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VAPA [cytosol]
Stable Identifier
R-HSA-9609920
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Vesicle-associated membrane protein-associated protein A, VAPA_HUMAN
Locations in the PathwayBrowser
Expand all
Protein localization (Homo sapiens)
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane (Homo sapiens)
SGTA binds Tail-anchored protein (Homo sapiens)
Tail-anchored protein:SGTA dimer [cytosol] (Homo sapiens)
Tail-anchored proteins [cytosol] (Homo sapiens)
VAPA [cytosol] (Homo sapiens)
Tail-anchored proteins [cytosol] (Homo sapiens)
VAPA [cytosol] (Homo sapiens)
Tail-anchored protein:ASNA1:ADP binds WRB:CAMLG at the endoplasmic reticulum membrane (Homo sapiens)
Tail-anchored protein:ASNA1:ADP [cytosol] (Homo sapiens)
Tail-anchored proteins [cytosol] (Homo sapiens)
VAPA [cytosol] (Homo sapiens)
Tail-anchored protein:ASNA1:ADP:WRB:CAMLG [endoplasmic reticulum membrane] (Homo sapiens)
Tail-anchored protein:ASNA1:ADP [cytosol] (Homo sapiens)
Tail-anchored proteins [cytosol] (Homo sapiens)
VAPA [cytosol] (Homo sapiens)
Tail-anchored protein:ASNA1:ADP:WRB:CAMLG dissociates yielding Tail-anchored protein in the endoplasmic reticulum membrane (Homo sapiens)
Tail-anchored protein:ASNA1:ADP:WRB:CAMLG [endoplasmic reticulum membrane] (Homo sapiens)
Tail-anchored protein:ASNA1:ADP [cytosol] (Homo sapiens)
Tail-anchored proteins [cytosol] (Homo sapiens)
VAPA [cytosol] (Homo sapiens)
Tail-anchored protein:SGTA dimer binds BAG6:GET4:UBL4A and ASNA1:ATP (Homo sapiens)
Tail-anchored protein:SGTA dimer [cytosol] (Homo sapiens)
Tail-anchored proteins [cytosol] (Homo sapiens)
VAPA [cytosol] (Homo sapiens)
Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP [cytosol] (Homo sapiens)
Tail-anchored protein:SGTA dimer [cytosol] (Homo sapiens)
Tail-anchored proteins [cytosol] (Homo sapiens)
VAPA [cytosol] (Homo sapiens)
Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP dissociates and ASNA1 hydrolyzes ATP yielding Tail-anchored protein:ASNA1:ADP (Homo sapiens)
Tail-anchored protein:ASNA1:ADP [cytosol] (Homo sapiens)
Tail-anchored proteins [cytosol] (Homo sapiens)
VAPA [cytosol] (Homo sapiens)
Tail-anchored protein:ASNA1:ATP [cytosol] (Homo sapiens)
Tail-anchored proteins [cytosol] (Homo sapiens)
VAPA [cytosol] (Homo sapiens)
Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP [cytosol] (Homo sapiens)
Tail-anchored protein:SGTA dimer [cytosol] (Homo sapiens)
Tail-anchored proteins [cytosol] (Homo sapiens)
VAPA [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9P0L0 VAPA
Gene Names
VAPA, VAP33
Chain
initiator methionine:, chain:2-249
Reference Genes
BioGPS Gene:9218 VAPA
COSMIC (genes):VAPA VAPA
CTD Gene:9218 VAPA
dbSNP Gene:9218 VAPA
ENSEMBL:ENSG00000101558 VAPA
ENSEMBL_homo_sapiens_GENE:ENSG00000101558.14 VAPA
HGNC:12648 VAPA
KEGG Gene (Homo sapiens):9218 VAPA
Monarch:9218 VAPA
NCBI Gene:9218 VAPA
OMIM:605703 VAPA
UCSC:Q9P0L0 VAPA
Reference Transcript
RefSeq:NM_194434.2 VAPA
RefSeq:NM_003574.5 VAPA
Other Identifiers
11725316_x_at
11725317_s_at
11743255_a_at
11743256_s_at
11743257_x_at
11754029_a_at
11754086_x_at
16850944
208780_PM_x_at
208780_x_at
225198_PM_at
225198_at
228480_PM_at
228480_at
239750_PM_x_at
239750_x_at
3638294
3638295
3778602
3778603
3778610
3778612
3778615
3778618
3778619
3778622
3778626
3778627
3778628
3778629
3778630
3778631
3778632
3778633
38801_at
46029_r_at
54663_at
63624_at
8020129
88498_at
89329_at
9218
A_23_P207957
A_23_P382199
A_33_P3419460
GE55653
GE576751
GE81305
GE86002
GE88533
GO:0000139
GO:0005515
GO:0005634
GO:0005635
GO:0005764
GO:0005773
GO:0005783
GO:0005789
GO:0005794
GO:0005829
GO:0005856
GO:0005886
GO:0005923
GO:0006629
GO:0006686
GO:0006888
GO:0008017
GO:0008092
GO:0015630
GO:0015914
GO:0015918
GO:0016020
GO:0016192
GO:0019076
GO:0019904
GO:0023052
GO:0030154
GO:0030301
GO:0031175
GO:0031410
GO:0031965
GO:0031982
GO:0033149
GO:0035577
GO:0035627
GO:0042803
GO:0043123
GO:0043226
GO:0044828
GO:0044829
GO:0045296
GO:0046982
GO:0048471
GO:0048856
GO:0061024
GO:0061025
GO:0061817
GO:0070161
GO:0070972
GO:0090114
HMNXSV003039333
Hs.165195.0.S1_3p_at
Hs.165195.1.A1_3p_at
Hs.65082.0.A1_3p_at
ILMN_1690822
ILMN_1779410
ILMN_2405190
PH_hs_0029289
TC18000049.hg
g8099349_3p_a_at
g8099349_3p_x_at
Participates
as a member of
Tail-anchored proteins [cytosol] (Homo sapiens)
Other forms of this molecule
VAPA [endoplasmic reticulum membrane]
VAPA [azurophil granule membrane]
VAPA [plasma membrane]
Inferred To
VAPA [cytosol]
(Bos taurus)
VAPA [cytosol]
(Canis familiaris)
VAPA [cytosol]
(Dictyostelium discoideum)
VAPA [cytosol]
(Gallus gallus)
VAPA [cytosol]
(Plasmodium falciparum)
VAPA [cytosol]
(Sus scrofa)
vpr-1 [cytosol]
(Caenorhabditis elegans)
Vapa [cytosol]
(Mus musculus)
Vapa [cytosol]
(Rattus norvegicus)
scs2 [cytosol]
(Schizosaccharomyces pombe)
vapa [cytosol]
(Xenopus tropicalis)
SCS2 [cytosol]
(Saccharomyces cerevisiae)
Vap33 [cytosol]
(Drosophila melanogaster)
vapal [cytosol]
(Danio rerio)
Cross References
RefSeq
NP_919415.2
,
NP_003565.4
OpenTargets
ENSG00000101558
HPA
ENSG00000101558-VAPA
GeneCards
Q9P0L0
Ensembl
ENST00000400000
,
ENSP00000345656
,
ENST00000340541
,
ENSG00000101558
,
ENSP00000382880
PRO
Q9P0L0
Pharos - Targets
Q9P0L0
PDB
6TQR
,
2RR3
Interactors (22)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P22059 OSBP
1
OSBP [cytosol]
(R-HSA-429725)
0.848
9
UniProt:Q13188 STK3
4
p-T180-STK3(1-322) [cytosol]
(R-HSA-2028696)
STK3(323-491) [cytosol]
(R-HSA-2028684)
STK3(1-491) [cytosol]
(R-HSA-2028280)
p-T180-STK3(1-491) [cytosol]
(R-HSA-2028274)
0.725
5
UniProt:P17612 PRKACA
4
PRKACA [mitochondrial matrix]
(R-HSA-9838291)
PRKACA [ciliary base]
(R-HSA-5610402)
PRKACA [nucleoplasm]
(R-HSA-111936)
PRKACA [cytosol]
(R-HSA-57844)
0.725
5
UniProt:P05090 APOD
1
APOD [extracellular region]
(R-HSA-5216199)
0.718
6
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.713
4
UniProt:P35372 OPRM1
1
OPRM1 [plasma membrane]
(R-HSA-60951)
0.675
4
UniProt:O15173 PGRMC2
4
PGRMC2 [nuclear envelope]
(R-HSA-9707674)
PGRMC2 [nucleoplasm]
(R-HSA-9707859)
PGRMC2 [endoplasmic reticulum membrane]
(R-HSA-9714349)
PGRMC2 [endosome membrane]
(R-HSA-9715090)
0.666
5
UniProt:Q8WXG1 RSAD2
1
RSAD2 [endoplasmic reticulum membrane]
(R-HSA-5624199)
0.661
10
UniProt:Q13043 STK4
4
STK4(1-487) [cytosol]
(R-HSA-201627)
p-T183-STK4(1-326) [cytosol]
(R-HSA-2028682)
p-T183-STK4(1-487) [cytosol]
(R-HSA-2028258)
STK4(327-487) [cytosol]
(R-HSA-2028668)
0.643
5
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.64
13
UniProt:Q9NZN5 ARHGEF12
1
ARHGEF12 [cytosol]
(R-HSA-416560)
0.615
6
UniProt:O95070 YIF1A
1
YIF1A [endoplasmic reticulum membrane]
(R-HSA-535599)
0.602
3
UniProt:P27824 CANX
2
CANX [lumenal side of endoplasmic reticulum membrane]
(R-HSA-983091)
CANX [endoplasmic reticulum lumen]
(R-HSA-195906)
0.569
5
UniProt:Q8N661 TMEM86B
1
TMEM86B [endoplasmic reticulum membrane]
(R-HSA-8874443)
0.556
3
UniProt:Q7Z5P4 HSD17B13
1
HSD17B13 [cytosol]
(R-HSA-8862029)
0.556
3
UniProt:Q15125 EBP
1
EBP [endoplasmic reticulum membrane]
(R-HSA-195697)
0.556
3
UniProt:Q8NBQ5 HSD17B11
1
HSD17B11 [cytosol]
(R-HSA-5693370)
0.556
3
UniProt:O00559 EBAG9
1
EBAG9 [Golgi membrane]
(R-HSA-9018507)
0.556
3
UniProt:P04626 ERBB2
20
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 Y772_A775dup [plasma membrane]
(R-HSA-9665652)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
0.547
2
UniProt:Q07065 CKAP4
7
CKAP4 [endoplasmic reticulum lumen]
(R-HSA-8956737)
p-CKAP4 [endoplasmic reticulum lumen]
(R-HSA-8956926)
CKAP4 [azurophil granule membrane]
(R-HSA-6799559)
CKAP4 [plasma membrane]
(R-HSA-5686306)
CKAP4 [specific granule membrane]
(R-HSA-6799552)
PALM-C100-CKAP4 [plasma membrane]
(R-HSA-5686280)
PALM-C100-CKAP4 [lamellar body]
(R-HSA-5686285)
0.527
3
UniProt:Q05209 PTPN12
2
PTPN12 [cytosol]
(R-HSA-432933)
PTPN12 [nucleoplasm]
(R-HSA-9008905)
0.527
3
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
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