Reactome | p-S37,T41,S45, CTNNB1 [cytosol]

p-S37,T41,S45, CTNNB1 [cytosol]

Stable Identifier

R-HSA-8942369

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-S45-beta catenin

Icon

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P35222 CTNNB1

Gene Names

CTNNB1, CTNNB, OK/SW-cl.35, PRO2286

Chain

initiator methionine:1, chain:2-781

Reference Genes

BioGPS Gene:1499 CTNNB1

COSMIC (genes):CTNNB1 CTNNB1

CTD Gene:1499 CTNNB1

dbSNP Gene:1499 CTNNB1

ENSEMBL:ENSG00000168036 CTNNB1

HGNC:2514 CTNNB1

KEGG Gene (Homo sapiens):1499 CTNNB1

Monarch:1499 CTNNB1

NCBI Gene:1499 CTNNB1

OMIM:116806 CTNNB1

UCSC:P35222 CTNNB1

Reference Transcript

Other Identifiers

0001990132

11722167_s_at

11747387_a_at

11747388_x_at

11748951_a_at

11748952_x_at

11749021_s_at

11749022_x_at

11750680_x_at

1499

1554411_at

16939558

201533_at

2618941

2618942

2618945

2618946

2618952

2618953

2618955

2618957

2618958

2618959

2618960

2618961

2618962

2618965

2618967

2618969

2618971

2618973

2618975

2618978

2618980

2618981

2618982

2618983

40777_at

8079021

A_14_P106050

A_14_P131897

A_23_P29495

A_23_P29499

A_33_P3421695

GE60116

GE752547

GO:0000209

GO:0000278

GO:0000791

GO:0000902

GO:0000922

GO:0001085

GO:0001102

GO:0001569

GO:0001837

GO:0002052

GO:0003674

GO:0003682

GO:0003713

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0005911

GO:0005912

GO:0005925

GO:0005938

GO:0006464

GO:0006810

GO:0007010

GO:0007049

GO:0007059

GO:0007155

GO:0007165

GO:0007223

GO:0007267

GO:0007399

GO:0008013

GO:0008022

GO:0008134

GO:0008150

GO:0008219

GO:0008283

GO:0008285

GO:0009056

GO:0009058

GO:0009790

GO:0010718

GO:0010909

GO:0016020

GO:0016032

GO:0016055

GO:0016323

GO:0016328

GO:0016342

GO:0016525

GO:0019827

GO:0019899

GO:0019900

GO:0019903

GO:0022607

GO:0030054

GO:0030154

GO:0030331

GO:0030877

GO:0030997

GO:0032355

GO:0032481

GO:0032991

GO:0032993

GO:0033234

GO:0034330

GO:0034333

GO:0034394

GO:0034641

GO:0035257

GO:0035315

GO:0035635

GO:0035995

GO:0036023

GO:0040007

GO:0042493

GO:0042995

GO:0043065

GO:0043066

GO:0043161

GO:0043226

GO:0043525

GO:0044325

GO:0044334

GO:0044336

GO:0044403

GO:0045202

GO:0045294

GO:0045296

GO:0045765

GO:0045892

GO:0045893

GO:0045944

GO:0045976

GO:0046332

GO:0048145

GO:0048471

GO:0048646

GO:0048660

GO:0048856

GO:0050767

GO:0051091

GO:0051149

GO:0051276

GO:0051571

GO:0060070

GO:0060828

GO:0061154

GO:0061324

GO:0061549

GO:0065003

GO:0070062

GO:0070369

GO:0070411

GO:0070602

GO:0071363

GO:0071681

GO:0071944

GO:0072182

GO:0090279

GO:0098609

GO:1904798

GO:1904837

GO:1904886

GO:1904948

GO:1904954

GO:1990138

GO:1990907

GO:1990909

GO:2000008

GO:2000144

HMNXSV003034293

Hs2.171271.2.S1_3p_s_at

ILMN_1651617

ILMN_1726641

ILMN_1746396

ILMN_1757350

PH_hs_0024820

TC03000214.hg

X87838_at

g4503130_3p_at

Participates

as a component of

p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)

Other forms of this molecule

CTNNB1 S45A [cytosol]

CTNNB1 S45F [cytosol]

CTNNB1 S45C [cytosol]

CTNNB1 S45Y [cytosol]

CTNNB1 S45N [cytosol]

CTNNB1 S45P [cytosol]

pT41,S45-CTNNB1 S37P [cytosol]

pT41,S45-CTNNB1 S37F [cytosol]

pT41,S45-CTNNB1 S37A [cytosol]

pT41,S45-CTNNB1 S37Y [cytosol]

pT41,S45-CTNNB1 S37C [cytosol]

pS37,T41,S45-CTNNB1 S33A [cytosol]

pS37,T41,S45-CTNNB1 S33T [cytosol]

pS37,T41,S45-CTNNB1 S33C [cytosol]

pS37,T41,S45-CTNNB1 S33F [cytosol]

pS37,T41,S45-CTNNB1 S33P [cytosol]

pS37,T41,S45-CTNNB1 S33Y [cytosol]

pS45-CTNNB1 T41N [cytosol]

pS45-CTNNB1 T41A [cytosol]

pS45-CTNNB1 T41I [cytosol]

Ub-K,p-Y-CTNNB1 [cytosol]

p-Y-CTNNB1 [cytosol]

p-S552-CTNNB1 [nucleoplasm]

p-S552-CTNNB1 [cytosol]

CTNNB1 [plasma membrane]

p-S45 CTNNB1 [cytosol]

p-T41,S45 CTNNB1 [cytosol]

p-S33,S37,T41,S45 CTNNB1 [cytosol]

CTNNB1(116-376) [cytosol]

CTNNB1(1-115) [cytosol]

CTNNB1 [cytosol]

CTNNB1 [nucleoplasm]

Inferred To

phospho-arm [cytosol] (Drosophila melanogaster)

phospho-ctnnb1 [cytosol] (Danio rerio)

phospho-Ctnnb1 [cytosol] (Mus musculus)

phospho-Ctnnb1 [cytosol] (Rattus norvegicus)

phospho-CTNNB1 [cytosol] (Canis familiaris)

phospho-CTNNB1 [cytosol] (Gallus gallus)

phospho-CTNNB1 [cytosol] (Sus scrofa)

phospho-hmp-2 [cytosol] (Caenorhabditis elegans)

Ghost homologue of p-S37,T41,S45, CTNNB1 [cytosol] (Bos taurus)

Modified Residues

Name

O-phospho-L-serine at 45

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 41

Coordinate

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at 37

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001895.1, NP_001091680.1, XP_016861227.1, XP_005264943.1, NP_001091679.1

OpenTargets

ENSG00000168036

ZINC - Substances

CTNB1_HUMAN

ZINC target

P35222

PRO

P35222

PDB

3DIW, 6M90, 6O9C, 3SLA, 2G57, 6O9B, 1LUJ, 3FQN, 6WNX, 1T08, 1G3J, 6M92, 3FQR, 2GL7, 1QZ7, 6M91, 2Z6H, 1JDH, 6M93, 6WLX, 1JPW, 3SL9, 6M94, 1TH1, 3TX7, 4DJS, 1P22

Target Pathogen

5b354852be737e166372e9f6

HPA

ENSG00000168036-CTNNB1

GeneCards

P35222

Ensembl

ENSP00000495076, ENSP00000387455, ENST00000642315, ENST00000646369, ENST00000642426, ENST00000643031, ENSP00000379486, ENST00000349496, ENSP00000493533, ENST00000431914, ENSG00000168036, ENSP00000494411, ENST00000643297, ENST00000643541, ENST00000405570, ENSP00000496021, ENST00000643977, ENSP00000496180, ENSP00000495450, ENST00000646725, ENST00000643992, ENSP00000495360, ENSP00000494845, ENSP00000385604, ENSP00000495244, ENSP00000494677, ENSP00000379488, ENST00000642992, ENSP00000401599, ENSP00000495992, ENSP00000493610, ENST00000645982, ENSP00000412219, ENSP00000494914, ENSP00000409302, ENSP00000494053, ENSP00000495719, ENST00000433400, ENST00000645320, ENST00000396183, ENST00000396185, ENST00000647390, ENST00000450969, ENST00000441708, ENST00000644867, ENSP00000496385, ENST00000642248, ENSP00000344456, ENST00000645210

ZINC - Predictions - Purchasable

CTNB1_HUMAN

Orphanet

15819

HMDB Protein

HMDBP02169

Interactors (108)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NQB0 TCF7L2	4	TCF7L2 R397W [nucleoplasm] (R-HSA-5339696) TCF7L2 K485fs25* [nucleoplasm] (R-HSA-5334040) pT201,T212-TCF7L2 [nucleoplasm] (R-HSA-4411392) TCF7L2 [nucleoplasm] (R-HSA-201923)	0.97	27
UniProt:P25054 APC	86	APC C1410* [cytosol] (R-HSA-9666925) APC R213* [cytosol] (R-HSA-9666924) APC K1310* [cytosol] (R-HSA-9666926) APC R499* [cytosol] (R-HSA-9666927) APC R1450* [cytosol] (R-HSA-5251499) APC G1357* [cytosol] (R-HSA-9666940) APC L1488* [cytosol] (R-HSA-9666941) APC S1400* [cytosol] (R-HSA-9666942) APC S1346* [cytosol] (R-HSA-9666943) APC R405* [cytosol] (R-HSA-9666936) APC S1281* [cytosol] (R-HSA-9666937) APC E1573* [cytosol] (R-HSA-9666938) APC R805* [cytosol] (R-HSA-9666939) APC R1386* [cytosol] (R-HSA-9666932) APC S1327* [cytosol] (R-HSA-9666933) APC E1209* [cytosol] (R-HSA-9666934) APC Q1469* [cytosol] (R-HSA-9666935) APC R564* [cytosol] (R-HSA-9666928) APC E1536* [cytosol] (R-HSA-9666929) APC G1288* [cytosol] (R-HSA-9666930) APC G1312* [cytosol] (R-HSA-9666931) APC R283* [cytosol] (R-HSA-9666988) APC Q1367* [cytosol] (R-HSA-9666989) APC E1353* [cytosol] (R-HSA-9666990) APC R332* [cytosol] (R-HSA-9666991) APC K993* [cytosol] (R-HSA-9666984) APC R876* [cytosol] (R-HSA-9666985) APC R302* [cytosol] (R-HSA-9666986) APC E1309* [cytosol] (R-HSA-9666987) APC Y935* [cytosol] (R-HSA-9666980) APC E1286* [cytosol] (R-HSA-9666981) APC Q1378* [cytosol] (R-HSA-9666982) APC R554* [cytosol] (R-HSA-9666983) APC S1356* [cytosol] (R-HSA-9666976) APC R232* [cytosol] (R-HSA-9666977) APC E1379* [cytosol] (R-HSA-9666978) APC E984* [cytosol] (R-HSA-9666979) APC R1114* [cytosol] (R-HSA-9666996) APC S1282* [cytosol] (R-HSA-9666997) APC Q1328* [cytosol] (R-HSA-9666998) APC E1295* [cytosol] (R-HSA-9666992) APC E1151* [cytosol] (R-HSA-9666993) APC E1322* [cytosol] (R-HSA-9666994) APC E1345* [cytosol] (R-HSA-9666995) APC K1308* [cytosol] (R-HSA-9666956) APC S1344* [cytosol] (R-HSA-9666957) APC E1577* [cytosol] (R-HSA-9666958) APC Q1127* [cytosol] (R-HSA-9666959) APC E1464* [cytosol] (R-HSA-9666952) APC E1317* [cytosol] (R-HSA-9666953) APC G1309Dfs4 [cytosol] (R-HSA-4791251) APC W1049 [cytosol] (R-HSA-9666954) APC Q1429* [cytosol] (R-HSA-9666955) APC L1564* [cytosol] (R-HSA-9666948) APC Q1294* [cytosol] (R-HSA-9666949) APC K1363* [cytosol] (R-HSA-9666950) APC E1408* [cytosol] (R-HSA-9666951) APC E1284* [cytosol] (R-HSA-9666944) APC E1374* [cytosol] (R-HSA-9666945) APC Q767* [cytosol] (R-HSA-9666946) APC E941* [cytosol] (R-HSA-9666947) APC Q1303* [cytosol] (R-HSA-9666972) APC S943* [cytosol] (R-HSA-9666973) APC E1306* [cytosol] (R-HSA-9666975) APC S895* [cytosol] (R-HSA-9666969) APC S1315* [cytosol] (R-HSA-9666970) APC G1412* [cytosol] (R-HSA-9666971) APC Y1376* [cytosol] (R-HSA-9666964) APC Q886* [cytosol] (R-HSA-9666965) APC S1392* [cytosol] (R-HSA-9666966) APC S1539* [cytosol] (R-HSA-9666967) APC E1451* [cytosol] (R-HSA-9666960) APC E1397* [cytosol] (R-HSA-9666961) APC Q1406* [cytosol] (R-HSA-9666962) APC E1544* [cytosol] (R-HSA-9666963) APC F1197* [cytosol] (R-HSA-5246655) APC Q1338* [cytosol] (R-HSA-5246654) APC S811* [cytosol] (R-HSA-5246652) APC I1417 fs2 [cytosol] (R-HSA-5246651) APC E1554 [cytosol] (R-HSA-5246648) p-ub-APC [cytosol] (R-HSA-3009421) K63polyUb-APC [cytosol] (R-HSA-5246690) APC [nucleoplasm] (R-HSA-3361755) APC(1-777) [cytosol] (R-HSA-2976014) APC(778-2843) [cytosol] (R-HSA-2976013) APC [cytosol] (R-HSA-2976015)	0.953	19
UniProt:P12830 CDH1	10	CDH1(751-882) [plasma membrane] (R-HSA-3827962) CDH1(732-882) [plasma membrane] (R-HSA-3827997) CDH1(155-750) [plasma membrane] (R-HSA-3828000) CDH1(155-700) [plasma membrane] (R-HSA-2534244) CDH1(701-882) [extracellular region] (R-HSA-2534158) Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002) p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938) CDH1(155-750) [plasma membrane] (R-HSA-202940) CDH1(751-882) [plasma membrane] (R-HSA-202929) CDH1(155-882) [plasma membrane] (R-HSA-198003)	0.949	15
UniProt:Q9NSA3 CTNNBIP1	1	CTNNBIP1 [nucleoplasm] (R-HSA-3772388)	0.948	14
UniProt:P49841 GSK3B	4	p-S9-GSK3B [cytosol] (R-HSA-3149577) GSK3B del304-316 [cytosol] (R-HSA-5339682) GSK3B [cytosol] (R-HSA-2997551) GSK3B [nucleoplasm] (R-HSA-2022823)	0.947	19
UniProt:O15169 AXIN1	11	AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 L396M [cytosol] (R-HSA-5251503) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 P255S [cytosol] (R-HSA-5251505) ub-AXIN1 [cytosol] (R-HSA-4641133) AXIN1 [cytosol] (R-HSA-195249) p-T519,S524,S531-AXIN1 [cytosol] (R-HSA-206040) RibC-AXIN1 [cytosol] (R-HSA-3640841) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864)	0.94	44
UniProt:P15884 TCF4	1	TCF4 [nucleoplasm] (R-HSA-445672)	0.94	22
UniProt:Q9Y297 BTRC	2	BTRC [nucleoplasm] (R-HSA-3361753) BTRC [cytosol] (R-HSA-174237)	0.926	8
UniProt:Q9UJU2 LEF1	2	LEF1 [nucleoplasm] (R-HSA-3214972) pT155,S166-LEF1 [nucleoplasm] (R-HSA-4411389)	0.893	10
UniProt:P10275 AR	4	SUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) PolyUb-AR [nucleoplasm] (R-HSA-6782984) AR [nucleoplasm] (R-HSA-446174) AR [cytosol] (R-HSA-5618082)	0.891	15
UniProt:P19022 CDH2	3	CDH2 [endoplasmic reticulum lumen] (R-HSA-8956761) p-CDH2 [endoplasmic reticulum lumen] (R-HSA-8956899) CDH2 [plasma membrane] (R-HSA-191429)	0.887	8
UniProt:P46937 YAP1	7	p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) p-5S-YAP1 [cytosol] (R-HSA-2028554) p-S127-YAP1 [cytosol] (R-HSA-2028553) YAP1 [cytosol] (R-HSA-1253345) YAP1 [nucleoplasm] (R-HSA-1253322)	0.881	14
UniProt:P33151 CDH5	2	VE-cadherin [plasma membrane] (R-HSA-418992) p-S665-VE-cadherin [plasma membrane] (R-HSA-5357435)	0.857	7
UniProt:P36402 TCF7	1	TCF7 [nucleoplasm] (R-HSA-3299543)	0.779	4
UniProt:P35221 CTNNA1	2	CTNNA1 [plasma membrane] (R-HSA-191735) CTNNA1 [cytosol] (R-HSA-191697)	0.758	4
UniProt:Q9UKB1 FBXW11	1	FBXW11 [cytosol] (R-HSA-976035)	0.723	4
UniProt:Q6P1J9 CDC73	1	CDC73 [nucleoplasm] (R-HSA-3322360)	0.714	10
UniProt:Q5JTC6 AMER1	5	AMER1 S210* [cytosol] (R-HSA-5251492) AMER1 R497* [cytosol] (R-HSA-9663943) AMER1 R358* [cytosol] (R-HSA-4839640) AMER1 R353* [cytosol] (R-HSA-9663939) AMER1 [cytosol] (R-HSA-1504189)	0.711	9
UniProt:P02511 CRYAB	1	CRYAB [nucleoplasm] (R-HSA-6806336)	0.709	6
UniProt:P63208 SKP1	2	SKP1 [cytosol] (R-HSA-174150) SKP1 [nucleoplasm] (R-HSA-187538)	0.692	3
UniProt:O35625 Axin1	8	Axin1 [cytosol] (R-MMU-4641133) Phospho Axin1 [cytosol] (R-MMU-206175) phospho-Axin1 [cytosol] (R-MMU-3640864) phospho-Axin1 [cytosol] (R-MMU-3640841) Axin1 [cytosol] (R-MMU-205727) Phospho (3 sites) Axin1 [cytosol] (R-MMU-205737) phospho-Axin1 [cytosol] (R-MMU-206040) Axin1 [cytosol] (R-MMU-195249)	0.688	4
UniProt:Q96AC1 FERMT2	1	FERMT2 [cytosol] (R-HSA-430275)	0.681	13
UniProt:O43707 ACTN4	3	ACTN4 [platelet alpha granule lumen] (R-HSA-198240) ACTN4 [extracellular region] (R-HSA-349729) ACTN4 [cytosol] (R-HSA-390558)	0.68	7
UniProt:Q08050 FOXM1	3	p-T611-FOXM1 [nucleoplasm] (R-HSA-4088026) p-T611,S730,S739-FOXM1 [nucleoplasm] (R-HSA-4088133) FOXM1 [nucleoplasm] (R-HSA-4088019)	0.672	16
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	14
UniProt:Q01826 SATB1	5	SUMO1-K744-SATB1 [nucleoplasm] (R-HSA-4615954) SUMO2,3-K744-SATB1 [nucleoplasm] (R-HSA-4615978) SATB1(255-763) [nucleoplasm] (R-HSA-352264) SATB1(1-254) [nucleoplasm] (R-HSA-352269) SATB1 [nucleoplasm] (R-HSA-201593)	0.66	9
UniProt:P55197 AF10			0.656	5
UniProt:Q13761 RUNX3	7	RUNX3 [cytosol] (R-HSA-8937797) RUNX3 [nucleoplasm] (R-HSA-8865393) Ac-K94,K171-RUNX3 [nucleoplasm] (R-HSA-8951965) PolyUb-K94,K148-RUNX3 [cytosol] (R-HSA-8952400) PolyUb-K94,K148-RUNX3 [nucleoplasm] (R-HSA-8952387) p-Y-RUNX3 [cytosol] (R-HSA-8937805) PolyUb-RUNX3 [nucleoplasm] (R-HSA-8952417)	0.656	12
UniProt:O00482-1 NR5A2	1	NR5A2-1 [nucleoplasm] (R-HSA-3008758)	0.65	5
UniProt:P19838 NFKB1	8	NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-968) [cytosol] (R-HSA-451607) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) 3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619)	0.646	3
UniProt:Q9GZV5 WWTR1	3	WWTR1 [nucleoplasm] (R-HSA-1629775) p-S89-WWTR1 [cytosol] (R-HSA-2028665) WWTR1 [cytosol] (R-HSA-1629773)	0.641	4
UniProt:P26358 DNMT1	2	DNMT1 [nucleoplasm] (R-HSA-212181) SUMO1-K-DNMT1 [nucleoplasm] (R-HSA-4655353)	0.628	8
UniProt:P14923 JUP	6	JUP [cornified envelope] (R-HSA-8847739) JUP [cytosol] (R-HSA-201598) JUP [specific granule lumen] (R-HSA-6799534) JUP [extracellular region] (R-HSA-6806309) JUP [ficolin-1-rich granule lumen] (R-HSA-6801028) JUP [plasma membrane] (R-HSA-437260)	0.615	3
UniProt:Q9YGY0 AXIN1			0.609	2
UniProt:P23470 PTPRG			0.609	2
UniProt:P08575 PTPRC	2	PTPRC [plasma membrane] (R-HSA-197931) PTPRC [secretory granule membrane] (R-HSA-6806150)	0.609	2
UniProt:Q12913 PTPRJ	2	PTPRJ [plasma membrane] (R-HSA-6785269) PTPRJ [specific granule membrane] (R-HSA-6799570)	0.609	2
UniProt:P49789 FHIT			0.602	4
UniProt:Q9UI47-1 CTNNA3			0.602	4
UniProt:P18012 IPAC			0.602	4
UniProt:P49023 PXN	4	PXN [plasma membrane] (R-HSA-180493) p-Y-PXN [plasma membrane] (R-HSA-9031680) PXN [cytosol] (R-HSA-210014) p-Y31,Y118-PXN [cytosol] (R-HSA-5218693)	0.602	4
UniProt:Q9UBN7 HDAC6	5	HDAC6 [late endosome lumen] (R-HSA-9659980) HDAC6 [nucleoplasm] (R-HSA-351589) HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [cytosol] (R-HSA-9646404) HDAC6 [lysosomal lumen] (R-HSA-9660002)	0.602	4
UniProt:Q9GZQ8 MAP1LC3B	3	MAP1LC3B(2-121) [cytosol] (R-HSA-5682674) MAP1LC3B [autophagosome membrane] (R-HSA-5683641) MAP1LC3B [cytosol] (R-HSA-5205651)	0.602	5
UniProt:P50402 EMD	4	EMD [cytosol] (R-HSA-9613988) EMD [nuclear envelope] (R-HSA-201573) EMD [endoplasmic reticulum membrane] (R-HSA-9613998) EMD [endosome membrane] (R-HSA-9715092)	0.591	3
UniProt:Q04206 RELA	6	MeK310-RELA [nucleoplasm] (R-HSA-8865233) SUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.589	3
UniProt:Q13308 PTK7			0.581	5
UniProt:Q9BZE0 GLIS2			0.581	6
IntAct:EBI-4399559 UBIQ			0.576	3
UniProt:O75564 JERKY			0.576	3
UniProt:Q13625 TP53BP2	1	TP53BP2 [nucleoplasm] (R-HSA-6799780)	0.576	5
UniProt:Q92793 CREBBP	3	FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) SUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877) CREBBP [nucleoplasm] (R-HSA-193545)	0.573	2
UniProt:P33724	3	CAV1 [early endosome membrane] (R-CFA-5368451) CAV1 [Golgi membrane] (R-CFA-204504) CAV1 [plasma membrane] (R-CFA-534994)	0.571	5
UniProt:P11388 TOP2A	3	SUMO2,3-TOP2A [nucleoplasm] (R-HSA-4641298) TOP2A [nucleoplasm] (R-HSA-1362276) SUMO1-K-TOP2A [nucleoplasm] (R-HSA-4641367)	0.57	5
UniProt:Q9Y2T1 AXIN2	4	RibC-AXIN2 [cytosol] (R-HSA-3640842) AXIN2 [cytosol] (R-HSA-3640821) Ub-RibC-AXIN2 [cytosol] (R-HSA-3640859) ub-AXIN2 [cytosol] (R-HSA-4641131)	0.564	2
UniProt:Q8TEK3 DOT1L	1	DOT1L [nucleoplasm] (R-HSA-3239030)	0.564	3
UniProt:Q9DBG9	1	Tax1bp3 [cytosol] (R-MMU-5666217)	0.558	3
UniProt:P01023 A2M	2	A2M [extracellular region] (R-HSA-49291) A2M [platelet alpha granule lumen] (R-HSA-139834)	0.556	3
UniProt:P62826 RAN	2	RAN [cytosol] (R-HSA-165540) RAN [nucleoplasm] (R-HSA-165528)	0.556	3
UniProt:P55212 CASP6	5	CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(194-293) [cytosol] (R-HSA-266128) CASP6 (1-293) [cytosol] (R-HSA-6798132)	0.556	3
UniProt:O00291 HIP1	1	HIP1 [cytosol] (R-HSA-8868153)	0.556	3
UniProt:O75400-2 PRPF40A			0.556	3
UniProt:Q14114-3 Q141143			0.556	3
UniProt:P0DN79 CBSL	1	PXLP-K119-CBSL [cytosol] (R-HSA-9644840)	0.556	3
UniProt:P13473-2 P134732			0.556	3
UniProt:P23560-2 BDNF			0.556	3
UniProt:P19404 NDUFV2	1	NDUFV2 [mitochondrial inner membrane] (R-HSA-163939)	0.556	3
UniProt:O14656-2 TOR1A			0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [cytosol] (R-HSA-5654207) SPRED1 [plasma membrane] (R-HSA-5658225)	0.556	3
UniProt:P51608 MECP2			0.556	3
UniProt:Q8WXH2 JPH3			0.556	3
UniProt:Q92915-2 FGF14			0.556	3
UniProt:G5E9A7 G5E9A7			0.556	3
UniProt:P04406 GAPDH	1	GAPDH [cytosol] (R-HSA-70428)	0.556	3
UniProt:P07900 HSP90AA1	8	HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.556	3
UniProt:P14136 GFAP	3	GFAP [lysosomal membrane] (R-HSA-9625195) p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:P00519 ABL1	5	p-S456-ABL1 [nucleoplasm] (R-HSA-5686576) p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) ABL1 [nucleoplasm] (R-HSA-5686579) ABL1 [cytosol] (R-HSA-375987) p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610)	0.544	2
UniProt:P12931 SRC	6	p-Y416-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.544	2
UniProt:Q9NYF0 DACT1	1	DACT1 [cytosol] (R-HSA-4641144)	0.537	3
UniProt:P11362 FGFR1	8	FGFR1 K656E [plasma membrane] (R-HSA-1614373) FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853241) FGFR1 N546K [plasma membrane] (R-HSA-1614377) FGFR1 R576W [plasma membrane] (R-HSA-2011844) p-6Y FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853142) p-8Y-FGFR1 K656E [plasma membrane] (R-HSA-2023356) p-8Y-FGFR1 N546K [plasma membrane] (R-HSA-2023358) p-8Y- FGFR1 R576W [plasma membrane] (R-HSA-2023361)	0.536	2
UniProt:Q8TEW0 PARD3	3	PARD3 [plasma membrane] (R-HSA-419980) PARD3 [cell junction] (R-HSA-2134481) PARD3 [cytosol] (R-HSA-419993)	0.536	2
IntAct:EBI-5237192 AXIN2			0.527	2
UniProt:P09803 Cdh1	6	Cdh1 [plasma membrane] (R-MMU-2534244) Epithelial-cadherin precursor [plasma membrane] (R-MMU-199081) Cdh1 [extracellular region] (R-MMU-2534158) Cdh1 [plasma membrane] (R-MMU-202940) Cdh1 [plasma membrane] (R-MMU-202929) Cdh1 [plasma membrane] (R-MMU-198003)	0.527	3
UniProt:Q9UKE5 TNIK	1	TNIK [cytosol] (R-HSA-3214889)	0.525	3
UniProt:Q9EPK5 Wwtr1	4	phospho-Wwtr1 [cytosol] (R-MMU-2028665) Wwtr1 [nucleoplasm] (R-MMU-2064930) Wwtr1 [cytosol] (R-MMU-1629773) Wwtr1 [nucleoplasm] (R-MMU-1629775)	0.525	2
UniProt:P14618 PKM	3	PKM [extracellular region] (R-HSA-6806491) PKM [ficolin-1-rich granule lumen] (R-HSA-6801387) PKM [secretory granule lumen] (R-HSA-6801401)	0.524	4
UniProt:A1Z199 A1Z199			0.524	2
UniProt:P14618-1 PKM	1	PKM-1 [cytosol] (R-HSA-71667)	0.524	3
UniProt:O14746 TERT	1	TERT [nucleoplasm] (R-HSA-163076)	0.524	2
UniProt:Q15599 NHRF2			0.508	2
UniProt:O00512 BCL9	1	BCL9 [nucleoplasm] (R-HSA-201714)	0.508	2
UniProt:Q03431 PTH1R	1	PTH1R [plasma membrane] (R-HSA-420479)	0.505	4
UniProt:P08069 IGF1R	3	IGF1R(31-736) [plasma membrane] (R-HSA-2404169) IGF1R(741-1367) [plasma membrane] (R-HSA-2404180) p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane] (R-HSA-2404172)	0.499	3
UniProt:Q9H6I2 SOX17	1	SOX17 [nucleoplasm] (R-HSA-5625834)	0.499	2
UniProt:Q92597 NDRG1	1	NDRG1 [cytosol] (R-HSA-5628834)	0.499	3
IntAct:EBI-6668710 TCF			0.499	3
UniProt:P18146 EGR1	1	EGR1 [nucleoplasm] (R-HSA-1031703)	0.499	7
UniProt:Q9Y265 RUVBL1	1	RUVBL1 [nucleoplasm] (R-HSA-418323)	0.499	3
UniProt:P49757 NUMB	1	NUMB [plasma membrane] (R-HSA-443595)	0.499	2
UniProt:Q9UI47 CTNA3			0.483	2
UniProt:Q99697 PITX2	1	PITX2 [nucleoplasm] (R-HSA-8864726)	0.483	2
UniProt:P16284 PECAM1	4	p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007) PECAM1 [plasma membrane] (R-HSA-114686) PECAM1 [secretory granule membrane] (R-HSA-6804778) PECAM1 [platelet alpha granule membrane] (R-HSA-61489)	0.483	3
UniProt:Q9JHQ5	1	Lztfl1 [cytosol] (R-MMU-5617789)	0.471	2
UniProt:P29474 NOS3	7	MyrG-NOS3 [Golgi membrane] (R-HSA-534995) 2xPalmC-MyrG-NOS3 [endocytic vesicle membrane] (R-HSA-535007) NOS3 [cytosol] (R-HSA-202114) MyrG-NOS3 [cytosol] (R-HSA-203687) 2xPalmC-MyrG-NOS3 [Golgi membrane] (R-HSA-203769) 2xPalmC-MyrG-NOS3 [plasma membrane] (R-HSA-534993) 2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane] (R-HSA-202139)	0.471	4
UniProt:O95071 UBR5			0.463	6
UniProt:Q14160 SCRIB	1	SCRIB [cytosol] (R-HSA-4608858)	0.463	2
UniProt:P46940 IQGAP1	3	IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [plasma membrane] (R-HSA-381681)	0.463	3
UniProt:Q14526 HIC1	2	HIC1 [nucleoplasm] (R-HSA-4090364) SUMO1-K333-HIC1 [nucleoplasm] (R-HSA-4090368)	0.463	2
UniProt:Q99593 TBX5	1	TBX5 [nucleoplasm] (R-HSA-2032786)	0.462	3

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