Reactome | PLD3 [plasma membrane]

PLD3 [plasma membrane]

Stable Identifier

R-HSA-2029042

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Phospholipase D3, PLD3_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8IV08 PLD3

Gene Names

PLD3

Chain

chain:1-490

Reference Genes

BioGPS Gene:23646 PLD3

COSMIC (genes):PLD3 PLD3

CTD Gene:23646 PLD3

dbSNP Gene:23646 PLD3

ENSEMBL:ENSG00000105223 PLD3

ENSEMBL_homo_sapiens_GENE:ENSG00000105223.21 PLD3

HGNC:17158 PLD3

KEGG Gene (Homo sapiens):23646 PLD3

Monarch:23646 PLD3

NCBI Gene:23646 PLD3

OMIM:615698 PLD3

UCSC:Q8IV08 PLD3

Reference Transcript

Other Identifiers

11715382_x_at

16862188

201050_3p_at

201050_PM_at

201050_at

23646

36151_at

3833390

3833444

3833445

3833448

3833450

3833451

3833452

3833454

3833455

3833456

3833457

3833458

3833459

3833463

3833464

3833465

3833466

3833468

3833470

3833472

3833473

3833474

3833475

3833476

3833477

3833478

64802_at

8028791

A_14_P115554

A_23_P27515

GE61425

GO:0000139

GO:0002376

GO:0003824

GO:0004518

GO:0004527

GO:0004630

GO:0005515

GO:0005576

GO:0005615

GO:0005764

GO:0005765

GO:0005768

GO:0005773

GO:0005783

GO:0005789

GO:0005794

GO:0006259

GO:0006954

GO:0010008

GO:0014902

GO:0016020

GO:0016787

GO:0030154

GO:0031410

GO:0031901

GO:0031902

GO:0043202

GO:0043226

GO:0045145

GO:0048856

GO:0070062

GO:0140097

GO:1900015

HMNXSV003004563

ILMN_1666976

ILMN_1724324

PH_hs_0023283

PH_hs_0039477

TC19000562.hg

TC19002136.hg

U60644_at

g7110640_3p_s_at

g7110640_3p_x_at

Participates

as a candidate of

PLD [plasma membrane] (Homo sapiens)

Other forms of this molecule

PLD3 [endoplasmic reticulum membrane]

Inferred To

PLD3 [plasma membrane] (Bos taurus)

PLD3 [plasma membrane] (Caenorhabditis elegans)

PLD3 [plasma membrane] (Canis familiaris)

PLD3 [plasma membrane] (Sus scrofa)

pld3 [plasma membrane] (Xenopus tropicalis)

Pld3 [plasma membrane] (Drosophila melanogaster)

Pld3 [plasma membrane] (Mus musculus)

Pld3 [plasma membrane] (Rattus norvegicus)

pldZ [plasma membrane] (Dictyostelium discoideum)

Cross References

RefSeq

XP_011524995.1, XP_016882036.1, XP_005258765.1, XP_005258764.1, XP_016882037.1, XP_016882038.1, NP_001026866.1, NP_036400.2, XP_005258767.1, XP_016882035.1, XP_011524994.1, NP_001278240.1, XP_005258761.1, XP_006723185.1, XP_005258766.1

OpenTargets

ENSG00000105223

GeneCards

Q8IV08

HPA

ENSG00000105223-PLD3

Ensembl

ENST00000409419, ENSP00000515122, ENST00000700620, ENSP00000515123, ENST00000409735, ENSP00000515110, ENSG00000105223, ENSP00000515112, ENST00000700621, ENST00000700630, ENST00000700631, ENST00000700623, ENSP00000515111, ENST00000409281, ENSP00000515107, ENST00000700632, ENST00000700633, ENSP00000515113, ENST00000700626, ENST00000700625, ENST00000700634, ENSP00000515116, ENSP00000515115, ENST00000700628, ENSP00000515118, ENST00000700637, ENSP00000515117, ENSP00000386938, ENST00000700616, ENSP00000515119, ENST00000409587, ENSP00000348901, ENST00000700619, ENSP00000387022, ENSP00000386293, ENSP00000387050, ENSP00000515120, ENSP00000515121, ENST00000356508

PRO

Q8IV08

Pharos - Targets

Q8IV08

Orphanet

25170

HMDB Protein

HMDBP07291

PDB

8Q1K, 8Q1X

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC8 8	2	8 [extracellular region] (R-COV-9755410) 8 [endoplasmic reticulum lumen] (R-COV-9727283)	0.527	2
UniProt:P19838 NFKB1	8	NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-968) [cytosol] (R-HSA-451607) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) 3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619)	0.524	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	7

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