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LPAR2 [plasma membrane]
Stable Identifier
R-HSA-419393
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Lysophosphatidic acid receptor 2, LPAR2_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR2 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR2 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR2 [plasma membrane] (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR2 [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR2 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR2 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Lysosphingolipid and LPA receptors (Homo sapiens)
LPA-binding receptors bind LPA (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR2 [plasma membrane] (Homo sapiens)
LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9HBW0 LPAR2
Gene Names
LPAR2, EDG4, LPA2
Chain
chain:1-348
Reference Genes
COSMIC (genes):LPAR2 LPAR2
ENSEMBL:ENSG00000064547 LPAR2
HGNC:3168 LPAR2
OMIM:605110 LPAR2
UCSC:Q9HBW0 LPAR2
Reference Transcript
RefSeq:NM_004720.5 LPAR2
RefSeq:XM_017027469.1 LPAR2
RefSeq:XM_017027468.1 LPAR2
RefSeq:XM_011528421.2 LPAR2
Other Identifiers
11723335_s_at
11725440_a_at
16870658
206722_PM_s_at
206722_s_at
206723_PM_s_at
206723_s_at
37769_at
3855857
3855858
3855859
3855860
3855861
3855862
3855863
3855864
3855865
3855866
3855867
3855869
3855870
45673_at
8035703
9170
A_23_P101829
A_23_P56228
GE54109
GO:0004930
GO:0005515
GO:0005737
GO:0005886
GO:0007165
GO:0007186
GO:0007189
GO:0007204
GO:0008289
GO:0009986
GO:0016020
GO:0019222
GO:0030139
GO:0030165
GO:0031410
GO:0035025
GO:0043226
GO:0043410
GO:0048787
GO:0060089
GO:0070915
GO:0098978
HMNXSV003044469
HMNXSV003048004
ILMN_1662741
ILMN_1805693
PH_hs_0003442
PH_hs_0006860
TC19001305.hg
g11038657_3p_a_at
g2735848_3p_a_at
g7706106_3p_a_at
Participates
as a member of
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
Inferred To
LPAR2 [plasma membrane]
(Bos taurus)
LPAR2 [plasma membrane]
(Canis familiaris)
LPAR2 [plasma membrane]
(Gallus gallus)
LPAR2 [plasma membrane]
(Sus scrofa)
Lpar2 [plasma membrane]
(Mus musculus)
Lpar2 [plasma membrane]
(Rattus norvegicus)
lpar2a [plasma membrane]
(Danio rerio)
lpar2 [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
XP_016882958.1
,
XP_011526723.1
,
NP_004711.2
,
XP_016882957.1
Guide to Pharmacology - Targets
273
ENSEMBL
ENSG00000064547
,
ENST00000542587
,
ENST00000586703
,
ENSP00000384665
,
ENST00000407877
,
ENSP00000465280
,
ENSP00000443256
OpenTargets
ENSG00000064547
ZINC - Substances
LPAR2_HUMAN
ZINC - Biogenic
LPAR2_HUMAN
ZINC target
Q9HBW0
PRO
Q9HBW0
GlyGen
Q9HBW0
PDB
4P0C
ZINC - Metabolites
LPAR2_HUMAN
GeneCards
LPAR2
HPA
ENSG00000064547-LPAR2
Pharos - Targets
Q9HBW0
ZINC - Predictions - Purchasable
LPAR2_HUMAN
HMDB Protein
HMDBP02847
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P17931 LGALS3
3
LGALS3 [plasma membrane]
(R-HSA-879445)
LGALS3 [secretory granule membrane]
(R-HSA-6803327)
LGALS3 [ficolin-1-rich granule membrane]
(R-HSA-6803307)
0.623
3
UniProt:P68871 HBB
8
HBB [lysosomal lumen]
(R-HSA-9625193)
HBB [cytosol]
(R-HSA-1008196)
HBB [late endosome lumen]
(R-HSA-9631108)
HBB [ficolin-1-rich granule lumen]
(R-HSA-6801015)
HBB [extracellular region]
(R-HSA-2168872)
HBB [tertiary granule lumen]
(R-HSA-6800191)
HBB [endocytic vesicle lumen]
(R-HSA-2230936)
CO-H+-HBB [cytosol]
(R-HSA-1237013)
0.527
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.499
3
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