Reactome | GRN [extracellular region]

GRN [extracellular region]

Stable Identifier

R-HSA-6806217

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Acrogranin, GRN_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P28799 GRN

Gene Names

GRN

Chain

signal peptide:1-17, chain:18-593, peptide:18-47, peptide:58-113, peptide:123-179, peptide:206-261, peptide:281-336, peptide:364-417, peptide:442-496, peptide:518-573

Reference Genes

BioGPS Gene:2896 GRN

COSMIC (genes):GRN GRN

CTD Gene:2896 GRN

dbSNP Gene:2896 GRN

ENSEMBL:ENSG00000030582.18 GRN

HGNC:4601 GRN

KEGG Gene (Homo sapiens):2896 GRN

Monarch:2896 GRN

NCBI Gene:2896 GRN

OMIM:138945 GRN

UCSC:P28799 GRN

Reference Transcript

Other Identifiers

0002510524

11716377_s_at

11745725_a_at

11745726_x_at

16834766

200678_PM_x_at

200678_x_at

211284_PM_s_at

211284_s_at

216041_PM_x_at

216041_x_at

2896

3722918

3722922

3722923

3722924

3722926

3722929

3722930

3722931

3722932

3722933

3722935

3722936

3722938

3722939

3722940

3722941

3722944

3722945

3722946

3722947

3722949

3722950

3722951

3722952

3722953

41198_at

8007620

80389_at

A_23_P49708

A_33_P3286278

GE59880

GO:0002265

GO:0002282

GO:0002376

GO:0003723

GO:0005125

GO:0005515

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005764

GO:0005765

GO:0005768

GO:0005770

GO:0005773

GO:0005783

GO:0005794

GO:0005802

GO:0005886

GO:0006457

GO:0006954

GO:0007040

GO:0007041

GO:0007042

GO:0007165

GO:0008083

GO:0010595

GO:0012501

GO:0016020

GO:0023052

GO:0030154

GO:0030335

GO:0031410

GO:0035578

GO:0043226

GO:0043524

GO:0043525

GO:0045766

GO:0048680

GO:0048856

GO:0048870

GO:0050679

GO:0050727

GO:0050821

GO:0051087

GO:0060266

GO:0070062

GO:0098542

GO:0098772

GO:0106016

GO:1900426

GO:1902564

GO:1903334

GO:1903979

GO:1905247

GO:1905673

HMNXSV003019734

HMNXSV003036408

ILMN_1724250

ILMN_1811702

PH_hs_0010684

TC17000570.hg

TC17002224.hg

X62320_at

g12653114_3p_a_at

Participates

as a member of

Azurophil granule lumen proteins [extracellular region] (Homo sapiens)

Other forms of this molecule

GRN [azurophil granule lumen]

Inferred To

grn [extracellular region] (Xenopus tropicalis)

GRN [extracellular region] (Bos taurus)

GRN [extracellular region] (Canis familiaris)

GRN [extracellular region] (Danio rerio)

GRN [extracellular region] (Gallus gallus)

GRN [extracellular region] (Sus scrofa)

pgrn-1 [extracellular region] (Caenorhabditis elegans)

Grn [extracellular region] (Mus musculus)

Grn [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

XP_005257310.1, NP_002078.1

OpenTargets

ENSG00000030582

GeneCards

P28799

HPA

ENSG00000030582-GRN

Ensembl

ENST00000639447, ENSP00000492014, ENSP00000053867, ENST00000053867, ENSG00000030582

PRO

P28799

Pharos - Targets

P28799

Orphanet

17726

PDB

2JYV, 2JYT, 2JYE, 2JYU, 1G26, 6NUG

Interactors (47)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.951	18
UniProt:O76003 GLRX3	1	GLRX3 [cytosol] (R-HSA-5691202)	0.87	9
UniProt:Q9UBE8 NLK	3	NLK [cytosol] (R-HSA-4411330) p-T298-NLK [cytosol] (R-HSA-4411398) p-T298-NLK [nucleoplasm] (R-HSA-4411376)	0.781	7
UniProt:P25490 YY1	1	YY1 [nucleoplasm] (R-HSA-4086091)	0.666	4
UniProt:P07237 P4HB	3	P4HB [endoplasmic reticulum lumen] (R-HSA-174692) p-P4HB [endoplasmic reticulum lumen] (R-HSA-8956902) HC53,56-P4HB [endoplasmic reticulum lumen] (R-HSA-3341287)	0.666	4
UniProt:P20333 TNFRSF1B	3	TNFRSF1B(27-?) [plasma membrane] (R-HSA-6785037) TNFRSF1B [plasma membrane] (R-HSA-5661484) TNFRSF1B [specific granule membrane] (R-HSA-6806149)	0.644	5
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.643	11
UniProt:Q15077 P2RY6	1	P2RY6 [plasma membrane] (R-HSA-417924)	0.556	3
UniProt:Q8NBJ7 SUMF2	1	SUMF2 [endoplasmic reticulum lumen] (R-HSA-1614305)	0.556	3
UniProt:O15534 PER1	4	p-S-PER1 [cytosol] (R-HSA-400310) p-S-PER1 [nucleoplasm] (R-HSA-3325590) PER1 [cytosol] (R-HSA-400373) Ub-p-S-PER1 [cytosol] (R-HSA-517831)	0.556	3
UniProt:Q9UIH9 KLF15	1	KLF15 [nucleoplasm] (R-HSA-8878735)	0.556	3
UniProt:Q96LC9 BMF	3	BMF [plasma membrane] (R-HSA-140209) p-BMF(1-89) [cytosol] (R-HSA-140529) p-BMF [mitochondrial outer membrane] (R-HSA-3145026)	0.556	3
UniProt:Q96DZ5 CLIP3	1	CLIP3 [cytosol] (R-HSA-5212669)	0.556	3
UniProt:Q8N5V2 NGEF	2	p-Y179-NGEF [cytosol] (R-HSA-3928441) NGEF [cytosol] (R-HSA-3006800)	0.556	3
UniProt:P62244 RPS15A	2	RPS15A [nucleoplasm] (R-HSA-6791191) RPS15A [cytosol] (R-HSA-72345)	0.556	3
UniProt:Q96FX8 PERP	1	PERP [plasma membrane] (R-HSA-6800837)	0.556	3
UniProt:Q49AN0 CRY2	4	p-S-CRY2 [cytosol] (R-HSA-400305) p-S-CRY2 [nucleoplasm] (R-HSA-400328) CRY2 [cytosol] (R-HSA-400255) Ub-p-S-CRY2 [nucleoplasm] (R-HSA-517935)	0.556	3
UniProt:Q99967 CITED2	1	CITED2 [nucleoplasm] (R-HSA-6804489)	0.556	3
UniProt:O75925 PIAS1	1	PIAS1 [nucleoplasm] (R-HSA-877307)	0.556	3
UniProt:Q8N6T3 ARFGAP1	1	ARFGAP1 [cytosol] (R-HSA-200464)	0.556	3
UniProt:Q12837 POU4F2	1	POU4F2 [nucleoplasm] (R-HSA-6804414)	0.556	6
UniProt:Q9P032 NDUFAF4	1	NDUFAF4 [mitochondrial inner membrane] (R-HSA-5689124)	0.556	3
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.556	3
UniProt:P34741 SDC2	20	SDC2 [plasma membrane] (R-HSA-2090052) p-Y179,Y191-SDC2 [plasma membrane] (R-HSA-4093306) SDC2 [lysosomal lumen] (R-HSA-2090083) HS(6)-SDC2 [lysosomal lumen] (R-HSA-2090064) HS(6)-SDC2 [Golgi lumen] (R-HSA-2076588) HS(5)-SDC2 [Golgi lumen] (R-HSA-2076320) Heparan-SDC2 [Golgi lumen] (R-HSA-2076608) Heparan(1)-SDC2 [Golgi lumen] (R-HSA-2076536) Heparan(2)-SDC2 [Golgi lumen] (R-HSA-2076397) Heparan(3)-SDC2 [Golgi lumen] (R-HSA-2076361) Heparan(4)-SDC2 [Golgi lumen] (R-HSA-2076576) HS(1)-SDC2 [Golgi lumen] (R-HSA-2076607) HS(2)-SDC2 [Golgi lumen] (R-HSA-2076603) HS(4)-SDC2 [Golgi lumen] (R-HSA-2076356) HS(3)-SDC2 [Golgi lumen] (R-HSA-2076443) HS(4)-SDC2 [plasma membrane] (R-HSA-2076683) HS(6)-SDC2 [plasma membrane] (R-HSA-2076661) HS(2)-SDC2 [plasma membrane] (R-HSA-2076644) HS(1)-SDC2 [plasma membrane] (R-HSA-2076643) HS(3)-SDC2 [plasma membrane] (R-HSA-2076631)	0.556	3
UniProt:P22692 IGFBP4	5	IGFBP4 [extracellular region] (R-HSA-381421) IGFBP4 [endoplasmic reticulum lumen] (R-HSA-8956754) p-IGFBP4 [endoplasmic reticulum lumen] (R-HSA-8957038) IGFBP4(157-237) [extracellular region] (R-HSA-381510) IGFBP4(22-156) [extracellular region] (R-HSA-381516)	0.556	3
UniProt:P47897 QARS1	2	QARS [cytosol] (R-HSA-379615) QARS [mitochondrial matrix] (R-HSA-379592)	0.556	3
UniProt:Q9Y297 BTRC	2	BTRC [cytosol] (R-HSA-174237) BTRC [nucleoplasm] (R-HSA-3361753)	0.556	3
UniProt:Q9UIJ7 AK3	1	AK3 [mitochondrial matrix] (R-HSA-1008241)	0.556	3
UniProt:Q9GZQ8 MAP1LC3B	3	MAP1LC3B [autophagosome membrane] (R-HSA-5683641) MAP1LC3B(2-121) [cytosol] (R-HSA-5682674) MAP1LC3B [cytosol] (R-HSA-5205651)	0.556	3
UniProt:Q9NW38 FANCL	1	FANCL [nucleoplasm] (R-HSA-419520)	0.556	3
UniProt:Q13569 TDG	3	polySUMO2,3-K330-TDG [nucleoplasm] (R-HSA-4551628) TDG [nucleoplasm] (R-HSA-65812) monoSUMO1-K330-TDG [nucleoplasm] (R-HSA-4551718)	0.556	3
UniProt:P60896 SEM1	2	SEM1 [nucleoplasm] (R-HSA-8866665) SEM1 [cytosol] (R-HSA-8866674)	0.556	3
UniProt:Q9UBX5 FBLN5	1	FBLN5 [extracellular region] (R-HSA-2161278)	0.556	3
UniProt:P54646 PRKAA2	4	PRKAA2 [cytosol] (R-HSA-200405) p-T172-PRKAA2 [cytosol] (R-HSA-200417) p-T172-PRKAA2 [nucleoplasm] (R-HSA-164171) PRKAA2 [nucleoplasm] (R-HSA-163682)	0.556	3
UniProt:O43597 SPRY2	8	p-Y55,Y227-SPRY2 [plasma membrane] (R-HSA-1295629) p-S111,S120-SPRY2 [cytosol] (R-HSA-1295590) SPRY2 [plasma membrane] (R-HSA-182924) SPRY2 [cytosol] (R-HSA-182949) p-Y55-SPRY2 [cytosol] (R-HSA-182950) p-S112,S115-SPRY2 [cytosol] (R-HSA-1295619) p-Y55,Y227-SPRY2 [plasma membrane] (R-HSA-934555) p-S112,S121-SPRY2 [plasma membrane] (R-HSA-934595)	0.556	3
UniProt:Q14671 PUM1	1	PUM1 [cytosol] (R-HSA-434211)	0.556	3
UniProt:O95070 YIF1A	1	YIF1A [endoplasmic reticulum membrane] (R-HSA-535599)	0.556	3
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.556	3
UniProt:O15540 FABP7	1	FABP7 [cytosol] (R-HSA-5216158)	0.556	3
UniProt:Q96PK6 RBM14	1	RBM14 [nucleoplasm] (R-HSA-8938345)	0.556	3
UniProt:P09017 HOXC4	1	HOXC4 [nucleoplasm] (R-HSA-5617871)	0.556	3
UniProt:Q16611 BAK1	2	BAK1 [mitochondrial outer membrane] (R-HSA-139896) BAK1 activated [mitochondrial outer membrane] (R-HSA-50690)	0.556	3
UniProt:Q9BT09 CNPY3	1	CNPY3 [endoplasmic reticulum lumen] (R-HSA-1678932)	0.556	3
UniProt:Q8WUK0 PTPMT1	1	PTPMT1 [mitochondrial inner membrane] (R-HSA-3446802)	0.556	3
UniProt:P46109 CRKL	2	CRKL [cytosol] (R-HSA-354384) p-CRKL [cytosol] (R-HSA-9024730)	0.547	2
UniProt:P98160 HSPG2	20	HSPG2(22-4196) [extracellular region] (R-HSA-3827968) HSPG2(4197-4391) [extracellular region] (R-HSA-3827980) HSPG2(22-?) [extracellular region] (R-HSA-2534251) HSPG2(?-4391) [extracellular region] (R-HSA-2534246) HSPG2(22-4391) [extracellular region] (R-HSA-1011570) HSPG2(22-4391) [lysosomal lumen] (R-HSA-2090077) HS(6)-HSPG2 [lysosomal lumen] (R-HSA-2090066) HS(6)-HSPG2 [Golgi lumen] (R-HSA-2076552) HS(5)-HSPG2 [Golgi lumen] (R-HSA-2076323) Heparan-HSPG2 [Golgi lumen] (R-HSA-2076367) Heparan(1)-HSPG2 [Golgi lumen] (R-HSA-2076585) Heparan(2)-HSPG2 [Golgi lumen] (R-HSA-2076335) Heparan(3)-HSPG2 [Golgi lumen] (R-HSA-2076334) Heparan(4)-HSPG2 [Golgi lumen] (R-HSA-2076395) HS(1)-HSPG2 [Golgi lumen] (R-HSA-2076366) HS(2)-HSPG2 [Golgi lumen] (R-HSA-2076426) HS(4)-HSPG2 [Golgi lumen] (R-HSA-2076495) HS(3)-HSPG2 [Golgi lumen] (R-HSA-2076384) GlcA-Gal-Gal-Xyl-HSPG2 [Golgi lumen] (R-HSA-2064023) HS(4)-HSPG2 [plasma membrane] (R-HSA-2076698)	0.53	3
UniProt:P09022 Hoxa1	1	Hoxa1 [nucleoplasm] (R-MMU-5617924)	0.508	2

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