Reactome | GART [cytosol]

GART [cytosol]

Stable Identifier

R-HSA-62498

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase, Trifunctional purine biosynthetic protein adenosine-3 (Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (GART) (GAR transformylase) (5'-phosphoribosylglycinamide transformylase)), Trifunctional purine biosynthetic protein adenosine-3, Phosphoribosylamine--glycine ligase , GARS, Glycinamide ribonucleotide synthetase, Phosphoribosylglycinamide synthetase, Phosphoribosylformylglycinamidine cyclo-ligase , AIRS, Phosphoribosyl-aminoimidazole synthetase, AIR synthase, Phosphoribosylglycinamide formyltransferase , GAR transformylase, 5'-phosphoribosylglycinamide transformylase

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P22102 GART

Gene Names

GART, PGFT, PRGS

Chain

initiator methionine:, chain:2-1010

Reference Genes

BioGPS Gene:2618 GART

COSMIC (genes):GART GART

CTD Gene:2618 GART

dbSNP Gene:2618 GART

ENSEMBL:ENSG00000159131 GART

HGNC:4163 GART

KEGG:hsa:2618 GART

Monarch:2618 GART

NCBI Gene:2618 GART

OMIM:138440 GART

UCSC:P22102 GART

Reference Transcript

Other Identifiers

11720968_a_at

11720969_a_at

11722930_x_at

11722931_a_at

11764014_x_at

16925194

210005_PM_at

210005_at

212378_PM_at

212378_at

212379_PM_at

212379_at

217445_PM_s_at

217445_s_at

230097_PM_at

230097_at

230766_PM_at

230766_at

244822_PM_at

244822_at

2618

38384_at

3929720

3929722

3929723

3929724

3929725

3929726

3929727

3929728

3929729

3929731

3929732

3929733

3929734

3929735

3929736

3929737

3929738

3929739

3929740

3929741

3929742

3929744

3929745

3929746

3929747

3929748

3929749

3929750

3929751

3929752

3929753

3929754

3929755

3929756

3929757

3929758

3929759

3929760

3929761

3929762

3929763

3929764

50801_at

75543_at

8070102

82304_at

A_23_P80098

A_24_P239140

A_24_P301846

A_24_P820372

GE59791

GE85120

GE894390

GO:0003360

GO:0003824

GO:0004637

GO:0004641

GO:0004644

GO:0005524

GO:0005829

GO:0006164

GO:0006177

GO:0006189

GO:0009058

GO:0009113

GO:0009168

GO:0016740

GO:0016874

GO:0021549

GO:0021987

GO:0043226

GO:0044208

GO:0046084

GO:0046872

GO:0048856

GO:0055086

GO:0070062

GO:0072522

GO:0097294

GO:1901135

HMNXSV003000881

HMNXSV003048682

Hs.113631.0.A1_3p_at

Hs.144097.0.A1_3p_at

Hs.164168.0.A1_3p_at

Hs.82285.1.S1_3p_at

Hs.82285.1.S2_3p_at

Hs.82285.2.S1_3p_a_at

ILMN_1679476

ILMN_1793220

ILMN_1800020

PH_hs_0004709

TC21000412.hg

X54199_s_at

g509032_3p_at

Inferred To

GART [cytosol] (Bos taurus)

GART [cytosol] (Caenorhabditis elegans)

GART [cytosol] (Canis familiaris)

GART [cytosol] (Dictyostelium discoideum)

GART [cytosol] (Drosophila melanogaster)

GART [cytosol] (Gallus gallus)

GART [cytosol] (Mus musculus)

GART [cytosol] (Saccharomyces cerevisiae)

GART [cytosol] (Schizosaccharomyces pombe)

GART [cytosol] (Sus scrofa)

Gart [cytosol] (Rattus norvegicus)

gart [cytosol] (Danio rerio)

gart [cytosol] (Xenopus tropicalis)

Cross References

ZINC - World Drugs

PUR2_HUMAN

Guide to Pharmacology - Targets

2612

OpenTargets

ENSG00000159131

ENSEMBL

ENST00000381815, ENST00000381831, ENSP00000371253, ENST00000361093, ENST00000573055, ENSP00000371236, ENSP00000354388, ENSP00000459532, ENSP00000371261, ENSP00000461700, ENSP00000459391, ENST00000571089, ENST00000575273, ENST00000381839

ZINC - FDA approved

PUR2_HUMAN

ZINC - Substances

PUR2_HUMAN

ZINC target

P22102

PRO

P22102

GlyGen

P22102

PDB

2V9Y, 4ZYT, 1MEO, 1MEN, 7JG4, 8FDY, 5J9F, 1NJS, 8FDX, 2QK4, 8FDZ, 8FE0, 4ZZ3, 4ZZ2, 1ZLX, 8FJW, 1ZLY, 4ZYZ, 4ZYY, 8FJX, 1RBQ, 1RBY, 4ZYV, 1RBZ, 4ZZ1, 4EW1, 4ZYU, 1RBM, 4ZZ0, 1RC0, 4EW2, 1RC1, 8FJV, 7JG3, 4EW3, 7JG0, 4ZYX, 4ZYW, 8FJY, 1MEJ

ZINC - Investigational

PUR2_HUMAN

HPA

ENSG00000159131-GART

Pharos - Targets

P22102

ZINC - Predictions - Purchasable

PUR2_HUMAN

HMDB Protein

HMDBP00330

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BT40 INPP5K	1	INPP5K [cytosol] (R-HSA-1806175)	0.527	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	8