Reactome  core curation, software development and outreach is supported by the National Institute of Health (U24HG012198, 2022-2027), the European Molecular Biology Laboratory and Open Targets (OTAR-006, 2015-2024). Additional NIH funding (U24HG011851, 2021-2026) is used to support the development of GO-CAM models, aligning the Gene Ontology and the Reactome data resources. Integration of Alliance of Genome Resources (AGR) and Uniprot data into the Reactome chatbot is supported by a Prototyping Award from York University.

Past funding:

Core Reactome activities have been supported by NIH grants U41HG003751 (2007-2022) and (2002-2006).

Development of the Reactome IDG (Illuminating the Druggable Genome) portal for pathway-based analysis and visualization of understudied proteins) was supported by NIH grant U01CA239069 (2019-2023). Improvements to Reactome’s TRUST-worthiness and Continuous Integration/Continuous Deployment (CI/CD) were supported by NIH supplementary grants U24HG12198-02S1 and U24HG12198-02S2, respectively. 

Rapid curation of the COVID-19 pathway was supported by NIH supplementary grant U41HG003751-13S1.

Development of tools to scale up biological pathway knowledge acquisition through text mining and crowdsourcing was supported by NIH supplementary grant U41HG003751-12S1.

Development of our cell lineage pathways was supported by a University of Toronto Medicine by Design Seed Fund (MbDNISF-2020-03).

Development of the Reactome GSA tool was supported by a grant from the European Union Marie Sklodowska-Curie Actions fund (2019).

Development of a Reactome portal for NURSA (Nuclear Receptor Signaling Atlas) was supported by NIH grant U24DK097748 (2017-2018).

Curation of neural stem cell signaling pathways was supported by a University of Toronto Medicine by Design grant (2016-2019).