Reactome | cleaved GPI-MELTF [extracellular region]

cleaved GPI-MELTF [extracellular region]

Stable Identifier

R-HSA-8941034

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

GPI-MELTF, fullName evidence="8"Melanotransferrin, TRFM_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P08582 MELTF

Gene Names

MELTF, MAP97, MFI2

Chain

signal peptide:1-19, chain:20-709, propeptide:710-738

Reference Genes

BioGPS Gene:4241 MELTF

COSMIC (genes):MELTF MELTF

CTD Gene:4241 MELTF

dbSNP Gene:4241 MELTF

ENSEMBL:ENSG00000163975 MELTF

HGNC:7037 MELTF

KEGG:hsa:4241 MELTF

Monarch:4241 MELTF

NCBI Gene:4241 MELTF

OMIM:155750 MELTF

UCSC:P08582 MELTF

Reference Transcript

Participates

as a member of

proteins with cleaved GPI-anchors [extracellular region] (Homo sapiens)

Other forms of this molecule

GPI-MELTF [plasma membrane]

p-MELTF [endoplasmic reticulum lumen]

MELTF [endoplasmic reticulum lumen]

Inferred To

Meltf [extracellular region] (Mus musculus)

Meltf [extracellular region] (Rattus norvegicus)

Tsf2 [extracellular region] (Drosophila melanogaster)

meltf [extracellular region] (Xenopus tropicalis)

otomp [extracellular region] (Danio rerio)

MELTF [extracellular region] (Bos taurus)

MELTF [extracellular region] (Canis familiaris)

MELTF [extracellular region] (Gallus gallus)

MELTF [extracellular region] (Sus scrofa)

Modified Residues

Name

L-cysteine amide (6-O-(2-aminoethylphosphono)-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-D-myo-inositol group) at 709

Coordinate

709

Modification

6-O-(2-aminoethylphosphono)-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-D-myo-inositol group

PsiMod Name

L-cysteine amide

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to L-cysteine amide.

Cross References

RefSeq

NP_005920.2, NP_201573.1

ENSEMBL

ENST00000296351, ENST00000296350, ENSP00000296351, ENSP00000296350, ENSG00000163975

OpenTargets

ENSG00000163975

GeneCards

MELTF

HPA

ENSG00000163975-MELTF

PRO

P08582

Pharos - Targets

P08582

HMDB Protein

HMDBP08698

PDB

6XR0

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.547	7

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