Reactome | TUBB2A [axonemal microtubule]

TUBB2A [axonemal microtubule]

Stable Identifier

R-HSA-5610431

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

axonemal microtubule

Synonyms

beta tubulin 2A

Locations in the PathwayBrowser

Expand all

Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Intraflagellar transport (Homo sapiens)
    - Anterograde IFT (Homo sapiens)
      - anterograde IFT trains [ciliary tip] (Homo sapiens)
        
        active kinesin-2 motors [ciliary tip] (Homo sapiens)
        
        acetylated microtubule [axonemal microtubule] (Homo sapiens)
        
        Ac K40 alpha tubulin-beta tubulin dimer [axonemal microtubule] (Homo sapiens)
        
        beta tubulin:GDP [axonemal microtubule] (Homo sapiens)
        
        beta tubulin [axonemal microtubule] (Homo sapiens)
        
        TUBB2A [axonemal microtubule] (Homo sapiens)
      - anterograde IFT trains [cilium] (Homo sapiens)
        
        active kinesin-2 motors [cilium] (Homo sapiens)
        
        acetylated microtubule [axonemal microtubule] (Homo sapiens)
        
        Ac K40 alpha tubulin-beta tubulin dimer [axonemal microtubule] (Homo sapiens)
        
        beta tubulin:GDP [axonemal microtubule] (Homo sapiens)
        
        beta tubulin [axonemal microtubule] (Homo sapiens)
        
        TUBB2A [axonemal microtubule] (Homo sapiens)
    - Assembly of the anterograde IFT train (Homo sapiens)
      - active kinesin-2 motors [cilium] (Homo sapiens)
        
        acetylated microtubule [axonemal microtubule] (Homo sapiens)
        
        Ac K40 alpha tubulin-beta tubulin dimer [axonemal microtubule] (Homo sapiens)
        
        beta tubulin:GDP [axonemal microtubule] (Homo sapiens)
        
        beta tubulin [axonemal microtubule] (Homo sapiens)
        
        TUBB2A [axonemal microtubule] (Homo sapiens)
      - anterograde IFT trains [cilium] (Homo sapiens)
        
        active kinesin-2 motors [cilium] (Homo sapiens)
        
        acetylated microtubule [axonemal microtubule] (Homo sapiens)
        
        Ac K40 alpha tubulin-beta tubulin dimer [axonemal microtubule] (Homo sapiens)
        
        beta tubulin:GDP [axonemal microtubule] (Homo sapiens)
        
        beta tubulin [axonemal microtubule] (Homo sapiens)
        
        TUBB2A [axonemal microtubule] (Homo sapiens)
    - Assembly of the retrograde IFT train (Homo sapiens)
      - active dynein-2 motors [ciliary tip] (Homo sapiens)
        
        acetylated microtubule [axonemal microtubule] (Homo sapiens)
        
        Ac K40 alpha tubulin-beta tubulin dimer [axonemal microtubule] (Homo sapiens)
        
        beta tubulin:GDP [axonemal microtubule] (Homo sapiens)
        
        beta tubulin [axonemal microtubule] (Homo sapiens)
        
        TUBB2A [axonemal microtubule] (Homo sapiens)
      - retrograde IFT trains [ciliary tip] (Homo sapiens)
        
        active dynein-2 motors [ciliary tip] (Homo sapiens)
        
        acetylated microtubule [axonemal microtubule] (Homo sapiens)
        
        Ac K40 alpha tubulin-beta tubulin dimer [axonemal microtubule] (Homo sapiens)
        
        beta tubulin:GDP [axonemal microtubule] (Homo sapiens)
        
        beta tubulin [axonemal microtubule] (Homo sapiens)
        
        TUBB2A [axonemal microtubule] (Homo sapiens)
    - Retrograde IFT (Homo sapiens)
      - retrograde IFT trains [ciliary tip] (Homo sapiens)
        
        active dynein-2 motors [ciliary tip] (Homo sapiens)
        
        acetylated microtubule [axonemal microtubule] (Homo sapiens)
        
        Ac K40 alpha tubulin-beta tubulin dimer [axonemal microtubule] (Homo sapiens)
        
        beta tubulin:GDP [axonemal microtubule] (Homo sapiens)
        
        beta tubulin [axonemal microtubule] (Homo sapiens)
        
        TUBB2A [axonemal microtubule] (Homo sapiens)
      - retrograde IFT trains [cilium] (Homo sapiens)
        
        active dynein-2 motors [cilium] (Homo sapiens)
        
        acetylated microtubule [axonemal microtubule] (Homo sapiens)
        
        Ac K40 alpha tubulin-beta tubulin dimer [axonemal microtubule] (Homo sapiens)
        
        beta tubulin:GDP [axonemal microtubule] (Homo sapiens)
        
        beta tubulin [axonemal microtubule] (Homo sapiens)
        
        TUBB2A [axonemal microtubule] (Homo sapiens)
    - The anterograde IFT train dissociates (Homo sapiens)
      - acetylated microtubule [axonemal microtubule] (Homo sapiens)
        
        Ac K40 alpha tubulin-beta tubulin dimer [axonemal microtubule] (Homo sapiens)
        
        beta tubulin:GDP [axonemal microtubule] (Homo sapiens)
        
        beta tubulin [axonemal microtubule] (Homo sapiens)
        
        TUBB2A [axonemal microtubule] (Homo sapiens)
      - anterograde IFT trains [ciliary tip] (Homo sapiens)
        
        active kinesin-2 motors [ciliary tip] (Homo sapiens)
        
        acetylated microtubule [axonemal microtubule] (Homo sapiens)
        
        Ac K40 alpha tubulin-beta tubulin dimer [axonemal microtubule] (Homo sapiens)
        
        beta tubulin:GDP [axonemal microtubule] (Homo sapiens)
        
        beta tubulin [axonemal microtubule] (Homo sapiens)
        
        TUBB2A [axonemal microtubule] (Homo sapiens)
    - The retrograde IFT train dissociates (Homo sapiens)
      - acetylated microtubule [axonemal microtubule] (Homo sapiens)
        
        Ac K40 alpha tubulin-beta tubulin dimer [axonemal microtubule] (Homo sapiens)
        
        beta tubulin:GDP [axonemal microtubule] (Homo sapiens)
        
        beta tubulin [axonemal microtubule] (Homo sapiens)
        
        TUBB2A [axonemal microtubule] (Homo sapiens)
      - retrograde IFT trains [cilium] (Homo sapiens)
        
        active dynein-2 motors [cilium] (Homo sapiens)
        
        acetylated microtubule [axonemal microtubule] (Homo sapiens)
        
        Ac K40 alpha tubulin-beta tubulin dimer [axonemal microtubule] (Homo sapiens)
        
        beta tubulin:GDP [axonemal microtubule] (Homo sapiens)
        
        beta tubulin [axonemal microtubule] (Homo sapiens)
        
        TUBB2A [axonemal microtubule] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13885 TUBB2A

Gene Names

TUBB2A, TUBB2

Chain

chain:1-445

Reference Genes

BioGPS Gene:7280 TUBB2A

COSMIC (genes):TUBB2A TUBB2A

CTD Gene:7280 TUBB2A

dbSNP Gene:7280 TUBB2A

ENSEMBL:ENSG00000137267 TUBB2A

HGNC:12412 TUBB2A

KEGG:hsa:7280 TUBB2A

Monarch:7280 TUBB2A

NCBI Gene:7280 TUBB2A

OMIM:615101 TUBB2A

UCSC:Q13885 TUBB2A

Reference Transcript

Other Identifiers

11719788_s_at

11719789_x_at

17015143

202154_PM_x_at

202154_x_at

204141_PM_at

204141_at

209372_PM_x_at

209372_x_at

213476_3p_x_at

213476_PM_x_at

213476_x_at

2939210

2939212

2939214

2939215

2939216

2939217

2939218

2939219

2939220

2939221

2939222

2939223

2939224

2939225

2939226

2939235

2939236

2939239

2939240

2939246

2939256

296_at

297_g_at

33678_i_at

39331_at

4050505

429_f_at

471_f_at

7280

8123644

A_19_P00804421

A_23_P19291

A_23_P501276

GE635882

GE79068

GO:0000226

GO:0000278

GO:0003824

GO:0003924

GO:0005198

GO:0005200

GO:0005515

GO:0005525

GO:0005634

GO:0005737

GO:0005856

GO:0005874

GO:0007010

GO:0007017

GO:0015630

GO:0016787

GO:0021987

GO:0043226

GO:0045171

GO:0046872

GO:0048856

GO:0070062

GO:0072686

GO:1903561

HMNXSV003044067

HMNXSV003055194

Hs.179661.3.S1_3p_x_at

ILMN_2038775

ILMN_2044813

PH_hs_0026825

TC06001226.hg

TC06003365.hg

TC06003368.hg

TC06003369.hg

g4507728_3p_at

Participates

as a candidate of

beta tubulin [axonemal microtubule] (Homo sapiens)

Other forms of this molecule

TUBB2A folding intermediate [cytosol]

TUBB2A unfolded [cytosol]

Polyglycyl-TUBB2A [cytosol]

Polyglutamyl-TUBB2A [cytosol]

TUBB2A [cytosol]

Inferred To

TUBB2A [axonemal microtubule] (Bos taurus)

TUBB2A [axonemal microtubule] (Caenorhabditis elegans)

TUBB2A [axonemal microtubule] (Gallus gallus)

TUBB2A [axonemal microtubule] (Mus musculus)

TUBB2A [axonemal microtubule] (Rattus norvegicus)

TUBB2A [axonemal microtubule] (Sus scrofa)

TUBB4B [axonemal microtubule] (Dictyostelium discoideum)

TUBB4B [axonemal microtubule] (Plasmodium falciparum)

TUBB2B [axonemal microtubule] (Canis familiaris)

tubb2b [axonemal microtubule] (Xenopus tropicalis)

Cross References

RefSeq

NP_001297244.1, NP_001060.1

ENSEMBL

ENST00000333628, ENSP00000369703

OpenTargets

ENSG00000137267

HPA

ENSG00000137267-TUBB2A

PRO

Q13885

Pharos - Targets

Q13885

GlyGen

Q13885

HMDB Protein

HMDBP08602

PDB

7NVN

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.666	5
UniProt:P55212 CASP6	5	CASP6(194-293) [cytosol] (R-HSA-266128) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6 (1-293) [cytosol] (R-HSA-6798132)	0.556	3
UniProt:Q14457 BECN1	4	BECN1 [cytosol] (R-HSA-1632841) p-S15-BECN1 [cytosol] (R-HSA-5682391) ISG15-K-BECN1 [cytosol] (R-HSA-9853030) K63polyUb-BECN1 [cytosol] (R-HSA-6782989)	0.556	3
UniProt:P04183 TK1	1	TK1 [cytosol] (R-HSA-73500)	0.553	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.547	3
UniProt:Q8N0Z6 TTC5	3	TTC5 [nucleoplasm] (R-HSA-6804264) p-S203-TTC5 [nucleoplasm] (R-HSA-6804261) p-S203,S221-TTC5 [nucleoplasm] (R-HSA-6804259)	0.527	4
UniProt:Q07954 LRP1	2	LRP1 [endocytic vesicle membrane] (R-HSA-2230981) LRP1 [plasma membrane] (R-HSA-1454844)	0.527	2
UniProt:P36404 ARL2	2	ARL2 [mitochondrial matrix] (R-HSA-5250216) ARL2 [cytosol] (R-HSA-5216230)	0.527	4
UniProt:P07437 TUBB	3	TUBB [extracellular region] (R-HSA-380317) TUBB [azurophil granule lumen] (R-HSA-6799370) TUBB [cytosol] (R-HSA-9020816)	0.527	3
UniProt:Q9HC35 EML4	12	EML4 [cytosol] (R-HSA-9647741) p-S,T-EML4 [cytosol] (R-HSA-9648096) EML4(1-496)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699812) EML4(1-223)-ALK(1059-1620) fusion [cytosol] (R-HSA-9699862) EML4(1-223)insKMSTREKNSQV-ALK(1059-1620) fusion [cytosol] (R-HSA-9699813) EML4(1-780)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9716113) EML4(1-569)-p-7Y-ALK(1078-1620) fusion [cytosol] (R-HSA-9716116) EML4(1-223)-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9699903) EML4(1-223)insKMSTREKNSQV-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9699885) EML4(1-486)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699918) EML4(1-569)-ALK(1078-1620) fusion [cytosol] (R-HSA-9716112) EML4(1-780)-ALK(1058-1620) fusion [cytosol] (R-HSA-9716119)	0.527	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.499	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	3