Reactome | RAC1 [secretory granule membrane]

RAC1 [secretory granule membrane]

Stable Identifier

R-HSA-6804770

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

secretory granule membrane

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External Reference Information

External Reference

UniProt:P63000 RAC1

Gene Names

RAC1, TC25, MIG5

Chain

chain:1-189, propeptide:190-192

Reference Genes

BioGPS Gene:5879 RAC1

COSMIC (genes):RAC1 RAC1

CTD Gene:5879 RAC1

dbSNP Gene:5879 RAC1

ENSEMBL:ENSG00000136238.19 RAC1

ENSEMBL:ENSG00000136238.20 RAC1

HGNC:9801 RAC1

KEGG Gene (Homo sapiens):5879 RAC1

Monarch:5879 RAC1

NCBI Gene:5879 RAC1

OMIM:602048 RAC1

UCSC:P63000 RAC1

Reference Transcript

Other Identifiers

11715576_at

11715577_x_at

11715578_s_at

11725303_a_at

11725304_s_at

11753603_s_at

1567458_3p_s_at

1567458_PM_s_at

1567458_s_at

17043405

2050_s_at

208640_PM_at

208640_at

208641_PM_s_at

208641_s_at

2768033

2768035

2768036

2768037

2768038

2780942

2989052

2989053

2989054

2989055

2989057

2989061

2989062

2989068

2989070

2989073

2989076

2989077

2989078

2989079

40864_at

5879

8131406

8180341

8180342

8180343

A_23_P215406

A_32_P217709

D25274_at

GE57124

GE79176

GO:0000166

GO:0001764

GO:0001934

GO:0002376

GO:0003376

GO:0003824

GO:0003924

GO:0003925

GO:0005515

GO:0005525

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005768

GO:0005783

GO:0005789

GO:0005794

GO:0005802

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0005925

GO:0005938

GO:0006954

GO:0007010

GO:0007015

GO:0007155

GO:0007160

GO:0007163

GO:0007264

GO:0008045

GO:0008360

GO:0008361

GO:0009611

GO:0009653

GO:0010310

GO:0010591

GO:0010592

GO:0010595

GO:0010764

GO:0010811

GO:0016020

GO:0016192

GO:0016477

GO:0016601

GO:0016787

GO:0019899

GO:0019901

GO:0023052

GO:0030027

GO:0030031

GO:0030032

GO:0030036

GO:0030041

GO:0030154

GO:0030334

GO:0030425

GO:0030667

GO:0030865

GO:0031116

GO:0031234

GO:0031410

GO:0031529

GO:0031996

GO:0032587

GO:0032707

GO:0032956

GO:0034330

GO:0034446

GO:0035025

GO:0035556

GO:0036211

GO:0036464

GO:0042470

GO:0042995

GO:0043020

GO:0043197

GO:0043226

GO:0043652

GO:0044877

GO:0045202

GO:0045428

GO:0045730

GO:0048012

GO:0048261

GO:0048856

GO:0048870

GO:0051022

GO:0051179

GO:0051492

GO:0051496

GO:0051668

GO:0051894

GO:0055038

GO:0060071

GO:0060090

GO:0060263

GO:0061024

GO:0065003

GO:0070062

GO:0071526

GO:0090023

GO:0097178

GO:0098772

GO:0098794

GO:0098978

GO:0101003

GO:1900026

GO:1902622

HMNXSV003046675

Hs.173737.0.A2_3p_at

Hs2.413489.1.S1_3p_s_at

ILMN_1652445

ILMN_2359789

PH_hs_0033233

TC04001163.hg

TC07000065.hg

g13279010_3p_a_at

Participates

as a member of

Secretory granule membrane proteins [secretory granule membrane] (Homo sapiens)

Other forms of this molecule

GGC-PalmC-RAC1 [plasma membrane]

RAC1 [ficolin-1-rich granule membrane]

RAC1 [endoplasmic reticulum membrane]

RAC1 [cytosol]

RAC1 [plasma membrane]

Inferred To

cRac1A [secretory granule membrane] (Gallus gallus)

rac1 [secretory granule membrane] (Danio rerio)

rac1 [secretory granule membrane] (Xenopus tropicalis)

RAC1 [secretory granule membrane] (Bos taurus)

RAC1 [secretory granule membrane] (Caenorhabditis elegans)

RAC1 [secretory granule membrane] (Canis familiaris)

RAC1 [secretory granule membrane] (Dictyostelium discoideum)

RAC1 [secretory granule membrane] (Drosophila melanogaster)

RAC1 [secretory granule membrane] (Mus musculus)

RAC1 [secretory granule membrane] (Rattus norvegicus)

RAC1 [secretory granule membrane] (Saccharomyces cerevisiae)

RAC1 [secretory granule membrane] (Sus scrofa)

Cross References

RefSeq

NP_061485.1, NP_008839.2

OpenTargets

ENSG00000136238

ZINC - Substances

RAC1_HUMAN

ZINC target

P63000

ZINC - Biogenic

RAC1_HUMAN

PRO

P63000

PDB

7AJK, 3SU8, 5N6O, 7SJ4, 2H7V, 5QQE, 3SUA, 5QQN, 7DPA, 5QQD, 1G4U, 3RYT, 1I4T, 2WKR, 5QQH, 4YON, 2WKQ, 5QQG, 1HH4, 6AGP, 3SBD, 1E96, 1FOE, 5QQJ, 6X1G, 5QQI, 2P2L, 2VRW, 2FJU, 5QQM, 1I4D, 5QQL, 2RMK, 1HE1, 5QU9, 3SBE, 3TH5, 5QQK, 5QQF, 2WKP, 1I4L, 5O33, 7USD, 3BJI, 5HZH, 7USE, 6TGC, 6BC1, 1RYF, 2YIN, 5FI0, 4GZM, 4GZL, 3B13, 1MH1, 2NZ8, 1RYH

HPA

ENSG00000136238-RAC1

GeneCards

P63000

Ensembl

ENST00000348035, ENSP00000258737, ENST00000356142, ENSG00000136238, ENSP00000348461

Pharos - Targets

P63000

ZINC - Predictions - Purchasable

RAC1_HUMAN

Orphanet

24845

HMDB Protein

HMDBP01778

Interactors (78)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13153 PAK1	6	Active PAK1 [cytosol] (R-HSA-8964622) p-S144-PAK1 [cytosol] (R-HSA-451339) PAK1 [plasma membrane] (R-HSA-3928409) p-S144,T423-PAK1 [plasma membrane] (R-HSA-3928472) PAK1 [cytosol] (R-HSA-162629) p-S144,T423-PAK1 [cytosol] (R-HSA-399819)	0.976	27
UniProt:P52565 ARHGDIA	1	ARHGDIA [cytosol] (R-HSA-194478)	0.927	11
UniProt:P53365 ARFIP2	1	ARFIP2 [cytosol] (R-HSA-6813848)	0.911	13
UniProt:P46940 IQGAP1	3	IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [plasma membrane] (R-HSA-381681)	0.893	11
UniProt:Q13177 PAK2	11	PAK2(1-524) [plasma membrane] (R-HSA-164946) p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) PAK2(213-524) [cytosol] (R-HSA-211653) p-S141,T402-PAK2 [cytosol] (R-HSA-399824) PAK2 [cytosol] (R-HSA-211604) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) p-5S-PAK2 [cytosol] (R-HSA-211609)	0.831	5
UniProt:Q14185 DOCK1	1	DOCK1 [cytosol] (R-HSA-372654)	0.734	10
UniProt:Q9UQB8 BAIAP2	1	BAIAP2 [cytosol] (R-HSA-442574)	0.728	4
UniProt:Q01105 SET	1	SET [nucleoplasm] (R-HSA-451201)	0.684	8
UniProt:Q14155 ARHGEF7	1	ARHGEF7 [cytosol] (R-HSA-430346)	0.676	8
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.666	5
UniProt:P19878 NCF2	2	NCF2 [cytosol] (R-HSA-1222600) p-T233-NCF2 [phagolysosome] (R-HSA-1996211)	0.658	3
UniProt:Q03135 CAV1	5	CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [early endosome membrane] (R-HSA-5368451) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [endocytic vesicle membrane] (R-HSA-535009)	0.641	3
UniProt:P19174 PLCG1	6	p-Y-PLCG1 [cytosol] (R-HSA-9029082) p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [plasma membrane] (R-HSA-167682) PLCG1 [cytosol] (R-HSA-202320) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084)	0.639	7
UniProt:Q92963 RIT1	1	RIT1 [plasma membrane] (R-HSA-187703)	0.619	5
UniProt:Q8IYU2 HACE1	1	HACE1 [cytosol] (R-HSA-8851654)	0.619	5
GTP [ChEBI:15996]	7	GTP [cilium] (R-ALL-5617813) GTP [early endosome membrane] (R-ALL-2130170) GTP [lysosomal membrane] (R-ALL-2213216) GTP [platelet dense granule lumen] (R-ALL-114625) GTP [cytoplasmic vesicle membrane] (R-ALL-1996291) GTP [ER to Golgi transport vesicle membrane] (R-ALL-983318) GTP [Golgi membrane] (R-ALL-1806221)	0.609	2
UniProt:Q98PK8 Q98PK8			0.607	5
UniProt:Q8WUI4-6 HDAC7			0.601	4
UniProt:Q7Z6J0 SH3RF1	1	SH3RF1 [cytosol] (R-HSA-5688968)	0.592	2
UniProt:P98170 XIAP	3	K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [nucleoplasm] (R-HSA-3322366) XIAP [cytosol] (R-HSA-50849)	0.591	3
UniProt:Q92608 DOCK2	3	DOCK2 [specific granule lumen] (R-HSA-6799558) DOCK2 [extracellular region] (R-HSA-6806310) DOCK2 [cytosol] (R-HSA-200938)	0.589	3
UniProt:P52757 CHN2	1	CHN2 [cytosol] (R-HSA-2980572)	0.589	4
UniProt:Q92619 ARHGAP45	4	HMHA1 [cytosol] (R-HSA-200621) HMHA1 [azurophil granule lumen] (R-HSA-6799228) HMHA1 [extracellular region] (R-HSA-6806219) HMHA1 [secretory granule lumen] (R-HSA-6800902)	0.571	3
UniProt:Q9BYG5 PARD6B	2	PARD6B [plasma membrane] (R-HSA-418193) PARD6B [cytosol] (R-HSA-419973)	0.567	3
UniProt:Q92556 ELMO1	1	ELMO1 [cytosol] (R-HSA-200932)	0.564	4
UniProt:P15498 VAV1	5	VAV1 [plasma membrane] (R-HSA-1045153) VAV1 [cytosol] (R-HSA-195066) p-Y174-VAV1 [cytosol] (R-HSA-437946) p-Y142,Y160,Y174-VAV1 [plasma membrane] (R-HSA-389323) p-Y-VAV1 [cytosol] (R-HSA-9029087)	0.558	2
UniProt:Q99750 MDFI			0.556	3
UniProt:Q8WTV1 THAP3			0.556	3
UniProt:P04271 S100B	1	S100B [extracellular region] (R-HSA-879433)	0.556	3
UniProt:Q01968 OCRL	4	OCRL [Golgi membrane] (R-HSA-434339) OCRL [cytoplasmic vesicle membrane] (R-HSA-434214) OCRL [plasma membrane] (R-HSA-3769049) OCRL [cytosol] (R-HSA-1806196)	0.556	3
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.556	5
UniProt:Q9Y6N9 USH1C	1	USH1C [cytosol] (R-HSA-9658864)	0.556	3
UniProt:P27986-2 PIK3R1			0.556	3
UniProt:O60784-2 TOM1			0.556	3
UniProt:P43405-2 P434052			0.556	3
UniProt:Q9UBQ0-2 VPS29			0.556	3
UniProt:Q96JM7-2 L3MBTL3			0.556	3
UniProt:P41227 NAA10			0.556	3
UniProt:Q8N5Z5 KCD17			0.556	3
UniProt:Q9BVJ6 UTP14A	1	UTP14A [nucleoplasm] (R-HSA-6790695)	0.556	3
UniProt:Q9UHV9 PFDN2	1	PFDN2 [cytosol] (R-HSA-379544)	0.556	3
UniProt:Q9UJX2 CDC23	2	CDC23 [cytosol] (R-HSA-174137) CDC23 [nucleoplasm] (R-HSA-174228)	0.556	3
UniProt:Q13387-4 MAPK8IP2			0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q06547-2 GABPB1	1	NRF2 beta-2 subunit [nucleoplasm] (R-HSA-1592200)	0.556	3
UniProt:P00491 PNP	7	PNP R234P [cytosol] (R-HSA-9735772) PNP E89K [cytosol] (R-HSA-9735781) PNP D128G [cytosol] (R-HSA-9735785) PNP [cytosol] (R-HSA-61933) PNP [secretory granule lumen] (R-HSA-6803318) PNP [extracellular region] (R-HSA-6806505) PNP [ficolin-1-rich granule lumen] (R-HSA-6803278)	0.556	3
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:Q9BRK4 LZTS2			0.556	3
IntAct:EBI-25834291 CCSB			0.556	3
UniProt:Q14457 BECN1	3	K63polyUb-BECN1 [cytosol] (R-HSA-6782989) p-S15-BECN1 [cytosol] (R-HSA-5682391) BECN1 [cytosol] (R-HSA-1632841)	0.556	3
UniProt:Q9NY61 AATF	1	AATF [cytosol] (R-HSA-205071)	0.556	3
UniProt:P41743 PRKCI	3	PRKCI [nucleoplasm] (R-HSA-9021345) PRKCI [cytosol] (R-HSA-58206) PRKCI [plasma membrane] (R-HSA-420005)	0.548	3
UniProt:P52306 RAP1GDS1	1	RAP1GDS1 [mitochondrial outer membrane] (R-HSA-9693756)	0.547	2
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130)	0.547	2
UniProt:Q53QZ3 ARHGAP15	1	ARHGAP15 [cytosol] (R-HSA-195145)	0.544	2
UniProt:Q8TEJ3 SH3R3			0.544	6
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P48039 MTNR1A	1	MTNR1A [plasma membrane] (R-HSA-419316)	0.527	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	9
UniProt:Q13490 BIRC2	5	K63polyUb-BIRC2 [cytosol] (R-HSA-5668512) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2(1-372) [cytosol] (R-HSA-202913) BIRC2(373-618) [cytosol] (R-HSA-202931) BIRC2 [cytosol] (R-HSA-50847)	0.525	2
UniProt:Q6P589 TNFAIP8L2	1	TNFAIP8L2 [cytosol] (R-HSA-8874472)	0.524	2
UniProt:P09669 COX6C	1	COX6C(3-75) [mitochondrial inner membrane] (R-HSA-164298)	0.508	2
UniProt:Q13576 IQGAP2	3	IQGAP2 [cytosol] (R-HSA-5625975) IQGAP2 [plasma membrane] (R-HSA-6804811) IQGAP2 [secretory granule membrane] (R-HSA-6804779)	0.508	2
UniProt:Q9BYG4 PARD6G	2	PARD6G [plasma membrane] (R-HSA-418192) PARD6G [cytosol] (R-HSA-419967)	0.508	2
UniProt:P42704 LRPPRC	1	LRPPRC [mitochondrial matrix] (R-HSA-5336174)	0.508	2
UniProt:P60660 MYL6	2	p-S20-MYL6 [cytosol] (R-HSA-445778) MYL6 [cytosol] (R-HSA-419186)	0.508	2
UniProt:Q86VI3 IQGAP3	1	IQGAP3 [cytosol] (R-HSA-5625977)	0.508	2
UniProt:P14649 MYL6B	2	MYL6B [cytosol] (R-HSA-445776) p-S20-MYL6B [cytosol] (R-HSA-445763)	0.508	2
UniProt:Q9NPB6 PARD6A	4	PARD6A [plasma membrane] (R-HSA-418187) PARD6A [cytosol] (R-HSA-420001) PARD6A [cell junction] (R-HSA-2134480) p-S345-PARD6A [plasma membrane] (R-HSA-2134533)	0.508	2
UniProt:P62158 CALM			0.508	2
UniProt:P27105 STOM	4	STOM [azurophil granule membrane] (R-HSA-6800997) STOM [plasma membrane] (R-HSA-6806258) STOM [specific granule membrane] (R-HSA-6799569) STOM [tertiary granule membrane] (R-HSA-6800960)	0.508	2
UniProt:Q9H9P5 UNKL	1	UNKL [cytosol] (R-HSA-8850900)	0.508	2
UniProt:O75369 FLNB	1	FLNB [cytosol] (R-HSA-354163)	0.499	2
UniProt:Q8N9S9-2 SNX31			0.488	2
UniProt:O75914 PAK3	3	p-S154,T436-PAK3 [plasma membrane] (R-HSA-3928479) p-S154,T436-PAK3 [cytosol] (R-HSA-5357471) PAK3 [cytosol] (R-HSA-428457)	0.471	2
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE			0.462	2
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE			0.462	2
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.462	5

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