Reactome | GRN [extracellular region]

GRN [extracellular region]

Stable Identifier

R-HSA-6806217

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Acrogranin, GRN_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P28799 GRN

Gene Names

GRN

Chain

signal peptide:1-17, chain:18-593, peptide:18-47, peptide:58-113, peptide:123-179, peptide:206-261, peptide:281-336, peptide:364-417, peptide:442-496, peptide:518-573

Reference Genes

BioGPS Gene:2896 GRN

COSMIC (genes):GRN GRN

CTD Gene:2896 GRN

dbSNP Gene:2896 GRN

ENSEMBL:ENSG00000030582 GRN

HGNC:4601 GRN

KEGG Gene (Homo sapiens):2896 GRN

Monarch:2896 GRN

NCBI Gene:2896 GRN

OMIM:138945 GRN

UCSC:P28799 GRN

Reference Transcript

Other Identifiers

0002510524

11716377_s_at

11745725_a_at

11745726_x_at

16834766

19394

1G26

200678_x_at

211284_s_at

216041_x_at

28747

2896

2JYE

2JYT

2JYU

2JYV

3722918

3722922

3722923

3722924

3722926

3722929

3722930

3722931

3722932

3722933

3722935

3722936

3722938

3722939

3722940

3722941

3722944

3722945

3722946

3722947

3722949

3722950

3722951

3722952

3722953

41198_at

8007620

80389_at

8763

A_23_P49708

A_33_P3286278

AAA58617

AAC09359

AAH00324

AAH10577

AAM94026

AAP35490

AF055008

AK023348

AK222522

AY124489

BAB14535

BAD96242

BC000324

BC010577

BT006844

CAA44196

CAB019394

CCDS11483

CH471178

EAW51599

EAW51600

ENSG00000030582

ENSP00000053867

ENSP00000492014

ENST00000053867

ENST00000053867.7

ENST00000639447

ENST00000639447.1

EntrezGene:2896

EntrezGene:GRN

g12653114_3p_a_at

GE59880

GO:0002265

GO:0002282

GO:0002376

GO:0003674

GO:0003723

GO:0005125

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005737

GO:0005764

GO:0005765

GO:0005768

GO:0005770

GO:0005773

GO:0005783

GO:0005794

GO:0005802

GO:0005886

GO:0006457

GO:0006810

GO:0006950

GO:0007034

GO:0007040

GO:0007041

GO:0007042

GO:0007165

GO:0008083

GO:0008150

GO:0008219

GO:0008283

GO:0010595

GO:0016020

GO:0016192

GO:0030154

GO:0030335

GO:0031410

GO:0035578

GO:0040011

GO:0042592

GO:0043226

GO:0043312

GO:0043524

GO:0043525

GO:0045766

GO:0048646

GO:0048680

GO:0048856

GO:0048870

GO:0050679

GO:0050821

GO:0051087

GO:0060266

GO:0070062

GO:0106016

GO:1900426

GO:1902564

GO:1903334

GO:1903979

GO:1905247

GO:1905673

GRN

GRN-201

GRN-222

HGNC:4601

HPA008763

HPA028747

ILMN_1724250

ILMN_1811702

IPR000118

IPR037277

IPR039036

K7EJY4

K7EK92

K7ELY1

K7EM89

K7EMR1

K7ENI2

K7ENN1

K7EPL0

K7EQ05

K7EQA7

K7EQK6

K7ERM2

LRG_661

M75161

MIM:138945

MIM:607485

MIM:614706

NM_002087

NP_002078

PF00396

PH_hs_0010684

SM00277

TC17000570.hg

TC17002224.hg

UPI00000015E0

UPI000002AACB

X62320

X62320_at

XM_024450730

XP_005257310

XP_024306498

Participant Of

hasMember

Azurophil granule lumen proteins [extracellular region]

Other forms of this molecule

GRN [azurophil granule lumen]

Inferred To

GRN [extracellular region] (Bos taurus)

GRN [extracellular region] (Caenorhabditis elegans)

GRN [extracellular region] (Canis familiaris)

GRN [extracellular region] (Danio rerio)

GRN [extracellular region] (Gallus gallus)

GRN [extracellular region] (Mus musculus)

GRN [extracellular region] (Rattus norvegicus)

GRN [extracellular region] (Sus scrofa)

GRN [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

XP_005257310.1, NP_002078.1

OpenTargets

ENSG00000030582

GeneCards

P28799

PRO

P28799

Orphanet

17726

PDB

2JYU, 1G26, 2JYV, 2JYT, 2JYE

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.841	9
UniProt:O76003 GLRX3	1	GLRX3 [cytosol] (R-HSA-5691202)	0.781	7
UniProt:Q9UBE8 NLK	3	p-T298-NLK [cytosol] (R-HSA-4411398) NLK [cytosol] (R-HSA-4411330) p-T298-NLK [nucleoplasm] (R-HSA-4411376)	0.718	6
UniProt:P20333 TNFRSF1B	3	TNFRSF1B [plasma membrane] (R-HSA-5661484) TNFRSF1B(27-?) [plasma membrane] (R-HSA-6785037) TNFRSF1B [specific granule membrane] (R-HSA-6806149)	0.644	5
UniProt:Q8N6T3 ARFGAP1	1	ARFGAP1 [cytosol] (R-HSA-200464)	0.556	3
UniProt:Q9NW38 FANCL	1	FANCL [nucleoplasm] (R-HSA-419520)	0.556	3
UniProt:O43597 SPRY2	8	p-S112,S121-SPRY2 [plasma membrane] (R-HSA-934595) SPRY2 [plasma membrane] (R-HSA-182924) SPRY2 [cytosol] (R-HSA-182949) p-S112,S115-SPRY2 [cytosol] (R-HSA-1295619) p-Y55,Y227-SPRY2 [plasma membrane] (R-HSA-934555) p-Y55,Y227-SPRY2 [plasma membrane] (R-HSA-1295629) p-S111,S120-SPRY2 [cytosol] (R-HSA-1295590) p-Y55-SPRY2 [cytosol] (R-HSA-182950)	0.556	3
UniProt:P98160 HSPG2	31	HSPG2(4197-4391) [extracellular region] (R-HSA-3827980) HSPG2(22-4196) [extracellular region] (R-HSA-3827968) HSPG2(22-?) [extracellular region] (R-HSA-2534251) HSPG2(?-4391) [extracellular region] (R-HSA-2534246) HSPG2(22-4391) [extracellular region] (R-HSA-1011570) HSPG2(22-4391) [plasma membrane] (R-HSA-174719) HSPG2(22-4391) [lysosomal lumen] (R-HSA-2090077) HS(6)-HSPG2 [lysosomal lumen] (R-HSA-2090066) HS(5)-HSPG2 [plasma membrane] (R-HSA-2076679) HS(3)-HSPG2 [plasma membrane] (R-HSA-2076627) HS(1)-HSPG2 [plasma membrane] (R-HSA-2076680) HS(2)-HSPG2 [plasma membrane] (R-HSA-2076659) HS(6)-HSPG2 [plasma membrane] (R-HSA-2076681) HS(4)-HSPG2 [plasma membrane] (R-HSA-2076698) HS(6)-HSPG2 [Golgi lumen] (R-HSA-2076552) HS(5)-HSPG2 [Golgi lumen] (R-HSA-2076323) Heparan-HSPG2 [Golgi lumen] (R-HSA-2076367) Heparan(1)-HSPG2 [Golgi lumen] (R-HSA-2076585) HSPG2(3687-4391) [extracellular region] (R-HSA-4088241) XylS-HSPG2(22-4391) [Golgi lumen] (R-HSA-2063972) Gal-Xyl-HSPG2 [Golgi lumen] (R-HSA-2064209) HSPG2(22-4391) [Golgi lumen] (R-HSA-2054109) Gal-Gal-Xyl-HSPG2 [Golgi lumen] (R-HSA-2063971) GlcA-Gal-Gal-Xyl-HSPG2 [Golgi lumen] (R-HSA-2064023) HS(3)-HSPG2 [Golgi lumen] (R-HSA-2076384) HS(4)-HSPG2 [Golgi lumen] (R-HSA-2076495) HS(2)-HSPG2 [Golgi lumen] (R-HSA-2076426) HS(1)-HSPG2 [Golgi lumen] (R-HSA-2076366) Heparan(4)-HSPG2 [Golgi lumen] (R-HSA-2076395) Heparan(3)-HSPG2 [Golgi lumen] (R-HSA-2076334) Heparan(2)-HSPG2 [Golgi lumen] (R-HSA-2076335)	0.53	3
UniProt:P09022 Hoxa1	1	Hoxa1 [nucleoplasm] (R-MMU-5617924)	0.508	2
UniProt:Q8WUK0 PTPMT1	1	PTPMT1 [mitochondrial inner membrane] (R-HSA-3446802)	0.488	2
UniProt:Q12837 POU4F2	1	POU4F2 [nucleoplasm] (R-HSA-6804414)	0.488	4
UniProt:P07237 P4HB	3	p-P4HB [endoplasmic reticulum lumen] (R-HSA-8956902) P4HB [endoplasmic reticulum lumen] (R-HSA-174692) HC53,56-P4HB [endoplasmic reticulum lumen] (R-HSA-3341287)	0.488	2