HSP90AA1 [cytosol]

Stable Identifier
R-HSA-192864
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
HSP90
Icon
HSP90AA1 [cytosol] icon
HSP90AA1 [cytosol] icon
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:P07900 HSP90AA1
Gene Names
HSP90AA1, HSP90A, HSPC1, HSPCA
Chain
initiator methionine:, chain:2-732
Reference Genes
BioGPS Gene:3320 HSP90AA1
COSMIC (genes):HSP90AA1 HSP90AA1
CTD Gene:3320 HSP90AA1
dbSNP Gene:3320 HSP90AA1
ENSEMBL:ENSG00000080824 HSP90AA1
HGNC:5253 HSP90AA1
KEGG:hsa:3320 HSP90AA1
Monarch:3320 HSP90AA1
NCBI Gene:3320 HSP90AA1
OMIM:140571 HSP90AA1
UCSC:P07900 HSP90AA1
Reference Transcript
Other Identifiers
11732996_at
11749934_s_at
11758308_s_at
16796829
210211_PM_s_at
210211_s_at
211968_PM_s_at
211968_s_at
211969_PM_at
211969_at
214328_PM_s_at
214328_s_at
2362304
2545387
2751645
2755868
2755880
2793561
2793563
2793567
32316_s_at
3320
3367313
3367314
3367315
3367316
3367317
3367319
3367320
3367322
3367324
3367325
3367327
3367328
3367329
3580178
3580180
3580181
3580182
3580183
3580184
3580185
3580186
3580187
3580188
3580189
3580190
3580191
3580192
3580193
3580194
3580195
3580196
3580197
3580198
3580199
3580200
3580201
3580202
3580203
3580204
3580205
3580206
3580207
3580208
3580209
3580210
3580211
3580217
3580218
3580219
3580230
7981335
A_23_P162866
A_23_P162874
A_33_P3665777
GE59722
GO:0001764
GO:0001934
GO:0002134
GO:0002135
GO:0002218
GO:0002230
GO:0002376
GO:0003009
GO:0003012
GO:0003723
GO:0003729
GO:0003824
GO:0005515
GO:0005524
GO:0005525
GO:0005576
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005829
GO:0005886
GO:0005929
GO:0006457
GO:0006839
GO:0006886
GO:0006914
GO:0006986
GO:0007004
GO:0007005
GO:0008092
GO:0009408
GO:0009409
GO:0009410
GO:0009651
GO:0009986
GO:0010592
GO:0010659
GO:0012501
GO:0016020
GO:0016323
GO:0016324
GO:0016787
GO:0016887
GO:0017098
GO:0019903
GO:0023026
GO:0030163
GO:0030235
GO:0030312
GO:0030911
GO:0031012
GO:0031396
GO:0031410
GO:0031526
GO:0031625
GO:0032200
GO:0032212
GO:0032273
GO:0032564
GO:0032728
GO:0032880
GO:0032991
GO:0034605
GO:0034774
GO:0036126
GO:0042026
GO:0042220
GO:0042307
GO:0042470
GO:0042802
GO:0042803
GO:0042826
GO:0042981
GO:0043025
GO:0043202
GO:0043209
GO:0043226
GO:0043254
GO:0043335
GO:0043627
GO:0044183
GO:0044294
GO:0044295
GO:0044325
GO:0045040
GO:0045429
GO:0045732
GO:0045793
GO:0046677
GO:0048156
GO:0048471
GO:0048870
GO:0050821
GO:0051020
GO:0051022
GO:0051082
GO:0051131
GO:0060452
GO:0061024
GO:0061684
GO:0062023
GO:0065003
GO:0070062
GO:0070182
GO:0071682
GO:0097110
GO:0097226
GO:0097524
GO:0097718
GO:0098586
GO:0098772
GO:0099072
GO:0140657
GO:0140662
GO:1902949
GO:1904813
GO:1905323
GO:1990782
HMNXSV003006689
HMNXSV003033460
Hs.289088.4.A1_3p_at
Hs.289088.4.A2_3p_a_at
ILMN_1691097
ILMN_2373515
PH_hs_0033549
TC14001526.hg
TC14002169.hg
X15183_at
g3287488_3p_a_at
Participates
as a component of
as a member of
as an input of
This entity regulates
Positively
Other forms of this molecule
HSP90AA1 [lysosomal lumen]
HSP90AA1 [nucleoplasm]
HSP90AA1 [plasma membrane]
HSP90AA1 [ficolin-1-rich granule lumen]
HSP90AA1 [extracellular region]
HSP90AA1 [secretory granule lumen]
HSP90AA1 [endocytic vesicle lumen]
Inferred To
Homologues of HSP90AA1 [cytosol] (Plasmodium falciparum)
Homologues of HSP90AA1 [cytosol] (Saccharomyces cerevisiae)
Homologues of HSP90AA1 [cytosol] (Sus scrofa)
HSP90AA1 [cytosol] (Bos taurus)
HSP90AA1 [cytosol] (Caenorhabditis elegans)
HSP90AA1 [cytosol] (Canis familiaris)
HSP90AA1 [cytosol] (Danio rerio)
HSP90AA1 [cytosol] (Dictyostelium discoideum)
HSP90AA1 [cytosol] (Drosophila melanogaster)
HSP90AA1 [cytosol] (Gallus gallus)
HSP90AA1 [cytosol] (Mus musculus)
HSP90AA1 [cytosol] (Plasmodium falciparum)
HSP90AA1 [cytosol] (Rattus norvegicus)
HSP90AA1 [cytosol] (Saccharomyces cerevisiae)
HSP90AA1 [cytosol] (Schizosaccharomyces pombe)
HSP90AA1 [cytosol] (Sus scrofa)
HSP90AA1 [cytosol] (Xenopus tropicalis)
Cross References
RefSeq
Guide to Pharmacology - Targets
OpenTargets
ENSEMBL
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
GlyGen
PDB
5ZR3, 2YKI, 5FNC, 3B27, 1UYC, 2WI3, 6CEO, 5XQE, 3R92, 4NH8, 6GPT, 2YE5, 1UY9, 3T0Z, 5J27, 5LR7, 6EL5, 2WI4, 4L94, 4CWT, 1UYF, 3R91, 5M4H, 2XDU, 2CCT, 6GR3, 2YK2, 5GGZ, 3VHC, 4CGQ, 2BT0, 2YE8, 4NH7, 2BYH, 6CYH, 7RY1, 6ELO, 4XIQ, 5LNZ, 4CGU, 2XHR, 2QG2, 2XDX, 4CWF, 8FFV, 8W4V, 5XRD, 4CWO, 3RKZ, 4AWQ, 8X2R, 6U98, 1UYD, 2JJC, 3OWB, 3B26, 3FT5, 4YKQ, 3INX, 6FCJ, 4L8Z, 7S8Z, 4CWS, 6GP8, 1UYG, 3Q6N, 5J6L, 6GP4, 2YI5, 2YEJ, 4JQL, 2CCU, 4O0B, 2YEE, 2YE7, 6GQR, 4BQG, 5LO5, 2YKC, 6GPY, 5J8U, 6HHR, 2H55, 2BZ5, 2XDS, 3T2S, 2XJX, 3B25, 6U9A, 2WI2, 7LT0, 5FND, 6U99, 3WQ9, 6FDP, 2BYI, 4XIP, 7KRJ, 4CGW, 7S95, 3Q6M, 2YE4, 5LR1, 5J20, 1UY6, 6U9B, 4CWN, 1UYH, 5J86, 4CWR, 2YKE, 2YEI, 7RY0, 3VHA, 4EFU, 6GR4, 2YED, 2YE6, 8KI4, 5J8M, 7L7I, 2XHX, 2YKB, 6GPR, 6CYG, 7UR3, 3QTF, 5OCI, 5ODX, 5J6M, 2WI7, 3OW6, 5NYH, 3BMY, 2XK2, 4O04, 3RLR, 4AWP, 3B24, 6EY8, 4R3M, 4EGK, 2XAB, 7S90, 7S98, 4CGV, 4W7T, 8W8K, 3OWD, 5VYY, 8AGI, 4L93, 2YEC, 2YK9, 8SBT, 5LO0, 8B7J, 5LRL, 6N8X, 6GQS, 6ELP, 7KW7, 6GPW, 6GPH, 3R4P, 7LSZ, 4YKZ, 4YKU, 2YEH, 4AIF, 2XDL, 3BM9, 5XRB, 4L90, 5NYI, 2WI1, 3RLQ, 2XJJ, 7S8Y, 3HYZ, 6B99, 6EY9, 3K99, 6EI5, 6LTK, 4L91, 2YE3, 1BYQ, 7S9I, 2UWD, 1UY7, 1UYI, 4CWQ, 3HEK, 2YJX, 2YEB, 6GR1, 5LO1, 8B7I, 3R4O, 1YC1, 6GPO, 5OD7, 7S9F, 6TN4, 6GPF, 3T10, 5LQ9, 3TUH, 4LWF, 2XDK, 4XIT, 2YEG, 3MNR, 4AWO, 3RLP, 4EFT, 3HYY, 5J6N, 8AGJ, 4FCP, 2FWY, 1YER, 2BUG, 6EYB, 6B9A, 4CWP, 5LS1, 7RXZ, 2VCJ, 6GQ6, 3T0H, 5J64, 5J2X, 5XR9, 3QDD, 4FCR, 4HY6, 2YJW, 3R4N, 7S9H, 6GR5, 6TN5, 2YE2, 5LO6, 3K98, 5XQD, 4YKY, 4LWI, 4YKT, 2K5B, 5M4E, 2YEA, 4O09, 2QG0, 3HZ1, 6OLX, 3WHA, 2FWZ, 2YI7, 2YI0, 6LSZ, 1YES, 4B7P, 3B28, 5CF0, 5T21, 1YC3, 6LTI, 7S99, 1UYK, 3HZ5, 5FNF, 2WI6, 5J82, 3D0B, 3EKR, 8FFW, 6GPP, 6LR9, 6KSQ, 4FCQ, 5J9X, 2VCI, 7S9G, 4EGI, 3VHD, 4LWH, 3FT8, 4YKX, 3K97, 4XIR, 2QFO, 7DMC, 2YEF, 4O07, 2YI6, 8AGL, 1YET, 2YKJ, 4EEH, 5XR5, 5XRE, 4YKW, 1OSF, 6F1N, 5J2V, 5LRZ, 1YC4, 1UY8, 1UYL, 6LT8, 7L7J, 5J80, 1UYE, 2WI5, 3HHU, 2XJG, 3T1K, 3R4M, 3EKO, 2CCS, 2BSM, 6ELN, 6GQU, 2YE9, 4EGH, 2QF6, 4BQJ, 3INW, 4O05, 4YKR, 6EYA, 5LNY, 3O0I, 2C2L, 4LWG, 4U93, 2XHT, 4LWE
ZINC - Investigational
IntEnz
GeneCards
HPA
Pharos - Targets
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (111)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q16543 CDC37  1 0.899 17
 UniProt:P53041 PPP5C  2 0.873 13
 UniProt:Q15185 PTGES3  2 0.857 9
 UniProt:P04626 ERBB2  20 0.856 6
 UniProt:P07900 HSP90AA1  8 0.851 6
 UniProt:Q9H6T3 RPAP3      0.85 7
 UniProt:P31948 STIP1  1 0.832 7
 UniProt:Q9UNE7 STUB1  1 0.831 9
 UniProt:Q13451 FKBP5  2 0.8 9
 UniProt:P06241 FYN  6 0.8 8
 UniProt:Q5S007 LRRK2  1 0.788 7
 UniProt:P08238 HSP90AB1  6 0.788 15
 UniProt:Q02790 FKBP4  3 0.784 9
 UniProt:P00533 EGFR  20 0.778 7
 UniProt:P04150 NR3C1  3 0.775 8
 UniProt:P50750 CDK9  1 0.744 6
 UniProt:P04049 RAF1  20 0.744 15
 UniProt:Q15831 STK11  2 0.744 6
 UniProt:Q99558 MAP3K14  5 0.744 5
 UniProt:P08107 HSP71      0.723 4
 UniProt:Q9UHD1 CHRD1      0.681 8
 UniProt:P05412 JUN  4 0.678 4
 UniProt:P12931 SRC  6 0.669 3
 UniProt:Q9Y6K9 IKBKG  12 0.669 4
 UniProt:Q14318 FKBP8  2 0.669 8
 UniProt:Q96QS6 PSKH2      0.669 3
 UniProt:O15111 CHUK  4 0.669 4
 UniProt:Q8IWD4 CC117      0.669 7
 UniProt:Q9BXA6 TSSK6      0.669 4
 UniProt:Q6VAB6 KSR2  1 0.669 6
 UniProt:Q9UQM7 CAMK2A  6 0.666 5
 UniProt:P05067 APP  20 0.666 5
 UniProt:P17612 PRKACA  4 0.666 4
 UniProt:O95433 AHSA1      0.659 6
 UniProt:P11802 CDK4  3 0.643 4
 UniProt:P61247 RPS3A  2 0.635 3
 UniProt:O43318-2 MAP3K7      0.623 5
 UniProt:P35467  1 0.618 4
 UniProt:Q8WVJ2 NUDC2      0.612 4
 UniProt:P43034 PAFAH1B1  1 0.612 5
 UniProt:Q9H0C5 BTBD1  1 0.61 4
 UniProt:Q9Y239 NOD1  1 0.589 2
 UniProt:Q13127 REST  1 0.57 4
 UniProt:P14616 INSRR      0.569 3
 UniProt:P10636-8 MAPT  3 0.569 11
 UniProt:Q7L3B6 CDC37L1  2 0.564 3
 UniProt:Q96Q40 CDK15      0.564 3
 UniProt:Q15750 TAB1  6 0.564 2
 UniProt:Q9NYJ8 TAB2  4 0.564 2
 UniProt:Q9Y243 AKT3  6 0.564 4
 UniProt:P00540 MOS      0.564 2
 UniProt:Q16671 AMHR2  1 0.564 3
 UniProt:Q8IWX7 UN45B      0.564 3
 UniProt:Q9NR20 DYRK4      0.564 2
 UniProt:P06239 LCK  4 0.564 3
 UniProt:Q9UHH9 IP6K2  1 0.558 2
 UniProt:Q14194 CRMP1  4 0.556 3
 UniProt:Q92993-2 KAT5      0.556 3
 UniProt:Q15438 CYTH1  2 0.556 3
 UniProt:Q8WUY3 PRUN2      0.556 3
 UniProt:Q6UY14-3 ADAMTSL4      0.556 3
 UniProt:Q6QEF8-4 CORO6      0.556 3
 UniProt:Q9H6R7-2 Q9H6R72      0.556 3
 UniProt:Q9BV29 CCD32      0.556 3
 UniProt:Q96LI6-3 Q96LI63      0.556 3
 UniProt:P35222 CTNNB1  20 0.556 3
 UniProt:P10599 TXN  4 0.556 3
 UniProt:P07814 EPRS1  1 0.544 2
 UniProt:P26196 DDX6  1 0.536 2
 UniProt:Q9H1R3 MYLK2      0.527 8
 UniProt:P68371 TUBB4B  8 0.527 2
 UniProt:Q71U36 TUBA1A  9 0.527 3
 UniProt:P08631 HCK  2 0.527 3
 UniProt:Q3B7T1 EDRF1      0.527 6
 UniProt:Q8N5M4 TTC9C      0.527 5
 UniProt:Q08881 ITK  3 0.527 2
 UniProt:O75676 RPS6KA4  1 0.527 3
 UniProt:P31749 AKT1  14 0.527 3
 UniProt:Q9HBY8 SGK2  1 0.527 2
 UniProt:Q15418 RPS6KA1  7 0.527 3
 UniProt:P19388 POLR2E  2 0.527 3
 UniProt:Q9H9G7 AGO3  1 0.527 2
 UniProt:P10398 ARAF  4 0.527 3
 UniProt:Q13131 PRKAA1  3 0.527 2
 UniProt:Q6J9G0 STYK1      0.527 2
 UniProt:Q92918 M4K1      0.527 2
 UniProt:Q15785 TOM34      0.527 4
 UniProt:Q8NFD2 ANKK1      0.527 2
 UniProt:Q9UQ88 CDK11A  1 0.527 4
 UniProt:P49761 CLK3      0.527 2
 UniProt:Q13618 CUL3  3 0.527 2
 UniProt:P11142 HSPA8  10 0.527 2
 UniProt:P36507 MAP2K2  12 0.527 3
 UniProt:O94966 USP19  1 0.527 7
 UniProt:P51451 BLK  2 0.527 3
 UniProt:P48729 CSNK1A1  2 0.527 4
 UniProt:Q13163 MAP2K5  1 0.527 3
 UniProt:P34932 HSPA4  2 0.527 2
 UniProt:O95801 TTC4      0.527 4
 UniProt:Q8TDR2 STK35      0.527 3
 UniProt:Q14004 CDK13  3 0.527 3
 UniProt:Q8WTQ7 GRK7  1 0.527 2
 UniProt:Q8N165 PDK1L      0.527 2
 UniProt:Q9H3Y6 SRMS  1 0.527 3
 UniProt:Q86YV6 MYLK4      0.527 2
 UniProt:Q96GD4 AURKB  3 0.527 2
 UniProt:P26882 PPID      0.525 4
 UniProt:Q96G23 CERS2  1 0.524 2
 UniProt:Q9D1P4 CHRD1      0.508 3
 UniProt:P12830 CDH1  8 0.499 2
 UniProt:P13569 CFTR  17 0.483 13
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