Reactome | CNOT1 [cytosol]

CNOT1 [cytosol]

Stable Identifier

R-HSA-429892

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

CCR4-NOT transcription complex subunit 1, CNOT1_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Homo sapiens)
        
        BTG2 binds CCR4-NOT complex (Homo sapiens)
        
        BTG2:CCR4-NOT [cytosol] (Homo sapiens)
        
        CCR4-NOT Complex [cytosol] (Homo sapiens)
        
        CNOT1 [cytosol] (Homo sapiens)
        
        CCR4-NOT Complex [cytosol] (Homo sapiens)
        
        CNOT1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:A5YKK6 CNOT1

Gene Names

CNOT1, CDC39, KIAA1007, NOT1, AD-005

Chain

chain:1-2376

Reference Genes

BioGPS Gene:23019 CNOT1

COSMIC (genes):CNOT1 CNOT1

CTD Gene:23019 CNOT1

dbSNP Gene:23019 CNOT1

ENSEMBL:ENSG00000125107 CNOT1

HGNC:7877 CNOT1

KEGG:hsa:23019 CNOT1

Monarch:23019 CNOT1

NCBI Gene:23019 CNOT1

OMIM:604917 CNOT1

UCSC:A5YKK6 CNOT1

Reference Transcript

Participates

as a component of

Inferred To

Cnot1 [cytosol] (Mus musculus)

Cnot1 [cytosol] (Rattus norvegicus)

CNOT1 [cytosol] (Bos taurus)

CNOT1 [cytosol] (Canis familiaris)

CNOT1 [cytosol] (Gallus gallus)

CNOT1 [cytosol] (Sus scrofa)

DG1040 [cytosol] (Dictyostelium discoideum)

cnot1 [cytosol] (Danio rerio)

cnot1 [cytosol] (Xenopus tropicalis)

Cross References

OpenTargets

ENSG00000125107

ENSEMBL

ENSP00000455635, ENSP00000456649, ENSP00000320949, ENSG00000125107, ENST00000569240, ENSP00000413113, ENST00000567188, ENST00000441024, ENST00000317147

HPA

ENSG00000125107-CNOT1

GeneCards

CNOT1

PRO

A5YKK6

Pharos - Targets

A5YKK6

Orphanet

CNOT1

GlyGen

A5YKK6

PDB

4CRU, 7VOI, 5ONA, 8BFI, 5FU7, 5ANR, 4J8S, 4CQO, 4GML, 4CT7, 8FY3, 4CT6, 4C0D, 4GMJ, 4CRW, 4CT4, 4CRV, 5FU6

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P22893	2	phospho-Zfp36 [cytosol] (R-MMU-450496) Zfp36 [cytosol] (R-MMU-450562)	0.558	5
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.527	3
UniProt:P47756 CAPZB	1	CAPZB [cytosol] (R-HSA-879409)	0.527	3
UniProt:P52907 CAPZA1	2	CAPZA1(265-276) [extracellular region] (R-HSA-879421) CAPZA1 [cytosol] (R-HSA-879363)	0.527	2
UniProt:Q8NDV7 TNRC6A	2	TNRC6A [nucleoplasm] (R-HSA-5578976) TNRC6A [cytosol] (R-HSA-427769)	0.499	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	8

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