Reactome | STIP1 [cytosol]

STIP1 [cytosol]

Stable Identifier

R-HSA-443857

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Stress-induced-phosphoprotein 1, STIP1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P31948 STIP1

Gene Names

STIP1

Chain

chain:1-543

Reference Genes

BioGPS Gene:10963 STIP1

COSMIC (genes):STIP1 STIP1

CTD Gene:10963 STIP1

dbSNP Gene:10963 STIP1

ENSEMBL:ENSG00000168439 STIP1

ENSEMBL_homo_sapiens_GENE:ENSG00000168439 STIP1

HGNC:11387 STIP1

KEGG Gene (Homo sapiens):10963 STIP1

Monarch:10963 STIP1

NCBI Gene:10963 STIP1

OMIM:605063 STIP1

UCSC:P31948 STIP1

Reference Transcript

Other Identifiers

0003780270

10963

11743041_a_at

11743042_a_at

16726224

17448

1ELR

1ELW

207_at

212009_s_at

213330_s_at

2LNI

2NC9

3334225

3334226

3334227

3334228

3334231

3334234

3334235

3334236

3334238

3334239

3334240

3334241

3334242

3334244

3334245

3334246

3334248

3334250

3334251

39291

3ESK

3FWV

4014309

4014313

44062

7940857

A_24_P327815

AAA58682

AAH02987

AAH39299

AAV38813

AAV38814

ACI46042

AK297319

AP005668

BAG59782

BC002987

BC039299

BT020010

BT020011

CAB017448

CAG38750

CCDS60827

CCDS60828

CCDS8058

CH471076

CR536512

EAW74196

EAW74197

EAW74198

ENSG00000168439

ENSP00000305958

ENSP00000351646

ENSP00000445957

ENST00000305218

ENST00000358794

ENST00000538945

EntrezGene:10963

F5GXD8

F5H783

FJ224350

GE58119

GO:0003674

GO:0003723

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005794

GO:0005829

GO:0008022

GO:0030544

GO:0032991

GO:0043209

GO:0043226

GO:0051087

GO:0051879

GO:0101031

H0YGI8

HGNC:11387

HPA039291

HPA044062

Hs.75612.1.A1_3p_a_at

Hs.75612.2.A1_3p_a_at

ILMN_1745906

ILMN_1789510

IPR006636

IPR011990

IPR013026

IPR013105

IPR019734

M86752

M86752_at

MIM:605063

NM_001282652

NM_001282653

NM_006819

NP_001269581

NP_001269582

NP_006810

PF07719

PF13181

PF13414

PF13424

PH_hs_0023292

SM00028

SM00727

STIP1

STIP1-201

STIP1-203

STIP1-207

TC11000585.hg

uc001nyk.2

uc010rnb.2

uc031xri.2

UPI000012D225

UPI00001FAA4C

UPI000204AE6B

V9HW72

Participant Of

input

STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein

output

hasComponent

Inferred To

STIP1_MOUSE [cytosol] (Mus musculus)

Ghost homologue of STIP1 [cytosol] (Taeniopygia guttata)

Homologues of STIP1 [cytosol] (Arabidopsis thaliana)

Homologues of STIP1 [cytosol] (Bos taurus)

Homologues of STIP1 [cytosol] (Danio rerio)

Homologues of STIP1 [cytosol] (Drosophila melanogaster)

Homologues of STIP1 [cytosol] (Oryza sativa)

STIP1 [cytosol] (Arabidopsis thaliana)

STIP1 [cytosol] (Bos taurus)

STIP1 [cytosol] (Caenorhabditis elegans)

STIP1 [cytosol] (Canis familiaris)

STIP1 [cytosol] (Danio rerio)

STIP1 [cytosol] (Dictyostelium discoideum)

STIP1 [cytosol] (Drosophila melanogaster)

STIP1 [cytosol] (Gallus gallus)

STIP1 [cytosol] (Oryza sativa)

STIP1 [cytosol] (Plasmodium falciparum)

STIP1 [cytosol] (Rattus norvegicus)

STIP1 [cytosol] (Saccharomyces cerevisiae)

STIP1 [cytosol] (Schizosaccharomyces pombe)

STIP1 [cytosol] (Sus scrofa)

STIP1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_006810.1, NP_001269582.1, NP_001269581.1

OpenTargets

ENSG00000168439

GeneCards

P31948

DOCK Blaster

3FWV, 3ESK, 1ELR, 1ELW

PRO

P31948

PDB

1ELW, 3ESK, 1ELR, 2LNI, 2NC9, 3FWV

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07900 HSP90AA1	7	HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864)	0.723	4
UniProt:P53041 PPP5C	2	PPP5C [nucleoplasm] (R-HSA-5683410) PPP5C [cytosol] (R-HSA-5675402)	0.623	4
UniProt:P04150 NR3C1	3	NR3C1 [cytosol] (R-HSA-5618118) SUMO1-K277,K293-NR3C1 [nucleoplasm] (R-HSA-4341106) NR3C1 [nucleoplasm] (R-HSA-879837)	0.61	5
UniProt:P08238 HSP90AB1	5	HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617)	0.59	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q96AP0 ACD	1	ACD [nucleoplasm] (R-HSA-174889)	0.508	2
UniProt:P00533 EGFR	58	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.508	2
UniProt:Q7L3B6 CDC37L1	2	CDC37L1 [platelet dense granule lumen] (R-HSA-8848903) CDC37L1 [extracellular region] (R-HSA-8848918)	0.499	2
UniProt:Q8IWD4 CC117			0.499	2