Reactome | SHMT2 [cytosol]

SHMT2 [cytosol]

Stable Identifier

R-HSA-9714752

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Serine hydroxymethyltransferase, mitochondrial, GLYM_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase cycle (Homo sapiens)
      - RHOG GTPase cycle (Homo sapiens)
        
        RHOG binds effectors at the plasma membrane (Homo sapiens)
        
        RHOG plasma membrane effectors [cytosol] (Homo sapiens)
        
        SHMT2 [cytosol] (Homo sapiens)
        
        RHOG:GTP:RHOG plasma membrane effectors [plasma membrane] (Homo sapiens)
        
        RHOG plasma membrane effectors [cytosol] (Homo sapiens)
        
        SHMT2 [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
24075985	A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses Zheng, H, Gupta, V, Patterson-Fortin, J, Bhattacharya, S, Katlinski, K, Wu, J, Varghese, B, Carbone, CJ, Aressy, B, Fuchs, SY, Greenberg, RA	Cell Rep	2013

External Reference Information

External Reference

UniProt:P34897 SHMT2

Gene Names

SHMT2

Chain

transit peptide:1-29, chain:30-504

Reference Genes

BioGPS Gene:6472 SHMT2

COSMIC (genes):SHMT2 SHMT2

CTD Gene:6472 SHMT2

dbSNP Gene:6472 SHMT2

ENSEMBL:ENSG00000182199 SHMT2

HGNC:10852 SHMT2

KEGG:hsa:6472 SHMT2

Monarch:6472 SHMT2

NCBI Gene:6472 SHMT2

OMIM:138450 SHMT2

UCSC:P34897 SHMT2

Reference Transcript

Other Identifiers

11746438_a_at

11747537_x_at

11750992_x_at

11756615_x_at

16752834

214095_PM_at

214095_at

214096_PM_s_at

214096_s_at

214437_3p_s_at

214437_PM_s_at

214437_s_at

3418008

3418009

3418010

3418011

3418012

3418013

3418014

3418015

3418016

3418017

3418018

3418019

3418020

3418021

3418022

3418023

3418024

3418025

3418026

3418027

3418028

3418029

3418030

3418031

3418032

3418033

3418034

3418035

3418036

3418037

3418038

3418039

3418040

3418041

3418042

36178_at

50836_i_at

6472

7956401

A_14_P122852

A_23_P158239

A_23_P169629

A_33_P3363245

GE59018

GO:0002082

GO:0003682

GO:0004372

GO:0005515

GO:0005634

GO:0005737

GO:0005739

GO:0005743

GO:0005759

GO:0005856

GO:0006231

GO:0006417

GO:0006520

GO:0006544

GO:0006545

GO:0006563

GO:0006564

GO:0006575

GO:0006730

GO:0008168

GO:0008284

GO:0008732

GO:0015630

GO:0015943

GO:0016020

GO:0016597

GO:0016740

GO:0019264

GO:0030170

GO:0032259

GO:0034340

GO:0035999

GO:0042645

GO:0042802

GO:0046653

GO:0051262

GO:0051289

GO:0055086

GO:0065003

GO:0070013

GO:0070062

GO:0070129

GO:0070536

GO:0070552

GO:1901135

GO:1903715

HMNXSV003011419

HMNXSV003058149

Hs.120911.0.S1_3p_at

Hs.2186.4.A1_3p_a_at

Hs.2186.4.A1_3p_x_at

Hs.75069.0.S1_3p_x_at

ILMN_1661264

PH_hs_0004269

PH_hs_0031312

TC12000525.hg

TC12002398.hg

U23143_at

Participates

as a candidate of

RHOG plasma membrane effectors [cytosol] (Homo sapiens)

Other forms of this molecule

PXLP-K280-SHMT2 [mitochondrial inner membrane]

Inferred To

SHMT2 [cytosol] (Bos taurus)

SHMT2 [cytosol] (Canis familiaris)

SHMT2 [cytosol] (Sus scrofa)

Shmt2 [cytosol] (Mus musculus)

Shmt2 [cytosol] (Rattus norvegicus)

shmt2 [cytosol] (Danio rerio)

shmt2 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_005403.2, NP_001159829.1, NP_001159831.1, NP_001159828.1, NP_001159830.1

OpenTargets

ENSG00000182199

ENSEMBL

ENSP00000406881, ENST00000414700, ENST00000328923, ENSP00000452315, ENSP00000333667, ENSP00000413770, ENST00000553474, ENST00000449049, ENSG00000182199, ENSP00000452419, ENST00000557487

HPA

ENSG00000182199-SHMT2

GeneCards

SHMT2

PRO

P34897

Pharos - Targets

P34897

GlyGen

P34897

HMDB Protein

HMDBP00792

PDB

6H3C, 6DK3, 8FJU, 8TLC, 8FJT, 9BOX, 6QVL, 6QVG, 6M5O, 4PVF, 6R8F, 5X3V, 8GKY, 8GKZ, 8T4O, 8GKS, 8GKU, 8GKW, 8T4P, 7BYI, 8GKT, 5V7I, 8SSJ, 8QI7, 8AQL

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P46736 BRCC3	2	BRCC3 [nucleoplasm] (R-HSA-5682577) BRCC3 [cytosol] (R-HSA-5691415)	0.723	4
UniProt:Q9NWV8 BABAM1	2	BABAM1 [nucleoplasm] (R-HSA-5682582) BABAM1 [cytosol] (R-HSA-5691418)	0.643	4
UniProt:Q9NXR7 BABAM2	2	BRE [nucleoplasm] (R-HSA-5682579) BRE [cytosol] (R-HSA-5691413)	0.643	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.615	10