Reactome | LMNA(1-646) [nuclear envelope]

LMNA(1-646) [nuclear envelope]

Stable Identifier

R-HSA-535479

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nuclear envelope

Synonyms

LMNA, Lamin-A/C, LMNA_HUMAN

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Unfolded Protein Response (UPR) (Homo sapiens)
    - IRE1alpha activates chaperones (Homo sapiens)
      - XBP1(S) activates chaperone genes (Homo sapiens)
        
        Expression of LMNA (Homo sapiens)
        
        LMNA(1-646) [nuclear envelope] (Homo sapiens)

External Reference Information

External Reference

UniProt:P02545 LMNA

Gene Names

LMNA, LMN1

Chain

chain:1-661, chain:1-646, propeptide:647-661, propeptide:662-664

Reference Genes

BioGPS Gene:4000 LMNA

COSMIC (genes):LMNA LMNA

CTD Gene:4000 LMNA

dbSNP Gene:4000 LMNA

ENSEMBL:ENSG00000160789 LMNA

ENSEMBL_homo_sapiens_GENE:ENSG00000160789.24 LMNA

HGNC:6636 LMNA

KEGG Gene (Homo sapiens):4000 LMNA

Monarch:4000 LMNA

NCBI Gene:4000 LMNA

OMIM:150330 LMNA

UCSC:P02545 LMNA

Reference Transcript

Other Identifiers

11719260_x_at

11719261_s_at

11752340_x_at

11752506_s_at

11752507_x_at

11752673_x_at

1554600_PM_s_at

1554600_s_at

16671914

203411_PM_s_at

203411_s_at

212086_PM_x_at

212086_x_at

212089_PM_at

212089_at

2361280

2361282

2361283

2361286

2361287

2361288

2361298

2361299

2361300

2361301

2361302

2361303

2361308

2361309

2361312

2361313

2361314

2361316

2361317

2361320

2361322

2361323

2361325

2361327

2361329

2361330

2361331

2361334

2361335

2361337

2361338

37377_i_at

37378_r_at

4000

71746_s_at

7906085

A_14_P114205

A_23_P34835

A_24_P162718

A_33_P3311285

A_33_P3408762

GE81529

GO:0003012

GO:0005198

GO:0005200

GO:0005515

GO:0005634

GO:0005635

GO:0005638

GO:0005652

GO:0005654

GO:0005694

GO:0005829

GO:0005856

GO:0005882

GO:0006325

GO:0006606

GO:0006886

GO:0006913

GO:0006997

GO:0006998

GO:0007005

GO:0007010

GO:0007097

GO:0007163

GO:0007517

GO:0008104

GO:0008285

GO:0010628

GO:0012501

GO:0016363

GO:0016607

GO:0023052

GO:0030154

GO:0030334

GO:0030951

GO:0031507

GO:0031647

GO:0031965

GO:0032200

GO:0032204

GO:0034504

GO:0035861

GO:0042802

GO:0043226

GO:0048471

GO:0048856

GO:0048870

GO:0051664

GO:0055015

GO:0061024

GO:0071456

GO:0072201

GO:0090201

GO:0090398

GO:0090435

GO:1900180

GO:1903243

GO:1990683

GO:2001237

HMNXSV003021995

HMNXSV003040267

HMNXSV003043843

HMNXSV003044458

Hs.77886.1.S1_3p_a_at

Hs.77886.2.S2_3p_at

Hs2.377973.4.S1_3p_s_at

ILMN_1696749

ILMN_1737394

M13452_s_at

PH_hs_0025504

g5031874_3p_a_at

Participates

as an output of

Expression of LMNA (Homo sapiens)

Other forms of this molecule

LMNA(1-567)-RAF1(279-648) fusion [cytosol]

LMNA(1-567)-p-RAF1(279-648) fusion [cytosol]

Cross References

RefSeq

NP_733821.1, NP_001269554.1, NP_001269555.1, NP_733822.1, NP_001269553.1, NP_005563.1, NP_001244303.1

OpenTargets

ENSG00000160789

HPA

ENSG00000160789-LMNA

GeneCards

P02545

Ensembl

ENSP00000503633, ENSP00000506904, ENSP00000502256, ENSP00000502091, ENSP00000421821, ENST00000473598, ENST00000448611, ENSP00000395597, ENSP00000355292, ENST00000361308, ENSG00000160789, ENST00000683032, ENSP00000357283, ENST00000675939, ENST00000676385, ENSP00000357282, ENST00000682650, ENST00000677389, ENST00000368301, ENST00000368300, ENST00000368299, ENSP00000506771, ENSP00000357284

PRO

P02545

Pharos - Targets

P02545

Orphanet

16364

PDB

2XV5, 6YF5, 6SNZ, 6YJD, 6RPR, 3V5B, 7YVD, 3V4W, 7X5D, 6JLB, 1IVT, 7D9N, 7CRG, 1IFR, 7Z21, 2YPT, 1X8Y, 3GEF, 7X1B, 3V4Q, 6GHD, 7WZZ

Interactors (90)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P20700 LMNB1	8	LMNB1 [nucleoplasm] (R-HSA-264867) LMNB1(1-231) [nuclear envelope] (R-HSA-352244) LMNB1(232-586) [nuclear envelope] (R-HSA-352248) LMNB1 [cytosol] (R-HSA-2995384) p-S395, S405-LMNB1 [nucleoplasm] (R-HSA-5228738) p-S23, S395, S405-LMNB1 [nucleoplasm] (R-HSA-5229018) LMNB1(2-586) [nuclear envelope] (R-HSA-912402) p-S23,S393-LMNB1 [nucleoplasm] (R-HSA-8868341)	0.933	23
UniProt:Q03252 LMNB2			0.849	10
UniProt:P50402 EMD	4	EMD [nuclear envelope] (R-HSA-201573) EMD [cytosol] (R-HSA-9613988) EMD [endoplasmic reticulum membrane] (R-HSA-9613998) EMD [endosome membrane] (R-HSA-9715092)	0.799	7
UniProt:Q9UII6 DS13B			0.781	7
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.774	23
UniProt:Q9UH99 SUN2	1	SUN2 [nuclear envelope] (R-HSA-912382)	0.723	5
UniProt:O75694 NUP155	2	NUP155 [cytosol] (R-HSA-9634170) NUP155 [nuclear envelope] (R-HSA-157690)	0.672	6
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.666	4
UniProt:P42166 TMPO			0.629	4
UniProt:P16104 H2AFX	7	Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317) H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583)	0.604	3
UniProt:Q0D2I5-5 IFFO1			0.576	4
UniProt:P42167 TMPO	1	TMPO [cytosol] (R-HSA-9714330)	0.569	4
UniProt:O60684 KPNA6	2	KPNA6 [nucleoplasm] (R-HSA-9734665) KPNA6 [cytosol] (R-HSA-9734672)	0.569	5
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.564	2
UniProt:O94901 SUN1	1	SUN1 [nuclear envelope] (R-HSA-912371)	0.564	2
UniProt:P62701 RPS4X	2	RPS4X [nucleoplasm] (R-HSA-6798713) RPS4X [cytosol] (R-HSA-72375)	0.556	3
UniProt:Q3B820 F161A			0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:Q96MN9-2 Q96MN92			0.556	3
UniProt:Q7Z698 SPRED2	2	SPRED2 [cytosol] (R-HSA-5654211) SPRED2 [plasma membrane] (R-HSA-5658229)	0.556	3
UniProt:Q96LX8 ZNF597	1	ZNF597 [nucleoplasm] (R-HSA-2127591)	0.556	3
UniProt:Q8WXF7 ATLA1			0.556	3
UniProt:Q86WT6-2 TRIM69			0.556	3
UniProt:Q70EL1-9 USP54			0.556	3
UniProt:Q9C0F3 ZNF436	1	ZNF436 [nucleoplasm] (R-HSA-1247538)	0.556	3
UniProt:P17024 ZNF20	1	ZNF20 [nucleoplasm] (R-HSA-975024)	0.556	3
UniProt:Q9NWB1-5 RBFOX1			0.556	3
UniProt:Q14585 ZN345			0.556	3
UniProt:Q6ZNH5 ZN497			0.556	3
IntAct:EBI-25842396 CCSB			0.556	3
UniProt:P60409 KRTAP10-7	1	KRTAP10-7 [cytosol] (R-HSA-6810279)	0.556	3
UniProt:Q04323-2 UBXN1			0.556	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:Q9BS31 ZNF649	1	ZNF649 [nucleoplasm] (R-HSA-2127585)	0.556	3
UniProt:O43309 ZSC12			0.556	3
UniProt:Q7Z3I7 ZN572			0.556	3
UniProt:Q8IZU1 FAM9A			0.556	3
UniProt:Q9Y4E8-2 USP15			0.556	3
UniProt:Q96EL1 INKA1			0.556	3
UniProt:P46379-2 BAG6			0.556	3
UniProt:Q9HBE1-4 PATZ1			0.556	3
UniProt:Q6H8Q1-8 ABLIM2			0.556	3
UniProt:Q9BZ95-3 Q9BZ953			0.556	3
UniProt:Q8N0Y2-2 ZNF444			0.556	3
UniProt:A6H8Z2-3 A6H8Z23			0.556	3
UniProt:O76041 NEBL			0.556	3
UniProt:Q99612 KLF6			0.556	3
UniProt:Q96GN5-2 CDCA7L			0.556	3
UniProt:Q96KP6 TNIP3	1	TNIP3 [cytosol] (R-HSA-561192)	0.556	3
UniProt:Q8TBE0 BAHD1			0.556	3
UniProt:Q8NEA9 GMCL2			0.556	3
UniProt:Q12986 NFX1			0.556	3
UniProt:Q5VYS8-5 TUT7			0.556	3
UniProt:Q03181-2 PPARD			0.556	3
UniProt:Q8NA54 IQUB			0.556	3
UniProt:Q8WVD3 RNF138	1	RNF138 [cytosol] (R-HSA-976008)	0.556	3
UniProt:Q8TCX5 RHPN1	1	RHPN1 [cytosol] (R-HSA-5667017)	0.556	3
UniProt:Q8TBZ8 ZNF564	1	ZNF564 [nucleoplasm] (R-HSA-1973885)	0.556	3
UniProt:Q14005-2 Q140052			0.556	3
UniProt:Q15776 ZKSCAN8	1	ZKSCAN8 [nucleoplasm] (R-HSA-974985)	0.556	3
UniProt:Q6ZNE9 RUFY4			0.556	3
UniProt:P10073 ZSC22			0.556	3
UniProt:P54274-2 TERF1			0.556	3
UniProt:P58499 FAM3B			0.556	3
UniProt:P10074 TZAP			0.556	3
UniProt:Q13133-3 NR1H3			0.556	3
UniProt:O75886 STAM2	2	Ub-STAM2 [cytosol] (R-HSA-6782781) STAM2 [cytosol] (R-HSA-182965)	0.556	3
UniProt:Q6X4W1-6 NSMF			0.556	3
UniProt:Q6ZN57 ZFP2	1	ZFP2 [nucleoplasm] (R-HSA-975018)	0.556	3
UniProt:Q3SX64 CMA1D			0.556	3
IntAct:EBI-25851697 CCSB			0.556	3
UniProt:Q8IYM2 SLN12			0.556	3
UniProt:Q8N488 RYBP	1	RYBP [nucleoplasm] (R-HSA-8937975)	0.556	3
UniProt:Q96DX5 ASB9	1	ASB9 [cytosol] (R-HSA-975424)	0.556	3
UniProt:Q9ULD4-2 Q9ULD42			0.556	3
UniProt:O75925 PIAS1	1	PIAS1 [nucleoplasm] (R-HSA-877307)	0.556	3
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.556	3
UniProt:Q96FA3 PELI1	2	PELI1 [cytosol] (R-HSA-450696) p-PELI1 [cytosol] (R-HSA-450815)	0.556	3
UniProt:Q8WW38 ZFPM2	1	ZFPM2 [nucleoplasm] (R-HSA-996726)	0.556	3
UniProt:Q13123 IK	1	IK [nucleoplasm] (R-HSA-9770239)	0.556	3
UniProt:Q9Y239 NOD1	1	NOD1 [cytosol] (R-HSA-168407)	0.556	3
UniProt:Q9D666 Sun1	1	Sun1 [nuclear envelope] (R-MMU-912375)	0.528	2
UniProt:P17029 ZKSCAN1	1	ZKSCAN1 [nucleoplasm] (R-HSA-975013)	0.527	2
UniProt:O75531 BANF1	4	p-T2,T3,S4-BANF1 [nucleoplasm] (R-HSA-2993896) BANF1 [nucleoplasm] (R-HSA-175030) BANF1 [cytosol] (R-HSA-175371) p-T2,T3,S4-BANF1 [cytosol] (R-HSA-2995375)	0.527	2
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.527	3
UniProt:P18054 ALOX12	1	ALOX12 [cytosol] (R-HSA-2142768)	0.508	4
UniProt:Q8NC56 LEMD2	1	LEMD2 [nuclear envelope] (R-HSA-3067329)	0.491	2
UniProt:Q9H2H8 PPIL3	1	PPIL3 [nucleoplasm] (R-HSA-8952110)	0.483	2
UniProt:O75937 DNAJC8	1	DNAJC8 [nucleoplasm] (R-HSA-53703)	0.483	3
UniProt:Q8WXH0-1 SYNE2			0.463	3

Cite Us!