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p-S20-MYL6 [cytosol]
Stable Identifier
R-HSA-445778
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Phosphorylated Myosin light polypeptide 6, MYL6, MYL6_HUMAN
Locations in the PathwayBrowser
Expand all
Muscle contraction (Homo sapiens)
Smooth Muscle Contraction (Homo sapiens)
ATP Hydrolysis By Myosin (Homo sapiens)
ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
ADP Bound Smooth Muscle Myosin Complex [cytosol] (Homo sapiens)
Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
p-S20-MYL6 [cytosol] (Homo sapiens)
ATP Bound Smooth Muscle Myosin Complex [cytosol] (Homo sapiens)
Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
p-S20-MYL6 [cytosol] (Homo sapiens)
ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
ATP Bound Smooth Muscle Myosin Complex [cytosol] (Homo sapiens)
Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
p-S20-MYL6 [cytosol] (Homo sapiens)
Calcium Binds Caldesmon (Homo sapiens)
Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
p-S20-MYL6 [cytosol] (Homo sapiens)
Inactive Myosin Actin Contractile Complex [plasma membrane] (Homo sapiens)
Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
p-S20-MYL6 [cytosol] (Homo sapiens)
Myosin Binds ATP (Homo sapiens)
ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
ATP Bound Smooth Muscle Myosin Complex [cytosol] (Homo sapiens)
Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
p-S20-MYL6 [cytosol] (Homo sapiens)
p-S CALD1-Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
p-S20-MYL6 [cytosol] (Homo sapiens)
Phosphorylation of Smooth Muscle Myosin Light Chains (Homo sapiens)
Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
p-S20-MYL6 [cytosol] (Homo sapiens)
Release Of ADP From Myosin (Homo sapiens)
ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
ADP Bound Smooth Muscle Myosin Complex [cytosol] (Homo sapiens)
Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
p-S20-MYL6 [cytosol] (Homo sapiens)
Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
p-S20-MYL6 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P60660 MYL6
Gene Names
MYL6
Chain
initiator methionine:1, chain:2-151
Reference Genes
BioGPS Gene:4637 MYL6
COSMIC - genes:MYL6 MYL6
CTD Gene:4637 MYL6
dbSNP Gene:4637 MYL6
ENSEMBL:ENSG00000092841 MYL6
HGNC:7587 MYL6
KEGG:hsa:4637 MYL6
Monarch:4637 MYL6
NCBI Gene:4637 MYL6
OMIM:609931 MYL6
UCSC:P60660 MYL6
Reference Transcript
RefSeq:NM_079423.4 MYL6
RefSeq:NM_021019.4 MYL6
Participates
as a member of
Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
Other forms of this molecule
MYL6 [cytosol]
Inferred To
phospho-Myl6 [cytosol]
(Mus musculus)
phospho-mlc-3 [cytosol]
(Caenorhabditis elegans)
phospho-Dmel\CG34435 [cytosol]
(Drosophila melanogaster)
phospho-Dmel\CG17237 [cytosol]
(Drosophila melanogaster)
phospho-mlc-6 [cytosol]
(Caenorhabditis elegans)
Homologues of p-S20-MYL6 [cytosol]
(Caenorhabditis elegans)
Homologues of p-S20-MYL6 [cytosol]
(Drosophila melanogaster)
Homologues of p-S20-MYL6 [cytosol]
(Plasmodium falciparum)
phospho-myl6 [cytosol]
(Danio rerio)
phospho-myl6 [cytosol]
(Xenopus tropicalis)
phospho-p-S20-MYL6 [cytosol]
(Dictyostelium discoideum)
phospho-p-S20-MYL6 [cytosol]
(Drosophila melanogaster)
phospho-p-S20-MYL6 [cytosol]
(Plasmodium falciparum)
phospho-p-S20-MYL6 [cytosol]
(Saccharomyces cerevisiae)
phospho-p-S20-MYL6 [cytosol]
(Schizosaccharomyces pombe)
phospho-MYL6 [cytosol]
(Bos taurus)
phospho-MYL6 [cytosol]
(Gallus gallus)
phospho-MYL6 [cytosol]
(Sus scrofa)
phospho-Mlc1 [cytosol]
(Drosophila melanogaster)
phospho-mlc-5 [cytosol]
(Caenorhabditis elegans)
phospho-mlc-7 [cytosol]
(Caenorhabditis elegans)
Modified Residues
Name
O-phospho-L-serine at 20
Coordinate
20
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_066299.2
,
NP_524147.2
ENSEMBL
ENSP00000448101
,
ENST00000547649
,
ENST00000548293
,
ENSG00000092841
,
ENST00000550697
,
ENSP00000446714
,
ENSP00000446955
OpenTargets
ENSG00000092841
GeneCards
MYL6
HPA
ENSG00000092841-MYL6
PRO
P60660
Pharos - Targets
P60660
GlyGen
P60660
HMDB Protein
HMDBP07824
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O43809 NUDT21
1
NUDT21 [nucleoplasm]
(R-HSA-72010)
0.742
5
UniProt:P35579 MYH9
3
MYH9 [cytosol]
(R-HSA-419173)
MYH9(2-1644)-ALK(1067-1620) fusion [cytosol]
(R-HSA-9715280)
MYH9(2-1644)-p-7Y-ALK(1067-1620) fusion [cytosol]
(R-HSA-9715279)
0.643
6
UniProt:P03372 ESR1
10
ESR1 [cytosol]
(R-HSA-9020968)
ESR1 [nucleoplasm]
(R-HSA-446168)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
0.642
3
UniProt:P63000 RAC1
7
RAC1 [plasma membrane]
(R-HSA-351141)
RAC1 [cytosol]
(R-HSA-442615)
Ub-RAC1 [plasma membrane]
(R-HSA-9959460)
GGC-PalmC-RAC1 [plasma membrane]
(R-HSA-2316446)
RAC1 [secretory granule membrane]
(R-HSA-6804770)
RAC1 [ficolin-1-rich granule membrane]
(R-HSA-6804802)
RAC1 [endoplasmic reticulum membrane]
(R-HSA-5672076)
0.638
3
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
0.615
19
UniProt:Q14164 IKBKE
5
IKBKE [cytosol]
(R-HSA-450225)
p-S172-IKBKE [cytosol]
(R-HSA-450278)
K63polyUb-K30,K401-IKBKE [cytosol]
(R-HSA-9730436)
p-S172-IKBKE [nucleoplasm]
(R-HSA-4755521)
monoSUMO1-K231-p-S172-IKBKE [nucleoplasm]
(R-HSA-4755535)
0.589
2
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:P46940 IQGAP1
3
IQGAP1 [cytosol]
(R-HSA-5626371)
IQGAP1 [secretory granule membrane]
(R-HSA-6804803)
IQGAP1 [plasma membrane]
(R-HSA-381681)
0.527
3
UniProt:P15336 ATF2
2
p-T69,T71-ATF2 [nucleoplasm]
(R-HSA-450243)
ATF2 [nucleoplasm]
(R-HSA-450336)
0.527
2
UniProt:P0DTC2 S
20
S(686-815) [plasma membrane]
(R-COV-9770188)
Spike S2' Fragment [plasma membrane]
(R-COV-9770189)
S1 [plasma membrane]
(R-COV-9769950)
fully glycosylated Spike [plasma membrane]
(R-COV-9733472)
nascent Spike [endoplasmic reticulum lumen]
(R-COV-9694796)
14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9694459)
Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9696892)
high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9696875)
high-mannose N-glycan folded Spike [endoplasmic reticulum lumen]
(R-COV-9696880)
high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9766369)
high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696943)
di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696920)
fully glycosylated Spike [virion membrane]
(R-COV-9698327)
complex N-glycan-PALM-Spike S1 Fragment [virion membrane]
(R-COV-9694638)
complex N-glycan-PALM-Spike S2 Fragment [virion membrane]
(R-COV-9694791)
complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane]
(R-COV-9694343)
complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane]
(R-COV-9694745)
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9698330)
complex N-glycan-PALM-Spike S2 Fragment [plasma membrane]
(R-COV-9769952)
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696997)
0.527
2
UniProt:P60953 CDC42
4
CDC42 [plasma membrane]
(R-HSA-449545)
CDC42 [cytosol]
(R-HSA-442630)
Ub-CDC42 [plasma membrane]
(R-HSA-9959463)
CDC42 [endoplasmic reticulum membrane]
(R-HSA-5672086)
0.527
2
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