Reactome | RPS15A [cytosol]

RPS15A [cytosol]

Stable Identifier

R-HSA-72345

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

40S small ribosomal protein 1A, P39027, 40S ribosomal protein S15a

Locations in the PathwayBrowser

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Cellular responses to external stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
    - EIF2AK4 (GCN2) binds tRNA (Homo sapiens)
      - EIF2AK4:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS15A [cytosol] (Homo sapiens)
      - tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS15A [cytosol] (Homo sapiens)
    - EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)
      - tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS15A [cytosol] (Homo sapiens)
      - tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS15A [cytosol] (Homo sapiens)
    - IMPACT binds GCN1 (Homo sapiens)
      - GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS15A [cytosol] (Homo sapiens)
      - IMPACT:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS15A [cytosol] (Homo sapiens)
    - p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
      - tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS15A [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS15A [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS15A [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS15A [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS15A [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS15A [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS15A [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS15A [cytosol] (Homo sapiens)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS15A [cytosol] (Homo sapiens)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS15A [cytosol] (Homo sapiens)
- rRNA processing (Homo sapiens)
  - rRNA processing in the nucleus and cytosol (Homo sapiens)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
      - 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS15A [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62244 RPS15A

Gene Names

RPS15A, OK/SW-cl.82

Chain

initiator methionine:1, chain:2-130

Reference Genes

BioGPS Gene:6210 RPS15A

COSMIC (genes):RPS15A RPS15A

CTD Gene:6210 RPS15A

dbSNP Gene:6210 RPS15A

ENSEMBL:ENSG00000134419 RPS15A

HGNC:10389 RPS15A

KEGG Gene (Homo sapiens):6210 RPS15A

Monarch:6210 RPS15A

NCBI Gene:6210 RPS15A

OMIM:603674 RPS15A

UCSC:P62244 RPS15A

Reference Transcript

Other Identifiers

0000870619

11723251_at

11753656_x_at

11753694_x_at

11757363_x_at

11758880_at

11758881_x_at

16824463

200781_s_at

235309_at

2409816

2410356

2456846

2456847

2904730

3129993

34316_at

34317_g_at

3650334

3650336

3650337

3683019

3683020

3683021

3683022

3683028

3683031

3683032

3683034

3683035

3683036

3900471

3900476

44303_at

47103

49788_at

4UG0

4V6X

5A2Q

5AJ0

5FLX

5LKS

5OA3

5T2C

5VYC

6210

6EK0

6FEC

6G18

6G4S

6G4W

6G51

6G53

6G5H

6G5I

6QZP

7999827

A_24_P221366

A_33_P3304282

AAH01697

AAH30569

AAH46113

AAI05274

AAI05293

AAO48936

AB007154

AB062400

AK054921

AK311976

AY208299

B2R4W8

BAA28592

BAB93487

BAG34915

BAG51444

BC001697

BC030569

BC046113

BC105273

BC105292

CAA44568

CAA59127

CCDS10571

CH471186

EAW50254

EAW50255

ENSG00000134419

ENSP00000318646

ENSP00000457000

ENSP00000458115

ENSP00000458528

ENST00000322989

ENST00000322989.8

ENST00000563390

ENST00000563390.5

ENST00000565420

ENST00000565420.5

ENST00000572008

ENST00000572008.5

EntrezGene:6210

EntrezGene:RPS15A

g4506688_3p_a_at

GE78955

GE87302

GO:0000184

GO:0003674

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005840

GO:0006412

GO:0006413

GO:0006605

GO:0006614

GO:0006810

GO:0007049

GO:0008150

GO:0008283

GO:0008284

GO:0009056

GO:0009058

GO:0009615

GO:0015031

GO:0016020

GO:0019083

GO:0022627

GO:0032991

GO:0034641

GO:0034655

GO:0043226

GO:0044403

GO:0045787

GO:0070062

H3BT37

H3BV27

HGNC:10389

HPA047103

Hs.9879.0.S1_3p_at

I3L246

I3L303

I3L3P7

ILMN_1787949

ILMN_2255310

ILMN_2337241

IPR000630

IPR035987

MIM:603674

MIM:618313

NM_001019

NM_001030009

NP_001010

NP_001025180

PF00410

PH_hs_0028251

RPS15A

RPS15A-201

RPS15A-203

RPS15A-205

RPS15A-208

TC16000914.hg

UPI0000002488

X62691

X62691_at

X84407

Participant Of

hasComponent

40S ribosomal complex [cytosol]

Other forms of this molecule

RPS15A [nucleoplasm]

Inferred To

Homologues of RPS15A [cytosol] (Schizosaccharomyces pombe)

RpS15Aa [cytosol] (Drosophila melanogaster)

rps15a [cytosol] (Danio rerio)

rps15a [cytosol] (Dictyostelium discoideum)

rps2202 [cytosol] (Schizosaccharomyces pombe)

rps-22 [cytosol] (Caenorhabditis elegans)

Rps15a [cytosol] (Mus musculus)

Rps15a [cytosol] (Rattus norvegicus)

RPS15A [cytosol] (Bos taurus)

RPS15A [cytosol] (Canis familiaris)

RPS15A [cytosol] (Gallus gallus)

RPS15A [cytosol] (Plasmodium falciparum)

RPS15A [cytosol] (Sus scrofa)

RPS15A [cytosol] (Xenopus tropicalis)

RPS22A [cytosol] (Saccharomyces cerevisiae)

rps2201 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_001010.2, NP_001025180.1

OpenTargets

ENSG00000134419

HPA

ENSG00000134419-RPS15A

GeneCards

P62244

Ensembl

ENST00000565420, ENSP00000458115, ENSP00000318646, ENST00000563390, ENSP00000457000, ENSG00000134419, ENSP00000458528, ENST00000322989, ENST00000572008

PRO

P62244

Orphanet

27943

PDB

6OLG, 5A2Q, 6IP6, 6G5I, 6OLF, 6IP5, 5LKS, 6G5H, 6OLE, 4V6X, 6EK0, 6OLZ, 5T2C, 5VYC, 5OA3, 5AJ0, 6G53, 6OLI, 6G18, 6IP8, 6G4W, 6OM0, 5FLX, 6G51, 6QZP, 6G4S, 4UG0, 6FEC, 6OM7

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:Q15843 NEDD8	17	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) K1881-CUL9-G76-NEDD8 [cytosol] (R-HSA-8955924) NEDD8 [nucleoplasm] (R-HSA-8955926) K705-CUL4A-G76-NEDD8 [nucleoplasm] (R-HSA-8952528) K859-CUL4B-G76-NEDD8 [nucleoplasm] (R-HSA-8952538) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739) NEDD8(77-88) [cytosol] (R-HSA-6782654) NEDD8(1-88) [cytosol] (R-HSA-5690794) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) K720-CUL1-G76-NEDD8 [cytosol] (R-HSA-8952534) K712-CUL3-G76-NEDD8 [cytosol] (R-HSA-8952531) K689-CUL2-G76-NEDD8 [cytosol] (R-HSA-8952526) K724-CUL5-G76-NEDD8 [cytosol] (R-HSA-8952018) NEDD8 [cytosol] (R-HSA-416969) K567-TGFBR2-G76-NEDD8 [cytosol] (R-HSA-4419906) K556-TGFBR2-G76-NEDD8 [cytosol] (R-HSA-4419907) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895)	0.527	2
UniProt:P03372 ESR1	8	SUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.527	3

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