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PSMD6 [nucleoplasm]
Stable Identifier
R-HSA-174316
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
26S proteasome non-ATPase regulatory subunit 6, 26S proteasome regulatory subunit S10, p42A, Proteasome regulatory particle subunit p44S10
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD6 [nucleoplasm] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD6 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD6 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD6 [nucleoplasm] (Homo sapiens)
Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD6 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD6 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD6 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD6 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15008 PSMD6
Gene Names
PSMD6, KIAA0107, PFAAP4
Chain
initiator methionine:1, chain:2-389
Reference Genes
BioGPS Gene:9861 PSMD6
COSMIC (genes):PSMD6 PSMD6
CTD Gene:9861 PSMD6
dbSNP Gene:9861 PSMD6
ENSEMBL:ENSG00000163636 PSMD6
HGNC:9564 PSMD6
KEGG Gene (Homo sapiens):9861 PSMD6
Monarch:9861 PSMD6
NCBI Gene:9861 PSMD6
OMIM:617857 PSMD6
UCSC:Q15008 PSMD6
Reference Transcript
RefSeq:NM_014814.2 PSMD6
RefSeq:NM_001271780.1 PSMD6
RefSeq:NM_001271779.1 PSMD6
RefSeq:NM_001271781.1 PSMD6
Other Identifiers
0001580465
11731415_a_at
11746510_x_at
16955771
202753_3p_at
202753_at
2679865
2679866
2679867
2679869
2679872
2679876
2679877
2679878
2679879
2679881
2679884
2679885
2679886
2679887
34680_s_at
36921
36922
5GJQ
5GJR
5L4K
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
5VGZ
5VHF
5VHH
5VHI
5VHS
6MSB
6MSD
6MSG
6MSH
6MSJ
6MSK
8088535
9861
A_23_P109928
AAF65540
AAH00630
AAH00904
AAH12369
AAQ09946
AAQ63402
AAS68366
AC012557
AF215935
AF530062
AK290205
AY359879
AY568086
BAA03497
BAF82894
BC000630
BC000904
BC012369
BX647742
C9J0E9
C9J7B7
CCDS2901
CCDS63677
CCDS63678
CCDS63679
CH471055
D14663
D14663_at
EAW65424
EAW65427
ENSG00000163636
ENSP00000295901
ENSP00000377952
ENSP00000418695
ENSP00000419227
ENST00000295901
ENST00000295901.8
ENST00000394431
ENST00000394431.6
ENST00000482510
ENST00000482510.5
ENST00000492933
ENST00000492933.5
EntrezGene:9861
EntrezGene:PSMD6
g7661913_3p_at
g7661913_3p_s_at
GE54973
GO:0000165
GO:0000209
GO:0000278
GO:0000502
GO:0002223
GO:0002376
GO:0002479
GO:0003674
GO:0005515
GO:0005575
GO:0005576
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005838
GO:0006464
GO:0006508
GO:0006520
GO:0006521
GO:0006810
GO:0006950
GO:0007049
GO:0007165
GO:0007267
GO:0008150
GO:0009056
GO:0009058
GO:0010972
GO:0016192
GO:0016579
GO:0016887
GO:0022624
GO:0030154
GO:0030234
GO:0031145
GO:0031146
GO:0031410
GO:0032991
GO:0033209
GO:0034641
GO:0034655
GO:0034774
GO:0038061
GO:0038095
GO:0043161
GO:0043226
GO:0043312
GO:0043488
GO:0043687
GO:0044281
GO:0048856
GO:0050790
GO:0050852
GO:0055085
GO:0060071
GO:0061418
GO:0070498
GO:0090090
GO:0090263
GO:1901990
GO:1902036
GO:1904813
HGNC:9564
HPA036921
HPA036922
ILMN_1779633
ILMN_2155998
IPR000717
IPR011990
IPR019585
IPR035268
IPR036390
MIM:617857
NM_001271779
NM_001271780
NM_001271781
NM_014814
NP_001258708
NP_001258709
NP_001258710
NP_055629
PF01399
PF10602
PH_hs_0016942
PSMD6
PSMD6-201
PSMD6-202
PSMD6-209
PSMD6-210
SM00088
SM00753
TC03001522.hg
UPI0000132787
UPI00001BE8DA
UPI000020AE76
UPI000020AE79
XM_005265619
XM_011534288
XM_017007569
XM_024453841
XP_005265676
XP_011532590
XP_016863058
XP_024309609
Participant Of
hasComponent
26S proteasome [nucleoplasm]
Other forms of this molecule
PSMD6 [secretory granule lumen]
PSMD6 [extracellular region]
PSMD6 [ficolin-1-rich granule lumen]
PSMD6 [cytosol]
Inferred To
PSMD6 [nucleoplasm] (Caenorhabditis elegans)
PSMD6 [nucleoplasm] (Canis familiaris)
PSMD6 [nucleoplasm] (Danio rerio)
PSMD6 [nucleoplasm] (Dictyostelium discoideum)
PSMD6 [nucleoplasm] (Drosophila melanogaster)
PSMD6 [nucleoplasm] (Mus musculus)
PSMD6 [nucleoplasm] (Rattus norvegicus)
PSMD6 [nucleoplasm] (Sus scrofa)
PSMD6 [nucleoplasm] (Xenopus tropicalis)
Ghost homologue of PSMD6 [nucleoplasm] (Bos taurus)
Cross References
RefSeq
NP_055629.1
,
NP_001258709.1
,
NP_001258708.1
,
NP_001258710.1
OpenTargets
ENSG00000163636
GeneCards
Q15008
PRO
Q15008
PDB
6MSJ
,
6MSK
,
5VFU
,
5L4K
,
6MSH
,
5VHI
,
5VFS
,
5VHF
,
5GJR
,
6MSG
,
5VFT
,
5VHH
,
6MSB
,
5T0J
,
5VFR
,
6MSD
,
5T0H
,
5VFP
,
5VGZ
,
5T0I
,
5VFQ
,
5GJQ
,
5T0G
,
5T0C
,
5LN3
,
5M32
,
5VHS
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O00487 PSMD14
5
PSMD14 [extracellular region]
(R-HSA-6806511)
PSMD14 [secretory granule lumen]
(R-HSA-6800926)
PSMD14 [cytosol]
(R-HSA-68722)
PSMD14 [nucleoplasm]
(R-HSA-174329)
PSMD14 [ficolin-1-rich granule lumen]
(R-HSA-6800419)
0.688
3
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [nucleoplasm]
(R-HSA-5689584)
UCHL5 [cytosol]
(R-HSA-1629778)
0.669
4
UniProt:Q9Y4K3 TRAF6
8
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [plasma membrane]
(R-HSA-936955)
TRAF6 [endosome membrane]
(R-HSA-450272)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
0.589
2
UniProt:P20133
2
RABGGTB [plasma membrane]
(R-SCE-6801098)
RABGGTB [cytosol]
(R-SCE-8870419)
0.556
3
UniProt:Q16186 ADRM1
1
ADRM1 [cytosol]
(R-HSA-5665939)
0.527
3
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.527
3
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