Reactome | SFPQ [nucleoplasm]

SFPQ [nucleoplasm]

Stable Identifier

R-HSA-3900138

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Splicing factor, proline- and glutamine-rich, SFPQ_HUMAN, PSF

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P23246 SFPQ

Gene Names

SFPQ, PSF

Chain

chain:1-707

Reference Genes

BioGPS Gene:6421 SFPQ

COSMIC (genes):SFPQ SFPQ

CTD Gene:6421 SFPQ

dbSNP Gene:6421 SFPQ

ENSEMBL:ENSG00000116560 SFPQ

ENSEMBL_homo_sapiens_GENE:ENSG00000116560.12 SFPQ

HGNC:10774 SFPQ

KEGG Gene (Homo sapiens):6421 SFPQ

Monarch:6421 SFPQ

NCBI Gene:6421 SFPQ

OMIM:605199 SFPQ

UCSC:P23246 SFPQ

Reference Transcript

Other Identifiers

11720474_a_at

11720475_x_at

16685076

201585_PM_s_at

201585_s_at

201586_PM_s_at

201586_s_at

2406078

2406079

2406080

2406081

2406082

2406083

2406089

2406091

2406093

2406094

2406095

2406096

2406098

2406100

2406101

2406102

2406103

2406104

40638_at

41199_s_at

54981_r_at

6421

76096_at

7914791

A_33_P3318292

GE61121

GO:0000122

GO:0000380

GO:0000724

GO:0000785

GO:0000976

GO:0002218

GO:0002376

GO:0003676

GO:0003677

GO:0003682

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0006281

GO:0006310

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0006397

GO:0006974

GO:0008380

GO:0012501

GO:0016071

GO:0016363

GO:0016607

GO:0023052

GO:0042382

GO:0042752

GO:0042754

GO:0042803

GO:0042826

GO:0043226

GO:0045087

GO:0045892

GO:0045944

GO:0048511

GO:0090575

GO:0098542

GO:1902177

HMNXSV003010292

HMNXSV003044369

Hs.180610.3.A1_3p_a_at

ILMN_1769931

PH_hs_0027942

X70944_s_at

g4826997_3p_a_at

Participates

as an input of

PTK6 phosphorylates SFPQ (Homo sapiens)

Other forms of this molecule

SFPQ [cytosol]

p-Y-SFPQ [nucleoplasm]

Inferred To

sfpq [nucleoplasm] (Danio rerio)

sfpq [nucleoplasm] (Xenopus tropicalis)

SFPQ [nucleoplasm] (Bos taurus)

SFPQ [nucleoplasm] (Canis familiaris)

SFPQ [nucleoplasm] (Dictyostelium discoideum)

SFPQ [nucleoplasm] (Gallus gallus)

SFPQ [nucleoplasm] (Plasmodium falciparum)

SFPQ [nucleoplasm] (Sus scrofa)

nono-1 [nucleoplasm] (Caenorhabditis elegans)

nonA [nucleoplasm] (Drosophila melanogaster)

Sfpq [nucleoplasm] (Mus musculus)

Sfpq [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_005057.1, XP_016857542.1, XP_005271169.1, XP_005271172.1, XP_005271170.1, XP_016857543.1

OpenTargets

ENSG00000116560

GeneCards

P23246

HPA

ENSG00000116560-SFPQ

Ensembl

ENST00000357214, ENSG00000116560, ENSP00000349748

PRO

P23246

Pharos - Targets

P23246

Orphanet

21871

HMDB Protein

HMDBP01953

PDB

4WIJ, 4WIK, 7PU5, 7LRU, 6NCQ, 7SP0, 6OWJ, 5WPA, 6WMZ, 7UJ1, 7UK1, 7LRQ, 4WII

Interactors (27)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15233 NONO			0.881	10
UniProt:P26599 PTBP1	1	PTBP1 [nucleoplasm] (R-HSA-71923)	0.702	4
UniProt:Q8WXF1 PSPC1			0.695	4
UniProt:P09012 SNRPA	1	SNRPA [nucleoplasm] (R-HSA-71915)	0.688	5
UniProt:Q06787 FMR1			0.667	3
UniProt:Q13882 PTK6	5	p-Y342-PTK6 [nucleoplasm] (R-HSA-8848937) p-Y342,Y447-PTK6 [cytosol] (R-HSA-8849103) p-Y351-PTK6 [cytosol] (R-HSA-8857570) PTK6 [cytosol] (R-HSA-8848000) p-Y342-PTK6 [cytosol] (R-HSA-8848007)	0.632	5
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	14
UniProt:P09651 HNRNPA1	2	HNRNPA1 [cytosol] (R-HSA-9727902) HNRNPA1 [nucleoplasm] (R-HSA-71927)	0.615	3
UniProt:P11387 TOP1	2	monoSUMO1-K117-TOP1 [nucleoplasm] (R-HSA-4641364) TOP1 [nucleoplasm] (R-HSA-4641363)	0.597	3
UniProt:Q9Y2W1 THRAP3	1	THRAP3 [nucleoplasm] (R-HSA-8932115)	0.576	6
UniProt:P35637 FUS	1	FUS [nucleoplasm] (R-HSA-72040)	0.564	2
UniProt:O60861 GAS7			0.564	2
UniProt:Q68DV7 RNF43	10	RNF43 E174* [plasma membrane] (R-HSA-5340574) RNF43 R330fs89 [plasma membrane] (R-HSA-5340581) RNF43 A169T [plasma membrane] (R-HSA-9666639) RNF43 R117Afs41 [plasma membrane] (R-HSA-9666664) RNF43 R132* [plasma membrane] (R-HSA-9666650) RNF43 P154L [plasma membrane] (R-HSA-9666646) RNF43 F69C [plasma membrane] (R-HSA-5340578) RNF43 [plasma membrane] (R-HSA-5323531) ub-RNF43 [plasma membrane] (R-HSA-5323547) RNF43 G659Vfs*41 [plasma membrane] (R-HSA-9666643)	0.556	3
UniProt:P51114 FXR1	2	FXR1(2-784)-BRAF(381-766) fusion [cytosol] (R-HSA-6802326) FXR1(2-784)-p-BRAF(381-766) fusion [cytosol] (R-HSA-6802530)	0.547	2
UniProt:Q96E39 RMXL1			0.527	2
UniProt:Q9H3L0 MMADHC	8	MMADHC [cytosol] (R-HSA-3149529) MMADHC R250* [cytosol] (R-HSA-3318608) MMADHC T182N [cytosol] (R-HSA-3318599) MMADHC L259P [cytosol] (R-HSA-3318587) MMADHC Y249C [cytosol] (R-HSA-3318584) MMADHC Y140* [cytosol] (R-HSA-3318633) MMADHC R54* [cytosol] (R-HSA-3318620) MMADHC S20* [cytosol] (R-HSA-3318573)	0.527	2
UniProt:P49366 DHPS	1	DHPS [cytosol] (R-HSA-204630)	0.527	2
UniProt:Q92922 SMARCC1	1	SMARCC1 [nucleoplasm] (R-HSA-389257)	0.527	2
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.527	2
UniProt:Q01844 EWS			0.527	2
UniProt:Q9HCD5 NCOA5			0.527	2
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	5
UniProt:O75146 HIP1R	3	HIP1R [cytosol] (R-HSA-8868155) HIP1R [Golgi membrane] (R-HSA-434348) HIP1R [cytoplasmic vesicle membrane] (R-HSA-434201)	0.527	2
UniProt:Q9BTC0 DIDO1			0.527	2
UniProt:Q9UBW7 ZMYM2	6	ZMYM2(1-913)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1839016) ZMYM2(1-913)-FGFR1(429-822) fusion [cytosol] (R-HSA-1604544) ZMYM2(1-1059)-p-4Y-FLT3(594-993) fusion [cytosol] (R-HSA-9703309) ZMYM2(1-1057)-p-5Y-FLT3(586-993) fusion [cytosol] (R-HSA-9703319) ZMYM2(1-1059)-FLT3(594-993) fusion [cytosol] (R-HSA-9703310) ZMYM2(1-1057)-FLT3(586-993) fusion [cytosol] (R-HSA-9703311)	0.524	4
UniProt:Q96ST3 SIN3A	2	SIN3A [nucleoplasm] (R-HSA-351657) monoSUMO1-SIN3A [nucleoplasm] (R-HSA-4086071)	0.524	2
UniProt:Q8AZK7 EBNA5			0.499	2

Cite Us!