Reactome | EEF2 [extracellular region]

EEF2 [extracellular region]

Stable Identifier

R-HSA-6806499

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

eEF2

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P13639 EEF2

Gene Names

EEF2, EF2

Chain

initiator methionine:1, chain:2-858

Reference Genes

BioGPS Gene:1938 EEF2

COSMIC (genes):EEF2 EEF2

CTD Gene:1938 EEF2

dbSNP Gene:1938 EEF2

ENSEMBL:ENSG00000167658 EEF2

HGNC:3214 EEF2

KEGG Gene (Homo sapiens):1938 EEF2

Monarch:1938 EEF2

NCBI Gene:1938 EEF2

OMIM:130610 EEF2

UCSC:P13639 EEF2

Reference Transcript

RefSeq:NM_001961.3 EEF2

Other Identifiers

0002760010

11715781_a_at

11715782_a_at

11715783_x_at

11748763_a_at

11748764_x_at

11751022_x_at

11757678_s_at

16867212

18671261

18671262

18671263

18671264

18671265

18671266

18671267

18671268

18671269

18671270

18671271

18671273

18671274

18671275

18671276

1938

200094_PM_s_at

200094_s_at

204102_PM_s_at

204102_s_at

36587_at

3846539

3846540

3846541

3846542

3846543

3846544

3846545

3846548

3846549

3846551

3846553

3846555

3846556

3846557

3846559

3846561

3846562

3846563

3846564

3846565

3846567

3846568

3846569

3846570

8032730

A_24_P87763

GE60349

GO:0000166

GO:0002244

GO:0002376

GO:0003674

GO:0003723

GO:0003746

GO:0003924

GO:0005515

GO:0005525

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0005844

GO:0005886

GO:0006412

GO:0006414

GO:0008135

GO:0008150

GO:0009058

GO:0016020

GO:0016235

GO:0019899

GO:0019901

GO:0030154

GO:0031410

GO:0032991

GO:0034641

GO:0034774

GO:0043022

GO:0043167

GO:0043226

GO:0045202

GO:0045296

GO:0045727

GO:0048856

GO:0070062

GO:1904813

GO:1990904

HMNXSV003054355

ILMN_1738383

PH_hs_0004308

TC19001054.hg

X51466_at

g4503482_3p_a_at

Participates

as a member of

Other forms of this molecule

EEF2 [ficolin-1-rich granule lumen]

EEF2 [secretory granule lumen]

aminocarboxypropyl EEF2 [cytosol]

Me-diphthine EEF2 [cytosol]

nascent EEF2 [cytosol]

diphthine EEF2 [cytosol]

EEF2 [cytosol]

ADP-ribo-EEF2 [cytosol]

Me3K525-EEF2 [cytosol]

Inferred To

cinC [extracellular region] (Dictyostelium discoideum)

eef-2 [extracellular region] (Caenorhabditis elegans)

eef2.1 [extracellular region] (Xenopus tropicalis)

eEF2 [extracellular region] (Drosophila melanogaster)

eef2l2 [extracellular region] (Danio rerio)

EEF2 [extracellular region] (Bos taurus)

EEF2 [extracellular region] (Canis familiaris)

EEF2 [extracellular region] (Gallus gallus)

EEF2 [extracellular region] (Plasmodium falciparum)

EEF2 [extracellular region] (Sus scrofa)

Homologues of EEF2 [extracellular region] (Danio rerio)

Homologues of EEF2 [extracellular region] (Dictyostelium discoideum)

eef2b [extracellular region] (Danio rerio)

eef2a.1 [extracellular region] (Danio rerio)

eef2a.2 [extracellular region] (Danio rerio)

efbA [extracellular region] (Dictyostelium discoideum)

eft201 [extracellular region] (Schizosaccharomyces pombe)

Eef2 [extracellular region] (Mus musculus)

Eef2 [extracellular region] (Rattus norvegicus)

EFT2 [extracellular region] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_001952.1

Guide to Pharmacology - Targets

2756

OpenTargets

ENSG00000167658

GeneCards

P13639

HPA

ENSG00000167658-EEF2

Ensembl

ENSP00000307940, ENSG00000167658, ENST00000309311

PRO

P13639

Pharos - Targets

P13639

Orphanet

22496

HMDB Protein

HMDBP02947

PDB

6D9J, 6Z6M, 6Z6N, 4V6X

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q9NRI5 DISC1			0.553	2
UniProt:Q16539 MAPK14	7	MAPK14 [secretory granule lumen] (R-HSA-6803300) MAPK14 [extracellular region] (R-HSA-6806453) MAPK14 [ficolin-1-rich granule lumen] (R-HSA-6803280) MAPK14 [nucleoplasm] (R-HSA-446223) MAPK14 [cytosol] (R-HSA-428933) p-T180,Y182-MAPK14 [cytosol] (R-HSA-428935) p-T180,Y182-MAPK14 [nucleoplasm] (R-HSA-446227)	0.527	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	2
UniProt:Q99714 HSD17B10	1	HSD17B10 [mitochondrial matrix] (R-HSA-70831)	0.499	3

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