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DSP [plasma membrane]
Stable Identifier
R-HSA-201580
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Desmoplakin
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Keratinization (Homo sapiens)
Formation of the cornified envelope (Homo sapiens)
CASP14 cleaves filaggrin (Homo sapiens)
Late cornified envelope [plasma membrane] (Homo sapiens)
Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
DSP [plasma membrane] (Homo sapiens)
Mature cornified envelope [plasma membrane] (Homo sapiens)
No FGN-cornified envelope:CDSN [plasma membrane] (Homo sapiens)
No FGN-Cornified envelope [plasma membrane] (Homo sapiens)
No FGN-late cornified envelope [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome network [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
DSP [plasma membrane] (Homo sapiens)
CDSN binds the cornified envelope (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
DSP [plasma membrane] (Homo sapiens)
Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
DSP [plasma membrane] (Homo sapiens)
Filaggrin binds Keratin tonofilament:Desmosome (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
DSP [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
DSP [plasma membrane] (Homo sapiens)
Fillagrin and keratin intermediate filaments polymerize forming a network (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
DSP [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
DSP [plasma membrane] (Homo sapiens)
Lamellar bodies bind the early cornified envelope (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
DSP [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
DSP [plasma membrane] (Homo sapiens)
Late envelope proteins bind cornified envelope:CDSN (Homo sapiens)
Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
DSP [plasma membrane] (Homo sapiens)
Late cornified envelope [plasma membrane] (Homo sapiens)
Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
DSP [plasma membrane] (Homo sapiens)
PERP binds desmosomes (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
DSP [plasma membrane] (Homo sapiens)
Desmosome:PERP [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
DSP [plasma membrane] (Homo sapiens)
Plasma membrane resorption (Homo sapiens)
Mature cornified envelope [plasma membrane] (Homo sapiens)
No FGN-cornified envelope:CDSN [plasma membrane] (Homo sapiens)
No FGN-Cornified envelope [plasma membrane] (Homo sapiens)
No FGN-late cornified envelope [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome network [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
DSP [plasma membrane] (Homo sapiens)
Reinforcement of the Cornified Envelope (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
DSP [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
DSP [plasma membrane] (Homo sapiens)
Keratin filaments bind cell-cell adhesion complexes (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
DSP [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
DSP [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of ficolin-rich granule membrane proteins (Homo sapiens)
Ficolin-rich granule membrane proteins [plasma membrane] (Homo sapiens)
DSP [plasma membrane] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Apoptotic execution phase (Homo sapiens)
Apoptotic cleavage of cellular proteins (Homo sapiens)
Apoptotic cleavage of cell adhesion proteins (Homo sapiens)
Caspase-mediated cleavage of Desmoplakin (Homo sapiens)
DSP [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RND1 GTPase cycle (Homo sapiens)
RND1 binds effectors (Homo sapiens)
RND1 effectors [cytosol] (Homo sapiens)
DSP [plasma membrane] (Homo sapiens)
RND1:GTP:RND1 effectors [plasma membrane] (Homo sapiens)
RND1 effectors [cytosol] (Homo sapiens)
DSP [plasma membrane] (Homo sapiens)
RND3 GTPase cycle (Homo sapiens)
RND3 binds effectors (Homo sapiens)
RND3 effectors [cytosol] (Homo sapiens)
DSP [plasma membrane] (Homo sapiens)
RND3:GTP:RND3 effectors [plasma membrane] (Homo sapiens)
RND3 effectors [cytosol] (Homo sapiens)
DSP [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P15924 DSP
Gene Names
DSP
Chain
chain:1-2871
Reference Genes
BioGPS Gene:1832 DSP
COSMIC (genes):DSP DSP
CTD Gene:1832 DSP
dbSNP Gene:1832 DSP
ENSEMBL:ENSG00000096696 DSP
ENSEMBL_homo_sapiens_GENE:ENSG00000096696.16 DSP
HGNC:3052 DSP
KEGG Gene (Homo sapiens):1832 DSP
Monarch:1832 DSP
NCBI Gene:1832 DSP
OMIM:125647 DSP
UCSC:P15924 DSP
Reference Transcript
RefSeq:NM_004415.3 DSP
RefSeq:NM_001008844.2 DSP
RefSeq:NM_001319034.1 DSP
Other Identifiers
11739501_a_at
11757507_s_at
17004612
1832
200606_PM_at
200606_at
2893793
2893795
2893796
2893797
2893800
2893801
2893802
2893804
2893807
2893808
2893809
2893810
2893811
2893812
2893813
2893814
2893815
2893816
2893817
2893818
2893819
2893820
2893821
2893822
2893823
2893824
2893825
2893826
2893827
2893828
2893829
2893830
2893831
2893832
2893833
2893834
2893835
2893836
2893837
2893838
2893839
2893840
36133_at
8116780
A_32_P157945
A_33_P3314574
A_33_P3402565
GE56076
GO:0001533
GO:0002934
GO:0003012
GO:0003013
GO:0003223
GO:0003723
GO:0005080
GO:0005198
GO:0005200
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005737
GO:0005856
GO:0005882
GO:0005886
GO:0005911
GO:0005912
GO:0005916
GO:0007010
GO:0007155
GO:0008544
GO:0014704
GO:0016020
GO:0016323
GO:0018149
GO:0030057
GO:0030154
GO:0030216
GO:0031410
GO:0034330
GO:0034332
GO:0036211
GO:0042060
GO:0043226
GO:0043588
GO:0045104
GO:0045109
GO:0048856
GO:0070062
GO:0070161
GO:0086073
GO:0086083
GO:0086091
GO:0090136
GO:0097110
GO:0098609
GO:0098631
GO:0098911
GO:0101003
GO:0150105
HMNXSV003057465
ILMN_1655614
ILMN_1659749
ILMN_1677032
PH_hs_0032773
TC06000060.hg
g4758199_3p_at
g4758199_3p_s_at
Participates
as a candidate of
RND3 effectors [cytosol] (Homo sapiens)
RND1 effectors [cytosol] (Homo sapiens)
as a component of
Desmosome [plasma membrane] (Homo sapiens)
as a member of
Ficolin-rich granule membrane proteins [plasma membrane] (Homo sapiens)
as an input of
Caspase-mediated cleavage of Desmoplakin (Homo sapiens)
Other forms of this molecule
DSP [cornified envelope]
DSP [ficolin-1-rich granule membrane]
DSP(?-?) [plasma membrane]
Inferred To
Dsp [plasma membrane]
(Mus musculus)
Dsp [plasma membrane]
(Rattus norvegicus)
dspa [plasma membrane]
(Danio rerio)
Ghost homologue of DSP [plasma membrane]
(Caenorhabditis elegans)
Ghost homologue of DSP [plasma membrane]
(Xenopus tropicalis)
DSP [plasma membrane]
(Bos taurus)
DSP [plasma membrane]
(Canis familiaris)
DSP [plasma membrane]
(Gallus gallus)
DSP [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_004406.2
,
NP_001008844.1
,
NP_001305963.1
OpenTargets
ENSG00000096696
GeneCards
P15924
HPA
ENSG00000096696-DSP
Ensembl
ENSP00000396591
,
ENSG00000096696
,
ENST00000418664
,
ENST00000379802
,
ENSP00000369129
PRO
P15924
Pharos - Targets
P15924
Orphanet
15895
PDB
3R6N
,
1LM5
,
5DZZ
,
1LM7
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15691 MAPRE1
1
MAPRE1 [cytosol]
(R-HSA-376240)
0.626
7
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
18
UniProt:P14923 JUP
6
JUP [cytosol]
(R-HSA-201598)
JUP [cornified envelope]
(R-HSA-8847739)
JUP [specific granule lumen]
(R-HSA-6799534)
JUP [extracellular region]
(R-HSA-6806309)
JUP [ficolin-1-rich granule lumen]
(R-HSA-6801028)
JUP [plasma membrane]
(R-HSA-437260)
0.573
3
UniProt:P07332 FES
1
FES [cytosol]
(R-HSA-396937)
0.564
2
UniProt:Q76353 Q76353
0.462
2
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