Reactome | STIP1 [cytosol]

STIP1

Stable Identifier

R-HSA-443857

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Stress-induced-phosphoprotein 1, STIP1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P31948 STIP1

Gene Names

STIP1

Chain

chain:1-543

Reference Genes

BioGPS Gene:10963 STIP1

COSMIC (genes):STIP1 STIP1

CTD Gene:10963 STIP1

dbSNP Gene:10963 STIP1

ENSEMBL:ENSG00000168439 STIP1

HGNC:11387 STIP1

KEGG Gene (Homo sapiens):hsa:10963 STIP1

Monarch:10963 STIP1

NCBI Gene:10963 STIP1

OMIM:605063 STIP1

UCSC:P31948 STIP1

Reference Transcript

Other Identifiers

0003780270

10963

11743041_a_at

11743042_a_at

16726224

17448

1ELR

1ELW

207_at

212009_s_at

213330_s_at

2LNI

2NC9

39291

3ESK

3FWV

44062

7940857

A_24_P327815

CAB017448

CCDS60827

CCDS60828

CCDS8058

ENSG00000168439

ENSP00000305958

ENSP00000351646

ENSP00000445957

ENST00000305218

ENST00000358794

ENST00000538945

EntrezGene:10963

GE58119

GO:0003723

GO:0005515

GO:0005634

GO:0005737

GO:0005794

GO:0005829

GO:0006950

GO:0008022

GO:0030544

GO:0043209

GO:0043234

GO:0051087

HGNC:11387

HPA039291

HPA044062

Hs.337295

Hs.618350

Hs.75612.1.A1_3p_a_at

Hs.75612.2.A1_3p_a_at

ILMN_1745906

ILMN_1789510

M86752_at

MIM:605063

NM_001282652

NM_001282653

NM_006819

NP_001269581

NP_001269582

NP_006810

PF07719

PF13181

PF13414

PF13424

PH_hs_0023292

SM00028

SM00727

STIP1

STIP1-201

STIP1-203

STIP1-207

TC11000585.hg

uc001nyk.2

uc010rnb.2

uc031xri.2

UPI000012D225

UPI00001FAA4C

UPI000204AE6B

V9HW72

Participant Of

input

STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein

hasComponent

output

Inferred To

STIP1_MOUSE [cytosol] (Mus musculus)

Ghost homologue of STIP1 [cytosol] (Taeniopygia guttata)

Homologues of STIP1 [cytosol] (Arabidopsis thaliana)

Homologues of STIP1 [cytosol] (Bos taurus)

Homologues of STIP1 [cytosol] (Danio rerio)

Homologues of STIP1 [cytosol] (Drosophila melanogaster)

Homologues of STIP1 [cytosol] (Oryza sativa)

STIP1 [cytosol] (Arabidopsis thaliana)

STIP1 [cytosol] (Bos taurus)

STIP1 [cytosol] (Caenorhabditis elegans)

STIP1 [cytosol] (Canis familiaris)

STIP1 [cytosol] (Danio rerio)

STIP1 [cytosol] (Dictyostelium discoideum)

STIP1 [cytosol] (Drosophila melanogaster)

STIP1 [cytosol] (Gallus gallus)

STIP1 [cytosol] (Oryza sativa)

STIP1 [cytosol] (Plasmodium falciparum)

STIP1 [cytosol] (Rattus norvegicus)

STIP1 [cytosol] (Saccharomyces cerevisiae)

STIP1 [cytosol] (Schizosaccharomyces pombe)

STIP1 [cytosol] (Sus scrofa)

STIP1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001269581.1, NP_001269582.1, NP_006810.1

GeneCards

P31948

DOCK Blaster

1ELW, 3FWV, 3ESK, 1ELR

PRO

P31948

PDB

2NC9, 3ESK, 1ELR, 3FWV, 1ELW, 2LNI

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07900 HSP90AA1	7	HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864)	0.723	4
UniProt:P53041 PPP5C	2	PPP5C [nucleoplasm] (R-HSA-5683410) PPP5C [cytosol] (R-HSA-5675402)	0.623	4
UniProt:P04150 NR3C1	2	NR3C1 [nucleoplasm] (R-HSA-879837) NR3C1 [cytosol] (R-HSA-5618118)	0.61	5
UniProt:P08238 HSP90AB1	5	HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399)	0.59	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q96AP0 ACD	1	ACD [nucleoplasm] (R-HSA-174889)	0.508	2
UniProt:P00533 EGFR	58	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.508	2
UniProt:Q7L3B6 CDC37L1	2	CDC37L1 [platelet dense granule lumen] (R-HSA-8848903) CDC37L1 [extracellular region] (R-HSA-8848918)	0.499	2
UniProt:Q8IWD4 CC117			0.499	2