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SEPT7 [cytosol]
Stable Identifier
R-HSA-5692671
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK6/MAPK4 signaling (Homo sapiens)
SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Homo sapiens)
SEPT7 [cytosol] (Homo sapiens)
SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 [cytosol] (Homo sapiens)
SEPT7 [cytosol] (Homo sapiens)
SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Homo sapiens)
SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 [cytosol] (Homo sapiens)
SEPT7 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16181 SEPTIN7
Gene Names
SEPTIN7, CDC10, SEPT7
Chain
initiator methionine:, chain:2-437
Reference Genes
BioGPS Gene:989 SEPTIN7
CTD Gene:989 SEPTIN7
dbSNP Gene:989 SEPTIN7
ENSEMBL:ENSG00000122545 SEPT7
ENSEMBL_homo_sapiens_GENE:ENSG00000122545.22 SEPTIN7
HGNC:1717 SEPTIN7
KEGG Gene (Homo sapiens):989 SEPTIN7
Monarch:989 SEPTIN7
NCBI Gene:989 SEPTIN7
OMIM:603151 SEPTIN7
UCSC:Q16181 SEPTIN7
Reference Transcript
RefSeq:NM_001788.5 SEPTIN7
Other Identifiers
11736062_s_at
11736063_s_at
11741022_x_at
11745246_x_at
17124454
213151_PM_s_at
213151_s_at
217721_PM_at
217721_at
2728795
2741346
2997092
2997094
2997096
2997098
2997099
2997106
2997115
2997120
2997121
2997122
2997130
2997134
2997135
2997137
2997143
2997146
2997147
2997157
2997159
2997160
2997161
2997162
2997163
2997164
2997165
2997166
2997167
2997199
2997200
2997202
3032373
3049205
3181548
3181558
32175_at
3373105
43525_at
8132292
989
A_23_P8482
A_24_P291973
GE81069
GO:0000166
GO:0000775
GO:0000776
GO:0000910
GO:0001725
GO:0003824
GO:0003924
GO:0005198
GO:0005515
GO:0005525
GO:0005576
GO:0005615
GO:0005634
GO:0005694
GO:0005737
GO:0005819
GO:0005829
GO:0005856
GO:0005886
GO:0005929
GO:0005930
GO:0005940
GO:0007049
GO:0007283
GO:0015630
GO:0016324
GO:0016476
GO:0016787
GO:0022414
GO:0030154
GO:0030496
GO:0031105
GO:0031514
GO:0032153
GO:0032154
GO:0042802
GO:0042995
GO:0043226
GO:0044782
GO:0045296
GO:0048856
GO:0051301
GO:0060090
GO:0060271
GO:0061640
GO:0070062
GO:0097227
GO:0097730
GO:1902857
HMNXSV003018615
HMNXSV003023469
Hs.184326.0.S2_3p_at
Hs.184326.1.S1_3p_a_at
ILMN_1729019
PH_hs_0028319
PH_hs_0033108
S72008_at
Participates
as an input of
SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Homo sapiens)
as a component of
SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 [cytosol] (Homo sapiens)
Inferred To
SEPTIN7 [cytosol]
(Bos taurus)
SEPTIN7 [cytosol]
(Canis familiaris)
SEPTIN7 [cytosol]
(Sus scrofa)
sept7a [cytosol]
(Danio rerio)
unc-59 [cytosol]
(Caenorhabditis elegans)
SEPT7 [cytosol]
(Drosophila melanogaster)
SEPT7 [cytosol]
(Gallus gallus)
SEPT7 [cytosol]
(Mus musculus)
SEPT7 [cytosol]
(Rattus norvegicus)
SEPT7 [cytosol]
(Saccharomyces cerevisiae)
SEPT7 [cytosol]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_001779.3
OpenTargets
ENSG00000122545
GeneCards
Q16181
HPA
ENSG00000122545-SEPTIN7
Ensembl
ENSG00000122545
,
ENSP00000516132
,
ENSP00000344868
,
ENST00000705486
,
ENST00000350320
PRO
Q16181
Pharos - Targets
Q16181
PDB
2QAG
,
6N0B
,
6N12
,
3T5D
,
3TW4
,
7M6J
,
6UQQ
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15019-1 SEPTIN2
0.728
8
UniProt:Q14141 SEPT6
0.669
3
UniProt:Q8IYM1 SEP12
0.655
17
UniProt:Q16181 SEPTIN7
1
SEPT7 [cytosol]
(R-HSA-5692671)
0.558
2
UniProt:Q9NVA2 SEP11
0.534
2
UniProt:P42208
1
SEPT2 [cytosol]
(R-MMU-5626657)
0.527
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
7
UniProt:Q9UHD8 SEPT9
0.482
2
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE
0.462
2
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE
0.462
2
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