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Computational inferred events
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RAC1
Stable Identifier
R-HSA-6804770
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
secretory granule membrane
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of secretory granule membrane proteins (Homo sapiens)
Secretory granule membrane proteins [secretory granule membrane] (Homo sapiens)
RAC1 [secretory granule membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P63000 RAC1
Gene Names
RAC1, TC25, MIG5
Chain
chain:1-189, propeptide:190-192
Reference Genes
BioGPS Gene:5879 RAC1
COSMIC (genes):RAC1 RAC1
CTD Gene:5879 RAC1
dbSNP Gene:5879 RAC1
ENSEMBL:ENSG00000136238 RAC1
HGNC:9801 RAC1
KEGG Gene (Homo sapiens):hsa:5879 RAC1
Monarch:5879 RAC1
NCBI Gene:5879 RAC1
OMIM:602048 RAC1
UCSC:P63000 RAC1
Reference Transcript
RefSeq:NM_018890.3 RAC1
RefSeq:NM_006908.4 RAC1
Other Identifiers
0002850037
0004060369
11715576_at
11715577_x_at
11715578_s_at
11725303_a_at
11725304_s_at
11753603_s_at
1567458_3p_s_at
1567458_s_at
17043405
1E96
1FOE
1G4U
1HE1
1HH4
1I4D
1I4L
1I4T
1MH1
1RYF
1RYH
2050_s_at
208640_at
208641_s_at
2FJU
2H7V
2NZ8
2P2L
2RMK
2VRW
2WKP
2WKQ
2WKR
2YIN
35994
3B13
3BJI
3RYT
3SBD
3SBE
3SU8
3SUA
3TH5
40864_at
47820
4GZL
4GZM
4YON
5879
5FI0
5HZH
5O33
8180341
8180342
8180343
A4D2P0
A4D2P1
A_23_P215406
A_32_P217709
AAA36537
AAA36544
AAD30547
AAH04247
AAH50687
AAI07749
AAM21111
AAP35785
AAQ16632
AAS07511
AAS07512
AAZ80485
AB451238
AB451363
AC009412
AF136373
AF498964
AJ132694
AJ132695
AK054993
AK291806
AK291815
AY279384
BAF84495
BAF84504
BAG51447
BAG70052
BAG70177
BC004247
BC050687
BC107748
BT007121
CAA10732
CAA10733
CAB035994
CAB53579
CCDS5348
CCDS5349
CH236963
CH878731
D25274_at
DQ165078
EAL23718
EAL23719
EAW55039
EAW55044
ENSG00000136238
ENSP00000258737
ENSP00000348461
ENST00000348035
ENST00000356142
EntrezGene:5879
g13279010_3p_a_at
GE57124
GE79176
GO:0000139
GO:0000166
GO:0000902
GO:0001934
GO:0002376
GO:0002551
GO:0003674
GO:0003924
GO:0004674
GO:0005515
GO:0005525
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005737
GO:0005783
GO:0005789
GO:0005794
GO:0005802
GO:0005829
GO:0005856
GO:0005884
GO:0005886
GO:0005925
GO:0006259
GO:0006461
GO:0006464
GO:0006468
GO:0006810
GO:0006928
GO:0006935
GO:0006950
GO:0006954
GO:0007010
GO:0007015
GO:0007155
GO:0007160
GO:0007165
GO:0007264
GO:0007267
GO:0007596
GO:0008150
GO:0008219
GO:0008283
GO:0008361
GO:0009058
GO:0009611
GO:0009653
GO:0010310
GO:0010591
GO:0010592
GO:0010811
GO:0016020
GO:0016192
GO:0016301
GO:0016601
GO:0017137
GO:0019899
GO:0019901
GO:0022607
GO:0030027
GO:0030032
GO:0030036
GO:0030041
GO:0030154
GO:0030168
GO:0030334
GO:0030667
GO:0031012
GO:0031116
GO:0031295
GO:0031410
GO:0031529
GO:0031996
GO:0032707
GO:0034330
GO:0034446
GO:0034641
GO:0035025
GO:0035556
GO:0036464
GO:0038095
GO:0038096
GO:0040011
GO:0042470
GO:0042592
GO:0042826
GO:0043065
GO:0043167
GO:0043197
GO:0043226
GO:0043312
GO:0044403
GO:0045453
GO:0045740
GO:0048010
GO:0048012
GO:0048013
GO:0048261
GO:0048856
GO:0048870
GO:0050690
GO:0051022
GO:0051056
GO:0051117
GO:0051492
GO:0051496
GO:0051668
GO:0051894
GO:0060071
GO:0060263
GO:0065003
GO:0070062
GO:0071260
GO:0071526
GO:0090023
GO:0101003
GO:1900026
HGNC:9801
HPA047820
Hs.173737.0.A2_3p_at
Hs2.413489.1.S1_3p_s_at
ILMN_1652445
ILMN_2359789
IPR001806
IPR005225
IPR027417
M29870
M31467
MIM:602048
NM_006908
NM_018890
NP_008839
NP_061485
PF00071
PH_hs_0033233
PR00449
RAC1
RAC1-201
RAC1-202
SM00173
SM00174
SM00175
TC04001163.hg
TC07000065.hg
uc003spw.4
uc003spx.4
UPI000000060F
UPI000002B20E
Participant Of
hasMember
Secretory granule membrane proteins [secretory granule membrane]
Other forms of this molecule
RAC1 [ficolin-1-rich granule membrane]
RAC1 [endoplasmic reticulum membrane]
GGC-PalmC-RAC1 [plasma membrane]
RAC1 [plasma membrane]
RAC1 [cytosol]
Inferred To
Homologues of RAC1 [secretory granule membrane] (Caenorhabditis elegans)
Homologues of RAC1 [secretory granule membrane] (Canis familiaris)
Homologues of RAC1 [secretory granule membrane] (Dictyostelium discoideum)
Homologues of RAC1 [secretory granule membrane] (Drosophila melanogaster)
Homologues of RAC1 [secretory granule membrane] (Gallus gallus)
Homologues of RAC1 [secretory granule membrane] (Oryza sativa)
RAC1 [secretory granule membrane] (Bos taurus)
RAC1 [secretory granule membrane] (Caenorhabditis elegans)
RAC1 [secretory granule membrane] (Canis familiaris)
RAC1 [secretory granule membrane] (Danio rerio)
RAC1 [secretory granule membrane] (Dictyostelium discoideum)
RAC1 [secretory granule membrane] (Drosophila melanogaster)
RAC1 [secretory granule membrane] (Gallus gallus)
RAC1 [secretory granule membrane] (Mus musculus)
RAC1 [secretory granule membrane] (Oryza sativa)
RAC1 [secretory granule membrane] (Rattus norvegicus)
RAC1 [secretory granule membrane] (Saccharomyces cerevisiae)
RAC1 [secretory granule membrane] (Sus scrofa)
RAC1 [secretory granule membrane] (Taeniopygia guttata)
RAC1 [secretory granule membrane] (Xenopus tropicalis)
Cross References
RefSeq
NP_061485.1
,
NP_008839.2
Brenda
3.6.5.2
GeneCards
P63000
ZINC - Substances
RAC1_HUMAN
DOCK Blaster
5HZH
,
2WKP
,
2WKQ
,
4GZL
,
2WKR
,
4GZM
,
1I4D
,
1MH1
,
1I4T
,
1I4L
,
1RYF
,
4YON
,
1HE1
,
1E96
,
1G4U
,
3TH5
,
3B13
,
1RYH
,
2YIN
,
3RYT
,
2H7V
,
1HH4
,
3SBE
,
3SBD
,
2FJU
,
3BJI
,
3SU8
,
3SUA
,
2P2L
,
2NZ8
,
5FI0
,
2VRW
,
1FOE
ZINC target
P63000
PRO
P63000
ZINC - Predictions - Purchasable
RAC1_HUMAN
Orphanet
24845
HMDB Protein
HMDBP01778
PDB
1I4T
,
1I4L
,
3SBD
,
3SBE
,
1MH1
,
3SU8
,
3SUA
,
1RYF
,
1RYH
,
2WKR
,
1G4U
,
2YIN
,
1HE1
,
3B13
,
1HH4
,
1I4D
,
3BJI
,
3RYT
,
5HZH
,
5FI0
,
2NZ8
,
2P2L
,
4YON
,
4GZM
,
2H7V
,
2FJU
,
4GZL
,
3TH5
,
1FOE
,
2WKQ
,
1E96
,
6BC1
,
2WKP
,
2VRW
,
5O33
,
5N6O
,
2RMK
Interactors (54)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13153 PAK1
5
p-S144,T423-PAK1 [plasma membrane]
(R-HSA-3928472)
PAK1 [plasma membrane]
(R-HSA-3928409)
p-S144-PAK1 [cytosol]
(R-HSA-451339)
PAK1 [cytosol]
(R-HSA-162629)
p-S144,T423-PAK1 [cytosol]
(R-HSA-399819)
0.976
27
UniProt:P52565 ARHGDIA
1
ARHGDIA [cytosol]
(R-HSA-194478)
0.919
9
UniProt:P53365 ARFIP2
1
ARFIP2 [cytosol]
(R-HSA-6813848)
0.818
9
UniProt:Q13177 PAK2
11
p-S141,T402-PAK2 [cytosol]
(R-HSA-399824)
PAK2(1-524) [plasma membrane]
(R-HSA-164946)
PAK2 [cytosol]
(R-HSA-211604)
p-5S-PAK2 [cytosol]
(R-HSA-211609)
PAK2(213-524) [cytosol]
(R-HSA-211653)
p-5S-PAK2(2-212) [cytosol]
(R-HSA-211588)
p-T402-PAK2(213-524) [cytosol]
(R-HSA-211654)
p-T402-PAK2(213-524) [nucleoplasm]
(R-HSA-211709)
K48polyUb-p-T402-PAK-2p43 [cytosol]
(R-HSA-3095873)
p-Y130,S141,T402-PAK2 [cytosol]
(R-HSA-5218705)
p-S141,T402-PAK2 [plasma membrane]
(R-HSA-5096524)
0.78
4
UniProt:P46940 IQGAP1
3
IQGAP1 [secretory granule membrane]
(R-HSA-6804803)
IQGAP1 [cytosol]
(R-HSA-5626371)
IQGAP1 [plasma membrane]
(R-HSA-381681)
0.78
5
UniProt:Q14185 DOCK1
1
DOCK1 [cytosol]
(R-HSA-372654)
0.734
10
UniProt:Q9UQB8 BAIAP2
1
BAIAP2 [cytosol]
(R-HSA-442574)
0.728
4
UniProt:Q01105 SET
1
SET [nucleoplasm]
(R-HSA-451201)
0.684
8
UniProt:Q14155 ARHGEF7
1
ARHGEF7 [cytosol]
(R-HSA-430346)
0.676
8
UniProt:P19878 NCF2
2
NCF2 [cytosol]
(R-HSA-1222600)
p-T233-NCF2 [phagolysosome]
(R-HSA-1996211)
0.658
3
UniProt:P19174 PLCG1
6
p-Y771,Y783,Y1254-PLCG1 [cytosol]
(R-HSA-202357)
p-4Y-PLCG1 [plasma membrane]
(R-HSA-167679)
PLCG1 [cytosol]
(R-HSA-202320)
p-Y771,Y783-PLCG1 [plasma membrane]
(R-HSA-1169084)
PLCG1 [plasma membrane]
(R-HSA-167682)
p-Y-PLCG1 [plasma membrane]
(R-HSA-593686)
0.639
7
UniProt:Q98PK8 Q98PK8
0.628
5
UniProt:P52757 CHN2
1
CHN2 [cytosol]
(R-HSA-2980572)
0.61
4
GTP [ChEBI:15996]
14
GTP [early endosome membrane]
(R-ALL-2130170)
GTP [cilium]
(R-ALL-5617813)
GTP [ER to Golgi transport vesicle membrane]
(R-ALL-983318)
GTP [lysosomal membrane]
(R-ALL-2213216)
GTP [platelet dense granule lumen]
(R-ALL-114625)
GTP [cytoplasmic vesicle membrane]
(R-ALL-1996291)
GTP [Golgi membrane]
(R-ALL-1806221)
GTP [extracellular region]
(R-ALL-114626)
GTP [Golgi lumen]
(R-ALL-8851242)
GTP [endocytic vesicle lumen]
(R-ALL-8851508)
GTP [endosome]
(R-ALL-190071)
GTP [mitochondrial matrix]
(R-ALL-113573)
GTP [cytosol]
(R-ALL-29438)
GTP [nucleoplasm]
(R-ALL-113571)
0.609
2
UniProt:Q7Z6J0 SH3RF1
1
SH3RF1 [cytosol]
(R-HSA-5688968)
0.592
2
UniProt:P98170 XIAP
3
XIAP [nucleoplasm]
(R-HSA-3322366)
K48pUb-XIAP [cytosol]
(R-HSA-5675477)
XIAP [cytosol]
(R-HSA-50849)
0.591
3
UniProt:Q92608 DOCK2
3
DOCK2 [extracellular region]
(R-HSA-6806310)
DOCK2 [specific granule lumen]
(R-HSA-6799558)
DOCK2 [cytosol]
(R-HSA-200938)
0.589
3
UniProt:Q92619 ARHGAP45
4
HMHA1 [secretory granule lumen]
(R-HSA-6800902)
HMHA1 [cytosol]
(R-HSA-200621)
HMHA1 [extracellular region]
(R-HSA-6806219)
HMHA1 [azurophil granule lumen]
(R-HSA-6799228)
0.571
3
UniProt:Q9BYG5 PARD6B
2
PARD6B [cytosol]
(R-HSA-419973)
PARD6B [plasma membrane]
(R-HSA-418193)
0.567
3
UniProt:Q92556 ELMO1
1
ELMO1 [cytosol]
(R-HSA-200932)
0.564
4
UniProt:P15498 VAV1
4
p-Y174-VAV1 [cytosol]
(R-HSA-437946)
p-Y142,Y160,Y174-VAV1 [plasma membrane]
(R-HSA-389323)
VAV1 [cytosol]
(R-HSA-195066)
VAV1 [plasma membrane]
(R-HSA-1045153)
0.558
2
UniProt:Q01968 OCRL
4
OCRL [cytoplasmic vesicle membrane]
(R-HSA-434214)
OCRL [Golgi membrane]
(R-HSA-434339)
OCRL [plasma membrane]
(R-HSA-3769049)
OCRL [cytosol]
(R-HSA-1806196)
0.556
3
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.556
5
UniProt:Q9Y6N9 USH1C
0.556
3
UniProt:Q9UJX2 CDC23
2
CDC23 [cytosol]
(R-HSA-174137)
CDC23 [nucleoplasm]
(R-HSA-174228)
0.556
3
UniProt:Q6A162 KRT40
1
KRT40 [cytosol]
(R-HSA-6809605)
0.556
3
UniProt:Q9BRK4 LZTS2
0.556
3
UniProt:P41743 PRKCI
3
PRKCI [cytosol]
(R-HSA-58206)
PRKCI [nucleoplasm]
(R-HSA-9021345)
PRKCI [plasma membrane]
(R-HSA-420005)
0.548
3
UniProt:Q53QZ3 ARHGAP15
1
ARHGAP15 [cytosol]
(R-HSA-195145)
0.544
2
UniProt:Q8TEJ3 SH3R3
0.544
6
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:P48039 MTNR1A
1
MTNR1A [plasma membrane]
(R-HSA-419316)
0.527
2
UniProt:Q13490 BIRC2
5
K48pUb-BIRC2 [cytosol]
(R-HSA-5675479)
K63polyUb-BIRC2 [cytosol]
(R-HSA-5668512)
BIRC2(1-372) [cytosol]
(R-HSA-202913)
BIRC2(373-618) [cytosol]
(R-HSA-202931)
BIRC2 [cytosol]
(R-HSA-50847)
0.525
2
UniProt:Q6P589 TNFAIP8L2
1
TNFAIP8L2 [cytosol]
(R-HSA-8874472)
0.524
2
UniProt:O75914 PAK3
3
p-S154,T436-PAK3 [cytosol]
(R-HSA-5357471)
p-S154,T436-PAK3 [plasma membrane]
(R-HSA-3928479)
PAK3 [cytosol]
(R-HSA-428457)
0.524
2
UniProt:P09669 COX6C
1
COX6C(3-75) [mitochondrial inner membrane]
(R-HSA-164298)
0.508
2
UniProt:Q13576 IQGAP2
3
IQGAP2 [secretory granule membrane]
(R-HSA-6804779)
IQGAP2 [plasma membrane]
(R-HSA-6804811)
IQGAP2 [cytosol]
(R-HSA-5625975)
0.508
2
UniProt:Q9BYG4 PARD6G
2
PARD6G [cytosol]
(R-HSA-419967)
PARD6G [plasma membrane]
(R-HSA-418192)
0.508
2
UniProt:P42704 LRPPRC
1
LRPPRC [mitochondrial matrix]
(R-HSA-5336174)
0.508
2
UniProt:P60660 MYL6
2
MYL6 [cytosol]
(R-HSA-419186)
p-S20-MYL6 [cytosol]
(R-HSA-445778)
0.508
2
UniProt:Q86VI3 IQGAP3
1
IQGAP3 [cytosol]
(R-HSA-5625977)
0.508
2
UniProt:P14649 MYL6B
2
p-S20-MYL6B [cytosol]
(R-HSA-445763)
MYL6B [cytosol]
(R-HSA-445776)
0.508
2
UniProt:Q9NPB6 PARD6A
4
PARD6A [cell junction]
(R-HSA-2134480)
PARD6A [plasma membrane]
(R-HSA-418187)
p-S345-PARD6A [plasma membrane]
(R-HSA-2134533)
PARD6A [cytosol]
(R-HSA-420001)
0.508
2
UniProt:P62158 CALM
0.508
2
UniProt:P27105 STOM
4
STOM [specific granule membrane]
(R-HSA-6799569)
STOM [azurophil granule membrane]
(R-HSA-6800997)
STOM [plasma membrane]
(R-HSA-6806258)
STOM [tertiary granule membrane]
(R-HSA-6800960)
0.508
2
UniProt:Q9H9P5 UNKL
1
UNKL [cytosol]
(R-HSA-8850900)
0.508
2
UniProt:Q03135 CAV1
5
CAV1 [early endosome membrane]
(R-HSA-5368451)
CAV1 [plasma membrane]
(R-HSA-534994)
CAV1 [lipid droplet]
(R-HSA-163510)
CAV1 [endocytic vesicle membrane]
(R-HSA-535009)
CAV1 [Golgi membrane]
(R-HSA-204504)
0.499
2
UniProt:O75369 FLNB
1
FLNB [cytosol]
(R-HSA-354163)
0.499
2
UniProt:Q99750 MDFI
0.488
2
UniProt:Q8N9S9-2 SNX31
0.488
2
IntAct:EBI-11958010 KRTAP10-3
0.488
2
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [ChEBI:18348]
6
PI(4,5)P2 [endoplasmic reticulum membrane]
(R-ALL-2023856)
PI(4,5)P2 [plasma membrane]
(R-ALL-179856)
PI(4,5)P2 [nucleoplasm]
(R-ALL-6810412)
PI(4,5)P2 [Golgi membrane]
(R-ALL-1806165)
PI(4,5)P2 [cytoplasmic vesicle membrane]
(R-ALL-8874467)
PI(4,5)P2 [early endosome membrane]
(R-ALL-8849966)
0.462
2
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate [ChEBI:16851]
7
PI(3,5)P2 [Golgi membrane]
(R-ALL-1806290)
PI(3,5)P2 [plasma membrane]
(R-ALL-1806224)
PI(3,5)P2 [early endosome membrane]
(R-ALL-1806205)
PI(3,5)P2 [late endosome membrane]
(R-ALL-1806289)
PI(3,5)P2 [phagophore assembly site membrane]
(R-ALL-5692959)
PI(3,5)P2 [endoplasmic reticulum membrane]
(R-ALL-6809774)
PI(3,5)P2 [lysosomal membrane]
(R-ALL-5334668)
0.462
2
UniProt:P27986 PIK3R1
15
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [cytosol]
(R-HSA-74789)
PIK3R1 [plasma membrane]
(R-HSA-198365)
0.462
5
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