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GGA1 [early endosome membrane]
Stable Identifier
R-HSA-8854136
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
early endosome membrane
Synonyms
ADP-ribosylation factor-binding protein GGA1, GGA1_HUMAN
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Rab regulation of trafficking (Homo sapiens)
TBC/RABGAPs (Homo sapiens)
TBC1D3 associates with RAB5 (Homo sapiens)
GGA1,2,3:RAB5:GTP:RABGEF1 [early endosome membrane] (Homo sapiens)
GGA1,2,3 [early endosome membrane] (Homo sapiens)
GGA1 [early endosome membrane] (Homo sapiens)
TBC1D3:GGA:RAB5:GTP:RABGEF1 [early endosome membrane] (Homo sapiens)
GGA1,2,3:RAB5:GTP:RABGEF1 [early endosome membrane] (Homo sapiens)
GGA1,2,3 [early endosome membrane] (Homo sapiens)
GGA1 [early endosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UJY5 GGA1
Gene Names
GGA1
Chain
chain:1-639
Reference Genes
BioGPS Gene:26088 GGA1
COSMIC (genes):GGA1 GGA1
CTD Gene:26088 GGA1
dbSNP Gene:26088 GGA1
ENSEMBL:ENSG00000100083 GGA1
ENSEMBL_homo_sapiens_GENE:ENSG00000100083.19 GGA1
HGNC:17842 GGA1
KEGG Gene (Homo sapiens):26088 GGA1
Monarch:26088 GGA1
NCBI Gene:26088 GGA1
OMIM:606004 GGA1
UCSC:Q9UJY5 GGA1
Reference Transcript
RefSeq:XM_006724229.1 GGA1
RefSeq:NM_001172687.1 GGA1
RefSeq:NM_001172688.1 GGA1
RefSeq:XM_011530122.1 GGA1
RefSeq:XM_017028760.1 GGA1
RefSeq:NM_013365.4 GGA1
RefSeq:XM_005261517.3 GGA1
RefSeq:XM_017028761.1 GGA1
RefSeq:XM_017028762.1 GGA1
RefSeq:NM_001001560.2 GGA1
RefSeq:XM_005261520.1 GGA1
Other Identifiers
11736096_a_at
11736097_a_at
16929782
218114_3p_at
218114_PM_at
218114_at
26088
3944780
3944781
3944782
3944783
3944784
3944791
3944792
3944793
3944797
3944798
3944799
3944800
3944801
3944802
3944805
3944809
3944810
3944814
3944815
3944816
3944818
3944820
3944821
3944822
3944823
3944825
45572_PM_s_at
45572_s_at
50277_PM_at
50277_at
8072825
A_23_P132294
A_33_P3305915
GE61116
GO:0003674
GO:0005515
GO:0005634
GO:0005654
GO:0005768
GO:0005769
GO:0005794
GO:0005802
GO:0005829
GO:0006886
GO:0006893
GO:0008104
GO:0008289
GO:0010008
GO:0015031
GO:0016020
GO:0016192
GO:0030163
GO:0031267
GO:0031410
GO:0031901
GO:0032991
GO:0034394
GO:0035091
GO:0042147
GO:0043001
GO:0043130
GO:0043226
GO:0043231
GO:0045732
GO:0051641
GO:0072659
GO:0097708
GO:1903441
HMNXSV003019050
ILMN_1658175
ILMN_1681668
PH_hs_0033137
TC22000283.hg
g9558728_3p_at
g9558728_3p_s_at
Participates
as a member of
GGA1,2,3 [early endosome membrane] (Homo sapiens)
Other forms of this molecule
GGA1 [endosome membrane]
Inferred To
Gga [early endosome membrane]
(Drosophila melanogaster)
apt-9 [early endosome membrane]
(Caenorhabditis elegans)
GGA1 [early endosome membrane]
(Gallus gallus)
GGA1 [early endosome membrane]
(Sus scrofa)
Cross References
RefSeq
XP_006724292.1
,
XP_016884251.1
,
XP_005261574.1
,
NP_001166158.1
,
XP_011528424.1
,
NP_001001560.1
,
XP_016884250.1
,
XP_005261577.1
,
NP_001166159.1
,
XP_016884249.1
,
NP_037497.1
OpenTargets
ENSG00000100083
GeneCards
Q9UJY5
HPA
ENSG00000100083-GGA1
Ensembl
ENSP00000341344
,
ENST00000325180
,
ENST00000406772
,
ENST00000381756
,
ENSP00000321288
,
ENSP00000385287
,
ENSP00000371175
,
ENST00000343632
,
ENSG00000100083
PRO
Q9UJY5
Pharos - Targets
Q9UJY5
HMDB Protein
HMDBP08420
PDB
1PY1
,
1NA8
,
3G2T
,
1OXZ
,
1X79
,
1UJK
,
2DWY
,
3G2S
,
3G2W
,
1O3X
,
2DWX
,
1NAF
,
1JWG
,
1UJJ
,
3G2V
,
1JWF
,
3G2U
,
1OM9
,
1NWM
,
1J2J
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q92673 SORL1
2
SORL1 [endosome membrane]
(R-HSA-8871475)
SORL1 [Golgi membrane]
(R-HSA-8871510)
0.744
5
UniProt:P56817 BACE1
8
BACE1 [endoplasmic reticulum lumen]
(R-HSA-6783326)
7K-BACE1 [endoplasmic reticulum lumen]
(R-HSA-5693006)
BACE1(22-45) [Golgi-associated vesicle lumen]
(R-HSA-5693069)
7K-BACE1 [Golgi-associated vesicle lumen]
(R-HSA-5693095)
7K-BACE1(46-501) [Golgi-associated vesicle lumen]
(R-HSA-5693106)
BACE1(46-501) [Golgi-associated vesicle lumen]
(R-HSA-5693105)
BACE1(46-501) [plasma membrane]
(R-HSA-5692933)
BACE1 [endosome membrane]
(R-HSA-5692942)
0.668
4
UniProt:P0CG47 UBB
20
UBB(77-152) [endocytic vesicle membrane]
(R-HSA-939253)
UBB(1-76) [endocytic vesicle membrane]
(R-HSA-939231)
UBB(153-228) [endocytic vesicle membrane]
(R-HSA-939171)
Ub-33-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783023)
Ub-109-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783008)
Ub-185-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783046)
Ub-215-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783002)
Ub-63-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783148)
Ub-139-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783012)
Ub-158-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783162)
Ub-6-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783014)
Ub-82-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783015)
Ub-163-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783025)
Ub-87-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6782998)
Ub-11-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783109)
Ub-124-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783131)
Ub-200-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783100)
Ub-48-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783165)
Ub-181-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783160)
Ub-29-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783070)
0.581
3
UniProt:P35579 MYH9
3
MYH9 [cytosol]
(R-HSA-419173)
MYH9(2-1644)-ALK(1067-1620) fusion [cytosol]
(R-HSA-9715280)
MYH9(2-1644)-p-7Y-ALK(1067-1620) fusion [cytosol]
(R-HSA-9715279)
0.558
2
UniProt:Q9NYZ3 GTSE1
4
GTSE1 [cytosol]
(R-HSA-8852264)
p-S435-GTSE1 [cytosol]
(R-HSA-8852316)
p-S435-GTSE1 [nucleoplasm]
(R-HSA-8852332)
p-T513,T526-GTSE1 [cytosol]
(R-HSA-8852308)
0.544
2
UniProt:P05412 JUN
4
p-S63,S73-JUN [cytosol]
(R-HSA-8868682)
JUN [nucleoplasm]
(R-HSA-450250)
p-S63,S73-JUN [nucleoplasm]
(R-HSA-450237)
JUN [cytosol]
(R-HSA-168194)
0.544
2
UniProt:P84080
2
ARF1 [cytosol]
(R-BTA-200826)
ARF1 [Golgi membrane]
(R-BTA-199971)
0.527
2
UniProt:Q14186 TFDP1
1
TFDP1 [nucleoplasm]
(R-HSA-68652)
0.527
2
UniProt:Q9Y3P9 RABGAP1
1
RABGAP1 [cytosol]
(R-HSA-8854144)
0.527
3
UniProt:Q96A65 EXOC4
2
EXOC4 [plasma membrane]
(R-HSA-264989)
EXOC4 [cytosol]
(R-HSA-5623381)
0.527
3
UniProt:P51790 CLCN3
1
CLCN3 [late endosome membrane]
(R-HSA-2671918)
0.527
3
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.519
6
UniProt:Q9NZ52 GGA3
3
GGA3 [endosome membrane]
(R-HSA-5692936)
GGA3 [recycling endosome membrane]
(R-HSA-8875655)
GGA3 [early endosome membrane]
(R-HSA-8854137)
0.508
4
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