Reactome | BAIAP2 [cytosol]

BAIAP2 [cytosol]

Stable Identifier

R-HSA-442574

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

IRSp53/58, Brain-specific angiogenesis inhibitor 1-associated protein 2, BAIP2_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9UQB8 BAIAP2

Gene Names

BAIAP2

Chain

chain:1-552

Reference Genes

BioGPS Gene:10458 BAIAP2

COSMIC (genes):BAIAP2 BAIAP2

CTD Gene:10458 BAIAP2

dbSNP Gene:10458 BAIAP2

ENSEMBL:ENSG00000175866 BAIAP2

ENSEMBL_homo_sapiens_GENE:ENSG00000175866.16 BAIAP2

HGNC:947 BAIAP2

KEGG Gene (Homo sapiens):10458 BAIAP2

Monarch:10458 BAIAP2

NCBI Gene:10458 BAIAP2

OMIM:605475 BAIAP2

UCSC:Q9UQB8 BAIAP2

Reference Transcript

Other Identifiers

10458

11722718_a_at

11722719_s_at

11722720_at

11726574_a_at

11739607_a_at

11749800_a_at

11749801_x_at

11754668_x_at

11762496_x_at

11762757_a_at

11762758_x_at

16838750

205293_PM_x_at

205293_x_at

205294_PM_at

205294_at

207832_PM_at

207832_at

209502_PM_s_at

209502_s_at

3737698

3737699

3737700

3737717

3737720

3737730

3737732

3737733

3737741

3737744

3737745

3737746

3737747

3737749

3737750

3737751

3737753

3737754

3737755

3737756

3737758

3737763

3737764

3737765

3737766

37761_at

8010562

A_24_P159648

GE53407

GO:0001221

GO:0001726

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005856

GO:0005874

GO:0005886

GO:0005912

GO:0007009

GO:0007010

GO:0007155

GO:0007409

GO:0008093

GO:0008286

GO:0008360

GO:0010976

GO:0015629

GO:0016020

GO:0016358

GO:0023052

GO:0030027

GO:0030141

GO:0030154

GO:0030165

GO:0030175

GO:0030182

GO:0030838

GO:0031410

GO:0032956

GO:0034330

GO:0035418

GO:0042802

GO:0042995

GO:0043005

GO:0043025

GO:0043197

GO:0043198

GO:0043226

GO:0044306

GO:0048167

GO:0048856

GO:0050804

GO:0050877

GO:0051017

GO:0051764

GO:0060076

GO:0060090

GO:0061003

GO:0061024

GO:0061845

GO:0061846

GO:0065003

GO:0070062

GO:0070064

GO:0071364

GO:0097060

GO:0097110

GO:0098609

GO:0098631

GO:0098641

GO:0098685

GO:0098793

GO:0098794

GO:0098978

GO:0099092

GO:0099175

GO:0099523

GO:0099524

GO:1905232

GO:1905274

GO:2000463

HMNXSV003014516

HMNXSV003026596

HMNXSV003056908

ILMN_1699727

ILMN_1705922

ILMN_2258749

PH_hs_0022412

TC17000924.hg

g12803352_3p_a_at

g4239983_3p_s_at

g9257198_3p_at

Participates

as a member of

as a candidate of

RAC3 effectors [cytosol] (Homo sapiens)

as an input of

RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)

as a component of

Inferred To

IRSp53 [cytosol] (Drosophila melanogaster)

Ghost homologue of BAIAP2 [cytosol] (Caenorhabditis elegans)

Ghost homologue of BAIAP2 [cytosol] (Dictyostelium discoideum)

Ghost homologue of BAIAP2 [cytosol] (Xenopus tropicalis)

Baiap2 [cytosol] (Mus musculus)

Baiap2 [cytosol] (Rattus norvegicus)

BAIAP2 [cytosol] (Bos taurus)

BAIAP2 [cytosol] (Canis familiaris)

BAIAP2 [cytosol] (Gallus gallus)

BAIAP2 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_006331.1, NP_059344.1, NP_001138360.1, XP_005257005.1, NP_059345.1

OpenTargets

ENSG00000175866

GeneCards

Q9UQB8

HPA

ENSG00000175866-BAIAP2

Ensembl

ENSP00000316338, ENSP00000458964, ENST00000435091, ENST00000428708, ENSP00000401022, ENSP00000413069, ENSG00000175866, ENST00000575712, ENST00000321280, ENST00000321300, ENSP00000315685

PRO

Q9UQB8

Pharos - Targets

Q9UQB8

HMDB Protein

HMDBP08316

PDB

1WDZ, 6ZEG, 6BCR, 1Y2O, 3RNJ, 6ZEI, 6BD1, 6BQT, 6BCY, 6BD2, 4JS0, 2YKT

Interactors (39)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.897	11
UniProt:Q12929 EPS8	1	EPS8 [cytosol] (R-HSA-9662382)	0.891	12
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.802	9
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.802	8
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.745	7
UniProt:Q9UQB8 BAIAP2	1	BAIAP2 [cytosol] (R-HSA-442574)	0.744	5
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.735	4
UniProt:P63000 RAC1	6	RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.728	4
UniProt:Q9UHR4 BAIAP2L1	1	BAIAP2L1 [cytosol] (R-HSA-9693276)	0.708	5
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.706	6
UniProt:Q9NZQ3 NCKIPSD	1	NCKIPSD [cytosol] (R-HSA-2197671)	0.678	3
UniProt:Q8IZP0 ABI1	2	p-5S-ABI1 [cytosol] (R-HSA-2029034) ABI1 [cytosol] (R-HSA-1671643)	0.669	4
UniProt:Q92558 WASF1	3	WASF1 [cytosol] (R-HSA-200965) p-Y151,S,T-WASF1 [cytosol] (R-HSA-5672390) p-Y151-WASF1 [cytosol] (R-HSA-2029058)	0.659	3
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.649	7
UniProt:Q9Y6W5 WASF2	3	WASF2 [cytosol] (R-HSA-200972) p-Y150,S343,T346-WASF2 [cytosol] (R-HSA-2130179) p-Y150-WASF2 [cytosol] (R-HSA-2130193)	0.643	5
UniProt:Q7L576 CYFIP1	5	CYFIP1 [specific granule lumen] (R-HSA-6800167) CYFIP1 [secretory granule lumen] (R-HSA-6800940) CYFIP1 [extracellular region] (R-HSA-6800473) CYFIP1 [tertiary granule lumen] (R-HSA-6800176) CYFIP1 [cytosol] (R-HSA-5672575)	0.643	3
UniProt:Q08509 Eps8	1	Eps8 [cytosol] (R-MMU-9662412)	0.639	8
UniProt:Q14678 KANK1	3	KANK1 [nucleoplasm] (R-HSA-9018640) p-12Y-KANK1(1-899)-PDGFRB(415-1106) fusion [plasma membrane] (R-HSA-9673890) KANK1(1-899)-PDGFRB(415-1106) fusion [plasma membrane] (R-HSA-9673593)	0.639	6
UniProt:P54259 ATN1	1	ATN1 [nucleoplasm] (R-HSA-6807083)	0.635	3
UniProt:Q03173 Enah	2	Enah [cytosol] (R-MMU-430212) Enah [cytosol] (R-MMU-426406)	0.591	3
UniProt:P60953 CDC42	3	CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086) CDC42 [cytosol] (R-HSA-442630) CDC42 [plasma membrane] (R-HSA-449545)	0.573	2
UniProt:P60709 ACTB	5	Unfolded ACTB [cytosol] (R-HSA-390462) ACTB [nucleoplasm] (R-HSA-3321990) ACTB [cytosol] (R-HSA-201861) ACTB [lysosomal membrane] (R-HSA-196160) ACTB [plasma membrane] (R-HSA-196016)	0.564	2
UniProt:Q9NZ81 PRR13			0.556	3
UniProt:Q13625-3 TP53BP2			0.556	3
UniProt:Q9UFG5 CS025			0.556	3
UniProt:Q15427 SF3B4	1	SF3B4 [nucleoplasm] (R-HSA-71975)	0.556	3
UniProt:O00401 WASL	4	N-WASP [cytosol] (R-HSA-201873) p-Y256-WASL [cytosol] (R-HSA-2197672) WASL [plasma membrane] (R-HSA-203010) WASL [endocytic vesicle membrane] (R-HSA-535012)	0.547	2
UniProt:Q9Y2A7 NCKAP1	1	NCKAP1 [cytosol] (R-HSA-200979)	0.527	3
UniProt:Q9NYB9 ABI2	2	ABI2 [cytosol] (R-HSA-1671647) p-4S-ABI2 [cytosol] (R-HSA-2029003)	0.527	2
UniProt:Q9P206 NHSL3			0.527	4
UniProt:Q8WUW1 BRK1	1	BRK1 [cytosol] (R-HSA-1671645)	0.527	2
UniProt:Q96F07 CYFIP2	1	CYFIP2 [cytosol] (R-HSA-1671642)	0.527	2
UniProt:Q96PV0 SYNGAP1	1	SYNGAP1 [cytosol] (R-HSA-5658217)	0.527	6
UniProt:Q8CFN2 Cdc42	3	CDC42 [endoplasmic reticulum membrane] (R-RNO-5672086) Cdc42 [cytosol] (R-RNO-428464) CDC42 [plasma membrane] (R-RNO-449545)	0.527	2
UniProt:Q7DB77 TIR			0.508	3
UniProt:P60953-2 CDC42			0.508	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	6
UniProt:P01116 KRAS	20	S-Farn-Me-PalmS KRAS [plasma membrane] (R-HSA-9674814) p-Y32-S-Farn-Me-PalmS KRAS [plasma membrane] (R-HSA-9674821) KRAS A146T [plasma membrane] (R-HSA-9649623) KRAS K147E [plasma membrane] (R-HSA-9651169) KRAS K147T [plasma membrane] (R-HSA-9651180) KRAS V14G [plasma membrane] (R-HSA-9651295) KRAS K147N [plasma membrane] (R-HSA-9651177) KRAS A146V [plasma membrane] (R-HSA-9649626) KRAS A146S [plasma membrane] (R-HSA-9649621) KRAS A146P [plasma membrane] (R-HSA-9649617) KRAS P34R [plasma membrane] (R-HSA-9651276) KRAS P34L [plasma membrane] (R-HSA-9651269) KRAS G12A [plasma membrane] (R-HSA-9649088) KRAS G12R [plasma membrane] (R-HSA-9649090) KRAS G13V [plasma membrane] (R-HSA-9649644) KRAS G13S [plasma membrane] (R-HSA-9649642) KRAS G13C [plasma membrane] (R-HSA-9649636) KRAS G13R [plasma membrane] (R-HSA-9649639) KRAS G13A [plasma membrane] (R-HSA-9649632) KRAS K5N [plasma membrane] (R-HSA-9651361)	0.483	2
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.471	4

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