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GCN1 [cytosol]
Stable Identifier
R-HSA-9633010
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
fullName evidence="6"eIF-2-alpha kinase activator GCN1, GCN1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to starvation (Homo sapiens)
Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
EIF2AK4 (GCN2) binds tRNA (Homo sapiens)
EIF2AK4:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
GCN1 [cytosol] (Homo sapiens)
tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
GCN1 [cytosol] (Homo sapiens)
EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)
tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
GCN1 [cytosol] (Homo sapiens)
tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
GCN1 [cytosol] (Homo sapiens)
IMPACT binds GCN1 (Homo sapiens)
GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
GCN1 [cytosol] (Homo sapiens)
IMPACT:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
GCN1 [cytosol] (Homo sapiens)
p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
GCN1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q92616 GCN1
Gene Names
GCN1, GCN1L1, KIAA0219
Chain
initiator methionine:, chain:2-2671
Reference Genes
BioGPS Gene:10985 GCN1
COSMIC (genes):GCN1 GCN1
CTD Gene:10985 GCN1
dbSNP Gene:10985 GCN1
ENSEMBL:ENSG00000089154 GCN1
HGNC:4199 GCN1
KEGG:hsa:10985 GCN1
Monarch:10985 GCN1
NCBI Gene:10985 GCN1
OMIM:605614 GCN1
UCSC:Q92616 GCN1
Reference Transcript
RefSeq:NM_006836.1 GCN1
Other Identifiers
10985
11717360_s_at
16771146
212139_PM_at
212139_at
216232_PM_s_at
216232_s_at
3474257
3474258
3474259
3474261
3474262
3474263
3474264
3474265
3474266
3474268
3474269
3474270
3474271
3474272
3474273
3474274
3474276
3474278
3474279
3474280
3474281
3474282
3474284
3474286
3474287
3474288
3474289
3474292
3474294
3474295
3474296
3474297
3474298
3474299
3474300
3474301
3474302
3474303
3474304
3474305
3474306
3474307
3474308
3474309
3474310
3474312
3474313
3474314
3474315
3474316
3474317
3474318
3474319
3474320
3474321
3474322
3474323
3474325
3474327
3474328
3474329
3474330
3474331
3474332
3474333
3474334
3474335
3474336
3474337
3474338
3474339
3474340
3474341
3474343
36603_at
7966938
A_23_P406105
D86973_at
GE57374
GO:0003723
GO:0005737
GO:0005829
GO:0005840
GO:0006417
GO:0008135
GO:0016020
GO:0019887
GO:0022626
GO:0034198
GO:0043226
GO:0043539
GO:0045182
GO:0045296
GO:0060090
GO:0072344
GO:0098772
GO:0140469
GO:0160127
GO:0170011
HMNXSV003016746
Hs.75354.0.S1_3p_at
Hs.75354.2.S1_3p_a_at
ILMN_1734312
PH_hs_0023586
PH_hs_0032559
TC12002034.hg
TC12003120.hg
Participates
as a component of
IMPACT:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
EIF2AK4:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
Cross References
ENSEMBL
ENST00000300648
,
ENSP00000300648
OpenTargets
ENSG00000089154
HPA
ENSG00000089154-GCN1
PRO
Q92616
Pharos - Targets
Q92616
GlyGen
Q92616
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13418 ILK
1
ILK [cytosol]
(R-HSA-432864)
0.643
3
UniProt:P01106 MYC
2
MYC [nucleoplasm]
(R-HSA-188379)
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
0.547
2
UniProt:Q14627 IL13RA2
1
IL13RA2 [extracellular region]
(R-HSA-449666)
0.527
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
8
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