Reactome | LPAR2 [plasma membrane]

LPAR2 [plasma membrane]

Stable Identifier

R-HSA-419393

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Lysophosphatidic acid receptor 2, LPAR2_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR2 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR2 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR2 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR2 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR2 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR2 [plasma membrane] (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR2 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR2 [plasma membrane] (Homo sapiens)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR2 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR2 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
        
        GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR2 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR2 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Lysosphingolipid and LPA receptors (Homo sapiens)
        
        LPA-binding receptors bind LPA (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR2 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR2 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9HBW0 LPAR2

Gene Names

LPAR2, EDG4, LPA2

Chain

chain:1-348

Reference Genes

COSMIC (genes):LPAR2 LPAR2

ENSEMBL:ENSG00000064547 LPAR2

HGNC:3168 LPAR2

OMIM:605110 LPAR2

UCSC:Q9HBW0 LPAR2

Reference Transcript

Other Identifiers

11723335_s_at

11725440_a_at

16870658

206722_PM_s_at

206722_s_at

206723_PM_s_at

206723_s_at

37769_at

3855857

3855858

3855859

3855860

3855861

3855862

3855863

3855864

3855865

3855866

3855867

3855869

3855870

45673_at

8035703

9170

A_23_P101829

A_23_P56228

GE54109

GO:0004930

GO:0005515

GO:0005737

GO:0005886

GO:0007165

GO:0007186

GO:0007189

GO:0007204

GO:0008289

GO:0009986

GO:0016020

GO:0019222

GO:0030139

GO:0030165

GO:0031410

GO:0035025

GO:0043226

GO:0043410

GO:0048787

GO:0060089

GO:0070915

GO:0098978

HMNXSV003044469

HMNXSV003048004

ILMN_1662741

ILMN_1805693

PH_hs_0003442

PH_hs_0006860

TC19001305.hg

g11038657_3p_a_at

g2735848_3p_a_at

g7706106_3p_a_at

Participates

as a member of

LPAR1,2,3,5 [plasma membrane] (Homo sapiens)

Inferred To

LPAR2 [plasma membrane] (Bos taurus)

LPAR2 [plasma membrane] (Canis familiaris)

LPAR2 [plasma membrane] (Gallus gallus)

LPAR2 [plasma membrane] (Sus scrofa)

Lpar2 [plasma membrane] (Mus musculus)

Lpar2 [plasma membrane] (Rattus norvegicus)

lpar2a [plasma membrane] (Danio rerio)

lpar2 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

XP_016882958.1, XP_011526723.1, NP_004711.2, XP_016882957.1

Guide to Pharmacology - Targets

273

ENSEMBL

ENSG00000064547, ENST00000542587, ENST00000586703, ENSP00000384665, ENST00000407877, ENSP00000465280, ENSP00000443256

OpenTargets

ENSG00000064547

ZINC - Substances

LPAR2_HUMAN

ZINC - Biogenic

LPAR2_HUMAN

ZINC target

Q9HBW0

PRO

Q9HBW0

GlyGen

Q9HBW0

PDB

4P0C

ZINC - Metabolites

LPAR2_HUMAN

GeneCards

LPAR2

HPA

ENSG00000064547-LPAR2

Pharos - Targets

Q9HBW0

ZINC - Predictions - Purchasable

LPAR2_HUMAN

HMDB Protein

HMDBP02847

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P17931 LGALS3	3	LGALS3 [plasma membrane] (R-HSA-879445) LGALS3 [secretory granule membrane] (R-HSA-6803327) LGALS3 [ficolin-1-rich granule membrane] (R-HSA-6803307)	0.623	3
UniProt:P68871 HBB	8	HBB [lysosomal lumen] (R-HSA-9625193) HBB [cytosol] (R-HSA-1008196) HBB [late endosome lumen] (R-HSA-9631108) HBB [ficolin-1-rich granule lumen] (R-HSA-6801015) HBB [extracellular region] (R-HSA-2168872) HBB [tertiary granule lumen] (R-HSA-6800191) HBB [endocytic vesicle lumen] (R-HSA-2230936) CO-H+-HBB [cytosol] (R-HSA-1237013)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.499	3