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PJA2 [cytosol]
Stable Identifier
R-HSA-975993
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin-protein ligase Praja-2, PJA2_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
PJA2 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
PJA2 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
PJA2 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
PJA2 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
PJA2 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
PJA2 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
PJA2 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
PJA2 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
PJA2 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
PJA2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43164 PJA2
Gene Names
PJA2, KIAA0438, RNF131
Chain
initiator methionine:, chain:2-708
Reference Genes
BioGPS Gene:9867 PJA2
COSMIC (genes):PJA2 PJA2
CTD Gene:9867 PJA2
dbSNP Gene:9867 PJA2
ENSEMBL:ENSG00000198961 PJA2
ENSEMBL_homo_sapiens_GENE:ENSG00000198961.10 PJA2
HGNC:17481 PJA2
KEGG Gene (Homo sapiens):9867 PJA2
Monarch:9867 PJA2
NCBI Gene:9867 PJA2
OMIM:619341 PJA2
UCSC:O43164 PJA2
Reference Transcript
RefSeq:XM_017010099.1 PJA2
RefSeq:NM_014819.4 PJA2
Other Identifiers
11719112_s_at
11719113_a_at
11719114_a_at
16998727
201133_PM_s_at
201133_s_at
2870403
2870404
2870405
2870408
2870409
2870413
2870414
2870415
2870416
2870417
2870419
2870420
2870421
2870427
33340_at
8113469
9867
A_23_P133470
GE81959
GO:0000139
GO:0002376
GO:0003824
GO:0004842
GO:0005515
GO:0005737
GO:0005783
GO:0005789
GO:0005794
GO:0005813
GO:0005815
GO:0005856
GO:0005886
GO:0005929
GO:0006954
GO:0007616
GO:0010738
GO:0014069
GO:0016020
GO:0016567
GO:0016740
GO:0023052
GO:0030163
GO:0034137
GO:0034236
GO:0034237
GO:0034451
GO:0036064
GO:0036211
GO:0043030
GO:0043161
GO:0043226
GO:0045087
GO:0045111
GO:0045202
GO:0046330
GO:0046872
GO:0050877
GO:0061630
GO:0098542
GO:0140096
GO:1900745
HMNXSV003039227
Hs.279849.0.S1_3p_a_at
ILMN_1688702
PH_hs_0023135
TC05001664.hg
Participates
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
Pja2 [cytosol]
(Mus musculus)
Pja2 [cytosol]
(Rattus norvegicus)
PJA2 [cytosol]
(Bos taurus)
PJA2 [cytosol]
(Canis familiaris)
PJA2 [cytosol]
(Dictyostelium discoideum)
PJA2 [cytosol]
(Gallus gallus)
PJA2 [cytosol]
(Sus scrofa)
Cross References
RefSeq
XP_016865588.1
,
NP_055634.3
OpenTargets
ENSG00000198961
GeneCards
O43164
HPA
ENSG00000198961-PJA2
Ensembl
ENSP00000355284
,
ENSG00000198961
,
ENSP00000354775
,
ENST00000361557
,
ENST00000361189
PRO
O43164
Pharos - Targets
O43164
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
6
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