] (Caenorhabditis elegans)

ATP2B1 [plasma membrane] (Canis familiaris)

ATP2B1 [plasma membrane] (Dictyostelium discoideum)

ATP2B1 [plasma membrane] (Gallus gallus)

ATP2B1 [plasma membrane] (Mus musculus)

ATP2B1 [plasma membrane] (Rattus norvegicus)

ATP2B1 [plasma membrane] (Saccharomyces cerevisiae)

ATP2B1 [plasma membrane] (Schizosaccharomyces pombe)

ATP2B1 [plasma membrane] (Sus scrofa)

mca-2 [plasma membrane] (Caenorhabditis elegans)

mca-3 [plasma membrane] (Caenorhabditis elegans)

atp2b1b [plasma membrane] (Danio rerio)

Homologues of ATP2B1 [plasma membrane] (Caenorhabditis elegans)

Homologues of ATP2B1 [plasma membrane] (Dictyostelium discoideum)

atp2b1 [plasma membrane] (Xenopus tropicalis)

PMCA [plasma membrane] (Drosophila melanogaster)

Cross References

Guide to Pharmacology - Targets

843

ENSEMBL

ENST00000705822, ENST00000359142, ENSP00000516172, ENST00000551310, ENSP00000392043, ENSP00000447041, ENSP00000352054, ENST00000428670

OpenTargets

ENSG00000070961

HPA

ENSG00000070961-ATP2B1

PRO

P20020

Pharos - Targets

P20020

HMDB Protein

HMDBP01200

PDB

6A69

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62158 CALM			0.527	2
UniProt:Q9Y639 NPTN	1	NPTN [plasma membrane] (R-HSA-8856422)	0.527	3
UniProt:P35613 BSG	2	BSG [plasma membrane] (R-HSA-197673) BSG [Golgi membrane] (R-HSA-204478)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	9
UniProt:P05919 vpu	6	VPU (P05919) protein [cytosol] (R-HIV-173223) VPU (P05919) [endoplasmic reticulum membrane] (R-HIV-180550) VPU (P05919) protein [extracellular region] (R-HIV-175522) VPU (P05919) protein [nucleoplasm] (R-HIV-175200) VPU (P05919) [Golgi membrane] (R-HIV-3149439) VPU (P05919) [plasma membrane] (R-HIV-3149423)	0.462	2

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