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HNRNPA1 [cytosol]
Stable Identifier
R-HSA-9727902
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
hnRNP A1, heterogeneous nuclear ribonucleoprotein A1
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
SARS-CoV-1-host interactions (Homo sapiens)
SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to HNRNPA1 (Homo sapiens)
HNRNPA1 [cytosol] (Homo sapiens)
HNRNPA1:SUMO1-K62-p-S177-Ncap dimer [cytosol] (Homo sapiens)
HNRNPA1 [cytosol] (Homo sapiens)
SARS-CoV-1 modulates host translation machinery (Homo sapiens)
SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to HNRNPA1 (Homo sapiens)
HNRNPA1 [cytosol] (Homo sapiens)
HNRNPA1:SUMO1-K62-p-S177-Ncap dimer [cytosol] (Homo sapiens)
HNRNPA1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P09651 HNRNPA1
Gene Names
HNRNPA1, HNRPA1
Chain
chain:1-372, initiator methionine:, chain:2-372
Reference Genes
BioGPS Gene:3178 HNRNPA1
COSMIC (genes):HNRNPA1 HNRNPA1
CTD Gene:3178 HNRNPA1
dbSNP Gene:3178 HNRNPA1
ENSEMBL:ENSG00000135486 HNRNPA1
ENSEMBL_homo_sapiens_GENE:ENSG00000135486.19 HNRNPA1
HGNC:5031 HNRNPA1
KEGG Gene (Homo sapiens):3178 HNRNPA1
Monarch:3178 HNRNPA1
NCBI Gene:3178 HNRNPA1
OMIM:164017 HNRNPA1
UCSC:P09651 HNRNPA1
Reference Transcript
RefSeq:NM_031157.3 HNRNPA1
RefSeq:XM_005268826.1 HNRNPA1
RefSeq:NM_002136.3 HNRNPA1
Other Identifiers
11719462_x_at
11753459_x_at
11757268_x_at
11757837_x_at
11760085_s_at
16653915
16653917
16653919
16653935
17121398
18670819
18670826
18670828
18670829
18670830
18670831
18670832
18670833
200016_PM_x_at
200016_x_at
213356_PM_x_at
213356_x_at
214280_PM_x_at
214280_x_at
221919_PM_at
221919_at
222040_PM_at
222040_at
2419664
2476772
2522587
2522588
2522590
2522594
2556148
2587727
2864551
2864554
2864559
2864560
2899946
2903184
3011012
3011016
3011024
3142600
3142601
31463_s_at
3149421
3178
3189273
3390725
3416482
3416484
3416485
3416487
3416488
3416489
3416490
3416491
3416492
3416494
3416496
3416498
3416499
3416500
3416501
3416502
3416503
3416504
3416505
3416506
3490721
3490722
3490724
3490732
3490734
3490736
34987_s_at
3588454
3660444
3660446
3660447
3660448
3660449
3660450
3660451
3660454
3660455
3692695
3803380
3803384
3803386
3803388
3803390
3803392
3803394
3803396
3851113
3851115
3851117
3851119
3851121
3851123
3851125
3988734
4015535
4015537
40211_at
67592_f_at
78639_at
7892556
7893164
7894307
7895274
7895520
7895532
7895606
7896111
7896184
7896228
7896384
7896421
7916562
7955890
7995574
8022814
8034313
A_24_P454313
A_32_P19431
A_32_P8015
A_33_P3384260
GE83213
GO:0000381
GO:0000398
GO:0003676
GO:0003677
GO:0003697
GO:0003723
GO:0003727
GO:0003730
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005681
GO:0005737
GO:0005829
GO:0006397
GO:0006405
GO:0006913
GO:0008380
GO:0016020
GO:0016071
GO:0019904
GO:0032200
GO:0032211
GO:0032212
GO:0035198
GO:0036002
GO:0042149
GO:0042802
GO:0043226
GO:0043231
GO:0043232
GO:0043484
GO:0051028
GO:0051168
GO:0051170
GO:0051179
GO:0060090
GO:0061752
GO:0070062
GO:0071013
GO:0098505
GO:0140693
GO:1903936
GO:1990000
GO:1990904
HMNXSV003023689
HMNXSV003029868
HMNXSV003052864
HMNXSV003055191
HMNXSV003058116
Hs.249495.3.S1_3p_a_at
Hs.249495.3.S1_3p_x_at
Hs.249495.4.S1_3p_at
ILMN_1661346
ILMN_1663447
ILMN_1815882
PH_hs_0029874
PH_hs_0036053
PH_hs_0037247
TC12000461.hg
TC12002381.hg
TC16001556.hg
U00947_s_at
X04347_s_at
X12671_rna1_at
X79536_at
g4504444_3p_x_at
Participates
as a component of
HNRNPA1:SUMO1-K62-p-S177-Ncap dimer [cytosol] (Homo sapiens)
as an input of
SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to HNRNPA1 (Homo sapiens)
Other forms of this molecule
HNRNPA1 [nucleoplasm]
Cross References
RefSeq
XP_005268883.1
,
NP_002127.1
,
NP_112420.1
OpenTargets
ENSG00000135486
ZINC - Substances
ROA1_HUMAN
GeneCards
P09651
HPA
ENSG00000135486-HNRNPA1
ZINC - Biogenic
ROA1_HUMAN
ZINC target
P09651
Ensembl
ENSG00000135486
,
ENST00000547566
,
ENSP00000447260
,
ENSP00000341826
,
ENST00000340913
,
ENSP00000446486
,
ENST00000547276
,
ENSP00000503610
,
ENST00000546500
,
ENSP00000449913
,
ENST00000677210
,
ENST00000550482
,
ENSP00000448617
PRO
P09651
Pharos - Targets
P09651
Orphanet
22023
PDB
2LYV
,
7ZJ2
,
1U1K
,
6DCL
,
1U1R
,
1U1L
,
5ZGD
,
4YOE
,
5MPG
,
1PO6
,
6BXX
,
1U1M
,
1U1N
,
1UP1
,
6J60
,
5MPL
,
2UP1
,
1U1O
,
5ZGL
,
7BX7
,
8RZV
,
1U1Q
,
1PGZ
,
2H4M
,
1L3K
,
1HA1
,
1U1P
Interactors (68)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q07666 KHDRBS1
3
p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm]
(R-HSA-8848970)
p-Y435,Y440,Y443-KHDRBS1 [cytosol]
(R-HSA-8848995)
KHDRBS1 [nucleoplasm]
(R-HSA-8848941)
0.875
10
UniProt:P07910 HNRNPC
3
HNRNPC [cytosol]
(R-HSA-9715136)
SUMO1-K250-HNRNPC [nucleoplasm]
(R-HSA-4570543)
HNRNPC [nucleoplasm]
(R-HSA-71933)
0.792
5
UniProt:P38159 RBMX
2
RBMX [cytosol]
(R-HSA-9715135)
RBMX [nucleoplasm]
(R-HSA-71939)
0.706
4
UniProt:P31943 HNRNPH1
1
HNRNPH1 [nucleoplasm]
(R-HSA-71941)
0.706
4
UniProt:Q8IUH3 RBM45
0.672
6
UniProt:P35637 FUS
1
FUS [nucleoplasm]
(R-HSA-72040)
0.671
5
UniProt:P22626 HNRNPA2B1
2
HNRNPA2B1 [extracellular exosome]
(R-HSA-8950304)
HNRNPA2B1 [nucleoplasm]
(R-HSA-71929)
0.669
3
UniProt:P31942 HNRH3
0.659
3
UniProt:P38919 EIF4A3
2
EIF4A3 [nucleoplasm]
(R-HSA-8849149)
EIF4A3 [cytosol]
(R-HSA-927868)
0.643
3
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [cytosol]
(R-COV-9694300)
p-S188,206-N [cytosol]
(R-COV-9729324)
p-8S-N [cytosol]
(R-COV-9729335)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
0.643
4
UniProt:P14866 HNRNPL
1
HNRNPL [nucleoplasm]
(R-HSA-71947)
0.615
3
UniProt:P23246 SFPQ
3
SFPQ [cytosol]
(R-HSA-9635505)
p-Y-SFPQ [nucleoplasm]
(R-HSA-8849461)
SFPQ [nucleoplasm]
(R-HSA-3900138)
0.615
3
UniProt:Q9NZB2 F120A
0.615
3
UniProt:Q96PK6 RBM14
1
RBM14 [nucleoplasm]
(R-HSA-8938345)
0.615
3
UniProt:P59595 N
9
N [cytosol]
(R-COV-9683625)
p-S177-N [cytosol]
(R-COV-9683754)
ADPr-p-S177-N [cytosol]
(R-COV-9686058)
SUMO1-K62-ADPr-p-S177-N [cytosol]
(R-COV-9682916)
SUMO1-K62-ADPr-p-S177-N [viral capsid]
(R-COV-9685478)
SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9683641)
N [plasma membrane]
(R-COV-9683611)
SUMO1-K62-ADPr-p-S177-N [nucleolus]
(R-COV-9683730)
SUMO1-K62-ADPr-p-S177-N [plasma membrane]
(R-COV-9686063)
0.602
3
UniProt:P27958-PRO_0000037577
0.599
4
UniProt:Q5BKZ1 ZN326
0.597
4
UniProt:P11387 TOP1
2
monoSUMO1-K117-TOP1 [nucleoplasm]
(R-HSA-4641364)
TOP1 [nucleoplasm]
(R-HSA-4641363)
0.597
4
UniProt:Q9NR30 DDX21
1
DDX21 [nucleoplasm]
(R-HSA-5250652)
0.564
2
UniProt:P51991 HNRNPA3
1
HNRNPA3 [nucleoplasm]
(R-HSA-71931)
0.564
2
UniProt:Q8NC51 SERB1
0.548
4
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.536
2
UniProt:P09651 HNRNPA1
2
HNRNPA1 [cytosol]
(R-HSA-9727902)
HNRNPA1 [nucleoplasm]
(R-HSA-71927)
0.536
2
UniProt:Q9Y5S9 RBM8A
2
RBM8A [cytosol]
(R-HSA-162462)
RBM8A [nucleoplasm]
(R-HSA-156659)
0.527
2
UniProt:Q09161 NCBP1
2
NCBP1 [nucleoplasm]
(R-HSA-51469)
NCBP1 [cytosol]
(R-HSA-162459)
0.527
3
UniProt:P43243 MATR3
0.527
2
UniProt:O75319 DUS11
0.527
2
UniProt:Q08211 DHX9
3
DHX9 [nucleoplasm]
(R-HSA-53517)
DHX9 [cytosol]
(R-HSA-847700)
p-DHX9 [cytosol]
(R-HSA-9836168)
0.527
2
UniProt:Q12906 ILF3
3
p-T188,T315-ILF3 [cytosol]
(R-HSA-9836381)
ILF3 [cytosol]
(R-HSA-450564)
ILF3 [nucleoplasm]
(R-HSA-9760401)
0.527
2
UniProt:Q9UHD9 UBQLN2
1
UBQLN2 [cytosol]
(R-HSA-8866007)
0.524
2
UniProt:Q8IZH2 XRN1
1
XRN1 [cytosol]
(R-HSA-429835)
0.519
2
UniProt:Q32P51 RA1L2
0.499
2
UniProt:Q14141 SEPT6
0.499
3
UniProt:Q14151 SAFB2
0.483
2
UniProt:Q15717 ELAVL1
6
ELAVL1 [nucleoplasm]
(R-HSA-450601)
p-S158,S221-ELAVL1 [nucleoplasm]
(R-HSA-450576)
p-S221,S318-ELAVL1 [nucleoplasm]
(R-HSA-450532)
ELAVL1 [cytosol]
(R-HSA-450582)
p-S221,S318-ELAVL1 [cytosol]
(R-HSA-450448)
p-S158,S221-ELAVL1 [cytosol]
(R-HSA-450376)
0.483
2
UniProt:Q15233 NONO
0.483
3
UniProt:Q13573 SNW1
1
SNW1 [nucleoplasm]
(R-HSA-351663)
0.483
2
UniProt:P17844 DDX5
4
DDX5 [nucleoplasm]
(R-HSA-3900136)
DDX5 [cytosol]
(R-HSA-9682643)
polySUMO2-K53-DDX5 [nucleoplasm]
(R-HSA-3900186)
monoSUMO1-K53-DDX5 [nucleoplasm]
(R-HSA-3900041)
0.483
2
UniProt:Q13151 HNRNPA0
1
HNRNPA0 [nucleoplasm]
(R-HSA-71925)
0.483
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
10
UniProt:Q96I24 FUBP3
0.483
2
UniProt:Q7L2J0 MEPCE
0.483
2
UniProt:Q9H0D6 XRN2
2
XRN2 [nucleoplasm]
(R-HSA-6791205)
XRN2 [cytosol]
(R-HSA-391297)
0.483
2
UniProt:Q6UN15 FIP1L1
9
p-11Y-FIP1L1(1-272)-PDGFRA(567-1069) fusion [cytosol]
(R-HSA-9673867)
p-11Y-FIP1L1(1-391)insAQCP-PDGFRA(577-1089) fusion [cytosol]
(R-HSA-9673879)
p-11Y-FIP1L1(1-392)insDCY-PDGFRA(585-1089) fusion [cytosol]
(R-HSA-9673621)
FIP1L1 [nucleoplasm]
(R-HSA-6805150)
FIP1L1(1-339)-PDGFRA(580-1089) fusion [cytosol]
(R-HSA-9672499)
FIP1L1(1-272)-PDGFRA(567-1089) fusion [cytosol]
(R-HSA-9672496)
FIP1L1(1-391)insAQCP-PDGFRA(577-1089) fusion [cytosol]
(R-HSA-9672502)
FIP1L1(1-392)insDCY-PDGFRA(585-1089) fusion [cytosol]
(R-HSA-9672506)
p-11Y-FIP1L1(1-339)-PDGFRA(580-1089) fusion [cytosol]
(R-HSA-9673872)
0.483
2
UniProt:O43823 AKAP8
0.483
2
UniProt:Q8IX01 SUGP2
0.483
2
UniProt:P26196 DDX6
1
DDX6 [cytosol]
(R-HSA-430032)
0.483
2
UniProt:Q86VM9 ZCH18
0.483
2
UniProt:Q12905 ILF2
5
ILF2 [cytosol]
(R-HSA-9836392)
ILF2 [tertiary granule lumen]
(R-HSA-6800995)
ILF2 [extracellular region]
(R-HSA-6799684)
ILF2 [ficolin-1-rich granule lumen]
(R-HSA-6801001)
ILF2 [specific granule lumen]
(R-HSA-6799611)
0.483
2
UniProt:P55265 ADAR
2
ADAR [nucleoplasm]
(R-HSA-53939)
ADAR1 [cytosol]
(R-HSA-9835955)
0.483
2
UniProt:P62316 SNRPD2
2
SNRPD2 [nucleoplasm]
(R-HSA-71901)
SNRPD2 [cytosol]
(R-HSA-191810)
0.483
2
UniProt:O95758 PTBP3
0.483
2
UniProt:Q96KR1 ZFR
0.483
2
UniProt:P78332 RBM6
0.483
2
UniProt:P55795 HNRNPH2
1
HNRNPH2 [nucleoplasm]
(R-HSA-71943)
0.483
2
UniProt:Q16630 CPSF6
2
CPSF6(1-490)-p-FGFR1(429-822) fusion [cytosol]
(R-HSA-1838987)
CPSF6(1-490)-FGFR1(429-822) fusion [cytosol]
(R-HSA-1614368)
0.483
2
UniProt:Q14966 ZNF638
1
ZNF638 [nucleoplasm]
(R-HSA-8939429)
0.483
2
UniProt:Q9UKV3 ACIN1
4
ACIN1 [cytosol]
(R-HSA-212519)
ACIN1(1094-1341) [cytosol]
(R-HSA-212516)
ACIN1(1-1093) [cytosol]
(R-HSA-212520)
ACIN1 [nucleoplasm]
(R-HSA-9770238)
0.483
2
UniProt:Q13285 NR5A1
3
NR5A1 [nucleoplasm]
(R-HSA-452955)
polySUMO2-K119,K194-NR5A1 [nucleoplasm]
(R-HSA-4546383)
monoSUMO1-K119,K194-NR5A1 [nucleoplasm]
(R-HSA-4546382)
0.483
2
UniProt:Q9UKV8 AGO2
2
AGO2 [nucleoplasm]
(R-HSA-5578701)
AGO2 [cytosol]
(R-HSA-209723)
0.483
2
UniProt:Q14498 RBM39
1
RBM39 [nucleoplasm]
(R-HSA-9770254)
0.483
2
UniProt:Q9BXP5 SRRT
1
SRRT [nucleoplasm]
(R-HSA-6814858)
0.483
2
UniProt:Q9HCK8 CHD8
1
CHD8 [nucleoplasm]
(R-HSA-3221598)
0.483
2
UniProt:Q15424 SAFB
3
SAFB [nucleoplasm]
(R-HSA-4085379)
polySUMO2,3-K231,K294-SAFB [nucleoplasm]
(R-HSA-4085357)
monoSUMO1-K231,K294-SAFB [nucleoplasm]
(R-HSA-4085343)
0.483
2
UniProt:P47756 CAPZB
1
CAPZB [cytosol]
(R-HSA-879409)
0.483
2
UniProt:P03372 ESR1
10
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.462
2
IntAct:EBI-6857440 NS3
0.462
2
UniProt:O60477 BRNP1
0.462
2
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