Reactome | NEDD4 [cytosol]

NEDD4 [cytosol]

Stable Identifier

R-HSA-975992

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

E3 ubiquitin-protein ligase NEDD4, NEDD4_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P46934 NEDD4

Gene Names

NEDD4, KIAA0093, NEDD4-1, RPF1, PIG53

Chain

initiator methionine:, chain:1-1319

Reference Genes

BioGPS Gene:4734 NEDD4

COSMIC (genes):NEDD4 NEDD4

CTD Gene:4734 NEDD4

dbSNP Gene:4734 NEDD4

ENSEMBL:ENSG00000069869 NEDD4

ENSEMBL_homo_sapiens_GENE:ENSG00000069869.17 NEDD4

HGNC:7727 NEDD4

KEGG Gene (Homo sapiens):4734 NEDD4

Monarch:4734 NEDD4

NCBI Gene:4734 NEDD4

OMIM:602278 NEDD4

UCSC:P46934 NEDD4

Reference Transcript

Other Identifiers

11725574_a_at

11735016_a_at

11750554_a_at

16809687

213012_PM_at

213012_at

32078_at

3625540

3625541

3625542

3625543

3625544

3625545

3625547

3625548

3625549

3625550

3625551

3625552

3625554

3625556

3625558

3625559

3625560

3625563

3625564

3625565

3625566

3625569

3625572

3625573

3625576

3625577

3625579

3625582

3625584

3625598

3625599

3625600

3625601

3625602

3625603

3625604

3625609

3625613

3625614

3625618

3625621

4734

7989094

A_23_P331379

A_32_P160883

D42055_at

GE57207

GO:0000122

GO:0000151

GO:0000785

GO:0002376

GO:0003824

GO:0004842

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005694

GO:0005737

GO:0005794

GO:0005829

GO:0005886

GO:0005938

GO:0006351

GO:0006355

GO:0006511

GO:0006622

GO:0006886

GO:0006913

GO:0006914

GO:0006974

GO:0007041

GO:0007399

GO:0007528

GO:0010766

GO:0016020

GO:0016192

GO:0016241

GO:0016327

GO:0016567

GO:0016740

GO:0019871

GO:0019899

GO:0019904

GO:0023052

GO:0030154

GO:0030163

GO:0030948

GO:0031175

GO:0031623

GO:0031698

GO:0032801

GO:0032991

GO:0034330

GO:0034644

GO:0034765

GO:0036211

GO:0042391

GO:0042921

GO:0043130

GO:0043162

GO:0043197

GO:0043226

GO:0044111

GO:0045087

GO:0045732

GO:0046755

GO:0046824

GO:0048471

GO:0048814

GO:0048856

GO:0050807

GO:0050815

GO:0050816

GO:0050847

GO:0051592

GO:0051897

GO:0055085

GO:0061630

GO:0070062

GO:0070063

GO:0070064

GO:0070534

GO:0098542

GO:0098772

GO:0140096

GO:1901016

GO:2000650

HMNXSV003043543

HMNXSV003056441

Hs.1565.0.S1_3p_at

ILMN_1703140

ILMN_1751407

ILMN_1807881

PH_hs_0000209

TC15001471.hg

Participates

as a component of

as an input of

as a member of

NEDD4,STUB1,WWP2 and XIAP [cytosol] (Homo sapiens)

as a candidate of

Inferred To

pub1 [cytosol] (Schizosaccharomyces pombe)

RSP5 [cytosol] (Saccharomyces cerevisiae)

nedd4a [cytosol] (Danio rerio)

Homologues of NEDD4 [cytosol] (Dictyostelium discoideum)

Homologues of NEDD4 [cytosol] (Schizosaccharomyces pombe)

Nedd4 [cytosol] (Drosophila melanogaster)

Nedd4 [cytosol] (Mus musculus)

Nedd4 [cytosol] (Rattus norvegicus)

pub3 [cytosol] (Schizosaccharomyces pombe)

NEDD4 [cytosol] (Bos taurus)

NEDD4 [cytosol] (Caenorhabditis elegans)

NEDD4 [cytosol] (Canis familiaris)

NEDD4 [cytosol] (Dictyostelium discoideum)

NEDD4 [cytosol] (Gallus gallus)

NEDD4 [cytosol] (Plasmodium falciparum)

NEDD4 [cytosol] (Sus scrofa)

pub2 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_001271268.1, NP_001271267.1, NP_940682.2, NP_001271269.1, NP_001316141.1, NP_006145.2

OpenTargets

ENSG00000069869

GeneCards

P46934

HPA

ENSG00000069869-NEDD4

Ensembl

ENSG00000069869, ENSP00000422705, ENST00000338963, ENST00000435532, ENSP00000424827, ENSP00000345530, ENSP00000410613, ENST00000506154, ENST00000508342

PRO

P46934

Pharos - Targets

P46934

HMDB Protein

HMDBP09283

PDB

5C91, 5C7J, 2KQ0, 3B7Y, 4BE8, 2XBB, 4N7H, 2XBF, 2KPZ, 4BBN, 4N7F, 5AHT, 2M3O

Interactors (30)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BZD6 TMG4			0.815	5
UniProt:P51168 SCNN1B	1	SCNN1B [plasma membrane] (R-HSA-2671900)	0.806	7
UniProt:Q99732 LITAF			0.788	7
UniProt:Q9Y3C5 RNF11			0.786	7
UniProt:Q96B67 ARRD3			0.731	4
UniProt:P37088 SCNN1A	2	Ub-SCNN1A [plasma membrane] (R-HSA-2684930) SCNN1A [plasma membrane] (R-HSA-2671922)	0.683	3
UniProt:P11362 FGFR1	9	FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853241) FGFR1 K656E [plasma membrane] (R-HSA-1614373) FGFR1 N546K [plasma membrane] (R-HSA-1614377) FGFR1 R576W [plasma membrane] (R-HSA-2011844) p-6Y-FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853142) p-8Y-FGFR1 K656E [plasma membrane] (R-HSA-2023356) p-8Y-FGFR1 N546K [plasma membrane] (R-HSA-2023358) p-8Y- FGFR1 R576W [plasma membrane] (R-HSA-2023361) FGFR1 [plasma membrane] (R-HSA-9756433)	0.672	26
UniProt:Q96PN7 TREF1			0.623	2
UniProt:O15350 TP73	3	PolyUb-TP73 [cytosol] (R-HSA-8957256) TP73 [cytosol] (R-HSA-8957239) TP73 [nucleoplasm] (R-HSA-6798094)	0.623	2
UniProt:Q9GZQ8 MAP1LC3B	3	MAP1LC3B [autophagosome membrane] (R-HSA-5683641) MAP1LC3B(2-121) [cytosol] (R-HSA-5682674) MAP1LC3B [cytosol] (R-HSA-5205651)	0.623	2
UniProt:Q9P2Y5 UVRAG	2	UVRAG [cytosol] (R-HSA-5668884) UVRAG [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9730510)	0.623	2
UniProt:P60484 PTEN	20	K48polyUb-PTEN [cytosol] (R-HSA-8874327) PolyUb-PTEN [nucleoplasm] (R-HSA-6782515) PTEN H93R [cytosol] (R-HSA-2318524) PTEN C124R [cytosol] (R-HSA-2317439) PTEN H93Y [cytosol] (R-HSA-2318520) PTEN R130G [cytosol] (R-HSA-2317339) PTEN H93D [cytosol] (R-HSA-2318550) PTEN R130L [cytosol] (R-HSA-2317430) PTEN H93A [cytosol] (R-HSA-2318544) PTEN G129E [cytosol] (R-HSA-2318509) PTEN S170N [cytosol] (R-HSA-2318408) PTEN R173P [cytosol] (R-HSA-2317480) PTEN R130Q [cytosol] (R-HSA-2317416) PTEN H93Q [cytosol] (R-HSA-2318565) PTEN G129R [cytosol] (R-HSA-2318501) PTEN H123Y [cytosol] (R-HSA-2318469) PTEN S170R [cytosol] (R-HSA-2318437) PTEN R173C [cytosol] (R-HSA-2317478) PTEN R173H [cytosol] (R-HSA-2317473) PTEN C124S [cytosol] (R-HSA-2317379)	0.591	4
UniProt:O15165 LRAD4			0.59	4
UniProt:P0CG47 UBB	20	UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-109-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-185-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-215-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783002) Ub-63-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783148) Ub-139-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783012) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-181-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070)	0.59	2
UniProt:Q8N4L2 PP4P2			0.59	2
UniProt:Q9NW97 TMM51			0.59	3
UniProt:Q8TB68 PRR7			0.59	2
UniProt:Q15884 EREP1			0.59	4
UniProt:Q96PG2 M4A10			0.59	2
UniProt:Q16655 MLANA	1	MLANA [melanosome membrane] (R-HSA-9825829)	0.59	2
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.564	3
UniProt:Q13571 LAPM5			0.547	2
UniProt:Q5XX06 VP40			0.544	3
UniProt:P28282 UL56			0.544	8
UniProt:Q8N5I2 ARRD1			0.527	3
UniProt:P60520 GABARAPL2	3	GABARAPL2 [autophagosome membrane] (R-HSA-5683633) GABARAPL2(1-117) [cytosol] (R-HSA-5682641) GABARAPL2 [cytosol] (R-HSA-5671758)	0.525	6
UniProt:O95166 GABARAP	3	GABARAP [autophagosome membrane] (R-HSA-5683634) GABARAP(1-117) [cytosol] (R-HSA-5682696) GABARAP [cytosol] (R-HSA-975521)	0.525	6
UniProt:Q9H0R8 GABARAPL1	3	GABARAPL1 [autophagosome membrane] (R-HSA-5683637) GABARAPL1(1-117) [cytosol] (R-HSA-5682659) GABARAPL1 [cytosol] (R-HSA-5671757)	0.525	6
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	9
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.463	3

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