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HSD17B12 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-548766
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Estradiol 17-beta-dehydrogenase 12
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Fatty acyl-CoA biosynthesis (Homo sapiens)
Synthesis of very long-chain fatty acyl-CoAs (Homo sapiens)
HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Homo sapiens)
HSD17B3,12 [endoplasmic reticulum membrane] (Homo sapiens)
HSD17B12 [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Metabolism of steroid hormones (Homo sapiens)
Androgen biosynthesis (Homo sapiens)
HSD17B3-like proteins reducde ANDST to TEST (Homo sapiens)
HSD17B3-like Proteins [endoplasmic reticulum membrane] (Homo sapiens)
HSD17B12 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q53GQ0 HSD17B12
Gene Names
HSD17B12, SDR12C1
Chain
chain:1-312
Reference Genes
BioGPS Gene:51144 HSD17B12
COSMIC (genes):HSD17B12 HSD17B12
CTD Gene:51144 HSD17B12
dbSNP Gene:51144 HSD17B12
ENSEMBL:ENSG00000149084.13 HSD17B12
HGNC:18646 HSD17B12
KEGG Gene (Homo sapiens):51144 HSD17B12
Monarch:51144 HSD17B12
NCBI Gene:51144 HSD17B12
OMIM:609574 HSD17B12
UCSC:Q53GQ0 HSD17B12
Reference Transcript
RefSeq:NM_016142.2 HSD17B12
Other Identifiers
0004210110
11731605_s_at
11750207_a_at
11759794_at
1554121_PM_at
1554121_at
1554122_PM_a_at
1554122_a_at
217869_PM_at
217869_at
3328100
3328101
3328126
3328129
3328130
3328141
3328145
3328147
3328162
3328163
3328169
3328170
3328171
3328172
49007_at
49468_at
51144
7939465
A_14_P106497
A_14_P123190
A_23_P371933
A_23_P47377
A_33_P3335042
GE62350
GE670552
GO:0001968
GO:0004303
GO:0005515
GO:0005518
GO:0005622
GO:0005737
GO:0005783
GO:0005789
GO:0006629
GO:0006633
GO:0006694
GO:0006703
GO:0006790
GO:0007155
GO:0008201
GO:0009923
GO:0010811
GO:0016020
GO:0016021
GO:0016491
GO:0016509
GO:0030198
GO:0030312
GO:0031012
GO:0032991
GO:0035338
GO:0043226
GO:0044594
GO:0050062
GO:0055086
GO:0102339
GO:0102340
GO:0102341
GO:0102342
GO:1901135
HMNXSV003033442
Hs2.132513.1.S1_3p_s_at
ILMN_1702168
ILMN_2094106
PH_hs_0022489
TC11000367.hg
g7705854_3p_at
Participates
as a member of
HSD17B3,12 [endoplasmic reticulum membrane] (Homo sapiens)
as a candidate of
HSD17B3-like Proteins [endoplasmic reticulum membrane] (Homo sapiens)
Inferred To
spidey [endoplasmic reticulum membrane]
(Drosophila melanogaster)
HSD17B12 [endoplasmic reticulum membrane]
(Bos taurus)
HSD17B12 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
HSD17B12 [endoplasmic reticulum membrane]
(Canis familiaris)
HSD17B12 [endoplasmic reticulum membrane]
(Danio rerio)
HSD17B12 [endoplasmic reticulum membrane]
(Dictyostelium discoideum)
HSD17B12 [endoplasmic reticulum membrane]
(Gallus gallus)
HSD17B12 [endoplasmic reticulum membrane]
(Mus musculus)
HSD17B12 [endoplasmic reticulum membrane]
(Plasmodium falciparum)
HSD17B12 [endoplasmic reticulum membrane]
(Rattus norvegicus)
HSD17B12 [endoplasmic reticulum membrane]
(Sus scrofa)
HSD17B12 [endoplasmic reticulum membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_057226.1
OpenTargets
ENSG00000149084
IntEnz
1.1.1.330
,
1.1.1.62
GeneCards
Q53GQ0
HPA
ENSG00000149084-HSD17B12
Ensembl
ENSP00000278353
,
ENSG00000149084
,
ENST00000395700
,
ENST00000278353
,
ENSP00000379052
PRO
Q53GQ0
Pharos - Targets
Q53GQ0
HMDB Protein
HMDBP08861
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P06396 GSN
7
GSN(200-270) [extracellular region]
(R-HSA-976940)
GSN [secretory granule lumen]
(R-HSA-6801486)
GSN [extracellular region]
(R-HSA-6806510)
GSN [ficolin-1-rich granule lumen]
(R-HSA-6801465)
GSN(404-782) [cytosol]
(R-HSA-350272)
GSN(28-403) [cytosol]
(R-HSA-201618)
GSN [cytosol]
(R-HSA-350275)
0.556
3
UniProt:P04049 RAF1
20
RAF1 [cytosol]
(R-HSA-167205)
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
0.527
2
UniProt:P05919 vpu
6
VPU (P05919) protein [extracellular region]
(R-HIV-175522)
VPU (P05919) protein [cytosol]
(R-HIV-173223)
VPU (P05919) protein [nucleoplasm]
(R-HIV-175200)
VPU (P05919) [endoplasmic reticulum membrane]
(R-HIV-180550)
VPU (P05919) [Golgi membrane]
(R-HIV-3149439)
VPU (P05919) [plasma membrane]
(R-HIV-3149423)
0.462
2
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