GAPDH

Stable Identifier
R-HSA-70428
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
glyceraldehyde-3-phosphate dehydrogenase monomer, glyceraldehyde 3-phosphate dehydrogenase, liver, glyceraldehyde 3-phosphate dehydrogenase, muscle, G3P2_HUMAN, G3P1_HUMAN, Glyceraldehyde 3-phosphate dehydrogenase, liver
Locations in the PathwayBrowser
Summation

While there are multiple human glyceraldehyde 3-phosphate dehydrogenase-like pseudogenes, there is only one glyceraldehyde 3-phosphate dehydrogenase gene expressed in somatic tissue (Benham and Povey 1989). Consistent with this conclusion, the homogeneous enzymes purified from various human tissues had indistinguishable physical and immunochemical properties (Heinz and Freimuller 1982), and studies of human erythrocytes of various ages suggested that variant forms of the enzyme arise as a result of post-translational modifications (Edwards et al. 1976). There is, however, an authentic second isoform of glyceraldehyde 3-phosphate dehydrogenase whose expression is confined to spermatogenic cells of the testis (Welch et al. 2000).

External Reference Information
External Reference
Gene Names
GAPDH, GAPD, CDABP0047, OK/SW-cl.12
Chain
initiator methionine:1, chain:2-335
Other Identifiers
00010+1.2.1.12
0001850181
0001940184
00710+1.2.1.12
11754912_x_at
16392
1U8F
1ZNQ
212581_x_at
213453_x_at
217398_3p_x_at
217398_x_at
2347474
2379956
2597
2962139
2FEH
3290165
3402626
3402627
3402628
3402629
3402630
3402632
3402635
3402636
3402637
3402638
3402640
3402642
3402643
3402645
3402647
3402648
3402649
3402651
3402652
3402653
3419406
3419414
35905_s_at
3992397
3GPD
4005331
4005332
4005336
40067
4006736
4WNC
4WNI
5197
61280
7953385
AAA52496
AAA52518
AAA53191
AAA86283
AAF99678
AAG01996
AAH01601
AAH04109
AAH09081
AAH13310
AAH23632
AAH25925
AAH26907
AAH29618
AAH83511
AAP35539
AAP88932
AB062273
AC006064
ACF94474
AF261085
AFFX-HUMGAPDH/M33197_3_at
AFFX-HUMGAPDH/M33197_5_at
AFFX-HUMGAPDH/M33197_M_at
AY007133
AY340484
BAB93466
BC001601
BC004109
BC009081
BC013310
BC023632
BC025925
BC026907
BC029618
BC083511
BT006893
CAA25833
CAA37794
CAB005197
CAB016392
CAG28599
CCDS58201
CCDS8549
CH471116
CR407671
E7EUT5
EAW88787
ENSG00000111640
ENSP00000229239
ENSP00000380067
ENSP00000380068
ENSP00000380070
ENSP00000478864
ENST00000229239
ENST00000396858
ENST00000396859
ENST00000396861
ENST00000619601
EntrezGene:2597
EU668321
GAPDH
GAPDH-201
GAPDH-203
GAPDH-204
GAPDH-205
GAPDH-211
GE80009
GO:0000226
GO:0002376
GO:0003674
GO:0004365
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005634
GO:0005635
GO:0005737
GO:0005811
GO:0005829
GO:0005856
GO:0005886
GO:0005975
GO:0006006
GO:0006091
GO:0006094
GO:0006096
GO:0006412
GO:0006417
GO:0006464
GO:0006810
GO:0006914
GO:0006915
GO:0006950
GO:0007010
GO:0008017
GO:0008092
GO:0008150
GO:0008219
GO:0009056
GO:0009058
GO:0010951
GO:0015630
GO:0016020
GO:0016241
GO:0016491
GO:0016620
GO:0016740
GO:0017148
GO:0019828
GO:0030234
GO:0031640
GO:0031965
GO:0031982
GO:0032991
GO:0034641
GO:0034655
GO:0035605
GO:0035606
GO:0042802
GO:0043226
GO:0043231
GO:0044281
GO:0044403
GO:0048471
GO:0050661
GO:0050715
GO:0050821
GO:0050832
GO:0051186
GO:0051287
GO:0051402
GO:0051873
GO:0052501
GO:0055114
GO:0061621
GO:0061844
GO:0070062
GO:0071346
GO:0097452
GO:0097718
GO:1990904
HGNC:4141
HPA040067
HPA061280
Hs.169476.4.A1_3p_s_at
Hs.169476.5.A1_3p_s_at
ILMN_1343295
ILMN_1802252
ILMN_2038778
IPR006424
IPR020828
IPR020829
IPR020830
IPR020831
IPR036291
J02642
J04038
M17851
M33197
MIM:138400
NM_001256799
NM_001289745
NM_001289746
NM_002046
NP_001243728
NP_001276674
NP_001276675
NP_002037
PF00044
PF02800
PH_hs_0037816
PR00078
SM00846
TC12000084.hg
TC12002203.hg
TC16001826.hg
uc001qop.4
uc031qfw.3
uc031yrl.2
uc031yrm.2
uc058kgh.1
UPI000013C8ED
UPI0000D4C7BD
V9HVZ4
X01677
X01677_f_at
X53778
Participant Of
Inferred To
Cross References
ZINC - Metabolites
ZINC - World Drugs
GeneCards
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
BRENDA (Homo sapiens)
ZINC - Predictions - Purchasable
HMDB Protein
PDB
Interactors (6)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P00533 EGFR  58 0.721 6
 UniProt:P12004 PCNA  5 0.571 3
 UniProt:Q9UHD2 TBK1  6 0.564 2
 UniProt:P04183 TK1  1 0.553 2
 UniProt:Q60823 Akt2  7 0.499 2
 UniProt:P00441 SOD1  5 0.499 3