Reactome | ATP5PB [mitochondrial inner membrane]

ATP5PB [mitochondrial inner membrane]

Stable Identifier

R-HSA-164537

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

ATP5F1, ATP synthase subunit b

Locations in the PathwayBrowser

Expand all

Organelle biogenesis and maintenance (Homo sapiens)

- Mitochondrial biogenesis (Homo sapiens)
  - Cristae formation (Homo sapiens)
    - F1Fo ATP synthase dimerizes (Homo sapiens)
      - F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(0) [mitochondrial inner membrane] (Homo sapiens)
        
        ATP5PB [mitochondrial inner membrane] (Homo sapiens)
      - F1Fo ATP synthase dimer [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(0) [mitochondrial inner membrane] (Homo sapiens)
        
        ATP5PB [mitochondrial inner membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P24539 ATP5PB

Gene Names

ATP5PB, ATP5F1

Chain

transit peptide:1-42, chain:43-256

Reference Genes

BioGPS Gene:515 ATP5PB

COSMIC (genes):ATP5PB ATP5PB

CTD Gene:515 ATP5PB

dbSNP Gene:515 ATP5PB

ENSEMBL:ENSG00000116459 ATP5F1

ENSEMBL_homo_sapiens_GENE:ENSG00000116459.11 ATP5PB

HGNC:840 ATP5PB

KEGG Gene (Homo sapiens):515 ATP5PB

Monarch:515 ATP5PB

NCBI Gene:515 ATP5PB

OMIM:603270 ATP5PB

Reference Transcript

RefSeq:NM_001688.4 ATP5PB

Other Identifiers

11734652_s_at

11734653_x_at

11734654_at

11734655_x_at

16668689

211755_PM_s_at

211755_s_at

2351821

2351822

2351830

2351832

2351833

2351835

2351837

2351838

2351839

2351840

2351841

2351843

2351845

243501_PM_at

243501_at

3792570

3812170

41228_r_at

515

68528_r_at

7903972

A_23_P46275

A_24_P659099

D28383_at

GE59857

GO:0000276

GO:0003824

GO:0005215

GO:0005515

GO:0005634

GO:0005739

GO:0005743

GO:0005753

GO:0005759

GO:0006091

GO:0006811

GO:0015078

GO:0015986

GO:0016020

GO:0016874

GO:0021762

GO:0042776

GO:0043226

GO:0045263

GO:0046933

GO:0048856

GO:0055085

GO:0055086

GO:1901135

GO:1902600

HMNXSV003050712

Hs.191834.0.A1_3p_at

ILMN_1672191

ILMN_1721989

ILMN_1899664

PH_hs_0004670

TC01000977.hg

X60221_at

g13543617_3p_s_at

Participates

as a component of

ATPase CF(0) [mitochondrial inner membrane] (Homo sapiens)

Inferred To

LOC119872230 [mitochondrial inner membrane] (Canis familiaris)

ATP5PB [mitochondrial inner membrane] (Bos taurus)

ATP5PB [mitochondrial inner membrane] (Gallus gallus)

ATP5PB [mitochondrial inner membrane] (Sus scrofa)

Atp5pb [mitochondrial inner membrane] (Mus musculus)

Atp5pb [mitochondrial inner membrane] (Rattus norvegicus)

ATPsynB [mitochondrial inner membrane] (Drosophila melanogaster)

asb-1 [mitochondrial inner membrane] (Caenorhabditis elegans)

atp5pb [mitochondrial inner membrane] (Danio rerio)

Cross References

RefSeq

NP_001679.2

Guide to Pharmacology - Targets

802

OpenTargets

ENSG00000116459

GeneCards

P24539

HPA

ENSG00000116459-ATP5PB

Ensembl

ENSG00000116459, ENST00000369722, ENSP00000358737

PRO

P24539

Pharos - Targets

P24539

HMDB Protein

HMDBP01419

PDB

8H9U, 8H9J, 8H9M, 8H9R, 8H9T, 8H9Q, 8H9K, 8H9G, 8H9F, 8H9N, 8H9V, 8H9S

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06576 ATP5F1B	6	ATP5B(1-47) [mitochondrial matrix] (R-HSA-8986172) ATP5B(1-529) [cytosol] (R-HSA-1267973) ATP5B(1-529) [mitochondrial intermembrane space] (R-HSA-1267985) ATP5B(1-529) [mitochondrial inner membrane] (R-HSA-1299440) ATP5B [mitochondrial inner membrane] (R-HSA-1299441) ATP5F1B [mitochondrial matrix] (R-HSA-164576)	0.669	5
UniProt:P10809 HSPD1	6	HSPD1 [mitochondrial matrix] (R-HSA-1299448) HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171)	0.615	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q14154 DELE1	3	DELE1 [mitochondrial inner membrane] (R-HSA-9840377) DELE1(143-515) [cytosol] (R-HSA-9840380) DELE1(143-515) [mitochondrial inner membrane] (R-HSA-9840386)	0.556	3
UniProt:Q9H244 P2RY12	1	P2RY12 [plasma membrane] (R-HSA-391959)	0.527	2
UniProt:P51451 BLK	2	MyrG2-BLK [plasma membrane] (R-HSA-9606871) BLK [cytosol] (R-HSA-983580)	0.527	2
UniProt:Q16581 C3AR1	3	C3AR1 [plasma membrane] (R-HSA-444727) C3AR1 [azurophil granule membrane] (R-HSA-6799517) C3AR1 [specific granule membrane] (R-HSA-6799516)	0.527	2
UniProt:P25103 TACR1	2	TACR1 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869122) TACR1 [plasma membrane] (R-HSA-380103)	0.527	2
UniProt:Q9H1C4 UNC93B1	4	UNC93B1 [Golgi membrane] (R-HSA-1679064) UNC93B1 [endoplasmic reticulum membrane] (R-HSA-1678930) UNC93B1 P345Pfs103 [endoplasmic reticulum membrane] (R-HSA-9628866) UNC93B1 L230Afs188 [endoplasmic reticulum membrane] (R-HSA-9628869)	0.527	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	6
UniProt:P05919 vpu	6	VPU (P05919) protein [cytosol] (R-HIV-173223) VPU (P05919) [endoplasmic reticulum membrane] (R-HIV-180550) VPU (P05919) protein [extracellular region] (R-HIV-175522) VPU (P05919) protein [nucleoplasm] (R-HIV-175200) VPU (P05919) [Golgi membrane] (R-HIV-3149439) VPU (P05919) [plasma membrane] (R-HIV-3149423)	0.462	2

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