Reactome | PSMD6 [nucleoplasm]

PSMD6 [nucleoplasm]

Stable Identifier

R-HSA-174316

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

26S proteasome non-ATPase regulatory subunit 6, 26S proteasome regulatory subunit S10, p42A, Proteasome regulatory particle subunit p44S10

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        PSMD6 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15008 PSMD6

Gene Names

PSMD6, KIAA0107, PFAAP4

Chain

initiator methionine:1, chain:2-389

Reference Genes

BioGPS Gene:9861 PSMD6

COSMIC (genes):PSMD6 PSMD6

CTD Gene:9861 PSMD6

dbSNP Gene:9861 PSMD6

ENSEMBL:ENSG00000163636.11 PSMD6

HGNC:9564 PSMD6

KEGG Gene (Homo sapiens):9861 PSMD6

Monarch:9861 PSMD6

NCBI Gene:9861 PSMD6

OMIM:617857 PSMD6

UCSC:Q15008 PSMD6

Reference Transcript

Other Identifiers

0001580465

11731415_a_at

11746510_x_at

16955771

202753_3p_at

202753_PM_at

202753_at

2679865

2679866

2679867

2679869

2679872

2679876

2679877

2679878

2679879

2679881

2679884

2679885

2679886

2679887

34680_s_at

8088535

9861

A_23_P109928

D14663_at

GE54973

GO:0000502

GO:0005515

GO:0005576

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005838

GO:0022624

GO:0030163

GO:0030234

GO:0031410

GO:0032991

GO:0034774

GO:0043161

GO:0043226

GO:0050790

GO:0098772

GO:1904813

HMNXSV003039793

ILMN_1779633

ILMN_2155998

PH_hs_0016942

TC03001522.hg

g7661913_3p_at

g7661913_3p_s_at

Participates

as a component of

26S proteasome [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PSMD6 [secretory granule lumen]

PSMD6 [extracellular region]

PSMD6 [ficolin-1-rich granule lumen]

PSMD6 [cytosol]

Inferred To

PSMD6 [nucleoplasm] (Bos taurus)

PSMD6 [nucleoplasm] (Danio rerio)

PSMD6 [nucleoplasm] (Gallus gallus)

PSMD6 [nucleoplasm] (Sus scrofa)

rpn-7 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of PSMD6 [nucleoplasm] (Canis familiaris)

Ghost homologue of PSMD6 [nucleoplasm] (Xenopus tropicalis)

Rpn7 [nucleoplasm] (Drosophila melanogaster)

Psmd6 [nucleoplasm] (Mus musculus)

Psmd6 [nucleoplasm] (Rattus norvegicus)

psmD6 [nucleoplasm] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001258709.1, NP_055629.1, NP_001258710.1, NP_001258708.1

OpenTargets

ENSG00000163636

GeneCards

Q15008

HPA

ENSG00000163636-PSMD6

Ensembl

ENSP00000295901, ENSP00000418695, ENSG00000163636, ENSP00000419227, ENST00000295901, ENST00000394431, ENSP00000377952, ENST00000492933, ENST00000482510

PRO

Q15008

Pharos - Targets

Q15008

PDB

5T0G, 5VFR, 5VHH, 6WJN, 5T0C, 5VFQ, 6MSH, 5VHF, 5T0J, 5LN3, 5GJR, 5M32, 5VFP, 5GJQ, 5VFU, 6MSG, 5VHS, 5VFT, 5T0I, 5VGZ, 6MSD, 6WJD, 5T0H, 5VHI, 5VFS, 6MSJ, 6MSK, 5L4K, 6MSB

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O00487 PSMD14	5	PSMD14 [secretory granule lumen] (R-HSA-6800926) PSMD14 [extracellular region] (R-HSA-6806511) PSMD14 [ficolin-1-rich granule lumen] (R-HSA-6800419) PSMD14 [nucleoplasm] (R-HSA-174329) PSMD14 [cytosol] (R-HSA-68722)	0.688	3
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.669	4
UniProt:Q9Y4K3 TRAF6	8	K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272)	0.589	2
UniProt:P20133	2	RABGGTB [cytosol] (R-SCE-8870419) RABGGTB [plasma membrane] (R-SCE-6801098)	0.556	3
UniProt:P62333 PSMC6	2	PSMC6 [nucleoplasm] (R-HSA-174319) PSMC6 [cytosol] (R-HSA-68783)	0.553	2
UniProt:Q16186 ADRM1	1	ADRM1 [cytosol] (R-HSA-5665939)	0.527	3
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3