Reactome | ERLIN2 [endoplasmic reticulum membrane]

ERLIN2 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-8866520

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Erlin-2, ERLN2_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O94905 ERLIN2

Gene Names

ERLIN2, C8orf2, SPFH2, UNQ2441/PRO5003/PRO9924

Chain

chain:1-339

Reference Genes

BioGPS Gene:11160 ERLIN2

COSMIC (genes):ERLIN2 ERLIN2

CTD Gene:11160 ERLIN2

dbSNP Gene:11160 ERLIN2

ENSEMBL:ENSG00000147475 ERLIN2

ENSEMBL_homo_sapiens_GENE:ENSG00000147475.17 ERLIN2

HGNC:1356 ERLIN2

KEGG Gene (Homo sapiens):11160 ERLIN2

Monarch:11160 ERLIN2

NCBI Gene:11160 ERLIN2

OMIM:611605 ERLIN2

UCSC:O94905 ERLIN2

Reference Transcript

Other Identifiers

11160

11731043_s_at

11731044_at

11731045_s_at

11735259_a_at

11735260_s_at

11741586_a_at

11741587_x_at

11745025_a_at

11745026_a_at

11759837_at

17067902

221542_PM_s_at

221542_s_at

221543_PM_s_at

221543_s_at

238615_PM_at

238615_at

3094237

3094244

3094246

3094247

3094248

3094249

3094250

3094251

3094252

3094253

3094254

3094255

3094256

3094257

3094258

3094259

3094260

3094261

3094262

3094263

3094264

3094265

3094266

3094267

3094269

3094273

3094281

3094283

3094285

3094287

3094288

3094289

37798_at

49388_at

79608_at

8145835

83018_at

A_23_P123440

A_24_P21266

A_24_P372217

A_24_P765540

A_33_P3363061

GE81734

GO:0005515

GO:0005783

GO:0005789

GO:0005829

GO:0005886

GO:0006629

GO:0008202

GO:0008203

GO:0008289

GO:0015485

GO:0016020

GO:0023052

GO:0030163

GO:0030433

GO:0031625

GO:0032933

GO:0032991

GO:0043226

GO:0045121

GO:0045540

GO:0045541

GO:0045717

HMNXSV003019948

HMNXSV003021170

HMNXSV003048012

Hs.125849.0.S2_3p_a_at

Hs.143848.0.A1_3p_at

ILMN_1700549

PH_hs_0031629

TC08000277.hg

g10241715_3p_a_at

Participates

as a component of

ERLIN1:ERLIN2 [endoplasmic reticulum membrane] (Homo sapiens)

Other forms of this molecule

EML4(1-186)insVSLKRRIELTVEYPWRCGALSPTSNCRTG-p-8Y-FGFR1(1-822) [plasma membrane]

EML4(1-186)insVSLKRRIELTVEYPWRCGALSPTSNCRTG-FGFR1(1-822) [plasma membrane]

Inferred To

erlin2 [endoplasmic reticulum membrane] (Danio rerio)

erlin2 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Erlin2 [endoplasmic reticulum membrane] (Mus musculus)

Erlin2 [endoplasmic reticulum membrane] (Rattus norvegicus)

Ghost homologue of ERLIN2 [endoplasmic reticulum membrane] (Drosophila melanogaster)

ERLIN2 [endoplasmic reticulum membrane] (Bos taurus)

ERLIN2 [endoplasmic reticulum membrane] (Canis familiaris)

ERLIN2 [endoplasmic reticulum membrane] (Gallus gallus)

ERLIN2 [endoplasmic reticulum membrane] (Sus scrofa)

erl-1 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001003790.1, NP_009106.1, XP_016868489.1, XP_005273449.1, NP_001003791.1

OpenTargets

ENSG00000147475

GeneCards

O94905

HPA

ENSG00000147475-ERLIN2

Ensembl

ENSP00000427847, ENST00000518586, ENST00000523107, ENST00000648919, ENST00000335171, ENST00000523887, ENSP00000335220, ENST00000519638, ENSG00000147475, ENSP00000428112, ENSP00000497100, ENSP00000473292, ENSP00000429903

PRO

O94905

Pharos - Targets

O94905

Orphanet

20466

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27824 CANX	2	CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.643	3
UniProt:P11021 HSPA5	6	HSPA5 [extracellular region] (R-HSA-351322) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498)	0.643	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	10
UniProt:Q86TM6 SYVN1	1	SYVN1(1-617) [endoplasmic reticulum membrane] (R-HSA-535496)	0.564	2
UniProt:Q9NWM8 FKBP14 gene	1	FKBP14 [endoplasmic reticulum lumen] (R-HSA-535607)	0.527	2