Reactome | GRN [extracellular region]

GRN [extracellular region]

Stable Identifier

R-HSA-6806217

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Acrogranin, GRN_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P28799 GRN

Gene Names

GRN

Chain

signal peptide:1-17, chain:18-593, peptide:18-47, peptide:58-113, peptide:123-179, peptide:206-261, peptide:281-336, peptide:364-417, peptide:442-496, peptide:518-573

Reference Genes

BioGPS Gene:2896 GRN

COSMIC (genes):GRN GRN

CTD Gene:2896 GRN

dbSNP Gene:2896 GRN

ENSEMBL:ENSG00000030582 GRN

HGNC:4601 GRN

KEGG:hsa:2896 GRN

Monarch:2896 GRN

NCBI Gene:2896 GRN

OMIM:138945 GRN

UCSC:P28799 GRN

Reference Transcript

Participates

as a member of

Azurophil granule lumen proteins [extracellular region] (Homo sapiens)

Other forms of this molecule

GRN [azurophil granule lumen]

Inferred To

grn [extracellular region] (Xenopus tropicalis)

GRN [extracellular region] (Bos taurus)

GRN [extracellular region] (Canis familiaris)

GRN [extracellular region] (Sus scrofa)

grnb [extracellular region] (Danio rerio)

Grn [extracellular region] (Mus musculus)

Grn [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

XP_005257310.1, NP_002078.1

OpenTargets

ENSG00000030582

ENSEMBL

ENST00000053867, ENSG00000030582, ENSP00000053867

GeneCards

GRN

HPA

ENSG00000030582-GRN

PRO

P28799

Pharos - Targets

P28799

GlyGen

P28799

Orphanet

GRN

PDB

6NUG, 8T8S, 1G26, 8T8R, 2JYU, 2JYV, 2JYE, 2JYT

Interactors (55)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.951	18
UniProt:O76003 GLRX3	1	GLRX3 [cytosol] (R-HSA-5691202)	0.87	9
UniProt:Q9UBE8 NLK	3	NLK [cytosol] (R-HSA-4411330) p-T298-NLK [cytosol] (R-HSA-4411398) p-T298-NLK [nucleoplasm] (R-HSA-4411376)	0.781	7
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.725	19
UniProt:P07602 PSAP	11	PSAP(326-340) [extracellular region] (R-HSA-5336179) PSAP(?-?) [extracellular region] (R-HSA-5336190) PSAP(195-273) [lysosomal lumen] (R-HSA-9840336) PSAP [lysosomal lumen] (R-HSA-9840325) PSAP(60-142) [lysosomal lumen] (R-HSA-351333) PSAP(311-391) [lysosomal membrane] (R-HSA-1605602) PSAP(405-486) [lysosomal lumen] (R-HSA-9840328) PSAP(311-391) [lysosomal lumen] (R-HSA-9851355) PSAP(17-524) [azurophil granule membrane] (R-HSA-6799212) PSAP(17-524) [plasma membrane] (R-HSA-6806262) PSAP(60-142) [extracellular region] (R-HSA-351338)	0.702	6
UniProt:P25490 YY1	1	YY1 [nucleoplasm] (R-HSA-4086091)	0.666	4
UniProt:P07237 P4HB	3	P4HB [endoplasmic reticulum lumen] (R-HSA-174692) p-P4HB [endoplasmic reticulum lumen] (R-HSA-8956902) HC53,56-P4HB [endoplasmic reticulum lumen] (R-HSA-3341287)	0.666	4
UniProt:P20333 TNFRSF1B	3	TNFRSF1B(27-?) [plasma membrane] (R-HSA-6785037) TNFRSF1B [specific granule membrane] (R-HSA-6806149) TNFRSF1B [plasma membrane] (R-HSA-5661484)	0.644	5
UniProt:Q13569 TDG	3	TDG [nucleoplasm] (R-HSA-65812) monoSUMO1-K330-TDG [nucleoplasm] (R-HSA-4551718) polySUMO2,3-K330-TDG [nucleoplasm] (R-HSA-4551628)	0.556	3
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.556	3
UniProt:P34741 SDC2	20	SDC2 [plasma membrane] (R-HSA-2090052) HS(4)-SDC2 [plasma membrane] (R-HSA-2076683) HS(6)-SDC2 [plasma membrane] (R-HSA-2076661) HS(2)-SDC2 [plasma membrane] (R-HSA-2076644) HS(1)-SDC2 [plasma membrane] (R-HSA-2076643) HS(3)-SDC2 [plasma membrane] (R-HSA-2076631) HS(5)-SDC2 [plasma membrane] (R-HSA-2076665) SDC2 [endoplasmic reticulum lumen] (R-HSA-8956741) p-SDC2 [endoplasmic reticulum lumen] (R-HSA-8956945) SDC2 [Golgi lumen] (R-HSA-2054101) XylS-SDC2 [Golgi lumen] (R-HSA-2064109) Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2064132) Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063988) GlcA-Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063997) Heparan-SDC2 [Golgi lumen] (R-HSA-2076608) Heparan(1)-SDC2 [Golgi lumen] (R-HSA-2076536) Heparan(2)-SDC2 [Golgi lumen] (R-HSA-2076397) Heparan(3)-SDC2 [Golgi lumen] (R-HSA-2076361) Heparan(4)-SDC2 [Golgi lumen] (R-HSA-2076576) HS(1)-SDC2 [Golgi lumen] (R-HSA-2076607)	0.556	3
UniProt:O43597 SPRY2	8	SPRY2 [cytosol] (R-HSA-182949) p-S110,S120-SPRY2 [cytosol] (R-HSA-1295590) p-Y55,Y227-SPRY2 [plasma membrane] (R-HSA-934555) SPRY2 [plasma membrane] (R-HSA-182924) p-S112,S121-SPRY2 [plasma membrane] (R-HSA-934595) p-S112,S115-SPRY2 [cytosol] (R-HSA-1295619) p-Y55,Y227-SPRY2 [plasma membrane] (R-HSA-1295629) p-Y55-SPRY2 [cytosol] (R-HSA-182950)	0.556	3
UniProt:Q14671 PUM1	1	PUM1 [cytosol] (R-HSA-434211)	0.556	3
UniProt:P54646 PRKAA2	4	PRKAA2 [cytosol] (R-HSA-200405) p-T172-PRKAA2 [cytosol] (R-HSA-200417) p-T172-PRKAA2 [nucleoplasm] (R-HSA-164171) PRKAA2 [nucleoplasm] (R-HSA-163682)	0.556	3
UniProt:Q8N5V2 NGEF	2	p-Y179-NGEF [cytosol] (R-HSA-3928441) NGEF [cytosol] (R-HSA-3006800)	0.556	3
UniProt:Q12837 POU4F2	1	POU4F2 [nucleoplasm] (R-HSA-6804414)	0.556	6
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.556	3
UniProt:Q8N6T3 ARFGAP1	1	ARFGAP1 [cytosol] (R-HSA-200464)	0.556	3
UniProt:Q9NW38 FANCL	2	FANCL [nucleoplasm] (R-HSA-419520) FANCL [cytosol] (R-HSA-420789)	0.556	3
UniProt:O15540 FABP7	1	FABP7 [cytosol] (R-HSA-5216158)	0.556	3
UniProt:Q9Y297 BTRC	2	BTRC [cytosol] (R-HSA-174237) BTRC [nucleoplasm] (R-HSA-3361753)	0.556	3
UniProt:Q15077 P2RY6	1	P2RY6 [plasma membrane] (R-HSA-417924)	0.556	3
UniProt:Q16611 BAK1	2	BAK1 [mitochondrial outer membrane] (R-HSA-139896) BAK1 activated [mitochondrial outer membrane] (R-HSA-50690)	0.556	3
UniProt:Q49AN0 CRY2	5	CRY2 [cytosol] (R-HSA-400255) p-S-CRY2 [nucleoplasm] (R-HSA-400328) p-S-CRY2 [cytosol] (R-HSA-400305) K48polyUb-K126,p-S-CRY2 [cytosol] (R-HSA-9932882) K48polyUb-K,p-S-CRY2 [nucleoplasm] (R-HSA-517935)	0.556	3
UniProt:Q96LC9 BMF	3	BMF [plasma membrane] (R-HSA-140209) p-BMF(1-89) [cytosol] (R-HSA-140529) p-BMF [mitochondrial outer membrane] (R-HSA-3145026)	0.556	3
UniProt:P09017 HOXC4	1	HOXC4 [nucleoplasm] (R-HSA-5617871)	0.556	3
UniProt:O75925 PIAS1	1	PIAS1 [nucleoplasm] (R-HSA-877307)	0.556	3
UniProt:Q9BT09 CNPY3	1	CNPY3 [endoplasmic reticulum lumen] (R-HSA-1678932)	0.556	3
UniProt:Q96FX8 PERP	1	PERP [plasma membrane] (R-HSA-6800837)	0.556	3
UniProt:Q9UIH9 KLF15	1	KLF15 [nucleoplasm] (R-HSA-8878735)	0.556	3
UniProt:Q96PK6 RBM14	1	RBM14 [nucleoplasm] (R-HSA-8938345)	0.556	3
UniProt:Q96DZ5 CLIP3	1	CLIP3 [cytosol] (R-HSA-5212669)	0.556	3
UniProt:Q14693 LPIN1	3	LPIN1 [endoplasmic reticulum membrane] (R-HSA-549157) LPIN1 [nuclear envelope] (R-HSA-4419927) p-S106-LPIN1 [nucleoplasm] (R-HSA-4419936)	0.556	3
UniProt:O15534 PER1	4	PER1 [cytosol] (R-HSA-400373) p-S-PER1 [nucleoplasm] (R-HSA-3325590) p-S-PER1 [cytosol] (R-HSA-400310) K48polyUb-K,p-S-PER1 [cytosol] (R-HSA-517831)	0.556	3
UniProt:Q8WUK0 DUSP23	1	PTPMT1 [mitochondrial inner membrane] (R-HSA-3446802)	0.556	3
UniProt:P47897 QARS1	2	QARS [cytosol] (R-HSA-379615) QARS [mitochondrial matrix] (R-HSA-379592)	0.556	3
UniProt:P40306 PSMB10	3	PSMB10 [cytosol] (R-HSA-68741) pro-PSMB10 [cytosol] (R-HSA-9908123) PSMB10(1-39) [cytosol] (R-HSA-9908142)	0.556	3
UniProt:P22692 IGFBP4	5	IGFBP4 [endoplasmic reticulum lumen] (R-HSA-8956754) p-IGFBP4 [endoplasmic reticulum lumen] (R-HSA-8957038) IGFBP4 [extracellular region] (R-HSA-381421) IGFBP4(157-237) [extracellular region] (R-HSA-381510) IGFBP4(22-156) [extracellular region] (R-HSA-381516)	0.556	3
UniProt:Q9GZQ8 MAP1LC3B	3	MAP1LC3B [cytosol] (R-HSA-5205651) MAP1LC3B(2-121) [cytosol] (R-HSA-5682674) MAP1LC3B [autophagosome membrane] (R-HSA-5683641)	0.556	3
UniProt:Q14145 KEAP1	3	KEAP1 [cytosol] (R-HSA-976038) ub-KEAP1 [cytosol] (R-HSA-9766647) Ub-KEAP1 [cytosol] (R-HSA-6782766)	0.556	3
UniProt:Q9P032 NDUFAF4	1	NDUFAF4 [mitochondrial inner membrane] (R-HSA-5689124)	0.556	3
UniProt:P60896 SEM1	2	SEM1 [cytosol] (R-HSA-8866674) SEM1 [nucleoplasm] (R-HSA-8866665)	0.556	3
UniProt:Q14457 BECN1	4	BECN1 [cytosol] (R-HSA-1632841) p-S15-BECN1 [cytosol] (R-HSA-5682391) ISG15-K-BECN1 [cytosol] (R-HSA-9853030) K63polyUb-BECN1 [cytosol] (R-HSA-6782989)	0.556	3
UniProt:Q99967 CITED2	1	CITED2 [nucleoplasm] (R-HSA-6804489)	0.556	3
UniProt:P62244 RPS15A	2	RPS15A [cytosol] (R-HSA-72345) RPS15A [nucleoplasm] (R-HSA-6791191)	0.556	3
UniProt:O95070 YIF1A	1	YIF1A [endoplasmic reticulum membrane] (R-HSA-535599)	0.556	3
UniProt:Q8NBJ7 SUMF2	1	SUMF2 [endoplasmic reticulum lumen] (R-HSA-1614305)	0.556	3
UniProt:Q9UIJ7 AK3	1	AK3 [mitochondrial matrix] (R-HSA-1008241)	0.556	3
UniProt:Q9UBX5 FBLN5	1	FBLN5 [extracellular region] (R-HSA-2161278)	0.556	3
UniProt:P46109 CRKL	2	CRKL [cytosol] (R-HSA-354384) p-CRKL [cytosol] (R-HSA-9024730)	0.547	2
UniProt:P98160 HSPG2	20	HSPG2(22-4196) [extracellular region] (R-HSA-3827968) HSPG2(4197-4391) [extracellular region] (R-HSA-3827980) HS(4)-HSPG2 [plasma membrane] (R-HSA-2076698) HS(6)-HSPG2 [plasma membrane] (R-HSA-2076681) HS(2)-HSPG2 [plasma membrane] (R-HSA-2076659) HS(1)-HSPG2 [plasma membrane] (R-HSA-2076680) HS(3)-HSPG2 [plasma membrane] (R-HSA-2076627) HS(5)-HSPG2 [plasma membrane] (R-HSA-2076679) HSPG2(3687-4391) [extracellular region] (R-HSA-4088241) HSPG2(22-4391) [Golgi lumen] (R-HSA-2054109) XylS-HSPG2(22-4391) [Golgi lumen] (R-HSA-2063972) Gal-Xyl-HSPG2 [Golgi lumen] (R-HSA-2064209) Gal-Gal-Xyl-HSPG2 [Golgi lumen] (R-HSA-2063971) GlcA-Gal-Gal-Xyl-HSPG2 [Golgi lumen] (R-HSA-2064023) Heparan-HSPG2 [Golgi lumen] (R-HSA-2076367) Heparan(1)-HSPG2 [Golgi lumen] (R-HSA-2076585) Heparan(2)-HSPG2 [Golgi lumen] (R-HSA-2076335) Heparan(3)-HSPG2 [Golgi lumen] (R-HSA-2076334) Heparan(4)-HSPG2 [Golgi lumen] (R-HSA-2076395) HS(1)-HSPG2 [Golgi lumen] (R-HSA-2076366)	0.53	3
UniProt:Q04721 NOTCH2	18	NOTCH2(1582-1665) [extracellular region] (R-HSA-157652) NOTCH2(1666-1696) [plasma membrane] (R-HSA-157628) NEXT2 [plasma membrane] (R-HSA-157225) NICD2 [cytosol] (R-HSA-157642) NICD2 [nucleoplasm] (R-HSA-157942) Glc,GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane] (R-HSA-1911428) Glc,Gal-GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane] (R-HSA-1911417) Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane] (R-HSA-1911505) 18xFucT-16xGlcS-FucS-NOTCH2(26-1581) [Golgi membrane] (R-HSA-1983676) NOTCH2(1582-2471) [Golgi membrane] (R-HSA-157017) 18xFucT-16xGlcS-FucS-NOTCH2(26-1581) [extracellular region] (R-HSA-1983678) NOTCH2(1582-2471) [plasma membrane] (R-HSA-157228) 18xFucT-16xGlcS-FucS-NOTCH2(26-2471) [Golgi membrane] (R-HSA-1472874) 18xFucT-16xGlcS-FucS-NOTCH2(26-2471) [endoplasmic reticulum membrane] (R-HSA-1467379) 18xFucT-FucS-NOTCH2(26-2471) [endoplasmic reticulum membrane] (R-HSA-1467363) Pre-NOTCH2 [endoplasmic reticulum membrane] (R-HSA-157025) FRINGE-modified NOTCH2 extracellular fragment (NECD2) [Golgi membrane] (R-HSA-1911520) FRINGE-modified NOTCH2 Extracellular Fragment (NECD2) [plasma membrane] (R-HSA-1911518)	0.527	2
UniProt:O00253 AGRP	1	AGRP [nucleoplasm] (R-HSA-9623016)	0.527	2
UniProt:P59665 DEFA1	9	DEFA1(20-94) [Golgi lumen] (R-HSA-1467282) DEFA1(66-94) [Golgi lumen] (R-HSA-975663) DEFA1(20-65) [Golgi lumen] (R-HSA-8864970) DEFA1(1-94) [Golgi lumen] (R-HSA-1467215) DEFA1(66-94) [extracellular region] (R-HSA-1461998) DEFA1(66-94) [azurophil granule lumen] (R-HSA-1470038) DEFA1(65-94) [extracellular region] (R-HSA-1462022) omega-N-(ADP-ribosyl)-L-arginine-DEFA1(65-94) [extracellular region] (R-HSA-1972397) DEFA1(65-94) [azurophil granule lumen] (R-HSA-1470053)	0.527	2
UniProt:P09022 Hoxa1	1	Hoxa1 [nucleoplasm] (R-MMU-5617924)	0.508	2

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