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Go!
GRN [extracellular region]
Stable Identifier
R-HSA-6806217
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Acrogranin, GRN_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of azurophil granule lumen proteins (Homo sapiens)
Azurophil granule lumen proteins [extracellular region] (Homo sapiens)
GRN [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P28799 GRN
Gene Names
GRN
Chain
signal peptide:1-17, chain:18-593, peptide:18-47, peptide:58-113, peptide:123-179, peptide:206-261, peptide:281-336, peptide:364-417, peptide:442-496, peptide:518-573
Reference Genes
BioGPS Gene:2896 GRN
COSMIC (genes):GRN GRN
CTD Gene:2896 GRN
dbSNP Gene:2896 GRN
ENSEMBL:ENSG00000030582 GRN
HGNC:4601 GRN
KEGG:hsa:2896 GRN
Monarch:2896 GRN
NCBI Gene:2896 GRN
OMIM:138945 GRN
UCSC:P28799 GRN
Reference Transcript
RefSeq:NM_002087.4 GRN
RefSeq:XM_005257253.1 GRN
Participates
as a member of
Azurophil granule lumen proteins [extracellular region] (Homo sapiens)
Other forms of this molecule
GRN [azurophil granule lumen]
Inferred To
grn [extracellular region]
(Xenopus tropicalis)
GRN [extracellular region]
(Bos taurus)
GRN [extracellular region]
(Canis familiaris)
GRN [extracellular region]
(Sus scrofa)
grnb [extracellular region]
(Danio rerio)
Grn [extracellular region]
(Mus musculus)
Grn [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
XP_005257310.1
,
NP_002078.1
OpenTargets
ENSG00000030582
ENSEMBL
ENST00000053867
,
ENSG00000030582
,
ENSP00000053867
GeneCards
GRN
HPA
ENSG00000030582-GRN
PRO
P28799
Pharos - Targets
P28799
GlyGen
P28799
Orphanet
GRN
PDB
6NUG
,
8T8S
,
1G26
,
8T8R
,
2JYU
,
2JYV
,
2JYE
,
2JYT
Interactors (55)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49639 HOXA1
1
HOXA1 [nucleoplasm]
(R-HSA-5617464)
0.951
18
UniProt:O76003 GLRX3
1
GLRX3 [cytosol]
(R-HSA-5691202)
0.87
9
UniProt:Q9UBE8 NLK
3
NLK [cytosol]
(R-HSA-4411330)
p-T298-NLK [cytosol]
(R-HSA-4411398)
p-T298-NLK [nucleoplasm]
(R-HSA-4411376)
0.781
7
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.725
19
UniProt:P07602 PSAP
11
PSAP(326-340) [extracellular region]
(R-HSA-5336179)
PSAP(?-?) [extracellular region]
(R-HSA-5336190)
PSAP(195-273) [lysosomal lumen]
(R-HSA-9840336)
PSAP [lysosomal lumen]
(R-HSA-9840325)
PSAP(60-142) [lysosomal lumen]
(R-HSA-351333)
PSAP(311-391) [lysosomal membrane]
(R-HSA-1605602)
PSAP(405-486) [lysosomal lumen]
(R-HSA-9840328)
PSAP(311-391) [lysosomal lumen]
(R-HSA-9851355)
PSAP(17-524) [azurophil granule membrane]
(R-HSA-6799212)
PSAP(17-524) [plasma membrane]
(R-HSA-6806262)
PSAP(60-142) [extracellular region]
(R-HSA-351338)
0.702
6
UniProt:P25490 YY1
1
YY1 [nucleoplasm]
(R-HSA-4086091)
0.666
4
UniProt:P07237 P4HB
3
P4HB [endoplasmic reticulum lumen]
(R-HSA-174692)
p-P4HB [endoplasmic reticulum lumen]
(R-HSA-8956902)
HC53,56-P4HB [endoplasmic reticulum lumen]
(R-HSA-3341287)
0.666
4
UniProt:P20333 TNFRSF1B
3
TNFRSF1B(27-?) [plasma membrane]
(R-HSA-6785037)
TNFRSF1B [specific granule membrane]
(R-HSA-6806149)
TNFRSF1B [plasma membrane]
(R-HSA-5661484)
0.644
5
UniProt:Q13569 TDG
3
TDG [nucleoplasm]
(R-HSA-65812)
monoSUMO1-K330-TDG [nucleoplasm]
(R-HSA-4551718)
polySUMO2,3-K330-TDG [nucleoplasm]
(R-HSA-4551628)
0.556
3
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.556
3
UniProt:P34741 SDC2
20
SDC2 [plasma membrane]
(R-HSA-2090052)
HS(4)-SDC2 [plasma membrane]
(R-HSA-2076683)
HS(6)-SDC2 [plasma membrane]
(R-HSA-2076661)
HS(2)-SDC2 [plasma membrane]
(R-HSA-2076644)
HS(1)-SDC2 [plasma membrane]
(R-HSA-2076643)
HS(3)-SDC2 [plasma membrane]
(R-HSA-2076631)
HS(5)-SDC2 [plasma membrane]
(R-HSA-2076665)
SDC2 [endoplasmic reticulum lumen]
(R-HSA-8956741)
p-SDC2 [endoplasmic reticulum lumen]
(R-HSA-8956945)
SDC2 [Golgi lumen]
(R-HSA-2054101)
XylS-SDC2 [Golgi lumen]
(R-HSA-2064109)
Gal-Xyl-SDC2 [Golgi lumen]
(R-HSA-2064132)
Gal-Gal-Xyl-SDC2 [Golgi lumen]
(R-HSA-2063988)
GlcA-Gal-Gal-Xyl-SDC2 [Golgi lumen]
(R-HSA-2063997)
Heparan-SDC2 [Golgi lumen]
(R-HSA-2076608)
Heparan(1)-SDC2 [Golgi lumen]
(R-HSA-2076536)
Heparan(2)-SDC2 [Golgi lumen]
(R-HSA-2076397)
Heparan(3)-SDC2 [Golgi lumen]
(R-HSA-2076361)
Heparan(4)-SDC2 [Golgi lumen]
(R-HSA-2076576)
HS(1)-SDC2 [Golgi lumen]
(R-HSA-2076607)
0.556
3
UniProt:O43597 SPRY2
8
SPRY2 [cytosol]
(R-HSA-182949)
p-S110,S120-SPRY2 [cytosol]
(R-HSA-1295590)
p-Y55,Y227-SPRY2 [plasma membrane]
(R-HSA-934555)
SPRY2 [plasma membrane]
(R-HSA-182924)
p-S112,S121-SPRY2 [plasma membrane]
(R-HSA-934595)
p-S112,S115-SPRY2 [cytosol]
(R-HSA-1295619)
p-Y55,Y227-SPRY2 [plasma membrane]
(R-HSA-1295629)
p-Y55-SPRY2 [cytosol]
(R-HSA-182950)
0.556
3
UniProt:Q14671 PUM1
1
PUM1 [cytosol]
(R-HSA-434211)
0.556
3
UniProt:P54646 PRKAA2
4
PRKAA2 [cytosol]
(R-HSA-200405)
p-T172-PRKAA2 [cytosol]
(R-HSA-200417)
p-T172-PRKAA2 [nucleoplasm]
(R-HSA-164171)
PRKAA2 [nucleoplasm]
(R-HSA-163682)
0.556
3
UniProt:Q8N5V2 NGEF
2
p-Y179-NGEF [cytosol]
(R-HSA-3928441)
NGEF [cytosol]
(R-HSA-3006800)
0.556
3
UniProt:Q12837 POU4F2
1
POU4F2 [nucleoplasm]
(R-HSA-6804414)
0.556
6
UniProt:Q99683 MAP3K5
1
MAP3K5 [cytosol]
(R-HSA-167709)
0.556
3
UniProt:Q8N6T3 ARFGAP1
1
ARFGAP1 [cytosol]
(R-HSA-200464)
0.556
3
UniProt:Q9NW38 FANCL
2
FANCL [nucleoplasm]
(R-HSA-419520)
FANCL [cytosol]
(R-HSA-420789)
0.556
3
UniProt:O15540 FABP7
1
FABP7 [cytosol]
(R-HSA-5216158)
0.556
3
UniProt:Q9Y297 BTRC
2
BTRC [cytosol]
(R-HSA-174237)
BTRC [nucleoplasm]
(R-HSA-3361753)
0.556
3
UniProt:Q15077 P2RY6
1
P2RY6 [plasma membrane]
(R-HSA-417924)
0.556
3
UniProt:Q16611 BAK1
2
BAK1 [mitochondrial outer membrane]
(R-HSA-139896)
BAK1 activated [mitochondrial outer membrane]
(R-HSA-50690)
0.556
3
UniProt:Q49AN0 CRY2
5
CRY2 [cytosol]
(R-HSA-400255)
p-S-CRY2 [nucleoplasm]
(R-HSA-400328)
p-S-CRY2 [cytosol]
(R-HSA-400305)
K48polyUb-K126,p-S-CRY2 [cytosol]
(R-HSA-9932882)
K48polyUb-K,p-S-CRY2 [nucleoplasm]
(R-HSA-517935)
0.556
3
UniProt:Q96LC9 BMF
3
BMF [plasma membrane]
(R-HSA-140209)
p-BMF(1-89) [cytosol]
(R-HSA-140529)
p-BMF [mitochondrial outer membrane]
(R-HSA-3145026)
0.556
3
UniProt:P09017 HOXC4
1
HOXC4 [nucleoplasm]
(R-HSA-5617871)
0.556
3
UniProt:O75925 PIAS1
1
PIAS1 [nucleoplasm]
(R-HSA-877307)
0.556
3
UniProt:Q9BT09 CNPY3
1
CNPY3 [endoplasmic reticulum lumen]
(R-HSA-1678932)
0.556
3
UniProt:Q96FX8 PERP
1
PERP [plasma membrane]
(R-HSA-6800837)
0.556
3
UniProt:Q9UIH9 KLF15
1
KLF15 [nucleoplasm]
(R-HSA-8878735)
0.556
3
UniProt:Q96PK6 RBM14
1
RBM14 [nucleoplasm]
(R-HSA-8938345)
0.556
3
UniProt:Q96DZ5 CLIP3
1
CLIP3 [cytosol]
(R-HSA-5212669)
0.556
3
UniProt:Q14693 LPIN1
3
LPIN1 [endoplasmic reticulum membrane]
(R-HSA-549157)
LPIN1 [nuclear envelope]
(R-HSA-4419927)
p-S106-LPIN1 [nucleoplasm]
(R-HSA-4419936)
0.556
3
UniProt:O15534 PER1
4
PER1 [cytosol]
(R-HSA-400373)
p-S-PER1 [nucleoplasm]
(R-HSA-3325590)
p-S-PER1 [cytosol]
(R-HSA-400310)
K48polyUb-K,p-S-PER1 [cytosol]
(R-HSA-517831)
0.556
3
UniProt:Q8WUK0 DUSP23
1
PTPMT1 [mitochondrial inner membrane]
(R-HSA-3446802)
0.556
3
UniProt:P47897 QARS1
2
QARS [cytosol]
(R-HSA-379615)
QARS [mitochondrial matrix]
(R-HSA-379592)
0.556
3
UniProt:P40306 PSMB10
3
PSMB10 [cytosol]
(R-HSA-68741)
pro-PSMB10 [cytosol]
(R-HSA-9908123)
PSMB10(1-39) [cytosol]
(R-HSA-9908142)
0.556
3
UniProt:P22692 IGFBP4
5
IGFBP4 [endoplasmic reticulum lumen]
(R-HSA-8956754)
p-IGFBP4 [endoplasmic reticulum lumen]
(R-HSA-8957038)
IGFBP4 [extracellular region]
(R-HSA-381421)
IGFBP4(157-237) [extracellular region]
(R-HSA-381510)
IGFBP4(22-156) [extracellular region]
(R-HSA-381516)
0.556
3
UniProt:Q9GZQ8 MAP1LC3B
3
MAP1LC3B [cytosol]
(R-HSA-5205651)
MAP1LC3B(2-121) [cytosol]
(R-HSA-5682674)
MAP1LC3B [autophagosome membrane]
(R-HSA-5683641)
0.556
3
UniProt:Q14145 KEAP1
3
KEAP1 [cytosol]
(R-HSA-976038)
ub-KEAP1 [cytosol]
(R-HSA-9766647)
Ub-KEAP1 [cytosol]
(R-HSA-6782766)
0.556
3
UniProt:Q9P032 NDUFAF4
1
NDUFAF4 [mitochondrial inner membrane]
(R-HSA-5689124)
0.556
3
UniProt:P60896 SEM1
2
SEM1 [cytosol]
(R-HSA-8866674)
SEM1 [nucleoplasm]
(R-HSA-8866665)
0.556
3
UniProt:Q14457 BECN1
4
BECN1 [cytosol]
(R-HSA-1632841)
p-S15-BECN1 [cytosol]
(R-HSA-5682391)
ISG15-K-BECN1 [cytosol]
(R-HSA-9853030)
K63polyUb-BECN1 [cytosol]
(R-HSA-6782989)
0.556
3
UniProt:Q99967 CITED2
1
CITED2 [nucleoplasm]
(R-HSA-6804489)
0.556
3
UniProt:P62244 RPS15A
2
RPS15A [cytosol]
(R-HSA-72345)
RPS15A [nucleoplasm]
(R-HSA-6791191)
0.556
3
UniProt:O95070 YIF1A
1
YIF1A [endoplasmic reticulum membrane]
(R-HSA-535599)
0.556
3
UniProt:Q8NBJ7 SUMF2
1
SUMF2 [endoplasmic reticulum lumen]
(R-HSA-1614305)
0.556
3
UniProt:Q9UIJ7 AK3
1
AK3 [mitochondrial matrix]
(R-HSA-1008241)
0.556
3
UniProt:Q9UBX5 FBLN5
1
FBLN5 [extracellular region]
(R-HSA-2161278)
0.556
3
UniProt:P46109 CRKL
2
CRKL [cytosol]
(R-HSA-354384)
p-CRKL [cytosol]
(R-HSA-9024730)
0.547
2
UniProt:P98160 HSPG2
20
HSPG2(22-4196) [extracellular region]
(R-HSA-3827968)
HSPG2(4197-4391) [extracellular region]
(R-HSA-3827980)
HS(4)-HSPG2 [plasma membrane]
(R-HSA-2076698)
HS(6)-HSPG2 [plasma membrane]
(R-HSA-2076681)
HS(2)-HSPG2 [plasma membrane]
(R-HSA-2076659)
HS(1)-HSPG2 [plasma membrane]
(R-HSA-2076680)
HS(3)-HSPG2 [plasma membrane]
(R-HSA-2076627)
HS(5)-HSPG2 [plasma membrane]
(R-HSA-2076679)
HSPG2(3687-4391) [extracellular region]
(R-HSA-4088241)
HSPG2(22-4391) [Golgi lumen]
(R-HSA-2054109)
XylS-HSPG2(22-4391) [Golgi lumen]
(R-HSA-2063972)
Gal-Xyl-HSPG2 [Golgi lumen]
(R-HSA-2064209)
Gal-Gal-Xyl-HSPG2 [Golgi lumen]
(R-HSA-2063971)
GlcA-Gal-Gal-Xyl-HSPG2 [Golgi lumen]
(R-HSA-2064023)
Heparan-HSPG2 [Golgi lumen]
(R-HSA-2076367)
Heparan(1)-HSPG2 [Golgi lumen]
(R-HSA-2076585)
Heparan(2)-HSPG2 [Golgi lumen]
(R-HSA-2076335)
Heparan(3)-HSPG2 [Golgi lumen]
(R-HSA-2076334)
Heparan(4)-HSPG2 [Golgi lumen]
(R-HSA-2076395)
HS(1)-HSPG2 [Golgi lumen]
(R-HSA-2076366)
0.53
3
UniProt:Q04721 NOTCH2
18
NOTCH2(1582-1665) [extracellular region]
(R-HSA-157652)
NOTCH2(1666-1696) [plasma membrane]
(R-HSA-157628)
NEXT2 [plasma membrane]
(R-HSA-157225)
NICD2 [cytosol]
(R-HSA-157642)
NICD2 [nucleoplasm]
(R-HSA-157942)
Glc,GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane]
(R-HSA-1911428)
Glc,Gal-GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane]
(R-HSA-1911417)
Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane]
(R-HSA-1911505)
18xFucT-16xGlcS-FucS-NOTCH2(26-1581) [Golgi membrane]
(R-HSA-1983676)
NOTCH2(1582-2471) [Golgi membrane]
(R-HSA-157017)
18xFucT-16xGlcS-FucS-NOTCH2(26-1581) [extracellular region]
(R-HSA-1983678)
NOTCH2(1582-2471) [plasma membrane]
(R-HSA-157228)
18xFucT-16xGlcS-FucS-NOTCH2(26-2471) [Golgi membrane]
(R-HSA-1472874)
18xFucT-16xGlcS-FucS-NOTCH2(26-2471) [endoplasmic reticulum membrane]
(R-HSA-1467379)
18xFucT-FucS-NOTCH2(26-2471) [endoplasmic reticulum membrane]
(R-HSA-1467363)
Pre-NOTCH2 [endoplasmic reticulum membrane]
(R-HSA-157025)
FRINGE-modified NOTCH2 extracellular fragment (NECD2) [Golgi membrane]
(R-HSA-1911520)
FRINGE-modified NOTCH2 Extracellular Fragment (NECD2) [plasma membrane]
(R-HSA-1911518)
0.527
2
UniProt:O00253 AGRP
1
AGRP [nucleoplasm]
(R-HSA-9623016)
0.527
2
UniProt:P59665 DEFA1
9
DEFA1(20-94) [Golgi lumen]
(R-HSA-1467282)
DEFA1(66-94) [Golgi lumen]
(R-HSA-975663)
DEFA1(20-65) [Golgi lumen]
(R-HSA-8864970)
DEFA1(1-94) [Golgi lumen]
(R-HSA-1467215)
DEFA1(66-94) [extracellular region]
(R-HSA-1461998)
DEFA1(66-94) [azurophil granule lumen]
(R-HSA-1470038)
DEFA1(65-94) [extracellular region]
(R-HSA-1462022)
omega-N-(ADP-ribosyl)-L-arginine-DEFA1(65-94) [extracellular region]
(R-HSA-1972397)
DEFA1(65-94) [azurophil granule lumen]
(R-HSA-1470053)
0.527
2
UniProt:P09022 Hoxa1
1
Hoxa1 [nucleoplasm]
(R-MMU-5617924)
0.508
2
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