Reactome | SEPT7 [cytosol]

SEPT7 [cytosol]

Stable Identifier

R-HSA-5692671

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q16181 SEPTIN7

Gene Names

SEPTIN7, CDC10, SEPT7

Chain

initiator methionine:1, chain:2-437

Reference Genes

BioGPS Gene:989 SEPTIN7

CTD Gene:989 SEPTIN7

dbSNP Gene:989 SEPTIN7

ENSEMBL:ENSG00000122545 SEPT7

HGNC:1717 SEPTIN7

KEGG Gene (Homo sapiens):989 SEPTIN7

Monarch:989 SEPTIN7

NCBI Gene:989 SEPTIN7

OMIM:603151 SEPTIN7

UCSC:Q16181 SEPTIN7

Reference Transcript

RefSeq:NM_001788.5 SEPTIN7

Other Identifiers

0002650161

0103130092

11736062_s_at

11736063_s_at

11741022_x_at

11745246_x_at

17124454

213151_s_at

217721_at

2728795

2741346

2997090

2997092

2997094

2997096

2997098

2997099

2997106

2997115

2997120

2997121

2997122

2997130

2997134

2997135

2997137

2997143

2997146

2997147

2997157

2997159

2997160

2997161

2997162

2997163

2997164

2997165

2997166

2997167

2997182

2997199

2997200

2997202

3032373

3032383

3049205

3181548

3181558

32175_at

3373105

43525_at

8132292

989

A_23_P8482

A_24_P291973

GE81069

GO:0000003

GO:0000166

GO:0000775

GO:0000776

GO:0000777

GO:0000902

GO:0001725

GO:0003674

GO:0003924

GO:0005198

GO:0005515

GO:0005525

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005694

GO:0005737

GO:0005819

GO:0005829

GO:0005856

GO:0005886

GO:0005929

GO:0005930

GO:0005940

GO:0007049

GO:0007283

GO:0008150

GO:0009790

GO:0015630

GO:0016324

GO:0016476

GO:0022607

GO:0030154

GO:0030496

GO:0031105

GO:0031514

GO:0032153

GO:0032154

GO:0032991

GO:0034613

GO:0042802

GO:0042995

GO:0043167

GO:0043226

GO:0045296

GO:0048856

GO:0051301

GO:0060090

GO:0060271

GO:0061640

GO:0070062

GO:0097227

GO:0097730

GO:1902857

HMNXSV003013343

HMNXSV003018615

HMNXSV003023469

Hs.184326.0.S2_3p_at

Hs.184326.1.S1_3p_a_at

ILMN_1729019

PH_hs_0033108

S72008_at

TC07000228.hg

Participates

as an input of

SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Homo sapiens)

as a component of

SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 [cytosol] (Homo sapiens)

Inferred To

SHS1 [cytosol] (Saccharomyces cerevisiae)

spn1 [cytosol] (Schizosaccharomyces pombe)

CDC12 [cytosol] (Saccharomyces cerevisiae)

SPR28 [cytosol] (Saccharomyces cerevisiae)

pnut [cytosol] (Drosophila melanogaster)

sept7a [cytosol] (Danio rerio)

spn7 [cytosol] (Schizosaccharomyces pombe)

SPR3 [cytosol] (Saccharomyces cerevisiae)

Septin7 [cytosol] (Mus musculus)

Septin7 [cytosol] (Rattus norvegicus)

spn6 [cytosol] (Schizosaccharomyces pombe)

CDC11 [cytosol] (Saccharomyces cerevisiae)

SEPT7 [cytosol] (Gallus gallus)

SEPTIN7 [cytosol] (Canis familiaris)

SEPTIN7 [cytosol] (Sus scrofa)

spn5 [cytosol] (Schizosaccharomyces pombe)

spn4 [cytosol] (Schizosaccharomyces pombe)

CDC3 [cytosol] (Saccharomyces cerevisiae)

Homologues of SEPT7 [cytosol] (Saccharomyces cerevisiae)

Homologues of SEPT7 [cytosol] (Schizosaccharomyces pombe)

spn3 [cytosol] (Schizosaccharomyces pombe)

unc-59 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001779.3

OpenTargets

ENSG00000122545

GeneCards

Q16181

HPA

ENSG00000122545-SEPT7

Ensembl

ENST00000399034, ENSP00000381992, ENSG00000122545

PRO

Q16181

PDB

3T5D, 2QAG, 6N12, 6N0B, 3TW4, 6UQQ

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15019-1 SEPTIN2			0.728	8
UniProt:Q14141 SEPT6			0.669	3
UniProt:Q8IYM1 SEP12			0.655	17
UniProt:Q16181 SEPTIN7	1	SEPT7 [cytosol] (R-HSA-5692671)	0.558	2
UniProt:Q9NVA2 SEP11			0.534	2
UniProt:P42208	1	Septin2 [cytosol] (R-MMU-5626657)	0.527	2
UniProt:Q9UHD8 SEPT9			0.482	2
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate [ChEBI:16851]	7	PI(3,5)P2 [plasma membrane] (R-ALL-1806224) PI(3,5)P2 [phagophore assembly site membrane] (R-ALL-5692959) PI(3,5)P2 [Golgi membrane] (R-ALL-1806290) PI(3,5)P2 [early endosome membrane] (R-ALL-1806205) PI(3,5)P2 [late endosome membrane] (R-ALL-1806289) PI(3,5)P2 [endoplasmic reticulum membrane] (R-ALL-6809774) PI(3,5)P2 [lysosomal membrane] (R-ALL-5334668)	0.462	2
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [ChEBI:18348]	6	PI(4,5)P2 [endoplasmic reticulum membrane] (R-ALL-2023856) PI(4,5)P2 [plasma membrane] (R-ALL-179856) PI(4,5)P2 [Golgi membrane] (R-ALL-1806165) PI(4,5)P2 [nucleoplasm] (R-ALL-6810412) PI(4,5)P2 [cytoplasmic vesicle membrane] (R-ALL-8874467) PI(4,5)P2 [early endosome membrane] (R-ALL-8849966)	0.462	2

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