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About
What is Reactome ?
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Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
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Table of Contents
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FAQ
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RPL3 [cytosol]
Stable Identifier
R-HSA-72448
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
60S ribosomal protein L3, HIV-1 TAR RNA binding protein B, TARBP-B
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to starvation (Homo sapiens)
Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
EIF2AK4 (GCN2) binds tRNA (Homo sapiens)
EIF2AK4:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)
tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
IMPACT binds GCN1 (Homo sapiens)
GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
IMPACT:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
Regulation of expression of SLITs and ROBOs (Homo sapiens)
Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
Translation of ROBO3.2 mRNA is negatively regulated by NMD (Homo sapiens)
Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Influenza Infection (Homo sapiens)
Influenza Viral RNA Transcription and Replication (Homo sapiens)
Viral mRNA Translation (Homo sapiens)
Synthesis of PB1-F2 (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
Viral Protein Synthesis (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Selenoamino acid metabolism (Homo sapiens)
Selenocysteine synthesis (Homo sapiens)
80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC (Homo sapiens)
80S:Met-tRNAi:mRNA:SECISBP2:Sec [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
Sec-tRNA(Sec):EEFSEC:GTP binds to 80S Ribosome (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Nonsense-Mediated Decay (NMD) (Homo sapiens)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
rRNA processing (Homo sapiens)
rRNA processing in the nucleus and cytosol (Homo sapiens)
Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Elongation (Homo sapiens)
Peptide chain elongation (Homo sapiens)
Aminoacyl-tRNA binds to the ribosome at the A-site (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
80S:aminoacyl tRNA:mRNA:eEF1A:GTP [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
Hydrolysis of eEF1A:GTP (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA:aminoacyl-tRNA [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
80S:aminoacyl tRNA:mRNA:eEF1A:GTP [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
Peptide transfer from P-site tRNA to the A-site tRNA (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA:aminoacyl-tRNA [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
Elongation complex with growing peptide chain [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
Translocation of ribosome by 3 bases in the 3' direction (Homo sapiens)
80S Ribosome:mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
Elongation complex with growing peptide chain [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
Formation of a pool of free 40S subunits (Homo sapiens)
Release of 40S and 60S subunits from the 80S ribosome (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
GTP hydrolysis and joining of the 60S ribosomal subunit (Homo sapiens)
The 60S subunit joins the translation initiation complex (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
eIF5B:GTP is hydrolyzed and released (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
L13a-mediated translational silencing of Ceruloplasmin expression (Homo sapiens)
Dissociation of L13a from the 60s ribosomal subunit (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
60s ribosomal complex lacking L13a subunit [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
Eukaryotic Translation Termination (Homo sapiens)
GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex (Homo sapiens)
Me-Q185-ETF1 dimer:eRF3:GDP:80S Ribosome:mRNA:peptidyl-tRNA Complex [cytosol] (Homo sapiens)
80S Ribosome:mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
Me-Q185-ETF1 dimer:eRF3:GTP:80S Ribosome:mRNA:peptidyl-tRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex (Homo sapiens)
80S Ribosome:mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
Me-Q185-ETF1 dimer:eRF3:GTP:80S Ribosome:mRNA:peptidyl-tRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex (Homo sapiens)
Me-Q185-ETF1 dimer:eRF3:GDP:80S Ribosome:mRNA:peptidyl-tRNA Complex [cytosol] (Homo sapiens)
80S Ribosome:mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
Me-Q185-ETF1 dimer:eRF3:GDP:80S Ribosome:mRNA:tRNA Complex [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
SRP-dependent cotranslational protein targeting to membrane (Homo sapiens)
Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Homo sapiens)
SRP:polypeptide+signal:ribosome [cytosol] (Homo sapiens)
ribosome:mRNA:polypeptide+signal [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
ribosome:mRNA:polypeptide+signal [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein (Homo sapiens)
cleaved polypeptide:Translocon [endoplasmic reticulum membrane] (Homo sapiens)
membrane-bound ribosome:mRNA:cleaved polypeptide [endoplasmic reticulum membrane] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
polypeptide+signal:Translocon [endoplasmic reticulum membrane] (Homo sapiens)
membrane-bound ribosome:mRNA:polypeptide+signal [endoplasmic reticulum membrane] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
Signal-containing nascent peptide translocates to endoplasmic reticulum (Homo sapiens)
SRP receptor:SRP:ribosome:polypeptide+signal [endoplasmic reticulum membrane] (Homo sapiens)
SRP:polypeptide+signal:ribosome [cytosol] (Homo sapiens)
ribosome:mRNA:polypeptide+signal [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
polypeptide+signal:Translocon [endoplasmic reticulum membrane] (Homo sapiens)
membrane-bound ribosome:mRNA:polypeptide+signal [endoplasmic reticulum membrane] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
Synthesis of nascent polypeptide containing signal sequence (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
ribosome:mRNA:polypeptide+signal [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
The SRP receptor binds the SRP:nascent peptide:ribosome complex (Homo sapiens)
SRP receptor:SRP:ribosome:polypeptide+signal [endoplasmic reticulum membrane] (Homo sapiens)
SRP:polypeptide+signal:ribosome [cytosol] (Homo sapiens)
ribosome:mRNA:polypeptide+signal [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
SRP:polypeptide+signal:ribosome [cytosol] (Homo sapiens)
ribosome:mRNA:polypeptide+signal [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL3,RPL3L [cytosol] (Homo sapiens)
RPL3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P39023 RPL3
Gene Names
RPL3, OK/SW-cl.32
Chain
initiator methionine:, chain:2-403
Reference Genes
BioGPS Gene:6122 RPL3
COSMIC (genes):RPL3 RPL3
CTD Gene:6122 RPL3
dbSNP Gene:6122 RPL3
ENSEMBL:ENSG00000100316 RPL3
HGNC:10332 RPL3
KEGG:hsa:6122 RPL3
Monarch:6122 RPL3
NCBI Gene:6122 RPL3
OMIM:604163 RPL3
UCSC:P39023 RPL3
Reference Transcript
RefSeq:NM_000967.3 RPL3
Other Identifiers
11738900_x_at
11754054_x_at
11762324_at
16935244
16935259
17119330
17119332
17126186
201217_3p_x_at
201217_PM_x_at
201217_x_at
211073_3p_x_at
211073_PM_x_at
211073_x_at
211666_PM_x_at
211666_x_at
212039_PM_x_at
212039_x_at
215963_3p_x_at
215963_PM_x_at
215963_x_at
2605078
2902246
2902248
2902250
2902259
2968133
3132376
31722_at
3551112
3551113
3579080
3579081
3579082
3930867
3961108
3961109
3961110
3961111
3961112
3961113
3961114
3961115
3961116
3961117
3961118
3961119
3961120
3961121
3961122
3961123
3961124
3961125
3961126
3961127
3961128
3961129
3961130
3961131
3961132
3961133
3961134
3961135
3961136
3961137
3961138
3961139
3961140
3961141
3961142
3961143
3961144
3961145
3961146
6122
8076209
8076219
8076221
8076223
A_21_P0000224
A_21_P0000225
A_21_P0000243
A_23_P68942
A_24_P766208
GE56062
GO:0002181
GO:0003723
GO:0003735
GO:0005198
GO:0005515
GO:0005634
GO:0005730
GO:0005737
GO:0005829
GO:0005840
GO:0005925
GO:0006412
GO:0022625
GO:0022626
GO:0032991
GO:0043226
GO:0070062
GO:0071353
GO:1990904
HMNXSV003006390
HMNXSV003014120
HMNXSV003026270
HMNXSV003038384
HMNXSV003040169
Hs.119598.2.A1_3p_x_at
ILMN_1653927
ILMN_1739086
ILMN_1878285
ILMN_2319994
ILMN_2319996
PH_hs_0029129
PH_hs_0040356
RNA33571|snoRNA_scaRNA_167_95
RNA33588|snoRNA_scaRNA_184_93
RNA33789|snoRNA_scaRNA_385_62
TC14002151.hg
TC22000804.hg
TC22000805.hg
X73460_at
g13623708_3p_s_at
g347963_3p_s_at
g4506648_3p_s_at
Participates
as a member of
RPL3,RPL3L [cytosol] (Homo sapiens)
Inferred To
Rpl3 [cytosol]
(Mus musculus)
Rpl3 [cytosol]
(Rattus norvegicus)
rpl-3 [cytosol]
(Caenorhabditis elegans)
RpL3 [cytosol]
(Drosophila melanogaster)
rpl3 [cytosol]
(Danio rerio)
rpl3 [cytosol]
(Dictyostelium discoideum)
rpl3 [cytosol]
(Xenopus tropicalis)
RPL3 [cytosol]
(Bos taurus)
RPL3 [cytosol]
(Canis familiaris)
RPL3 [cytosol]
(Gallus gallus)
RPL3 [cytosol]
(Plasmodium falciparum)
RPL3 [cytosol]
(Saccharomyces cerevisiae)
RPL3 [cytosol]
(Sus scrofa)
rpl301 [cytosol]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_000958.1
OpenTargets
ENSG00000100316
ENSEMBL
ENST00000216146
,
ENSP00000346001
HPA
ENSG00000100316-RPL3
PRO
P39023
Pharos - Targets
P39023
GlyGen
P39023
PDB
6Z6N
,
6Y6X
,
6OLI
,
8QFD
,
8OJ8
,
6ZMO
,
8FLE
,
8IFD
,
8IDT
,
8FL0
,
8FL7
,
6Y57
,
8FKX
,
6IP8
,
8FL6
,
8FKW
,
8IPY
,
6W6L
,
8GLP
,
5AJ0
,
8FL3
,
8FL4
,
8FL2
,
6Y2L
,
8FKY
,
6XA1
,
8OJ0
,
8IPD
,
7F5S
,
6QZP
,
8IDY
,
8QOI
,
8G60
,
8JDL
,
8JDJ
,
8OJ5
,
6OLF
,
7XNX
,
6OLE
,
7QVP
,
6Y0G
,
6OM0
,
8FLA
,
8A3D
,
8Y0X
,
8IE3
,
6OM7
,
4UG0
,
8INE
,
8FLB
,
7XNY
,
8FLD
,
8INK
,
6LSS
,
8FLC
,
8FKV
,
8IR1
,
8IR3
,
8FKU
,
8FL9
,
6IP5
,
6IP6
,
8FKR
,
8IPX
,
6LU8
,
8FKQ
,
8FKT
,
8OHD
,
6ZME
,
8FKZ
,
6LQM
,
8FKS
,
6ZM7
,
8FKP
,
5T2C
,
8JDK
,
8INF
,
8JDM
,
7BHP
,
6ZMI
,
8Y0W
,
6LSR
,
6Z6L
,
6Z6M
,
8G5Z
,
6OLG
,
4V6X
,
5LKS
,
8G6J
,
8G5Y
,
6OLZ
,
8G61
,
8FLF
,
8IFE
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63244 RACK1
1
GNB2L1 [cytosol]
(R-HSA-5626956)
0.638
3
UniProt:Q99558 MAP3K14
5
Active NIK [cytosol]
(R-HSA-5607646)
MAP3K14 [cytosol]
(R-HSA-168189)
p-MAP3K14 [cytosol]
(R-HSA-168187)
K48polyUb-NIK [cytosol]
(R-HSA-5668525)
p-T559-MAP3K14 [cytosol]
(R-HSA-5668531)
0.564
3
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.527
3
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.527
14
UniProt:P03372 ESR1
10
ESR1 [cytosol]
(R-HSA-9020968)
ESR1 [nucleoplasm]
(R-HSA-446168)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
0.462
2
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