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UMPS [cytosol]
Stable Identifier
R-HSA-73487
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase), Uridine 5'-monophosphate synthase (UMP synthase) (Includes: Orotate phosphoribosyltransferase (EC 2.4.2.10) (OPRtase); Orotidine 5'- phosphate decarboxylase (EC 4.1.1.23) (OMPdecase)), Uridine 5'-monophosphate synthase, UMP synthase, Orotate phosphoribosyltransferase , OPRtase, Orotidine 5'- phosphate decarboxylase , OMPdecase
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of nucleotides (Homo sapiens)
Nucleotide biosynthesis (Homo sapiens)
Pyrimidine biosynthesis (Homo sapiens)
UMPS dimer decarboxylates OMP to UMP (Homo sapiens)
UMPS dimer [cytosol] (Homo sapiens)
UMPS [cytosol] (Homo sapiens)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Homo sapiens)
UMPS dimer [cytosol] (Homo sapiens)
UMPS [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P11172 UMPS
Gene Names
UMPS, OK/SW-cl.21
Chain
initiator methionine:, chain:2-480
Reference Genes
BioGPS Gene:7372 UMPS
COSMIC (genes):UMPS UMPS
CTD Gene:7372 UMPS
dbSNP Gene:7372 UMPS
ENSEMBL:ENSG00000114491 UMPS
HGNC:12563 UMPS
KEGG:hsa:7372 UMPS
Monarch:7372 UMPS
NCBI Gene:7372 UMPS
OMIM:613891 UMPS
UCSC:P11172 UMPS
Reference Transcript
RefSeq:NM_000373.3 UMPS
Other Identifiers
11734683_at
11734684_s_at
11756373_a_at
16944894
16944912
202706_PM_s_at
202706_s_at
202707_PM_at
202707_at
215165_PM_x_at
215165_x_at
239800_PM_at
239800_at
2639876
2639878
2639879
2639880
2639881
2639882
2639883
2639884
2639885
2639886
2639887
2639888
2639890
2639891
2639893
2639895
2639896
2639898
33815_at
56609_at
73460_i_at
7372
8082229
83330_at
A_14_P102124
A_23_P6624
GE57485
GE743684
GO:0003824
GO:0004588
GO:0004590
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0006207
GO:0006221
GO:0006222
GO:0006225
GO:0007565
GO:0007595
GO:0016740
GO:0016757
GO:0016829
GO:0016831
GO:0019856
GO:0022414
GO:0042802
GO:0043226
GO:0044205
GO:0055086
GO:0071466
GO:1901135
HMNXSV003053917
Hs.176333.0.A1_3p_at
ILMN_1757437
J03626_rna1_s_at
PH_hs_0000276
TC03000644.hg
TC03002505.hg
g2081619_3p_a_at
Participates
as a component of
UMPS dimer [cytosol] (Homo sapiens)
Inferred To
r-l [cytosol]
(Drosophila melanogaster)
UMPS [cytosol]
(Bos taurus)
UMPS [cytosol]
(Caenorhabditis elegans)
UMPS [cytosol]
(Canis familiaris)
UMPS [cytosol]
(Dictyostelium discoideum)
UMPS [cytosol]
(Gallus gallus)
UMPS [cytosol]
(Mus musculus)
UMPS [cytosol]
(Rattus norvegicus)
UMPS [cytosol]
(Sus scrofa)
UMPS [cytosol]
(Xenopus tropicalis)
Cross References
OpenTargets
ENSG00000114491
ENSEMBL
ENSP00000232607
,
ENST00000232607
,
ENSG00000114491
ZINC - Substances
UMPS_HUMAN
ZINC target
P11172
PRO
P11172
GlyGen
P11172
PDB
3MW7
,
2QCD
,
2QCF
,
2QCH
,
6ZX0
,
2P1F
,
6YWT
,
6ZX2
,
7OQF
,
3BGJ
,
7OQK
,
7OQM
,
3L0N
,
6YVO
,
4HIB
,
7ASQ
,
4HKP
,
3BK0
,
3MO7
,
3EWU
,
6ZWY
,
3EX2
,
6YVM
,
6YVK
,
3DBP
,
3EWW
,
2EAW
,
3EX4
,
3EWY
,
3BVJ
,
2QCN
,
2QCL
,
2WNS
,
2QCE
,
2QCG
,
6ZX1
,
6YWU
,
6ZX3
,
3MI2
,
7OQI
,
7OV0
,
3EWZ
,
7Q1H
,
2V30
,
3EX6
,
7OTU
,
7AM9
,
2QCC
,
6ZWZ
,
3EWX
,
6YVL
,
3EX1
,
3L0K
,
2JGY
,
6YVN
,
3EX3
,
7OUZ
,
2QCM
,
3BGG
,
7OQN
,
3G3D
,
3G3M
HPA
ENSG00000114491-UMPS
GeneCards
UMPS
Pharos - Targets
P11172
Orphanet
UMPS
ZINC - Predictions - Purchasable
UMPS_HUMAN
HMDB Protein
HMDBP01045
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P54764 EPHA4
2
p-Y596,Y602-EPHA4 [plasma membrane]
(R-HSA-3928352)
EPHA4 [plasma membrane]
(R-HSA-2682325)
0.564
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
6
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