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PSMB6 [nucleoplasm]
Stable Identifier
R-HSA-174342
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Proteasome subunit beta type 6, Proteasome subunit beta type 6 precursor , Proteasome delta chain, Macropain delta chain, Multicatalytic endopeptidase complex delta chain, Proteasome subunit Y
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB6 [nucleoplasm] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB6 [nucleoplasm] (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB6 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB6 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB6 [nucleoplasm] (Homo sapiens)
Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB6 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB6 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB6 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB6 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P28072 PSMB6
Gene Names
PSMB6, LMPY, Y
Chain
initiator methionine:1, propeptide:2-34, chain:35-239
Reference Genes
BioGPS Gene:5694 PSMB6
COSMIC (genes):PSMB6 PSMB6
CTD Gene:5694 PSMB6
dbSNP Gene:5694 PSMB6
ENSEMBL:ENSG00000142507 PSMB6
HGNC:9543 PSMB6
KEGG Gene (Homo sapiens):5694 PSMB6
Monarch:5694 PSMB6
NCBI Gene:5694 PSMB6
OMIM:600307 PSMB6
Reference Transcript
RefSeq:NM_002798.2 PSMB6
Other Identifiers
0003140156
11757696_a_at
16829885
208827_at
3707200
3707201
3707203
3707204
3707205
3707206
3707208
3707209
3707210
3707211
5694
8003953
941_at
A_23_P15705
D29012_at
GE560878
GO:0000165
GO:0000209
GO:0000278
GO:0000502
GO:0002223
GO:0002376
GO:0002479
GO:0003674
GO:0004175
GO:0004298
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005839
GO:0006464
GO:0006508
GO:0006520
GO:0006521
GO:0006810
GO:0006950
GO:0007049
GO:0007165
GO:0007267
GO:0008150
GO:0008233
GO:0009056
GO:0009058
GO:0010498
GO:0010499
GO:0010972
GO:0016032
GO:0016579
GO:0016787
GO:0019774
GO:0030154
GO:0031145
GO:0031146
GO:0032991
GO:0033209
GO:0034641
GO:0034655
GO:0038061
GO:0038095
GO:0043161
GO:0043226
GO:0043488
GO:0043687
GO:0044281
GO:0044403
GO:0045296
GO:0048856
GO:0050852
GO:0051603
GO:0055085
GO:0060071
GO:0061418
GO:0070062
GO:0070498
GO:0090090
GO:0090263
GO:1901990
GO:1902036
ILMN_1666409
ILMN_1766135
PH_hs_0004444
PH_hs_0031333
TC17000052.hg
g12654058_3p_at
Participant Of
hasComponent
26S proteasome [nucleoplasm]
Other forms of this molecule
PSMB6 [cytosol]
Inferred To
psmB6 [nucleoplasm] (Dictyostelium discoideum)
Prosbeta1 [nucleoplasm] (Drosophila melanogaster)
pbs-1 [nucleoplasm] (Caenorhabditis elegans)
Homologues of PSMB6 [nucleoplasm] (Rattus norvegicus)
Ghost homologue of PSMB6 [nucleoplasm] (Xenopus tropicalis)
LOC100360846 [nucleoplasm] (Rattus norvegicus)
psmb6 [nucleoplasm] (Danio rerio)
PSMB6 [nucleoplasm] (Canis familiaris)
PSMB6 [nucleoplasm] (Sus scrofa)
Psmb6 [nucleoplasm] (Mus musculus)
Psmb6 [nucleoplasm] (Rattus norvegicus)
Cross References
RefSeq
NP_002789.1
Target Pathogen
5b354852be737e166372e991
OpenTargets
ENSG00000142507
HPA
ENSG00000142507-PSMB6
GeneCards
P28072
Ensembl
ENSP00000270586
,
ENST00000270586
,
ENSG00000142507
PRO
P28072
PDB
5VFR
,
4R67
,
5L4G
,
5VFQ
,
5LF1
,
6MSH
,
5LEZ
,
5VFS
,
6MSJ
,
5T0J
,
6MSK
,
5LF0
,
5LEY
,
5VFT
,
5VFP
,
6REY
,
6MSB
,
5LF4
,
6MSD
,
6MSE
,
6MSG
,
5LE5
,
5LF3
,
6KWY
,
6RGQ
,
5LF7
,
6XMJ
,
5M32
,
5T0C
,
5LF6
,
5LN3
,
5VFU
,
5T0I
,
4R3O
,
5VFO
,
5A0Q
,
6R70
,
5LEX
,
5T0H
,
5GJR
,
5T0G
,
5GJQ
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [nucleoplasm]
(R-HSA-5689584)
UCHL5 [cytosol]
(R-HSA-1629778)
0.564
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:P04578 env
7
Transmembrane protein gp41 (P04578) [cytosol]
(R-HIV-189359)
Surface protein gp120 (P04578) [cytosol]
(R-HIV-189269)
Glycosylated Envelope glycoprotein gp160 [Golgi membrane]
(R-HIV-3149443)
Envelope glycoprotein gp160 [endoplasmic reticulum membrane]
(R-HIV-189343)
Transmembrane protein gp41 [viral envelope]
(R-HIV-171195)
ENV [viral envelope]
(R-HIV-173439)
Surface protein gp120 [viral envelope]
(R-HIV-171211)
0.462
2
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