Reactome | SUMO-K-CRABP1 [cytosol]

SUMO-K-CRABP1 [cytosol]

Stable Identifier

R-HSA-5334807

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Cellular retinoic acid-binding protein 1, RABP1_HUMAN

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External Reference Information

External Reference

UniProt:P29762 CRABP1

Gene Names

CRABP1, RBP5

Chain

chain:1-137

Reference Genes

BioGPS Gene:1381 CRABP1

COSMIC (genes):CRABP1 CRABP1

COSMIC (genes):RBP5 CRABP1

CTD Gene:1381 CRABP1

dbSNP Gene:1381 CRABP1

ENSEMBL:ENSG00000166426 CRABP1

HGNC:2338 CRABP1

Monarch:1381 CRABP1

NCBI Gene:1381 CRABP1

OMIM:180230 CRABP1

UCSC:P29762 CRABP1

Reference Transcript

RefSeq:NM_004378.2 CRABP1

Other Identifiers

11723047_at

1381

16803492

205350_PM_at

205350_at

3603296

3603297

3603299

3603300

3603302

3603303

3603304

3603305

49212_at

542_at

543_g_at

7985159

A_33_P3216869

A_33_P3326483

GE58806

GO:0001972

GO:0005501

GO:0005504

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0007165

GO:0008289

GO:0015908

GO:0016918

GO:0019841

GO:0043226

HMNXSV003007730

PH_hs_0016729

S74445_at

TC15000728.hg

g4758051_3p_at

Participates

as an output of

CYP26A1,B1,C1 4-hydroxylate atRA (Homo sapiens)

as a component of

SUMO-CRABP1:atRA [cytosol] (Homo sapiens)

as an input of

CRABP1 binds atRA (Homo sapiens)

Inferred To

crabp1 [cytosol] (Xenopus tropicalis)

crabp1b [cytosol] (Danio rerio)

CRABP1 [cytosol] (Canis familiaris)

CRABP1 [cytosol] (Sus scrofa)

SUMO-K-CRABP1 [cytosol] (Bos taurus)

SUMO-K-CRABP1 [cytosol] (Caenorhabditis elegans)

SUMO-K-CRABP1 [cytosol] (Gallus gallus)

SUMO-K-CRABP1 [cytosol] (Mus musculus)

SUMO-K-CRABP1 [cytosol] (Rattus norvegicus)

fabp [cytosol] (Drosophila melanogaster)

Modified Residues

Name

sumoylated lysine at unknown position

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

Guide to Pharmacology - Targets

2529

ENSEMBL

ENST00000299529, ENSP00000299529

OpenTargets

ENSG00000166426

HPA

ENSG00000166426-CRABP1

PRO

P29762

Pharos - Targets

P29762

HMDB Protein

HMDBP01924

PDB

7A9Z, 7A9Y

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P30536 TSPO	1	TSPO [mitochondrial outer membrane] (R-HSA-2980957)	0.589	2
UniProt:O14745 NHRF1			0.556	3
UniProt:P07101-3 TH			0.556	3
UniProt:Q96PV0 SYNGAP1	1	SYNGAP1 [cytosol] (R-HSA-5658217)	0.527	4
UniProt:Q12798 CETN1	7	PolyUb-Misfolded CETN1 [late endosome lumen] (R-HSA-9659982) CETN1 [cilium] (R-HSA-9639700) Misfolded CETN1 [cilium] (R-HSA-9639714) Misfolded CETN1 [cytosol] (R-HSA-9640113) Ub-Misfolded CETN1 [cytosol] (R-HSA-9641110) PolyUb-Misfolded CETN1 [cytosol] (R-HSA-9641126) PolyUb-Misfolded CETN1 [lysosomal lumen] (R-HSA-9659990)	0.527	2
UniProt:P27958-PRO_0000037576			0.508	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.508	4

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