Reactome | UMPS [cytosol]

UMPS [cytosol]

Stable Identifier

R-HSA-73487

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase), Uridine 5'-monophosphate synthase (UMP synthase) (Includes: Orotate phosphoribosyltransferase (EC 2.4.2.10) (OPRtase); Orotidine 5'- phosphate decarboxylase (EC 4.1.1.23) (OMPdecase)), Uridine 5'-monophosphate synthase, UMP synthase, Orotate phosphoribosyltransferase , OPRtase, Orotidine 5'- phosphate decarboxylase , OMPdecase

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P11172 UMPS

Gene Names

UMPS, OK/SW-cl.21

Chain

initiator methionine:, chain:2-480

Reference Genes

BioGPS Gene:7372 UMPS

COSMIC (genes):UMPS UMPS

CTD Gene:7372 UMPS

dbSNP Gene:7372 UMPS

ENSEMBL:ENSG00000114491 UMPS

HGNC:12563 UMPS

KEGG:hsa:7372 UMPS

Monarch:7372 UMPS

NCBI Gene:7372 UMPS

OMIM:613891 UMPS

UCSC:P11172 UMPS

Reference Transcript

RefSeq:NM_000373.3 UMPS

Other Identifiers

11734683_at

11734684_s_at

11756373_a_at

16944894

16944912

202706_PM_s_at

202706_s_at

202707_PM_at

202707_at

215165_PM_x_at

215165_x_at

239800_PM_at

239800_at

2639876

2639878

2639879

2639880

2639881

2639882

2639883

2639884

2639885

2639886

2639887

2639888

2639890

2639891

2639893

2639895

2639896

2639898

33815_at

56609_at

73460_i_at

7372

8082229

83330_at

A_14_P102124

A_23_P6624

GE57485

GE743684

GO:0003824

GO:0004588

GO:0004590

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0006207

GO:0006221

GO:0006222

GO:0006225

GO:0007565

GO:0007595

GO:0016740

GO:0016757

GO:0016829

GO:0016831

GO:0019856

GO:0022414

GO:0042802

GO:0043226

GO:0044205

GO:0055086

GO:0071466

GO:1901135

HMNXSV003053917

Hs.176333.0.A1_3p_at

ILMN_1757437

J03626_rna1_s_at

PH_hs_0000276

TC03000644.hg

TC03002505.hg

g2081619_3p_a_at

Participates

as a component of

UMPS dimer [cytosol] (Homo sapiens)

Inferred To

r-l [cytosol] (Drosophila melanogaster)

UMPS [cytosol] (Bos taurus)

UMPS [cytosol] (Caenorhabditis elegans)

UMPS [cytosol] (Canis familiaris)

UMPS [cytosol] (Dictyostelium discoideum)

UMPS [cytosol] (Gallus gallus)

UMPS [cytosol] (Mus musculus)

UMPS [cytosol] (Rattus norvegicus)

UMPS [cytosol] (Sus scrofa)

UMPS [cytosol] (Xenopus tropicalis)

Cross References

OpenTargets

ENSG00000114491

ENSEMBL

ENSP00000232607, ENST00000232607, ENSG00000114491

ZINC - Substances

UMPS_HUMAN

ZINC target

P11172

PRO

P11172

GlyGen

P11172

PDB

3MW7, 2QCD, 2QCF, 2QCH, 6ZX0, 2P1F, 6YWT, 6ZX2, 7OQF, 3BGJ, 7OQK, 7OQM, 3L0N, 6YVO, 4HIB, 7ASQ, 4HKP, 3BK0, 3MO7, 3EWU, 6ZWY, 3EX2, 6YVM, 6YVK, 3DBP, 3EWW, 2EAW, 3EX4, 3EWY, 3BVJ, 2QCN, 2QCL, 2WNS, 2QCE, 2QCG, 6ZX1, 6YWU, 6ZX3, 3MI2, 7OQI, 7OV0, 3EWZ, 7Q1H, 2V30, 3EX6, 7OTU, 7AM9, 2QCC, 6ZWZ, 3EWX, 6YVL, 3EX1, 3L0K, 2JGY, 6YVN, 3EX3, 7OUZ, 2QCM, 3BGG, 7OQN, 3G3D, 3G3M

HPA

ENSG00000114491-UMPS

GeneCards

UMPS

Pharos - Targets

P11172

Orphanet

UMPS

ZINC - Predictions - Purchasable

UMPS_HUMAN

HMDB Protein

HMDBP01045

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P54764 EPHA4	2	p-Y596,Y602-EPHA4 [plasma membrane] (R-HSA-3928352) EPHA4 [plasma membrane] (R-HSA-2682325)	0.564	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	6