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CAPN1 [cytosol]
Stable Identifier
R-HSA-3288367
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Calpain-1 catalytic subunit ecNumber3.4.22.52/ecNumber, CAN1_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Keratinization (Homo sapiens)
Formation of the cornified envelope (Homo sapiens)
Cytoplasmic proteases cleave Profilaggrin producing Filaggrin (Homo sapiens)
Cytoplasmic profilaggrin processing proteases [cytosol] (Homo sapiens)
Calpain1 [cytosol] (Homo sapiens)
CAPN1 [cytosol] (Homo sapiens)
Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Homo sapiens)
CAPN:4xCa2+:CAPNS [cytosol] (Homo sapiens)
CAPN:4xCa2+ [cytosol] (Homo sapiens)
CAPN [cytosol] (Homo sapiens)
CAPN1 [cytosol] (Homo sapiens)
E-cadherin degradation by caspase-3 and calpain-1 (Homo sapiens)
Active caspase-3 heterotetramer, calpain-1 [cytosol] (Homo sapiens)
Calpain1 [cytosol] (Homo sapiens)
CAPN1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P07384 CAPN1
Gene Names
CAPN1, CANPL1, PIG30
Chain
initiator methionine:, chain:2-714
Reference Genes
BioGPS Gene:823 CAPN1
COSMIC (genes):CAPN1 CAPN1
CTD Gene:823 CAPN1
dbSNP Gene:823 CAPN1
ENSEMBL:ENSG00000014216 CAPN1
ENSEMBL_homo_sapiens_GENE:ENSG00000014216.16 CAPN1
HGNC:1476 CAPN1
KEGG Gene (Homo sapiens):823 CAPN1
Monarch:823 CAPN1
NCBI Gene:823 CAPN1
OMIM:114220 CAPN1
UCSC:P07384 CAPN1
Reference Transcript
RefSeq:NM_001198869.1 CAPN1
RefSeq:NM_001198868.1 CAPN1
RefSeq:XM_006718698.1 CAPN1
RefSeq:NM_005186.3 CAPN1
RefSeq:XM_011545292.1 CAPN1
Other Identifiers
11747222_a_at
11754307_x_at
16726734
200752_PM_s_at
200752_s_at
3334955
3334956
3334957
3334958
3334959
3334960
3334961
3334962
3334964
3334966
3334968
3334969
3334971
3334973
3334974
3334978
3334981
3334982
3334983
3334984
3334985
3334987
3334991
3334993
3334994
3334995
3334997
3334998
3334999
3335000
3335001
3335002
33908_at
7941179
823
A_23_P138835
GE62274
GO:0001533
GO:0003824
GO:0004198
GO:0005509
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005739
GO:0005764
GO:0005773
GO:0005829
GO:0005886
GO:0005925
GO:0006508
GO:0006914
GO:0008233
GO:0008234
GO:0008284
GO:0016020
GO:0016241
GO:0016787
GO:0023052
GO:0031410
GO:0032801
GO:0043226
GO:0046872
GO:0048856
GO:0050790
GO:0055085
GO:0060056
GO:0070062
GO:0097264
GO:0110158
GO:0140096
GO:1904813
GO:2000310
HMNXSV003037649
ILMN_1705261
PH_hs_0023994
TC11000620.hg
TC11002725.hg
X04366_at
g12408655_3p_a_at
Participates
as a member of
CAPN [cytosol] (Homo sapiens)
as a component of
Calpain1 [cytosol] (Homo sapiens)
Calpain1 [cytosol] (Homo sapiens)
Other forms of this molecule
CAPN1 [plasma membrane]
CAPN1 [extracellular region]
CAPN1 [ficolin-1-rich granule lumen]
Inferred To
Homologues of CAPN1 [cytosol]
(Sus scrofa)
capn1 [cytosol]
(Danio rerio)
capn1 [cytosol]
(Xenopus tropicalis)
CAPN1 [cytosol]
(Bos taurus)
CAPN1 [cytosol]
(Canis familiaris)
CAPN1 [cytosol]
(Mus musculus)
CAPN1 [cytosol]
(Rattus norvegicus)
CAPN1 [cytosol]
(Sus scrofa)
Cross References
RefSeq
XP_006718761.1
,
NP_005177.2
,
NP_001185798.1
,
XP_011543594.1
,
NP_001185797.1
Guide to Pharmacology - Targets
2336
OpenTargets
ENSG00000014216
ZINC - Substances
CAN1_HUMAN
ZINC - Biogenic
CAN1_HUMAN
ZINC target
P07384
PRO
P07384
PDB
1ZCM
,
2ARY
,
7X79
,
7W7O
,
8GX3
ZINC - Metabolites
CAN1_HUMAN
HPA
ENSG00000014216-CAPN1
GeneCards
P07384
Ensembl
ENST00000524773
,
ENSP00000435272
,
ENST00000279247
,
ENSP00000434176
,
ENST00000527323
,
ENSP00000431686
,
ENSP00000431984
,
ENST00000533820
,
ENSG00000014216
,
ENST00000533129
,
ENSP00000279247
Pharos - Targets
P07384
ZINC - Predictions - Purchasable
CAN1_HUMAN
HMDB Protein
HMDBP07544
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P18031 PTPN1
2
PTPN1 [cytosol]
(R-HSA-210625)
PTPN1 [endosome membrane]
(R-HSA-9815895)
0.676
4
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.604
7
UniProt:Q96CV9 OPTN
6
OPTN [recycling endosome membrane]
(R-HSA-8854141)
p-S177-OPTN [nucleoplasm]
(R-HSA-2562595)
p-S177-OPTN [cytosol]
(R-HSA-2562525)
OPTN [Golgi membrane]
(R-HSA-2161111)
OPTN [cytosol]
(R-HSA-9687907)
p-S177,S473,S513-OPTN [cytosol]
(R-HSA-9687840)
0.556
3
UniProt:Q92934 BAD
4
p-S99-BAD [cytosol]
(R-HSA-198335)
BAD [cytosol]
(R-HSA-50662)
BAD [mitochondrial outer membrane]
(R-HSA-114242)
p-S91-BAD [cytosol]
(R-HSA-217297)
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:P20810 CAST
1
CAST [cytosol]
(R-HSA-8848644)
0.527
3
UniProt:Q8TCZ2 CD99L2
1
CD99L2 [plasma membrane]
(R-HSA-8867207)
0.527
2
UniProt:P17931 LGALS3
3
LGALS3 [ficolin-1-rich granule membrane]
(R-HSA-6803307)
LGALS3 [secretory granule membrane]
(R-HSA-6803327)
LGALS3 [plasma membrane]
(R-HSA-879445)
0.527
3
UniProt:P40763 STAT3
12
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
p-STAT3 [cytosol]
(R-HSA-8982823)
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701435)
p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701429)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
0.508
2
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