Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
SEPT7 [cytosol]
Stable Identifier
R-HSA-5692671
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK6/MAPK4 signaling (Homo sapiens)
SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Homo sapiens)
SEPT7 [cytosol] (Homo sapiens)
SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 [cytosol] (Homo sapiens)
SEPT7 [cytosol] (Homo sapiens)
SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Homo sapiens)
SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 [cytosol] (Homo sapiens)
SEPT7 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16181 SEPTIN7
Gene Names
SEPTIN7, CDC10, SEPT7
Chain
initiator methionine:1, chain:2-437
Reference Genes
BioGPS Gene:989 SEPTIN7
CTD Gene:989 SEPTIN7
dbSNP Gene:989 SEPTIN7
ENSEMBL:ENSG00000122545 SEPT7
HGNC:1717 SEPTIN7
KEGG Gene (Homo sapiens):989 SEPTIN7
Monarch:989 SEPTIN7
NCBI Gene:989 SEPTIN7
OMIM:603151 SEPTIN7
UCSC:Q16181 SEPTIN7
Reference Transcript
RefSeq:NM_001788.5 SEPTIN7
Other Identifiers
0002650161
0103130092
11736062_s_at
11736063_s_at
11741022_x_at
11745246_x_at
17124454
213151_s_at
217721_at
2728795
2741346
2997090
2997092
2997094
2997096
2997098
2997099
2997106
2997115
2997120
2997121
2997122
2997130
2997134
2997135
2997137
2997143
2997146
2997147
2997157
2997159
2997160
2997161
2997162
2997163
2997164
2997165
2997166
2997167
2997182
2997199
2997200
2997202
3032373
3032383
3049205
3181548
3181558
32175_at
3373105
43525_at
8132292
989
A_23_P8482
A_24_P291973
GE81069
GO:0000003
GO:0000166
GO:0000775
GO:0000776
GO:0000777
GO:0000902
GO:0001725
GO:0003674
GO:0003924
GO:0005198
GO:0005515
GO:0005525
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005694
GO:0005737
GO:0005819
GO:0005829
GO:0005856
GO:0005886
GO:0005929
GO:0005930
GO:0005940
GO:0007049
GO:0007283
GO:0008150
GO:0009790
GO:0015630
GO:0016324
GO:0016476
GO:0022607
GO:0030154
GO:0030496
GO:0031105
GO:0031514
GO:0032153
GO:0032154
GO:0032991
GO:0034613
GO:0042802
GO:0042995
GO:0043167
GO:0043226
GO:0045296
GO:0048856
GO:0051301
GO:0060090
GO:0060271
GO:0061640
GO:0070062
GO:0097227
GO:0097730
GO:1902857
HMNXSV003013343
HMNXSV003018615
HMNXSV003023469
Hs.184326.0.S2_3p_at
Hs.184326.1.S1_3p_a_at
ILMN_1729019
PH_hs_0033108
S72008_at
TC07000228.hg
Participates
as an input of
SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Homo sapiens)
as a component of
SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 [cytosol] (Homo sapiens)
Inferred To
SHS1 [cytosol]
(Saccharomyces cerevisiae)
spn1 [cytosol]
(Schizosaccharomyces pombe)
CDC12 [cytosol]
(Saccharomyces cerevisiae)
SPR28 [cytosol]
(Saccharomyces cerevisiae)
pnut [cytosol]
(Drosophila melanogaster)
sept7a [cytosol]
(Danio rerio)
spn7 [cytosol]
(Schizosaccharomyces pombe)
SPR3 [cytosol]
(Saccharomyces cerevisiae)
Septin7 [cytosol]
(Mus musculus)
Septin7 [cytosol]
(Rattus norvegicus)
spn6 [cytosol]
(Schizosaccharomyces pombe)
CDC11 [cytosol]
(Saccharomyces cerevisiae)
SEPT7 [cytosol]
(Gallus gallus)
SEPTIN7 [cytosol]
(Canis familiaris)
SEPTIN7 [cytosol]
(Sus scrofa)
spn5 [cytosol]
(Schizosaccharomyces pombe)
spn4 [cytosol]
(Schizosaccharomyces pombe)
CDC3 [cytosol]
(Saccharomyces cerevisiae)
Homologues of SEPT7 [cytosol]
(Saccharomyces cerevisiae)
Homologues of SEPT7 [cytosol]
(Schizosaccharomyces pombe)
spn3 [cytosol]
(Schizosaccharomyces pombe)
unc-59 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001779.3
OpenTargets
ENSG00000122545
GeneCards
Q16181
HPA
ENSG00000122545-SEPT7
Ensembl
ENST00000399034
,
ENSP00000381992
,
ENSG00000122545
PRO
Q16181
PDB
3T5D
,
2QAG
,
6N12
,
6N0B
,
3TW4
,
6UQQ
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15019-1 SEPTIN2
0.728
8
UniProt:Q14141 SEPT6
0.669
3
UniProt:Q8IYM1 SEP12
0.655
17
UniProt:Q16181 SEPTIN7
1
SEPT7 [cytosol]
(R-HSA-5692671)
0.558
2
UniProt:Q9NVA2 SEP11
0.534
2
UniProt:P42208
1
Septin2 [cytosol]
(R-MMU-5626657)
0.527
2
UniProt:Q9UHD8 SEPT9
0.482
2
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate [ChEBI:16851]
7
PI(3,5)P2 [plasma membrane]
(R-ALL-1806224)
PI(3,5)P2 [phagophore assembly site membrane]
(R-ALL-5692959)
PI(3,5)P2 [Golgi membrane]
(R-ALL-1806290)
PI(3,5)P2 [early endosome membrane]
(R-ALL-1806205)
PI(3,5)P2 [late endosome membrane]
(R-ALL-1806289)
PI(3,5)P2 [endoplasmic reticulum membrane]
(R-ALL-6809774)
PI(3,5)P2 [lysosomal membrane]
(R-ALL-5334668)
0.462
2
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [ChEBI:18348]
6
PI(4,5)P2 [endoplasmic reticulum membrane]
(R-ALL-2023856)
PI(4,5)P2 [plasma membrane]
(R-ALL-179856)
PI(4,5)P2 [Golgi membrane]
(R-ALL-1806165)
PI(4,5)P2 [nucleoplasm]
(R-ALL-6810412)
PI(4,5)P2 [cytoplasmic vesicle membrane]
(R-ALL-8874467)
PI(4,5)P2 [early endosome membrane]
(R-ALL-8849966)
0.462
2
© 2021
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text