p-S1108,S1148,S1192-EIF4G1 [cytosol]

Stable Identifier
R-HSA-165762
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
eIF4G-P
Locations in the PathwayBrowser
Expand all
General
Serine residues 1108, 1148, 1192 of the EIF4G1 isoform in Raught et al. (2000) correspond to serine residues 1147, 1185, and 1231 of the UniProt reference sequence.
Literature References
PubMed ID Title Journal Year
10654941 Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI

Raught, B, Gingras, AC, Gygi, SP, Imataka, H, Morino, S, Gradi, A, Aebersold, R, Sonenberg, N

EMBO J 2000
External Reference Information
External Reference
UniProt:Q04637 EIF4G1
Gene Names
EIF4G1, EIF4F, EIF4G, EIF4GI
Chain
chain:1-1599, initiator methionine:1
Reference Genes
BioGPS Gene:1981 EIF4G1
COSMIC - genes:EIF4G1 EIF4G1
CTD Gene:1981 EIF4G1
dbSNP Gene:1981 EIF4G1
ENSEMBL:ENSG00000114867 EIF4G1
HGNC:3296 EIF4G1
KEGG:hsa:1981 EIF4G1
Monarch:1981 EIF4G1
NCBI Gene:1981 EIF4G1
OMIM:600495 EIF4G1
UCSC:Q04637 EIF4G1
Reference Transcript
Participates
as an output of
Other forms of this molecule
EIF4G1 [cytosol]
Inferred To
phospho-tif471 [cytosol] (Schizosaccharomyces pombe)
phospho-EIF4G1 [cytosol] (Bos taurus)
phospho-EIF4G1 [cytosol] (Canis familiaris)
phospho-EIF4G1 [cytosol] (Gallus gallus)
phospho-EIF4G1 [cytosol] (Sus scrofa)
phospho-ifg-1 [cytosol] (Caenorhabditis elegans)
phospho-eif4g [cytosol] (Dictyostelium discoideum)
phospho-eIF4G1 [cytosol] (Drosophila melanogaster)
phospho-Eif4g1 [cytosol] (Mus musculus)
phospho-TIF4631 [cytosol] (Saccharomyces cerevisiae)
phospho-eif4g1 [cytosol] (Xenopus tropicalis)
Homologues of p-S1108,S1148,S1192-EIF4G1 [cytosol] (Plasmodium falciparum)
Homologues of p-S1108,S1148,S1192-EIF4G1 [cytosol] (Saccharomyces cerevisiae)
phospho-p-S1108,S1148,S1192-EIF4G1 [cytosol] (Plasmodium falciparum)
phospho-p-S1108,S1148,S1192-EIF4G1 [cytosol] (Rattus norvegicus)
phospho-TIF4632 [cytosol] (Saccharomyces cerevisiae)
Modified Residues
Name
O-phospho-L-serine at 1147
Coordinate
1147
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1185
Coordinate
1185
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1231
Coordinate
1231
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
OpenTargets
ENSEMBL
GeneCards
HPA
PRO
Pharos - Targets
GlyGen
Orphanet
PDB
Interactors (28)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P60842 EIF4A1  1 0.966 18
 UniProt:P06730 EIF4E  1 0.937 15
 UniProt:P11940 PABPC1  1 0.835 6
 UniProt:Q14240 EIF4A2  1 0.656 4
 UniProt:Q9BWF3-1 RBM4      0.591 4
 UniProt:Q9UGR2 Z3H7B      0.567 3
 UniProt:Q9BUB5 MKNK1  1 0.564 3
 UniProt:P23116  1 0.564 2
 UniProt:P55884 EIF3B  1 0.564 2
 UniProt:O00571 DDX3X  4 0.557 3
 UniProt:P61981 YWHAG  1 0.528 3
 UniProt:Q13347 EIF3I  1 0.527 2
 UniProt:P10636-8 MAPT  3 0.527 4
 UniProt:Q13112 CAF1B      0.527 2
 ChEBI:50210 7-METHYL-GTP      0.527 3
 UniProt:Q06787 FMR1      0.527 2
 UniProt:P03372 ESR1  10 0.527 3
 UniProt:O75822 EIF3J  1 0.524 2
 UniProt:Q14103-4 HNRNPD  2 0.499 3
 UniProt:Q9J0X9 Q9J0X9      0.499 3
 UniProt:Q13283 G3BP1  1 0.491 2
 UniProt:P13569 CFTR  17 0.483 7
 UniProt:P62280 RPS11  2 0.483 2
 UniProt:P06748 NPM1  11 0.483 2
 UniProt:P51116 FXR2      0.483 2
 UniProt:P26196 DDX6  1 0.483 2
 UniProt:Q00721 NSP3      0.482 2
 UniProt:Q09161 NCBP1  2 0.462 2
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